Dr Hannah R Nieto BSc MBBS MRCS PhD

Hannah Nieto

Institute of Metabolism and Systems Research
Academic Clinical Lecturer

Contact details

Address
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Hannah is an NIHR Academic Clinical Lecturer in Otorhinolaryngology (ENT surgery) working in the IMSR, supervised by Professor Chris McCabe and Mr Neil Sharma. Her interests are thyroid cancer, molecular genomics, bioinformatics and sequencing.

Qualifications

  • PhD in Molecular Biology, Univeristy of Birmingham, 2020
  • FRCS, Royal College of Surgeons England, 2021
  • MBBS, Imperial College London, 2009
  • BSc (Hons) in Medical Sciences with Surgery and Anaesthesia, Imperial College London, 2007

Biography

Hannah is an NIHR Academic Clinical Lecturer in Otorhinolaryngology (ENT surgery) working in the field of thyroid molecular genomics, with an interest in thyroid cancer and bioinformatics. She enjoys teaching, training junior doctors in theatre, clinics and other clinical settings, teaching regularly at the UoB early years small group teaching sessions and at the West Midlands Emergency ENT course. She is supervised in her current role by by Prof Chris McCabe and Mr Neil Sharma.

Teaching

  • Thyroid and HPA small group teaching sessions, University of Birmingham 2015 – current
  • ENT West Midlands emergency course 2019 – current
  • ITM fellowship teaching - weekly teaching medical students (year 3) on clincal examinations, 2015-2016
  • Anatomy demonstrator under Professor Peter Abrahams 2010 – 2011

Other activities

  • British Thyroid Association Executive committee, 2019 - current
  • Student & Foundation Doctors in Otolaryngology (SFO) committee academic representative,  2020 - present
  • ENT Head and Neck SpR at the Queen Elizabeth Hospital, Oct 2020 - current
  • ENT Higher Surgical Training Representative - Representing HST trainees at Health Education England West Midlands Regional HST meetings (and one HEE WM Postgraduate School of Surgery meeting), Oct 2018 – Oct 2020

Publications

Recent publications

Article

Read, M, Brookes, K, Zha, L, Manivannan, S, Kim, J, Kocbiyik, M, Fletcher, A, Gorvin, CM, Firth, G, Fruhwirth, G, Nicola, J, Jhiang, S, Ringel, M, Campbell, M, Sunassee, K, Blower, P, Boelaert, K, Nieto, H, Smith, V & McCabe, C 2023, 'Combined Vorinostat and Chloroquine Inhibit Sodium Iodide Symporter Endocytosis and Enhance Radionuclide Uptake In Vivo', Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-23-2043

Zannat, R, Lee, J, Muzaffar, J, Read, M, Brookes, K, Sharma, N, Boelaert, K, McCabe, C & Nieto, H 2023, 'The potential interaction between medical treatment and radioiodine treatment success: A systematic review.', Frontiers in Endocrinology, vol. 13, 1061555. https://doi.org/10.3389/fendo.2022.1061555

Abstract

Brookes, K, Zha, L, Small, B, Kim, J, Manivannan, S, Thornton, C, Kannappan, V, Wang, W, Nieto, H, Sunassee, K, Blower, P, Smith, V, Read, M & McCabe, C 2023, 'A copper-based metabolite of disulfiram upregulates sodium iodide symporter (NIS) gene expression to enhance thyroidal uptake of radionuclides in vivo', Endocrine Abstracts, vol. 94, OC7.1. https://doi.org/10.1530/endoabs.94.OC7.1

Manivannan, S, Banga, D, Kocbiyik, M, Read, M, Zha, L, Brookes, K, Nieto, H, McCabe, C & Smith, V 2023, 'A critical role for the proto-oncogene PBF in regulating cellular adhesion and motility in thyroid cancer', Endocrine Abstracts, vol. 94, OC2.6. https://doi.org/10.1530/endoabs.94.OC2.6

Brookes, K, Zha, L, Kim, J, Small, B, Kocbiyik, M, Manivannan, S, Kannappan, V, Wang, W, Sunassee, K, Blower, P, Nieto, H, Smith, V, Read, M & McCabe, C 2023, 'Copper-based therapeutics increase sodium/iodide symporter (NIS) transcription and enhance radioiodide uptake in thyroid cancer cells', Endocrine Abstracts, vol. 90, OC11.1. https://doi.org/10.1530/endoabs.90.OC11.1

Manivannan, S, Kocbiyik, M, Alshahrani, M, El-Asrag, ME, Zha, L, Brookes, K, Nieto, H, Read, M, Beggs, A, McCabe, C & Smith, V 2023, 'Elucidating the mechanisms via which the proto-oncogene PBF stimulates cell motility in thyroid tumour progression', Thyroid Research, vol. 16, no. S1, PO2, pp. 6-6. https://doi.org/10.1186/s13044-023-00170-8

Manivannan, S, Kocbiyik, M, Alshahrani, M, EI-Asrag, M, Zha, L, Brookes, K, Nieto, H, Read, M, Beggs, A, McCabe, C & Smith, V 2023, 'Elucidating the mechanisms via which the proto-oncogene Pbf stimulates cell motility in thyroid tumor progression', Thyroid, vol. 33, no. S1, Poster 338, pp. A62-A62. https://doi.org/10.1089/thy.2023.29156.abstracts

Brookes, K, Zha, L, Kim, J, Kocbiyik, M, Manivannan, S, Sunassee, K, Blower, P, Nieto, H, Smith, V, Read, M & McCabe, C 2023, 'Exploiting endocytic factors as druggable targets to enhance sodium iodide symporter activity with clinical implications for radioiodide therapy', Thyroid Research, vol. 16, no. Supplement 1, OR4, pp. 4-4. https://doi.org/10.1186/s13044-023-00170-8

Brookes, K, Zha, L, Kim, J, Kocbiyik, M, Manivannan, S, Sunassee, K, Blower, P, Nieto, H, Smith, V, Read, M & McCabe, C 2023, 'Exploiting endocytic factors as druggable targets to enhance sodium iodide symporter activity with clinical implications for radioiodide therapy', Thyroid, vol. 33, no. S1, Poster 273, pp. A33-A34. https://doi.org/10.1089/thy.2023.29156.abstracts

Read, M, Brookes, K, Zha, L, Manivannan, S, Kim, J, Firth, G, Sunassee, K, Blower, P, Boelaert, K, Nieto, H, Smith, V & McCabe, C 2023, 'Manipulating NIS endocytosis as a druggable target to enhance radioiodide uptake and prognostic indictor of thyroid cancer recurrence', Endocrine Abstracts, vol. 94, OC2.1. https://doi.org/10.1530/endoabs.94.OC2.1

Zha, L, Brookes, K, Kim, J, Small, B, Kocbiyik, M, Manivannan, S, Nieto, H, Bottegoni, G, Cox, L, Kannappan, V, Wang, W, Sunassee, K, Blower, P, Smith, V, Read, M & McCabe, C 2023, 'Rational drug design of VCP inhibitors to enhance NIS function in radioiodide therapy', Thyroid Research, vol. 16, no. S1, OR3, pp. 4-4. https://doi.org/10.1186/s13044-023-00170-8

Read, M, Zha, L, Brookes, K, Kim, J, Small, B, Kocbiyik, M, Manivannan, S, Bottegoni, G, Cox, L, Kannappan, V, Wang, W, Sunassee, K, Blower, P, Nieto, H, Smith, V & McCabe, C 2023, 'Rational drug design of VCP inhibitors to enhance nis function in radioiodide therapy', Thyroid, vol. 33, no. S1, Oral 8, pp. A4-A4. https://doi.org/10.1089/thy.2023.29156.abstracts

Read, M, Brookes, K, Zha, L, Thornton, C, Kim, J, Fletcher, A, Firth, G, Sunassee, K, Blower, P, Nieto, H, Smith, V & McCabe, C 2022, 'Dissecting endocytic mechanisms reveals new molecular targets to enhance sodium iodide symporter activity with clinical relevance to radioiodide therapy', Thyroid, vol. 32, no. S1, OC29, pp. A92-A92. https://doi.org/10.1089/thy.2022.29137.abstracts

Preprint

Read, M, Brookes, K, Zha, L, Manivannan, S, Kim, J, Kocbiyik, M, Fletcher, A, Gorvin, CM, Firth, G, Fruhwirth, G, Nicola, J, Jhiang, S, Ringel, M, Campbell, M, Sunassee, K, Blower, P, Boelaert, K, Nieto, H, Smith, V & McCabe, C 2023 'Dissecting endocytic mechanisms reveals new molecular targets to enhance sodium iodide symporter activity with clinical relevance to radioiodide therapy' bioRxiv. https://doi.org/10.1101/2023.05.22.541733

Review article

Jamshaid, W, Jamshaid, M, Coulson, C, Sharma, N, Muzaffar, J & Nieto, H 2023, 'A systematic review on the efficacy of tranexamic acid in head and neck surgery', Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery, vol. 48, no. 4, pp. 527-539. https://doi.org/10.1111/coa.14059

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