Dr Jamie Scriven MBChB, DTMH, MRes, PhD, FRCP, FHEA

• PGCert in Medical Education, University of Warwick 2022
• Fellow of the Royal College of Physicians 2020
• PhD in Tropical Medicine, Liverpool School of Tropical Medicine 2015
• MRes in Clinical Sciences, University of Liverpool 2011
• Diploma in Tropical Medicine and Hygiene, Liverpool School of Tropical Medicine 2007
• Membership of the Royal College of Physicians (UK), 2004
• MBChB, University of Edinburgh, 2001

Jamie Scriven trained in Medicine at the University of Edinburgh. Following clinical work in Scotland and Australia, and research in Bolivia and Papua New Guinea, he moved to the West Midlands in 2007 to train in Infectious Diseases.

In 2010 he gained a place on the Liverpool Wellcome Trust Clinical PhD programme, spending 3-years at the University of Cape Town, South Africa, studying brain specific immune responses in patients with HIV-associated cryptococcal meningitis. He gained his PhD in 2015 and has continued this work with further support from the MRC and NIH, focusing on host-directed immune therapy in cryptococcal meningitis and CSF immune responses in TB meningitis.

Developing new tests and therapies to improve neurological outcome in meningitis is a parallel research aim, and he is currently pursuing ideas to has secured NIH funding to develop non-invasive retinal imaging to diagnose and predict the development of raised intracranial pressure in Cryptococcal meningitis, and the use of transcranial doppler to better understand cerebral haemodynamics among patients with TB meningitis. He also has an interest in difficult to treat infections, and is the Birmingham Principal investigator for the SNAP trial (pragmatic platform RCT aiming to improve treatment of Staphylococcus aureus bacteraemia) and in 2016 spent time with the UK Health Security Agency investigating a outbreak of Mycobacterium chimaera blood stream infections, following cardiac surgery.

University of Birmingham, MBChB Y3 Specialty Lead for Infection
Personal Academic Tutor, University of Birmingham
Senior Academic Tutor, University Hospitals Birmingham
Guest lecturer, Liverpool School of Tropical Medicine, Warwick Medical School

Dr Scriven focuses primarily on translational research and clinical trials aiming to improve understanding and outcomes in meningitis, particularly in low-resource countries. 

Immune pathology and the development of host-directed therapy in Meningitis
During his doctoral work and since then, Dr Scriven has worked on a variety of projects in South Africa, Malawi and Uganda utilising techniques such as flow cytometry, proteomics and transcriptomics to improve understanding of host immune pathology in Cryptococcal and Tuberculous meningitis. These projects have been in collaboration with local researchers and collaborators from the London School of Hygiene and Tropical Medicine and University of Minnesota and have provided vital insights into the disease pathology of these conditions.

Improving the diagnosis and management of raised intracranial pressure in Cryptococcal meningitis
Adapting techniques from neuroscience and collaborating with experts in neuro-ophthalmology, Dr Scriven is currently working on projects in Uganda that are studying a variety of retinal imaging techniques to determine whether they can be used as non-invasive measures of raised intracranial pressure.

Understanding changes in cerebral haemodynamics and the development of stroke in TB meningitis
In collaboration with brain blood flow physiologists at the University of Birmingham, Dr Scriven is working on projects that use transcranial doppler to improve understanding of the relationship between cerebral haemodynamic changes, immune response, and stroke in patients with TB meningitis.

Use of metagenomic next-generation sequencing to improve diagnosis of brain infections
In collaboration with the Loman lab, the NIHR BBRC Infection and Acute Medicine theme, Dr Scriven has been involved in projects examining how next generation sequencing could be used to diagnose brain infections.

Mycobacterium chimaera infections following cardiac surgery
Working with Public Health England (now UK Health Security Agency) Dr Scriven led the clinical aspects of a public health investigation into an outbreak of disseminated Mycobacterial chimaera infections following cardiac surgery. This produced vital information on the spectrum of disease to inform clinicians and important data on outcome, highlighting the importance of repeat surgery to remove infected prosthetic material.