Dr Cristina L Ronchi MD, PhD

Dr Cristina Ronchi

Institute of Metabolism and Systems Research
Reader in Endocrine Oncology

Contact details

Telephone
+44(0)121 414 8756
Email
c.l.ronchi@bham.ac.uk
Twitter
@CryRonchi
View my research portal
Address
Institute of Metabolism and System Research
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
B15 2TT

Cristina Ronchi is an Endocrinologist and clinician scientist with long-standing expertise in endocrine tumors. Her research field mostly focuses on genetic studies and investigations of molecular markers involved in the pathogenesis and prognosis of adrenocortical neoplasia.  She is particularly active in research dissemination and collaborates with several world-leading groups around Europe. Clinically active as a Consultant in Endocrinology, she actively participates in clinical trials. Dr Ronchi is regularly involved in teaching undergraduate and postgraduate students at the School of Medicine.

Qualifications

  • Reader in Endocrine Oncology (UK)
  • Honorary Consultant in Endocrinology 2018 (UK)
  • MsSc 2014 (Germany)
  • PhD 2008 (Italy)
  • CCT in Endocrinology & Diabetes 2005 (Italy)
  • MBChB 2000 (Italy)

Biography

Dr Ronchi studied medicine and obtained the Specialisation in Endocrinology at the University of Milan (Italy). From 2010 to 2017 she worked at the Division of Endocrinology at the University Hospital of Würzburg (Germany), where she also led the section “Translational Tumor Endocrinology”.

She has obtained several fellowships, prizes and grants as financial support for her projects. She has published more than 90 peer-reviewed journal articles and attended more than 110 national and international conferences as presenting author or invited speaker. Dr Ronchi is a member of four scientific societies and active as peer-reviewer for journals, grants and conferences.  She is member of the Editorial Board of JCEM, Endocrine Oncology and Frontiers Endocrinology. Dr Ronchi is head of the NAPACA working group of the European Network for the Study of Adrenal Tumours. Furthermore, she has been active in clinical activities as an Endocrinologist since 2005 and is involved in several clinical trials.  She regularly takes part in didactic activities including the supervision of undergraduate students.

Teaching

University of Birmingham, United Kingdom

Adrenal Lecture MBChB Year 1

SGT MBChB Year 1 and 2 (Adrenal, Endocrine Disorders)

Personal Academic Tutor MBChB Year 1 and 2 since 2019

Leader of MBChB Year 1 research Taster Experience

Undergraduate supervision: BMedSc (Clinical Sciences Intercalated Degree) course

 

University Hospital of Würzburg, Germany

Integrated Seminar “Endocrinological  Pathophysiology”- Medical School

Integrated Seminar “Tumorbiology” (Endocrine Tumors) - Medical School

Lection “Pathophysiology and Pathobiochemistry” (Endocrinology) - Biomedicine School

Lection “Clinical Chemistry und Laboratorium diagnostics” (Endocrinology) - Medical School

Seminar “Clinical Endocrinology” - Medical School

Lection and Seminar “Clinical Oncology” (Endocrinology) - Master in Biochemistry

Seminar “Rare Disease” (Endocrinology) - Medical School

Practical Seminar “Clinical cases” (Endocrinology) - Medical School

Postgraduate supervision

2013-2020 supervision of three MD Students (Esther Henning graduated 2020, Valeria Laufs graduated 2020, Raimunde Liang planned 2021)

2014-2020 Co-Supervision of two PhD Students

  • Juliane Lippert (collaboration with the Institute of Human Genetics, Würzburg, PhD planned for 2020)
  • Barbara Altieri (collaboration with the University of Rome, PhD finished 2019)

 Dr Ronchi is currently available for supervision of self-funded PhD students.

Research

  • Genetic studies in endocrine tumors.
  • Adrenocortical tumors: Pathogenesis of adrenocortical tumors and Cushing Syndrome. Prognostic and predictive molecular markers. Molecular targets for innovative cancer therapies. Precision medicine.
  • Pituitary tumors: patho-physiology, clinic characterisation and treatment.
  • Neuroendocrinology: patho-physiology, clinic and therapy of GH excess and deficiency. Therapeutic applications of somatostatin analogs. Regulation of ghrelin secretion in physiological and pathological conditions.

Other activities

  • 2022-present            Member of the Editorial Board of Journal Clinical Endocrinology & Metabolism
  • 2021-present            Member of the Editorial Board of Endocrine Oncology
  • 2021-present            Head of the Non Aldosterone-Producing AdrenoCortical Adenomas Scientific Board (ENS@T) 
  • 2019- present           Member of the Editorial Board of Precision Medicine Journal
  • 2018-present            Member of the IMSR Executive Board (UoB)
  • 2018-present            Member of the AdrenoCortical Carcinoma Scientific Board (ENS@T)
  • 2016-2021                Member of the Non Aldosterone-Producing AdrenoCortical Adenomas Scientific Board (ENS@T)
  • 2016-present            Member of the Editorial Board of the Journal of Endocrine Society
  • 2015-present            Member of the Reviewer Editorial Board of Frontiers in Endocrinology
  • 2018-2020                IMSR Seminar Organiser (UoB)
  • 2016-2018                Member of the Task Force on Personalised Medicine and Precision Oncology at the University Hospital of Wuerzburg (Germany)
  • 05/2014                    Qualification for Genetic Counselling (Germany)

Publications

Recent publications

Article

Deutschbein, T, Reimondo, G, Di Dalmazi, G, Bancos, I, Patrova, J, Vassiliadi, DA, Nekić, AB, Debono, M, Lardo, P, Ceccato, F, Petramala, L, Prete, A, Chiodini, I, Ivović, M, Pazaitou-panayiotou, K, Alexandraki, KI, Hanzu, FA, Loli, P, Yener, S, Langton, K, Spyroglou, A, Kocjan, T, Zacharieva, S, Valdés, N, Ambroziak, U, Suzuki, M, Detomas, M, Puglisi, S, Tucci, L, Delivanis, DA, Margaritopoulos, D, Dusek, T, Maggio, R, Scaroni, C, Concistrè, A, Ronchi, CL, Altieri, B, Mosconi, C, Diamantopoulos, A, Iñiguez-ariza, NM, Vicennati, V, Pia, A, Kroiss, M, Kaltsas, G, Chrisoulidou, A, Marina, LV, Morelli, V, Arlt, W, Letizia, C, Boscaro, M, Stigliano, A, Kastelan, D, Tsagarakis, S, Athimulam, S, Pagotto, U, Maeder, U, Falhammar, H, Newell-price, J, Terzolo, M & Fassnacht, M 2022, 'Age-dependent and sex-dependent disparity in mortality in patients with adrenal incidentalomas and autonomous cortisol secretion: an international, retrospective, cohort study', The Lancet Diabetes and Endocrinology. https://doi.org/10.1016/S2213-8587(22)00100-0

Elhassan, YS, Altieri, B, Berhane, S, Cosentini, D, Calabrese, A, Haissaguerre, M, Kastelan, D, Fragoso, MCBV, Bertherat, J, Al Ghuzlan, A, Haak, HR, Boudina, M, Canu, L, Loli, P, Sherlock, M, Kimpel, O, Laganà, M, Sitch, AJ, Kroiss, M, Arlt, W, Terzolo, M, Berruti, A, Deeks, J, Libe, R, Fassnacht, M & Ronchi, CL 2022, 'S-GRAS score for prognostic classification of adrenocortical carcinoma: an international, multicenter ENSAT study', European Journal of Endocrinology , vol. 186, no. 1, pp. 25-36. https://doi.org/10.1530/EJE-21-0510

Jouinot, A, Lippert, J, Sibony, M, Violon, F, Jeanpierre, L, De Murat, D, Armignacco, R, Septier, A, Perlemoine, K, Letourneur, F, Izac, B, Ragazzon, B, Leroy, K, Pasmant, E, North, M, Gaujoux, S, Dousset, B, Groussin, L, Libe, R, Terris, B, Fassnacht, M, Ronchi, CL, Bertherat, J & Assie, G 2022, 'Transcriptome in paraffin samples for the diagnosis and prognosis of adrenocortical carcinoma', European Journal of Endocrinology, vol. 186, no. 6, pp. 607-617. https://doi.org/10.1530/EJE-21-1228

Marquardt, A, Landwehr, L-S, Ronchi, C, Dalmazi, GD, Riester, A, Kollmannsberger, P, Altieri, B, Fassnacht, M & Sbiera, S 2021, 'Identifying new potential biomarkers in adrenocortical tumors based on mRNA expression data using machine learning', Cancers, vol. 13, no. 18, 4671. https://doi.org/10.3390/cancers13184671

Bothou, C, Sharma, A, Oo, A, Kim, B, Perge, P, Igaz, P, Ronchi, C, Shapiro, I & Hantel, C 2021, 'Novel insights into the molecular regulation of ribonucleotide reductase in adrenocortical carcinoma treatment', Cancers, vol. 13, no. 16, 4200. https://doi.org/10.3390/cancers13164200

Weigand, I, Ronchi, C, Vanselow, JT, Bathon, K, Lenz, K, Herterich, S, Schlosser, A, Kroiss, M, Fassnacht, M, Calebiro, D & Sbiera, S 2021, 'PKA Cα subunit mutation triggers caspase-dependent RIIβ subunit degradation via Ser114 phosphorylation', Science Advances, vol. 7, no. 8, eabd4176. https://doi.org/10.1126/sciadv.abd4176

Mueller, JW, Vogg, N, Lightning, TA, Weigand, I, Ronchi, C, Foster, P & Kroiss, M 2021, 'Steroid sulfation in adrenal tumors', Journal of Clinical Endocrinology and Metabolism, vol. 2021, no. 00, dgab182. https://doi.org/10.1210/clinem/dgab182

Lippert, J, Fassnacht, M & Ronchi, C 2021, 'The role of molecular profiling in adrenocortical carcinoma', Clinical Endocrinology. https://doi.org/10.1111/cen.14629

Majidi, F, Martino, S, Kondakci, M, Antke, C, Haase, M, Chortis, V, Arlt, W, Ronchi, C, Fassnacht, M, Laurent, C, Petit, J-M, Casasnovas, O, Habra, M, Kanji, A, Salvatori, R, Ho, ATN, Spyroglou, A, Beuschlein, F, Villa, D, Limvorapitak, W, Engelbrekt Wahlin, B, Gimm, O, Rudelius, M, Schott, M, Germing, U, Haas, R & Gattermann, N 2020, 'Clinical spectrum of primary adrenal lymphoma: results of a multicenter cohort study', European Journal of Endocrinology, vol. 183, no. 4, pp. 453–462. https://doi.org/10.1530/EJE-19-0506

Altieri, B, Sbiera, S, Herterich, S, De Francia, S, Della Casa, S, Calabrese, A, Pontecorvi, A, Quinkler, M, Kienitz, T, Mannelli, M, Canu, L, Angelousi, A, Chortis, V, Kroiss, M, Terzolo, M, Fassnacht, M & Ronchi, CL 2020, 'Effects of germline CYP2W1*6 and CYP2B6*6 single nucleotide polymorphisms on mitotane treatment in adrenocortical carcinoma: a multicenter ENSAT study', Cancers, vol. 12, no. 2, 359. https://doi.org/10.3390/cancers12020359, https://doi.org/10.3390/cancers12020359

Weigand, I, Altieri, B, Lacombe, A, Basile, V, Kircher, S, Landwehr, L-S, Schreiner, J, Zerbini, M, Ronchi, C, Megerle, F, Berruti, A, Canu, L, Volante, M, Paiva, I, Della Casa, S, Sbiera, S, Fassnacht, M, Fragoso, M, Terzolo, M & Kroiss, M 2020, 'Expression of SOAT1 in adrenocortical carcinoma and response to mitotane monotherapy: an ENSAT multicenter study', The Journal of clinical endocrinology and metabolism. https://doi.org/10.1210/clinem/dgaa293

Drougat, L, Settas, N, Ronchi, C, Bathon, K, Calebiro, D, Gutierrez, A, Haydar, S, Voutetakis, A, London, E, Faucz, FR & Stratakis, C 2020, 'Genomic and sequence variants of protein kinase A regulatory subunit type 1β (PRKAR1B) in patients with adrenocortical disease and Cushing syndrome', Genetics in Medicine. https://doi.org/10.1038/s41436-020-00958-1

Editorial

Ronchi, C & Altieri, B 2022, 'Special issue: Present and future of personalised medicine for endocrine cancers', Journal of Personalised Medicine , vol. 12, no. 5, 710. https://doi.org/10.3390/jpm12050710

Review article

Detomas, M, Pivonello, C, Pellegrini, B, Landwehr, L, Sbiera, S, Pivonello, R, Ronchi, CL, Colao, A, Altieri, B & De Martino, MC 2022, 'MicroRNAs and long non-coding RNAs in adrenocortical carcinoma', Cells, vol. 11, no. 14, 2234. https://doi.org/10.3390/cells11142234

Crona, J & Ronchi, C 2020, 'ENSAT registry-based randomized clinical trials for adrenocortical carcinoma', European Journal of Endocrinology. https://doi.org/10.1530/EJE-20-0800

View all publications in research portal