Dr Christian Ludwig

Christian Ludwig

Institute of Metabolism and Systems Research
Senior Lecturer in Metabolic Biophysics
IMSR Lead for Academic Integrity

Contact details

Address
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Funded by the Higher Education Founding Council of England (HEFCE)

Biography

Career History

  • 2015 - Lecturer for Metabolic Biophysics, University of Birmingham
  • 2008-2015 -Scientific Officer for Biomolecular NMR Spectroscopy, University of Birmingham
  • 2004-2008 - Computer Systems Architect (HWB-NMR), University of Birmingham
  • 2001-2004 - Postdoctoral Research Fellow, St. George’s Hospital Medical School, London
  • 2001- PhD (Biochemistry), JWG University Frankfurt
  • 1995- Diploma (Biochemistry), JWB University Frankfurt

Research

Research in Christian's group is focused on the development of novel experimental and analytical approaches to map metabolic pathway activities without necessarily assuming a particular metabolism model for a given cell type with a strong focus on studying metabolism of ex-vivo perfused kidneys.

The primary method the research group uses and is developing is NMR- and GC/MS-based metabolic pathway analysis and tracking stable isotope tracer-based metabolic flux (http://nmrlab.org.uk). These approaches are driving the growth of disease diagnostics through their ability to map and quantitate systems of metabolites which are linked to genetic and proteomic alterations. The approach would is geared to identify new pathways and metabolic responses. Mammalian cells present a diversity of complex metabolic networks that are compartmentalized and governed by poorly understood regulatory processes. Hence it is very difficult to predict the parts of the metabolic pathways that are important.

The research group's approach is based on Combined Analysis of NMR and MS Spectra (CANMS), leading to synergies which allow for the accurate identification of isotopomer distributions from key metabolites that can then be used as input for guiding metabolism simulation.

Group members

PhD Students: Jay Nath; Thomas Smith

Major collaborators

Dan Tennant (University of Birmingham), Marta Cascante (University of Barcelona), Adrian Harris (University of Oxford), Stefano Tiziani (University of Austen, Texas), Farhat Khanim (University of Birmingham), Ulrich Günther (University of Birmingham), Patrick Pollard (University of Edinburgh), Guy Pratt (University of Birmingham)

Publications

Recent publications

Article

Singhal, R, Tahrani, A, Ludwig, C & Mahawar, K 2020, 'Global 30-day outcomes of bariatric surgEry iN thE coVid-19 erA (The GENEVA Cohort Study)', The Lancet Diabetes and Endocrinology.

Schnelle, M, Chong, M, Zoccarato, A, Elkenani, M, Sawyer, GJ, Hasenfuss, G, Ludwig, C & Shah, AM 2020, 'In vivo [U-13C]glucose labeling to assess heart metabolism in murine models of pressure and volume overload', American Journal of Physiology-Heart and Circulatory Physiology, pp. 422-431. https://doi.org/10.1152/ajpheart.00219.2020

Jeeves, M, Roberts, J & Ludwig, C 2020, 'Optimised collection of non-uniformly sampled 2D-HSQC NMR spectra for use in metabolic flux analysis', Magnetic Resonance in Chemistry. https://doi.org/10.1002/mrc.5089

Titma, T, Shin, MJ, Ludwig, C, Günther, UL, Pikta, M, Zemtsovskaja, G, Viigimaa, M, Tanner, R & Samoson, A 2019, 'The metabolic profile of stable ischemic heart disease by serum 1H NMR', Applied Magnetic Resonance, vol. 50, no. 4, pp. 527-539. https://doi.org/10.1007/s00723-018-1084-0

Smith, T, Patel, K, Munford, H, Peet, A, Tennant, D, Jeeves, M & Ludwig, C 2018, 'High-Speed Tracer Analysis of Metabolism (HS-TrAM)', Wellcome Open Research. https://doi.org/10.12688/wellcomeopenres.13387.1

Oakey, LA, Fletcher, R, Elhassan, Y, Cartwright, D, Doig, C, Garten, A, Thakker, A, Maddocks, ODK, Zhang, T, Tennant, D, Ludwig, C & Lavery, G 2018, 'Metabolic tracing reveals novel adaptations to skeletal muscle cell energy production pathways in response to NAD+ depletion', Wellcome Open Research. https://doi.org/10.12688/wellcomeopenres.14898.1

Hollinshead, K, Munford, H, Eales, K, Bardella, C, Li, C, Escribano Gonzalez, C, Thakker, A, Nonnenmacher, Y, Kluckova, K, Jeeves, M, Murren, R, Cuozzo, F, Ye, D, Laurenti, G, Zhu, W, Hiller, K, Hodson, D, Hua, W, Tomlinson, I, Ludwig, C, Mao, Y & Tennant, D 2018, 'Oncogenic IDH1 mutations promote enhanced proline synthesis through PYCR1 to support the maintenance of mitochondrial redox homeostasis', Cell Reports, vol. 22, no. 12, pp. 3107–3114. https://doi.org/10.1016/j.celrep.2018.02.084

Duprey, J-LHA, Bassani, DM, Hyde, EI, Jonusauskas, G, Ludwig, C, Rodger, A, Spencer, N, Vyle, JS, Wilkie, J, Zhao, Z-Y & Tucker, JHR 2018, 'Rationalisation of a mechanism for sensing single point variants in target DNA using anthracene-tagged base discriminating probes', Organic and Biomolecular Chemistry, vol. 16, no. 35, pp. 6576-6585. https://doi.org/10.1039/c8ob01710g

Sahloul, M, Karim, A, Chohan, KS, Tahrani, AA, Mahawar, K, Richardson, M, Ludwig, C, Daskalakis, M & Singhal, R 2018, 'Roux-en-Y Gastric Bypass: Does the Direction of Staples Matter?', Obesity surgery, vol. 28, no. 9, pp. 2868-2873. https://doi.org/10.1007/s11695-018-3275-z

Patel, K, Smith, TB, Neil, DA, Thakker, A, Tsuchiya, Y, Higgs, EB, Hodges, NJ, Ready, AR, Nath, J & Ludwig, C 2018, 'The effects of oxygenation on ex vivo kidneys undergoing Hypothermic Machine Perfusion', Transplantation. https://doi.org/10.1097/TP.0000000000002542

Schober, D, Jacob, D, Wilson, M, Cruz, JA, Marcu, A, Grant, JR, Moing, A, Deborde, C, De Figueiredo, LF, Haug, K, Rocca-Serra, P, Easton, J, Ebbels, TMD, Hao, J, Ludwig, C, Günther, UL, Rosato, A, Klein, MS, Lewis, IA, Luchinat, C, Jones, AR, Grauslys, A, Larralde, M, Yokochi, M, Kobayashi, N, Porzel, A, Griffin, JL, Viant, MR, Wishart, DS, Steinbeck, C, Salek, RM & Neumann, S 2018, 'nmrML: A Community Supported Open Data Standard for the Description, Storage, and Exchange of NMR Data', Analytical Chemistry, vol. 90, no. 1, pp. 649-656. https://doi.org/10.1021/acs.analchem.7b02795

Chong, MG, Jayaraman, A, Marin, S, Selivanov, V, de Atauri Carulla, P, Tennant, D, Cascante, M, Gunther, U & Ludwig, C 2017, 'Combined Analysis of NMR and MS Spectra (CANMS)', Angewandte Chemie (International Edition) , vol. 56, no. 15, 201611634, pp. 4140-4144. https://doi.org/10.1002/anie.201611634

Reed, MAC, Singhal, R, Ludwig, C, Carrigan, JB, Ward, DG, Taniere, P, Alderson, D & Günther, UL 2017, 'Metabolomic Evidence for a Field Effect in Histologically Normal and Metaplastic Tissues in Patients with Esophageal Adenocarcinoma', Neoplasia, vol. 19, no. 3, pp. 165-174. https://doi.org/10.1016/j.neo.2016.11.003

Chapter

Heude, C, Nath, J, Carrigan, JB & Ludwig, C 2017, Nuclear magnetic resonance strategies for metabolic analysis. in Metabolomics: From Fundamentals to Clinical Applications. Advances in Experimental Medicine and Biology, vol. 965, Springer, pp. 45-76. https://doi.org/10.1007/978-3-319-47656-8_3

Working paper

Stanulović, VS, Reed, MAC, Patani, H, Potluri, S, Georgiadou, E, Roberts, J, Sarkar, S, Pratt, G, Jones, AM, Günther, U, Ludwig, C & Hoogenkamp, M 2020 'Proliferation and survival of T-cell acute lymphoblastic leukaemia depends on mTOR-regulated glutamine uptake and EAAT1-dependent conversion of glutamine to aspartate and nucleotides' bioRxiv. https://doi.org/10.1101/2020.02.08.939694

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