Dr Andreas Yiangou

Dr Andreas Yiangou

Department of Metabolism and Systems Science
Academic Clinical Lecturer Neurology

Contact details

Email
a.yiangou@bham.ac.uk
View my research portal
Address
Metabolic Neurology
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Dr Andreas Yiangou is a post-CCT Academic Clinical Lecturer in Neurology at the University of Birmingham and Honorary Stepping-up Consultant Neurologist at University Hospitals Birmingham. His clinical and research interests focus on headache disorders, idiopathic intracranial hypertension (IIH), cerebrospinal fluid disorders and the mechanisms linking intracranial pressure, metabolism and headache. 

Qualifications

  • CCT Neurology, GMC 2026
  • PhD, University of Birmingham 2025
  • MRCP (UK),Royal College of Physicians 2017
  • PGCert, Teaching & Learning in Clinical Practice, Edge Hill University 2016
  • MBBS, Barts and the London SMD, QMUL 2014
  • BSc (Hons) Biomedical Sciences, Kings College, University of London 2009

Biography

Dr Andreas Yiangou is a post-CCT Academic Clinical Lecturer in Neurology at the University of Birmingham and an Honorary Stepping-up Consultant Neurologist at University Hospitals Birmingham NHS Foundation Trust.

He completed his undergraduate medical training at Barts and The London School of Medicine and Dentistry before undertaking an Academic Foundation Programme in Liverpool. He subsequently joined the Birmingham neurology academic training programme as an Academic Clinical Fellow and later Academic Clinical Lecturer within the Lab Group led by Professor Alex Sinclair. 

He was awarded a Clinical Research Training Fellowship funded by the Association of British Neurologists and Guarantors of Brain to investigate the mechanisms driving headache in idiopathic intracranial hypertension (IIH). This work formed the basis of his PhD at the University of Birmingham and included the IIH Provoke randomised clinical trial investigating the role of calcitonin gene-related peptide (CGRP) and intracranial pressure physiology in IIH.

He completed specialist training and obtained his CCT in Neurology in 2026. He is currently continuing his academic work as a post-CCT Clinical Lecturer alongside an Honorary Stepping-up Consultant Neurologist role and will shortly aiming to commence a Consultant Neurologist post at University Hospitals Birmingham. His clinical interests include headache disorders, IIH and other cerebrospinal fluid disorders.

Research

Dr Yiangou's research focuses on understanding the mechanisms and developing new treatments for headache disorders and idiopathic intracranial hypertension (IIH), with particular interests in intracranial pressure physiology, trigeminovascular mechanisms, cerebrovascular haemodynamics and metabolic drivers of neurological disease.

His doctoral research included IIH Provoke, a randomised placebo-controlled human experimental study investigating the role of calcitonin gene-related peptide (CGRP) in headache in IIH. This work demonstrated that CGRP can provoke migraine-like headache in people with IIH and has contributed to understanding the relationship between headache biology and intracranial pressure.

He is involved in IIH Advance, investigating new therapeutic approaches targeting the metabolic and intracranial pressure mechanisms of IIH. His wider research includes mTBI-Predict, a multidisciplinary programme investigating biomarkers, mechanisms and outcomes following mild traumatic brain injury, alongside work examining headache following traumatic brain injury.

His broader research interests include novel headache therapeutics, physiological and biomarker approaches to intracranial pressure disorders and the translation of mechanistic studies into clinical trials.

Other activities

  • Specialty Registrar Neurology – Sandwell and West Birmingham Hospitals NHS Trust & Queen Elizabeth University Hospital Birmingham NHS Trust (2018 – present)
  • Academic Clinical Fellow Neurology - Sandwell and West Birmingham Hospitals NHS Trust (2016 – 2018)
  • Academic Foundation Doctor Medical Education – Aintree University Hospital NHS Trust, Liverpool (2014 -2016)
  • Simulation Teaching Fellow - Centre for Simulation and Patient Safety, Liverpool (2014 - 2016)
  • School of Medicine Recognised Teacher – University of Liverpool (2014 - 2016)

Publications

Recent publications

Article

Yiangou, A, Phu Do, T, Mollan, SP, Thaller, M, Mitchell, JL, Mugo, CW, Tsermoulas, G, Hill, LJ, Lucas, SJE, Ashina, M & Sinclair, AJ 2026, 'Calcitonin gene-related peptide induces headache attacks in people with idiopathic intracranial hypertension', Brain. https://doi.org/10.1093/brain/awag126

Yiangou, A, Phu Do, T, Grech, O, Mugo, CW, Thomas, CN, Gew, J, Lange, MG, Gee, M, Mollan, SP, Hill, LJ, Lucas, SJE, Ashina, M & Sinclair, AJ 2026, 'CGRP-provoked headache is associated with a neuroimmune signature in idiopathic intracranial hypertension', The Journal of Headache and Pain, vol. 27, no. 1, 159. https://doi.org/10.1186/s10194-026-02385-0

Hill, LJ, Begum, G, Thomas, CN, Hubbard, JC, Mugo, C, Alimajstorovic, Z, Botfield, HF, Lyons, HS, Thaller, M, Yiangou, A, Ludwig, C, Grech, O, Mitchell, JL, Mollan, SP & Sinclair, AJ 2026, 'Identifying MicroRNA Biomarkers in Idiopathic Intracranial Hypertension: A Pilot Study', Neurology, vol. 107, no. 1, e218162. https://doi.org/10.1212/WNL.0000000000218162

Berman, G, Yiangou, A, Thaller, M, Capewell, N, Holding, D, Tsermoulas, G, Sinclair, AJ, Blanch, RJ & Mollan, S 2026, 'Optical Coherence Tomography imaging device comparison study in papilloedema secondary to Idiopathic Intracranial Hypertension', Eye.

Grech, O, Mugo, W, Hill, LJ, Heaselgrave, SR, Alimajstorovic, Z, Yiangou, A, Lyons, HS, Mitchell, J, Lavery, GG, Fulton, D & Sinclair, AJ 2026, 'The metabolic consequences of evoked spreading depolarization in brain slices', Scientific Reports. https://doi.org/10.1038/s41598-026-37175-w

Mitchell, JL, Lyons, HS, Walker, JK, Yiangou, A, Thaller, M, Grech, O, Alimajstorovic, Z, Tsermoulas, G, Brock, K, Mollan, SP & Sinclair, AJ 2025, 'A randomized sequential cross-over trial evaluating five purportedly ICP-lowering drugs in idiopathic intracranial hypertension', Headache: The Journal of Head and Face Pain, vol. 65, no. 2, pp. 258-268. https://doi.org/10.1111/head.14897

Lyons, HS, Sassani, M, Brunger, H, Lake, A, Jefferies, B, Thaller, M, Yiangou, A, Homer, V, Dharm-Datta, S, Ellis, H, Matharu, M, Hill, LJ, Mitchell, JL & Sinclair, AJ 2025, 'Introduction of a classification interview for post-traumatic headache after concussion', Journal of Headache and Pain, vol. 26, no. 1, 206. https://doi.org/10.1186/s10194-025-02149-2

Sassani, M, Mitchell, JL, Yiangou, A, Davies, N, Sawlani, V, Mollan, SP, Wagshul, ME & Sinclair, AJ 2025, 'Non-invasive assessment of intracranial compliance in idiopathic intracranial hypertension: an MRI-ICP study', Eye (London, England). https://doi.org/10.1038/s41433-024-03547-7

Grech, O, Mitchell, JL, Lyons, HS, Yiangou, A, Thaller, M, Tsermoulas, G, Brock, K, Mollan, SP & Sinclair, AJ 2024, 'Effect of glucagon like peptide-1 receptor agonist exenatide, used as an intracranial pressure lowering agent, on cognition in Idiopathic Intracranial Hypertension', Eye, vol. 38, no. 7, pp. 1374-1379. https://doi.org/10.1038/s41433-023-02908-y

Yiangou, A, Weaver, SRC, Thaller, M, Mitchell, JL, Lyons, HS, Tsermoulas, G, Mollan, SP, Lucas, SJE & Sinclair, AJ 2024, 'The Impact of Valsalva Manoeuvres and Exercise on Intracranial Pressure and Cerebrovascular Dynamics in Idiopathic Intracranial Hypertension', Neuro-Ophthalmology, vol. 48, no. 2, pp. 122-133. https://doi.org/10.1080/01658107.2023.2281433

Alimajstorovic, Z, Mitchell, J, Yiangou, A, Hancox, T, Southam, A, Grech, O, Ottridge, R, Winder, C, Tahrani, A, Tan, TM, Mollan, S, Dunn, W & Sinclair, A 2023, 'Determining the role of novel metabolic pathways in driving intracranial pressure reduction after weight loss', Brain Communications, vol. 5, no. 5, fcad272. https://doi.org/10.1093/braincomms/fcad272

Yiangou, A, Mollan, S & Sinclair, A 2023, 'Idiopathic intracranial hypertension: a step change in understanding the disease mechanisms', Nature Reviews Neurology.

Abstract

Hill, L, Begum, G, Hubbard, J, Mugo, C, Botfield, H, Lyons, H, Thaller, M, Yiangou, A, Grech, O, Mitchell, J, Mollan, S & Sinclair, A 2025, 'Identifying candidate molecular biomarkers in idiopathic intracranial hypertension patients (P7-2.008)', Neurology, vol. 104, no. 7 Supplement 1, 4448. https://doi.org/10.1212/WNL.0000000000211678

Review article

Gew, J, Hyder, YF, Grech, O, Brunstetter, T, Tarver, W, Mason, SS, Gibson, CR, Polk, JD, Schneider, VS, van Baalen, M, Mitchell, JL, Yiangou, A, Mollan, SP & Sinclair, AJ 2026, 'Spaceflight-associated neuro-ocular syndrome (SANS): expert consensus on diagnosis and management', Eye. https://doi.org/10.1038/s41433-026-04651-6

UK mTBI Predict Consortium, Lyons, HS, Sassani, M, Thaller, M, Yiangou, A, Grech, O, Mollan, SP, Wilson, DR, Lucas, SJE, Mitchell, JL, Hill, LJ & Sinclair, AJ 2024, 'Evaluating the Phenotypic Patterns of Post-Traumatic Headache: A Systematic Review of Military Personnel', Military medicine. https://doi.org/10.1093/milmed/usae353

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