Dr Hannah R Nieto BSc MBBS MRCS PhD

Hannah Nieto

Institute of Metabolism and Systems Research
Academic Clinical Lecturer

Contact details

Address
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Hannah is an NIHR Academic Clinical Lecturer in Otorhinolaryngology (ENT surgery) working in the IMSR, supervised by Professor Chris McCabe and Mr Neil Sharma. Her interests are thyroid cancer, molecular genomics, bioinformatics and sequencing.

Qualifications

  • PhD in Molecular Biology, Univeristy of Birmingham, 2020
  • FRCS, Royal College of Surgeons England, 2021
  • MBBS, Imperial College London, 2009
  • BSc (Hons) in Medical Sciences with Surgery and Anaesthesia, Imperial College London, 2007

Biography

Hannah is an NIHR Academic Clinical Lecturer in Otorhinolaryngology (ENT surgery) working in the field of thyroid molecular genomics, with an interest in thyroid cancer and bioinformatics. She enjoys teaching, training junior doctors in theatre, clinics and other clinical settings, teaching regularly at the UoB early years small group teaching sessions and at the West Midlands Emergency ENT course. She is supervised in her current role by by Prof Chris McCabe and Mr Neil Sharma.

Teaching

  • Thyroid and HPA small group teaching sessions, University of Birmingham 2015 – current
  • ENT West Midlands emergency course 2019 – current
  • ITM fellowship teaching - weekly teaching medical students (year 3) on clincal examinations, 2015-2016
  • Anatomy demonstrator under Professor Peter Abrahams 2010 – 2011

Other activities

  • British Thyroid Association Executive committee, 2019 - current
  • Student & Foundation Doctors in Otolaryngology (SFO) committee academic representative,  2020 - present
  • ENT Head and Neck SpR at the Queen Elizabeth Hospital, Oct 2020 - current
  • ENT Higher Surgical Training Representative - Representing HST trainees at Health Education England West Midlands Regional HST meetings (and one HEE WM Postgraduate School of Surgery meeting), Oct 2018 – Oct 2020

Publications

Recent publications

Article

Zannat, R, Lee, J, Muzaffar, J, Read, M, Brookes, K, Sharma, N, Boelaert, K, McCabe, C & Nieto, H 2023, 'The potential interaction between medical treatment and radioiodine treatment success: A systematic review.', Frontiers in Endocrinology, vol. 13, 1061555. https://doi.org/10.3389/fendo.2022.1061555

Fletcher, A, Read, M, Thornton, C, Larner, D, Poole, V, Brookes, K, Nieto, H, Alshahrani, M, Thompson, R, Lavery, G, Landa, I, Fagin, JA, Campbell, MJ, Boelaert, K, Turnell, A, Smith, V & McCabe, C 2020, 'Targeting novel sodium iodide symporter interactors ADP-ribosylation factor 4 and valosin-containing protein enhances radioiodine uptake', Cancer Research, vol. 80, no. 1, pp. 102–115. https://doi.org/10.1158/0008-5472.CAN-19-1957

Alshahrani, M, Fletcher, A, Thornton, C, Brookes, K, Nieto, H, Thompson, R, Read, M, Boelaert, K, McCabe, C & Smith, V 2018, 'Biochemical analysis of radioiodine uptake enhancement in endocrine cancer', Endocrine Abstracts, vol. 59, OC2.4. https://doi.org/10.1530/endoabs.59.OC2.4

Read, M, Modasia, B, Fletcher, A, Thompson, R, Brookes, K, Rae, P, Nieto, H, Poole, V, Roberts, S, Campbell, M, Boelaert, K, Turnell, A, Smith, V, Mehanna, H & McCabe, C 2018, 'PTTG and PBF functionally interact with p53 and predict overall survival in head and neck cancer', Cancer Research, vol. 78, no. 20, pp. 5863-5876. https://doi.org/10.1158/0008-5472.CAN-18-0855

Abstract

Brookes, K, Zha, L, Kim, J, Small, B, Kocbiyik, M, Manivannan, S, Kannappan, V, Wang, W, Sunassee, K, Blower, P, Nieto, H, Smith, V, Read, M & McCabe, C 2023, 'Copper-based therapeutics increase sodium/iodide symporter (NIS) transcription and enhance radioiodide uptake in thyroid cancer cells', Endocrine Abstracts, vol. 90, OC11.1. https://doi.org/10.1530/endoabs.90.OC11.1

Read, M, Brookes, K, Zha, L, Thornton, C, Kim, J, Fletcher, A, Firth, G, Sunassee, K, Blower, P, Nieto, H, Smith, V & McCabe, C 2022, 'Dissecting endocytic mechanisms reveals new molecular targets to enhance sodium iodide symporter activity with clinical relevance to radioiodide therapy', Thyroid, vol. 32, no. S1, OC29, pp. A92-A92. https://doi.org/10.1089/thy.2022.29137.abstracts

Zha, L, Brookes, K, Thornton, C, Fletcher, A, Kim, J, Sunassee, K, Blower, P, Nieto, H, Smith, V, Read, M & McCabe, C 2022, 'Enhancing radioiodide uptake by addressing the mechanism of sodium/iodide symporter (NIS) endocytosis', Endocrine Abstracts, vol. 86, OC6.2. https://doi.org/10.1530/endoabs.86.OC6.2

Manivannan, S, Alshahrani, M, Thornton, C, Raja, S, Kocbiyik, M, Zha, L, Brookes, K, Nieto, H, Read, M, McCabe, C & Smith, V 2022, 'Promotion of thyroid cancer cell migration and invasion by the proto-oncogene PBF is mediated by FGD1 and N-WASP', Thyroid, vol. 32, no. S1, OC27, pp. A91-A91. https://doi.org/10.1089/thy.2022.29137.abstracts

Read, M, Brookes, K, Zha, L, Moolla, M, Kocbiyik, M, Manivannan, S, Hoare, R, Kannappan, V, Wang, W, Sunassee, K, Blower, P, Nieto, H, Smith, V & McCabe, C 2022, 'Repurposing disulfiram as a therapeutic agent to enhance sodium iodide symporter activity in radioiodide therapy', Endocrine Abstracts, vol. 86, OC2.6. https://doi.org/10.1530/endoabs.86.OC2.6

Brookes, K, Zha, L, Moolla, M, Kim, J, Kocbiyik, M, Manivannan, S, Nieto, H, Kannappan, V, Wang, W, Sunassee, K, Blower, P, Smith, V, Read, M & McCabe, C 2022, 'Repurposing of disulfiram and diethyldithiocarbamate (DDC)-metal complexes to enhance sodium iodide symporter function in radioiodide therapy', Thyroid, vol. 32, no. S1, OC40, pp. A96-A97. https://doi.org/10.1089/thy.2022.29137.abstracts

Thornton, C, Brookes, K, Fletcher, A, Nieto, H, Zha, L, Kocbiyik, M, Read, M, Smith, V & McCabe, C 2021, 'AP-2 and moesin regulate the internalisation of the sodium-iodide symporter and affect I125 Uptake in thyroid cancer cells', Endocrine Abstracts, vol. 77, OC6.4. https://doi.org/10.1530/endoabs.77.OC6.4

Read, M, Brookes, K, Thornton, C, Nieto, H, Zha, L, Fletcher, A, Boelaert, K, Smith, V & McCabe, C 2021, 'An emerging role for proteostasis modulators targeting NIS activity to enhance radioiodide therapy in thyroid cancer', Endocrine Abstracts, vol. 77, OC2.2. https://doi.org/10.1530/endoabs.77.OC2.2

Read, M, Brookes, K, Fletcher, A, Thornton, C, Alshahrani, M, Khan, R, Nieto, H, Adcock, H, Webster, J, Cox, L, Alderwick, L, Boelaert, K, Smith, V & McCabe, C 2020, 'Drug repurposing identifies inhibitors of the proteostasis network to augment radioiodine uptake in combinatorial approaches targeting thyroid cancer', Journal of the Endocrine Society, vol. 4, no. Issue Supplement 1, OR28-03. https://doi.org/10.1210/jendso/bvaa046.2135

Read, M, Modasia, B, Fletcher, A, Thompson, R, Brookes, K, Nieto, H, Campbell, M, Boelaert, K, Turnell, A, Smith, V, Mehanna, H & McCabe, C 2018, 'Oncogenic action of pituitary-tumor transforming gene (PBF) in head and neck cancer is associated with poorer overall survival', Endocrine Abstracts, vol. 59, P119. https://doi.org/10.1530/endoabs.59.P119

Preprint

Read, M, Brookes, K, Zha, L, Manivannan, S, Kim, J, Kocbiyik, M, Fletcher, A, Gorvin, CM, Firth, G, Fruhwirth, G, Nicola, J, Jhiang, S, Ringel, M, Campbell, M, Sunassee, K, Blower, P, Boelaert, K, Nieto, H, Smith, V & McCabe, C 2023 'Dissecting endocytic mechanisms reveals new molecular targets to enhance sodium iodide symporter activity with clinical relevance to radioiodide therapy' bioRxiv. https://doi.org/10.1101/2023.05.22.541733

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