Dr Christian Ludwig

Dr Christian Ludwig

Institute of Metabolism and Systems Research
Lecturer in Metabolic Biophysics

Funded by: Higher Education Founding Council of England (HEFCE)

Career History

 2015  Lecturer for Metabolic Biophysics, University of Birmingham
 2008-2015      Scientific Officer for Biomolecular NMR Spectroscopy, University of Birmingham
 2004-2008              Computer Systems Architect (HWB-NMR), University of Birmingham
 2001-2004      Postdoctoral Research Fellow, St. George’s Hospital Medical School, London
 2001    PhD (Biochemistry), JWG University Frankfurt
 1995      Diploma (Biochemistry), JWB University Frankfurt

Research

Research in my group is focused on the development of novel experimental and analytical approaches to map metabolic pathway activities without necessarily assuming a particular metabolism model for a given cell type with a strong focus on studying metabolism of ex-vivo perfused kidneys.

The primary method we use and develop is NMR- and GC/MS-based metabolic pathway analysis and tracking stable isotope tracer-based metabolic flux (http://nmrlab.org.uk). These approaches are driving the growth of disease diagnostics through their ability to map and quantitate systems of metabolites which are linked to genetic and proteomic alterations. The approach would is geared to identify new pathways and metabolic responses. Mammalian cells present a diversity of complex metabolic networks that are compartmentalized and governed by poorly understood regulatory processes. Hence it is very difficult to predict the parts of the metabolic pathways that are important.

Our approach is based on Combined Analysis of NMR and MS Spectra (CANMS), leading to synergies which allow for the accurate identification of isotopomer distributions from key metabolites that can then be used as input for guiding metabolism simulation.

Group members

PhD Students: Jay Nath; Thomas Smith

Major collaborators

Dan Tennant (University of Birmingham), Marta Cascante (University of Barcelona), Adrian Harris (University of Oxford), Stefano Tiziani (University of Austen, Texas), Farhat Khanim (University of Birmingham), Ulrich Günther (University of Birmingham), Patrick Pollard (University of Edinburgh), Guy Pratt (University of Birmingham)

Publications

Selected Recent Publications

Nath J, Guy AJ, Smith TB, Cobbold M, Inston NG, Hodson J, Tennant DA, Ludwig C*, Ready AR*. Metabolomic Perfusate Analysis during Kidney Machine Perfusion: The Pig Provides an Appropriate Model for Human Studies. PLoS ONE, 2014, 9(12) DOI: 0.1371/journal.pone.0114818

Guy AJ, Nath J, Cobbold M, Ludwig C, Tennant DA, Inston NG, Ready AR. Metabolomic Analysis of Perfusate During Hypothermic Machine Perfusion of Human Cadaveric Kidneys. Transplantation, 2014. DOI: 10.1097/TP.0000000000000398

Adam J, Yang M, Bauerschmidt C, Kitagawa M, O'Flaherty L, Maheswaran P, Ozkan G, Sahgal N, Baban D, Kato K, Saito K, Iino K, Igarashi K, Stratford M, Pugh C, Tennant DA, Ludwig C, Davies B, Ratcliffe PJ, El-Bahrawy M, Ashrafian H, Soga T and Pollard PJ. A Role for Cytosolic Fumarate Hydratase in Urea Cycle Metabolism and Renal Neoplasia Cell Reports, 2013. 3(5):1440-1448 DOI: 10.1016/j.celrep.2013.04.006

View all publications in research portal