Professor Matthew Broome BSc (Hons), MBChB (Hons), PGCAP, PhD, PhD, FRCPsych

Professor Matthew Broome

School of Psychology
Professor of Psychiatry and Youth Mental Health
Director of the Institute for Mental Health

Contact details

Address
School of Psychology
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Youth Mental Health - Birmingham HeroesMatthew is an academic psychiatrist and Director of the Institute for Mental Health at the University.  He is a leader in the field of early psychosis and in the philosophy and ethics of mental health.

Qualifications

BSc (Hons), MBChB (Hons), PGCAP, PhD, PhD, FRCPsych

Matthew is medical doctor and who has undertaken postgraduate training in psychiatry.  He works clinically as Honorary Consultant Psychiatrist in Birmingham.  Matthew has PhDs in both Psychiatry (neuroimaging and cognitive neuropsychology) and in Philosophy.

Biography

Matthew studied as an undergraduate at the University of Birmingham, where he graduated with degrees in Neuropharmacology and in Medicine.  After working as a junior doctor in the University Hospitals in Birmingham, he moved to the South London and Maudsley NHS Foundation Trust to undertake training in postgraduate psychiatry at the Maudsley Hospital, Bethlem Royal Hospital, and the National Hospital for Neurology and Neurosurgery.  After attaining his MRCPsych, Matthew was clinical research fellow and subsequently Lecturer at the Institute of Psychiatry, where he undertook his first PhD. During this time, he helped the development of novel Early Intervention in Psychosis services in South London, and specifically the OASIS service for those who may be in the prodromal phase of illness.

 

In 2006, Matthew was appointed as Associate Clinical Professor of Psychiatry at the University of Warwick and, in 2013, Senior Clinical Research Fellow in Psychiatry at the University of Oxford.  He remains affiliated to St Hilda’s College and is a Distinguished Research Fellow in the Oxford Uehiro Centre for Practical Ethics, University of Oxford.  In 2017, he returned to the University of Birmingham to take up his current post. In parallel to his University role, Matthew is Honorary Consultant Psychiatrist to the East Birmingham Early Intervention in Psychosis service, part of Birmingham Women’s and Children’s NHS Foundation Trust, and is NIHR CRN West Midlands Clinical Research Lead.

Teaching

Matthew teaching on the School of Psychology undergraduate Psychology courses and is part of the leadership team for the Institute for Mental Health MSc in Mental Health. He co-leads (with Lisa Bortolotti) the module in the Philosophy and Ethics of Mental Health and Wellbeing.

Postgraduate supervision

Matthew is interested in supervising students in the following areas:

  • Delusions
  • Prodromal Psychosis and the ARMS/UHR
  • Mood instability and dysregulation
  • The relationship between autism and schizophrenia
  • Functional neuroimaging and psychiatry
  • Phenomenological psychopathology
  • Interdisciplinary mental health
  • Philosophy and ethics of mental health

Please contact Matthew directly.

Current Doctoral Research Students

Delfina Bilello

Joseph Houlders 

Aneela Khan

Eugenia Lancellotta

Noorit Larson

Lucy Prior

Rosa Ritunanno

Jess Williams

Post-doctoral Research Fellows

Clara Humpston

Isabel Morales-Munoz

Research

Research interests:

Early psychosis (first episode and prodrome), delusion formation, mood instability, autism and schizophrenia, GABA, psychiatric neuroimaging, phenomenological psychopathology,  philosophy and ethics of mental health, interdisciplinary mental health, youth mental health, medical humanities.

Researcher identifier numbers:

orcid.org/0000-0002-6963-8884
Scopus Author ID: 7006823993

Other activities

Matthew is Deputy Editor of The British Journal of Psychiatry, and editor for the Oxford University Press book series, International Perspectives in Philosophy and Psychiatry.

Matthew is an Executive Committee member of the International Association of Youth Mental Health. 

Publications

Google scholar  |  Researchgate.net

Edited books: 

Thompson, A.D., Broome, M.R., (forthcoming in 2020) Risk Factors for psychosis: Paradigms, mechanisms, and prevention.  Elsevier Press.

Stanghellini, G., Broome, M.R, Raballo, A., Fernandez, A.V., Fusar-Poli, P., Rosfort, R. (2019) The Oxford Handbook of Phenomenological Psychopathology.  Oxford University Press.

Broome, M.R., Bottlender, R., Rosler, M., Stieglitz, R-D. (2017) Manual for Assessment and Documentation of Psychopathology in Psychiatry.  Hogrefe.

Broome, M., Harland, R., Owen, G. S., & Stringaris, A. (2013). The Maudsley Reader in Phenomenological Psychiatry. Cambridge University Press.

Broome, M. R., Bortolotti, L. (2009). Psychiatry as cognitive neuroscience. Oxford University Press.

Peer-reviewed journal articles: 

2019

Marwaha, S., Briley, P. M., Perry, A., Rankin, P., DiFlorio, A., Craddock, N., ... Jones, L. (2019). Explaining why childhood abuse is a risk factor for poorer clinical course in bipolar disorder: a path analysis of 923 people with bipolar I disorder. Psychological Medicine. https://doi.org/10.1017/S0033291719002411

Modinos, G., Broome, M., & McGuire, PK. (2019). Neural circuitry of novelty salience processing in psychosis risk: association with clinical outcome. Schizophrenia bulletin. https://doi.org/10.1093/schbul/sbz089

 Leighton, S., Upthegrove, R., Krishnadas, R., Benros, M., Broome, M., Gkoutos, G., ... Mallikarjun, P. (2019). Development and validation of multivariable prediction models of remission, recovery and quality of life outcomes in people with first episode psychosis: a machine learning approach. The Lancet Digital Health. https://doi.org/10.1016/S2589-7500(19)30121-9

Pyle, M., Broome, M. R., Joyce, E., MacLennan, G., Norrie, J., Freeman, D., ... Morrison, A. P. (2019). Study protocol for a randomised controlled trial of CBT vs antipsychotics vs both in 14-18-year-olds: Managing Adolescent first episode Psychosis: a feasibility study (MAPS). Trials, 20(1), [395]. https://doi.org/10.1186/s13063-019-3506-1

Stanghellini, G., Broome, M., Fernandez, A., Fusar-Poli, P., Raballo, A., & Rosfort, R. (2019). The Oxford Handbook of Phenomenological Psychopathology. Oxford University Press.

De Cates, A., Catone, G., Bebbington, P., & Broome, M. (2019). Attempting to disentangle the relationship between impulsivity and longitudinal self-harm: Epidemiological analysis of United Kingdom household survey data. International Journal of Social Psychiatry, 65(2), 114-122. https://doi.org/10.1177/0020764019827986

Catone, G., Signoriello, S., Pisano, S., Siciliano, M., Russo, K., Marotta, R., ... Pascotto, A. (2019). Epidemiological pattern of bullying using a multi-assessment approach: Results from the Bullying and Youth Mental Health Naples Study (BYMHNS). Child Abuse and Neglect, 89, 18-28. https://doi.org/10.1016/j.chiabu.2018.12.018

Chen, R., Zhu, X., Wright, L., Drescher, J., Gao, Y., Wu, L., ... Broome, M. R. (2019). Suicidal ideation and attempted suicide amongst Chinese transgender persons: National population study. Journal of Affective Disorders, 245, 1126-1134. https://doi.org/10.1016/j.jad.2018.12.011

Humpston, C. S., Adams, R. A., Benrimoh, D., Broome, M. R., Corlett, P. R., Gerrans, P., ... Linden, D. E. J. (2019). From computation to the first-person: auditory-verbal hallucinations and delusions of thought interference in schizophrenia-spectrum psychoses. Schizophrenia bulletin, 45(Supplement 1), S56-S66. https://doi.org/10.1093/schbul/sby073

2018

Marwaha, S., Price, C., Scott, J., Weich, S., Cairns, A., Dale, J., ... Broome, M. (2018). Affective instability in those with and without mental disorders: a case control study. Journal of Affective Disorders, 241, 492-498. https://doi.org/10.1016/j.jad.2018.08.046

Bould, H., Carnegie, R., Allward, H., Bacon, E., Lambe, E., Sapseid, M., ... Munafo, M. (2018). Effects of exposure to bodies of different sizes on perception of and satisfaction with own body size: two randomized studies. Royal Society Open Science, 5, [171387]. https://doi.org/10.1098/rsos.171387

Mallikarjun, P., Lalousis, P. A., Dunne, T., Heinze, K., Reniers, R., Broome, M., ... Upthegrove, R. (2018). Aberrant salience network functional connectivity in auditory verbal hallucinations: a first episode psychosis sample. Translational Psychiatry, 8, [69]. https://doi.org/10.1038/s41398-018-0118-6, https://doi.org/10.1038/s41398-018-0118-6

Modinos, G., Şimşek, F., Horder, J., Bossong, M., Bonoldi, I., Azis, M., ... McGuire, P. (2018). Cortical GABA in Subjects at Ultra-High Risk of Psychosis: Relationship to Negative Prodromal Symptoms. International Journal of Neuropsychopharmacology, 21(2), 114-119. https://doi.org/10.1093/ijnp/pyx076

Modinos, G., Şimşek, F., Horder, J., Bossong, M., Bonoldi, I., Azis, M., ... McGuire, P. (2018). Prefrontal GABA levels, hippocampal resting perfusion and the risk of psychosis. Neuropsychopharmacology. https://doi.org/10.1038/s41386-017-0004-6

2017 

Passby, L. & Broome., M. (2017). Thought Disorder. British Journal of Psychiatry Advances.

de Cates, A. N., Rees, K., Jollant, F., Perry, B., Bennett, K., Joyce, K., Leyden E., Harmer C., Hawton K., van Heeringen K., Broome, M. R. (2017). Are neurocognitive factors associated with repetition of self-harm? A systematic review.  Neurosci Biobehav Rev72, 261-277. doi:10.1016/j.neubiorev.2016.10.032

James, A. C., & Broome, M. R. (2017). Antipsychotics in adolescent-onset psychosis: a work in progress. The Lancet Psychiatry4(8), e16-e17. doi:10.1016/S2215-0366(17)30287-0

Modinos, G., Şimşek, F., Horder, J., Bossong, M., Bonoldi, I., Azis, M., . . . McGuire, P. (2017). Cortical GABA In Subjects At Ultra-High Risk Of Psychosis: Relationship To Negative Prodromal Symptoms. International Journal of Neuropsychopharmacology. doi:10.1093/ijnp/pyx076

Moffa, G., Catone, G., Kuipers, J., Kuipers, E., Freeman, D., Marwaha, S., . . . Bebbington, P. (2017). Using Directed Acyclic Graphs in Epidemiological Research in Psychosis: An Analysis of the Role of Bullying in Psychosis.. Schizophrenia Bulletin. doi:10.1093/schbul/sbx013

Xi, Y., Chen, R., Yan, F., Ma, X., Rakofsky, J. J., Tang, L., . . . Broome, M. R. (2017). Low post-traumatic stress disorder rate in Chinese in Beijing, China.. Asian journal of psychiatry30, 79-83. doi:10.1016/j.ajp.2017.07.003 

2016

De Cates, A. N., & Broome, M. R. (2016). Can we use neurocognition to predict repetition of self-harm, and why might this be clinically useful? A perspective. Frontiers in Psychiatry7(JAN). doi:10.3389/fpsyt.2016.00007

Eyden, J., Winsper, C., Wolke, D., Broome, M. R., & MacCallum, F. (2016). A systematic review of the parenting and outcomes experienced by offspring of mothers with borderline personality pathology: Potential mechanisms and clinical implications. Clinical Psychology Review47, 85-105. doi:10.1016/j.cpr.2016.04.002

Heron, J., & Broome, M. (2016). ‘There’s the record, closed and final’: Rough for Theatre II as Psychiatric Encounter. Journal of Medical Humanities37(2), 171-181. doi:10.1007/s10912-015-9376-y

Humpston, C. S., & Broome, M. R. (2016). The Spectra of Soundless Voices and Audible Thoughts: Towards an Integrative Model of Auditory Verbal Hallucinations and Thought Insertion. Review of Philosophy and Psychology7(3), 611-629. doi:10.1007/s13164-015-0232-9

Majid, M., Tadros, M., Tadros, G., Singh, S., Broome, M. R., & Upthegrove, R. (2016). Young people who self-harm: a prospective 1-year follow-up study. Social Psychiatry and Psychiatric Epidemiology51(2), 171-181.

Marwaha, S., Gordon-Smith, K., Broome, M., Briley, P. M., Perry, A., Forty, L., . . . Jones, L. (2016). Affective instability, childhood trauma and major affective disorders. Journal of affective disorders190, 764-771.

Marwaha, S., Thompson, A., Upthegrove, R., & Broome, M. R. (2016). Fifteen years on - early intervention for a new generation. The British journal of Psychiatry: the journal of mental science209(3), 186-188.

Read, R., Moberly, N. J., Salter, D., & Broome, M. R. (2016). Concepts of Mental Disorders in Trainee Clinical Psychologists. Clinical Psychology and Psychotherapy. doi:10.1002/cpp.2013

Thompson, A., Marwaha, S., & Broome, M. R. (2016). At-risk mental state for psychosis: Identification and current treatment approaches. Advances in Psychiatric Treatment22(3), 186-193. doi:10.1192/apt.bp.115.015487

Toynbee, M., Al-Diwani, A. A., Clacey, J., & Broome, M. R. (2016). Should junior doctors strike? Journal of Medical Ethics42(3), 167-170.

Upthegrove, R., Broome, M. R., Caldwell, K., Ives, J., Oyebode, F., & Wood, S. J. (2016). Understanding auditory verbal hallucinations: A systematic review of current evidence. Acta Psychiatrica Scandinavica133(5), 352-367. doi:10.1111/acps.12531 

2015

Broome, M. R., & de Cates, A. (2015). Choosing death in depression: A commentary on 'Treatment-resistant major depressive disorder and assisted dying'. Journal of Medical Ethics. doi:10.1136/medethics-2015-102812

Broome, M. R., He, Z., Iftikhar, M., Eyden, J., & Marwaha, S. (2015). Neurobiological and behavioural studies of affective instability in clinical populations: a systematic review. Neuroscience and Biobehavioral Reviews51, 243-254.

Broome, M. R., Saunders, K. E., Harrison, P. J., & Marwaha, S. (2015). Mood instability: significance, definition and measurement. The British Journal of Psychiatry: the journal of mental science207(4), 283-285.

Catone, G., Marwaha, S., Kuipers, E., Lennox, B., Freeman, D., Bebbington, P., & Broome, M. (2015). Bullying victimisation and risk of psychotic phenomena: Analyses of British national survey data. The Lancet Psychiatry2(7), 618-624. doi:10.1016/S2215-0366(15)00055-3

Falkenberg, I., Chaddock, C., Murray, R. M., McDonald, C., Modinos, G., Bramon, E., Walshe, M., Broome., M., McGuire P., Allen, P. (2015). Failure to deactivate medial prefrontal cortex in people at high risk for psychosis. European Psychiatry: the journal of the Association of European Psychiatrists30(5), 633-640.

Gibbs, M., Winsper, C., Marwaha, S., Gilbert, E., Broome, M., & Singh, S. P. (2015). Cannabis use and mania symptoms: a systematic review and meta-analysis.. Journal of affective disorders171, 39-47.

Kristensen, Z. E., & Broome, M. R. (2015). Autistic Traits in an Internet Sample of Gender    Variant UK Adults. International Journal of Transgenderism16(4), 234-245. doi:10.1080/15532739.2015.1094436

Marwaha, S., Thompson, A., Bebbington, P., Singh, S. P., Freeman, D., Winsper, C., & Broome, M. R. (2015). Adult attention deficit hyperactivity symptoms and psychosis: Epidemiological evidence from a population survey in England. Psychiatry Research  229(1-2), 49-56. doi:10.1016/j.psychres.2015.07.075

Shaikh, M., Dutt, A., Broome, M. R., Vozmediano, A. G., Ranlund, S., Diez, A., . . . Bramon, E. (2015). Sensory gating deficits in the attenuated psychosis syndrome. Schizophrenia Research161(2-3), 277-282.

Stein, K., & Broome, M. R. (2015). Neuroprogression in schizophrenia: pathways and underpinning clinical staging and therapeutic corollaries. The Australian and New Zealand journal of psychiatry49(2), 183-184.

Valmaggia, L. R., Byrne, M., Day, F., Broome, M. R., Johns, L., Howes, O., . . . McGuire, P. K. (2015). Duration of untreated psychosis and need for admission in patients who engage with mental health services in the prodromal phase.. The British journal of Psychiatry: the journal of mental science207(2), 130-134.

Winton-Brown, T. T., Broome, M. R., Allen, P., Valli, I., Howes, O., Garety, P. A., . . . McGuire, P. (2015). Misattributing speech and jumping to conclusions: A longitudinal study in people at high risk of psychosis. European Psychiatry30(1), 32-37. doi:10.1016/j.eurpsy.2014.09.416 

2014

Barry, E., Broome, M., & Heron, J. (2014). Not I: Beckett and psychiatry -- psychiatry in literature. The British Journal of Psychiatry204(3), 239. doi:10.1192/bjp.bp.113.130120

Bortolotti, L., Broome, M. R., & Mameli, M. (2014). Delusions and Responsibility for Action: Insights from the Breivik Case. Neuroethics7(3), 377-382. doi:10.1007/s12152-013-9198-4

Broome, M., Heron, J., & Barry, E. (2014). Beckett and psychiatry - in 100 words. The British Journal of Psychiatry204(2), 150. doi:10.1192/bjp.bp.112.122804

Catone, G., Lindau, J. F., & Broome, M. R. (2014). Phenomenological psychopathology and the neurosciences. Journal of Psychopathology20(4), 358-365.

Fulford, K. W. M., Bortolotti, L., & Broome, M. (2014). Taking the long view: An emerging framework for translational psychiatric science. World Psychiatry13(2), 110-117. doi:10.1002/wps.20139

Goghari, V. M., Brett, C., Tabraham, P., Johns, L., Valmaggia, L., Broome, M., . . . McGuire, P. (2014). Spatial working memory ability in individuals at ultra high risk for psychosis. Journal of Psychiatric Research50(1), 100-105. doi:10.1016/j.jpsychires.2013.12.010

Marwaha, S., Broome, M. R., Bebbington, P. E., Kuipers, E., & Freeman, D. (2014). Mood instability and psychosis: analyses of British national survey data.. Schizophrenia bulletin40(2), 269-277.

Marwaha, S., He, Z., Broome, M., Singh, S. P., Scott, J., Eyden, J., & Wolke, D. (2014). How is affective instability defined and measured? A systematic review. Psychological Medicine44(9), 1793-1808.

Modinos, G., Allen, P., Frascarelli, M., Tognin, S., Valmaggia, L., Xenaki, L., . . . Fusar-Poli, P. (2014). Are we mapping psychosis risk? Neuroanatomical signature of affective disorders in subjects at ultra-high risk.. Psychological medicine44(16), 3491-3501.

Stanghellini, G., & Broome, M. R. (2014). Psychopathology as the basic science of psychiatry. The British journal of psychiatry : the journal of mental science205(3), 169-170. 

2013

Bortolotti, L., Broome, M. R., & Mameli, M. (2013). Delusions and Responsibility for Action: Insights from the Breivik Case. Neuroethics, 1-6. doi:10.1007/s12152-013-9198-4

Broome, M. R., Zányi, E., Hamborg, T., Selmanovic, E., Czanner, S., Birchwood, M., . . . Singh, S. P. (2013). A High-Fidelity Virtual Environment for the Study of Paranoia. Schizophrenia Research and Treatment2013, 1-7. doi:10.1155/2013/538185

Guo, S., Kendrick, K. M., Zhang, J., Broome, M., Yu, R., Liu, Z., & Feng, J. (2013). Brain-wide functional inter-hemispheric disconnection is a potential biomarker for schizophrenia and distinguishes it from depression. NeuroImage: Clinical2(1), 818-826. doi:10.1016/j.nicl.2013.06.008

Marwaha, S., Parsons, N., & Broome, M. (2013). Mood instability, mental illness and suicidal ideas: Results from a household survey. Social Psychiatry and Psychiatric Epidemiology48(9), 1431-1437. doi:10.1007/s00127-013-0653-7

Marwaha, S., Parsons, N., Flanagan, S., & Broome, M. (2013). The prevalence and clinical associations of mood instability in adults living in England: Results from the Adult Psychiatric Morbidity Survey 2007. Psychiatry Research205(3), 262-268. doi:10.1016/j.psychres.2012.09.036

McCarthy-Jones, S., Krueger, J., Larøi, F., Broome, M., & Fernyhough, C. (2013). Stop, look, listen: The need for philosophical phenomenological perspectives on auditory verbal hallucinations. Frontiers in Human Neuroscience, (MAR). doi:10.3389/fnhum.2013.00127

Ratcliffe, M., Broome, M. R., Smith, B., & Bowden, H. (2013). A Bad Case of the Flu? The Comparative Phenomenology of Depression and Somatic Illness. Journal of Consciousness Studies20(7-8), 198-218.

Shaikh, M., Hall, M. H., Schulze, K., Dutt, A., Li, K., Williams, I., Walshe M., Constante M., Broome M., . . . Bramon, E. (2013). Effect of DISC1 on the P300 waveform in psychosis. Schizophrenia Bulletin39(1), 161-167. doi:10.1093/schbul/sbr101 

2012

Allen, P., Luigjes, J., Howes, O. D., Egerton, A., Hirao, K., Valli, I., Kaimbitz, J., Fusar-Poli, P., Broome, M., McGuire, P. (2012). Transition to psychosis associated with prefrontal and subcortical dysfunction in ultra-high-risk individuals. Schizophrenia Bulletin38(6), 1268-1276. doi:10.1093/schbul/sbr194

Arcuri, S. M., Broome, M. R., Giampetro, V., Amaro Jr, E., Kircher, T. T. J., Williams, S. C. R., . . . McGuire, P. K. (2012). Faulty Suppression of Irrelevant Material in Patients with Thought Disorder Linked to Attenuated Frontotemporal Activation. Schizophrenia Research and Treatment2012, 1-12. doi:10.1155/2012/176290

Bortolotti, L., & Broome, M. R. (2012). Affective dimensions of the phenomenon of double bookkeeping in delusions. Emotion Review4(2), 187-191. doi:10.1177/1754073911430115

Broome, M. (2012). Reality, realness, and the natural attitude. Philosophy, Psychiatry and Psychology19(2), 115-118. doi:10.1353/ppp.2012.0022

Broome, M. R., Day, F., Valli, I., Valmaggia, L., Johns, L. C., Howes, O., . . . McGuire, P. K. (2012). Delusional ideation, manic symptomatology and working memory in a cohort at clinical high-risk for psychosis: A longitudinal study. European Psychiatry27(4), 258-263. doi:10.1016/j.eurpsy.2010.07.008

Broome, M., & Fusar-Poli, P. (2012). Philosophical issues in the prodromal phase of psychosis. Current Pharmaceutical Design18(4), 596-605. doi:10.2174/138161212799316190

Carletti, F., Woolley, J. B., Bhattacharyya, S., Perez-Iglesias, R., Fusar Poli, P., Valmaggia, L., . . . McGuire, P. K. (2012). Alterations in white matter evident before the onset of psychosis. Schizophrenia Bulletin38(6), 1170-1179. doi:10.1093/schbul/sbs053

Fifield, P., & Broome, M. (2012). Intimations of immortality. Philosophy, Psychiatry and Psychology19(2), 141-144. doi:10.1353/ppp.2012.0017

Lord, L. D., Allen, P., Expert, P., Howes, O., Broome, M., Lambiotte, R., . . . Turkheimer, F. E. (2012). Functional brain networks before the onset of psychosis: A prospective fMRI study with graph theoretical analysis. NeuroImage: Clinical1(1), 91-98. doi:10.1016/j.nicl.2012.09.008

Shaikh, M., Valmaggia, L., Broome, M. R., Dutt, A., Lappin, J., Day, F., . . . Bramon, E. (2012). Reduced mismatch negativity predates the onset of psychosis. Schizophrenia Research134(1), 42-48. doi:10.1016/j.schres.2011.09.022

Stoyanov, D., Stanghellini, G., & Broome, M. (2012). Conceptual issues in psychiatric neuroimaging: An update. Current Topics in Medicinal Chemistry12(21), 2348-2356. 

2011

Fusar-Poli, P., Broome, M. R., Matthiasson, P., Woolley, J. B., Mechelli, A., Johns, L. C., . . . McGuire, P. (2011). Prefrontal function at presentation directly related to clinical outcome in people at ultrahigh risk of psychosis. Schizophrenia Bulletin37(1), 189-198. doi:10.1093/schbul/sbp074

Fusar-Poli, P., Broome, M. R., Woolley, J. B., Johns, L. C., Tabraham, P., Bramon, E., . . . McGuire, P. (2011). Altered brain function directly related to structural abnormalities in people at ultra high risk of psychosis: Longitudinal VBM-fMRI study. Journal of Psychiatric Research45(2), 190-198. doi:10.1016/j.jpsychires.2010.05.012

Fusar-Poli, P., Crossley, N., Woolley, J., Carletti, F., Perez-Iglesias, R., Broome, M., . . . McGuire, P. (2011). White matter alterations related to p300 abnormalities in individuals at high risk for psychosis: An MRI-EEG study. Journal of Psychiatry and Neuroscience36(4), 239-248. doi:10.1503/jpn.100083

Fusar-Poli, P., Crossley, N., Woolley, J., Carletti, F., Perez-Iglesias, R., Broome, M., . . . McGuire, P. (2011). Gray matter alterations related to P300 abnormalities in subjects at high risk for psychosis: Longitudinal MRI-EEG study. NeuroImage55(1), 320-328. doi:10.1016/j.neuroimage.2010.11.075

Fusar-Poli, P., Howes, O. D., Allen, P., Broome, M., Valli, I., Asselin, M. C., . . . McGuire, P. (2011). Abnormal prefrontal activation directly related to pre-synaptic striatal dopamine dysfunction in people at clinical high risk for psychosis. Molecular Psychiatry16(1), 67-75. doi:10.1038/mp.2009.108

Fusar-Poli, P., Stone, J. M., Broome, M. R., Valli, I., Mechelli, A., McLean, M. A., . . . McGuire, P. K. (2011). Thalamic glutamate levels as a predictor of cortical response during executive functioning in subjects at high risk for psychosis. Archives of General Psychiatry68(9), 881-890. doi:10.1001/archgenpsychiatry.2011.46

Wuyts, P., Broome, M., & McGuire, P. (2011). Assessing the mental state through a blog: Psychiatry in the 21st century?. Psychiatrist35(10), 361-363. doi:10.1192/pb.bp.110.030825 

2010

Broome, M., & Bortolotti, L. (2010). What's wrong with mental disorders? Psychological Medicine40(11), 1783-1785. doi:10.1017/S0033291709992352

Broome, M. R., Bortolotti, L., & Mameli, M. (2010). Moral responsibility and mental illness: A case study. Cambridge Quarterly of Healthcare Ethics19(2), 179-187. doi:10.1017/S0963180109990442

Broome, M. R., Fusar-Poli, P., Matthiasson, P., Woolley, J. B., Valmaggia, L., Johns, L. C., . . . McGuire, P. K. (2010). Neural correlates of visuospatial working memory in the at-risk mental state. Psychological Medicine40(12), 1987-1999. doi:10.1017/S0033291710000280

Broome, M. R., Matthiasson, P., Fusar-Poli, P., Woolley, J. B., Johns, L. C., Tabraham, P., . . . McGuire, P. K. (2010). Neural correlates of movement generation in the 'at-risk mental state'. Acta Psychiatrica Scandinavica122(4), 295-301. doi:10.1111/j.1600-0447.2009.01524.x

Fusar-Poli, P., Broome, M. R., Matthiasson, P., Woolley, J. B., Johns, L. C., Tabraham, P., . . . McGuire, P. (2010). Spatial working memory in individuals at high risk for psychosis: Longitudinal fMRI study. Schizophrenia Research123(1), 45-52. doi:10.1016/j.schres.2010.06.008

Fusar-Poli, P., Broome, M., & Stanghellini, G. (2010). From Brentano to mirror neurons: Bridging phenomenology and clinical neuroscience. Psychiatry Research - Neuroimaging183(3), 245-246. doi:10.1016/j.pscychresns.2010.02.002

Fusar-Poli, P., Howes, O. D., Allen, P., Broome, M., Valli, I., Asselin, M. C., . . . McGuire, P. K. (2010). Abnormal frontostriatal interactions in people with prodromal signs of psychosis: A multimodal imaging study. Archives of General Psychiatry67(7), 683-691. doi:10.1001/archgenpsychiatry.2010.77

Johns, L. C., Allen, P., Valli, I., Winton-Brown, T., Broome, M., Woolley, J., . . . McGuire, P. (2010). Impaired verbal self-monitoring in individuals at high risk of psychosis. Psychological Medicine40(9), 1433-1442. doi:10.1017/S0033291709991991

Pretorius, J. L., Albeniz, A., & Broome, M. (2010). Olive Tree community treatment centre for individuals with personality disorder: Naturalistic service evaluation. Psychiatrist34(1), 12-20. doi:10.1192/pb.bp.108.023192 

2009

Benetti, S., Mechelli, A., Picchioni, M., Broome, M., Williams, S., & McGuire, P. (2009). Functional integration between the posterior hippocampus and prefrontal cortex is impaired in both first episode schizophrenia and the at risk mental state. Brain132(9), 2426-2436. doi:10.1093/brain/awp098

Bortolotti, L., & Broome, M. (2009). A role for ownership and authorship in the analysis of thought insertion. Phenomenology and the Cognitive Sciences8(2), 205-224. doi:10.1007/s11097-008-9109-z

Broome, M. R., & Carel, H. (2009). The Ubiquity of Moods. Philosophy, Psychiatry and Psychology16(3), 267-271. doi:10.1353/ppp.0.0246

Broome, M. R., Matthiasson, P., Fusar-Poli, P., Woolley, J. B., Johns, L. C., Tabraham, P., . . . McGuire, P. K. (2009). Neural correlates of executive function and working memory in the 'at-risk mental state'. British Journal of Psychiatry194(1), 25-33. doi:10.1192/bjp.bp.107.046789

Crossley, N. A., Mechelli, A., Fusar-Poli, P., Broome, M. R., Matthiasson, P., Johns, L. C., . . . McGuire, P. K. (2009). Superior temporal lobe dysfunction and frontotemporal dysconnectivity in subjects at risk of psychosis and in first-episode psychosis. Human Brain Mapping30(12), 4129-4137. doi:10.1002/hbm.20834

Fusar-Poli, P., Broome, M., Barale, F., & Stanghellini, G. (2009). Why is psychiatric imaging clinically unreliable? Epistemological perspectives in clinical neuroscience. Psychotherapy and Psychosomatics78(5), 320-321. doi:10.1159/000229771

Fusar-Poli, P., Howes, O., Valli, I., Allen, P., Broome, M., Grasby, P., & McGuire, P. (2009). Multimodal functional imaging investigation before and after the onset of psychosis. International Journal of Neuropsychopharmacology12(4), 579-581. doi:10.1017/S146114570800953X

Harland, R., Antonova, E., Owen, G. S., Broome, M., Landau, S., Deeley, Q., & Murray, R. (2009). A study of psychiatrists' concepts of mental illness. Psychological Medicine39(6), 967-976. doi:10.1017/S0033291708004881

Howes, O. D., Montgomery, A. J., Asselin, M. C., Murray, R. M., Valli, I., Tabraham, P., . . . Grasby, P. M. (2009). Elevated striatal dopamine function linked to prodromal signs of schizophenia. Archives of General Psychiatry66(1), 13-20. doi:10.1001/archgenpsychiatry.2008.514

Valmaggia, L. R., McCrone, P., Knapp, M., Woolley, J. B., Broome, M. R., Tabraham, P., . . . McGuire, P. K. (2009). Economic impact of early intervention in people at high risk of psychosis. Psychological Medicine39(10), 1617-1626. doi:10.1017/S0033291709005613

Zányi, E., Selmanovic, E., Broome, M., Czanner, S., Birchwood, M., Chalmers, A., & Singh, S. (2009). Interactive highly realistic virtual reality as a tool for understanding the genesis and treatment of psychotic symptoms. Annual Review of CyberTherapy and Telemedicine7(1), 138-140. 

2008

Bortolotti, L., & Broome, M. R. (2008). Delusional beliefs and reason giving. Philosophical Psychology21(6), 821-841. doi:10.1080/09515080802516212

Bramon, E., Shaikh, M., Broome, M., Lappin, J., Bergé, D., Day, F., . . . McGuire, P. (2008). Abnormal P300 in people with high risk of developing psychosis. NeuroImage41(2), 553-560. doi:10.1016/j.neuroimage.2007.12.038

Broome, M. R. (2008). Philosophy as the Science of Value: Neo-Kantianism as a Guide to Psychiatric Interviewing. Philosophy, Psychiatry and Psychology15(2), 107-116. doi:10.1353/ppp.0.0172

Broome, M. R., Johns, L. C., Valli, I., Woolley, J. B., Tabraham, P., Brett, C., . . . McGuire, P. K. (2007). Delusion formation and reasoning biases in those at clinical high risk for psychosis. British Journal of Psychiatry191(SUPPL. 51). doi:10.1192/bjp.191.51.s38

Fu, C. H. Y., Brammer, M. J., Yágüez, L., Allen, P., Matsumoto, K., Johns, L., Broome, M.,  McGuire, P. K. (2008). Erratum to "Increased superior temporal activation associated with external misattributions of self-generated speech in schizophrenia" [Schizophrenia Research 100 (1-3) 361-363] (DOI:10.1016/j.schres.2007.10.023). Schizophrenia Research105(1-3), 384. doi:10.1016/j.schres.2008.07.009

Fu, C. H. Y., Brammer, M. J., Yágüez, L., Allen, P., Matsumoto, K., Johns, L., . . . van Haren, N. (2008). Increased superior temporal activation associated with external misattributions of self-generated speech in schizophrenia. Schizophrenia Research100(1-3), 361-363. doi:10.1016/j.schres.2007.10.023 

2007

Beckford, L., & Broome, M. R. (2007). Ethics and the payment of research subjects. Psychiatry6(2), 83-85. doi:10.1016/j.mppsy.2006.11.001

Bortolotti, L., & Broome, M. R. (2007). If You Did Not Care, You Would Not Notice: Recognition and Estrangement in Psychopathology. Philosophy, Psychiatry and Psychology14(1), 39-42.

Fusar-Poli, P., Broome, M. R., Matthiasson, P., Williams, S. C. R., Brammer, M., & McGuire, P. K. (2007). Effects of acute antipsychotic treatment on brain activation in first episode psychosis: An fMRI study. European Neuropsychopharmacology17(6-7), 492-500. doi:10.1016/j.euroneuro.2007.01.003

Fusar-Poli, P., & Broome, M. R. (2007). Love and brain: From mereological fallacy to "folk" neuroimaging. Psychiatry Research - Neuroimaging154(3), 285-286. doi:10.1016/j.pscychresns.2006.11.001

Fusar-Poli, P., Perez, J., Broome, M., Borgwardt, S., Placentino, A., Caverzasi, E., . . . McGuire, P. (2007). Neurofunctional correlates of vulnerability to psychosis: A systematic review and meta-analysis. Neuroscience and Biobehavioral Reviews31(4), 465-484. doi:10.1016/j.neubiorev.2006.11.006

Howes, O. D., Weinstein, S., Tabraham, P., Valmaggia, L., Broome, M., & McGuire, P. (2007). Slang and schizophrenia. British Medical Journal335(7633), 1294.

Lappin, J. M., Morgan, K. D., Valmaggia, L. R., Broome, M. R., Woolley, J. B., Johns, L. C., . . . McGuire, P. K. (2007). Insight in individuals with an At Risk Mental State. Schizophrenia Research90(1-3), 238-244. doi:10.1016/j.schres.2006.11.018

Picchioni, M., Matthiasson, P., Broome, M., Giampietro, V., Brammer, M., Mathes, B., . . . McGuire, P. (2007). Medial temporal lobe activity at recognition increases with the duration of mnemonic delay during an object working memory task. Human Brain Mapping28(11), 1235-1250. doi:10.1002/hbm.20357

Valmaggia, L. R., Freeman, D., Green, C., Garety, P., Swapp, D., Antley, A., Precott, C., Fowler, D., Kuipers, E.,  Bebbington, P., Slater, M.,  .Broome, M.,  McGuire, P. K. (2007). Virtual reality and paranoid ideations in people with an 'at-risk mental state' for psychosis. Br J Psychiatry Suppl51, s63-s68. doi:10.1192/bjp.191.51.s63 

2006

Broome, M. (2006). Taxonomy and Ontology in Psychiatry: A Survey of Recent Literature. Philosophy, Psychiatry and Psychology13(4), 303-319. doi:10.1353/ppp.2007.0026

Fusar-Poli, P., & Broome, M. R. (2006). Conceptual issues in psychiatric neuroimaging. Current Opinion in Psychiatry19(6), 608-612. doi:10.1097/01.yco.0000245750.98749.1b 

2005

Broome, M. R. (2005). Suffering and Eternal Recurrence of the Same: The Neuroscience, Psychopathology, and Philosophy of Time. Philosophy, Psychiatry and Psychology12(3), 187-194. doi:10.1353/ppp.2006.0001

Broome, M. R., Woolley, J. B., Johns, L. C., Valmaggia, L. R., Tabraham, P., Gafoor, R., . . . McGuire, P. K. (2005). Outreach and support in south London (OASIS): Implementation of a clinical service for prodromal psychosis and the at risk mental state. European Psychiatry20(5-6), 372-378. doi:10.1016/j.eurpsy.2005.03.001

Broome, M. R., Woolley, J. B., Tabraham, P., Johns, L. C., Bramon, E., Murray, G. K., . . . Murray, R. M. (2005). What causes the onset of psychosis? Schizophrenia Research79(1), 23-34. doi:10.1016/j.schres.2005.02.007 

2004

Allen, P. P., Johns, L. C., Fu, C. H. Y., Broome, M. R., Vythelingum, G. N., & McGuire, P. K. (2004). Misattribution of external speech in patients with hallucinations and delusions. Schizophrenia Research69(2-3), 277-287. doi:10.1016/j.schres.2003.09.008

Bebbington, P. E., & Broome, M. R. (2004). Exploiting the interface between philosophy and psychiatry. International Review of Psychiatry16(3), 179-183. doi:10.1080/09540260400003834

Broome, M. R. (2004). A neuroscience of hysteria?. Current Opinion in Psychiatry17(6), 465-469. doi:10.1097/00001504-200411000-00008

Broome, M. R. (2004). The Rationality of Psychosis and Understanding the Deluded. Philosophy, Psychiatry and Psychology11(1), 35-41. doi:10.1353/ppp.2004.0035 

2003

Kuperberg, G. R., Broome, M. R., McGuire, P. K., David, A. S., Eddy, M., Ozawa, F., . . . Fischl, B. (2003). Regionally localized thinning of the cerebral cortex in schizophrenia. Archives of General Psychiatry60(9), 878-888. doi:10.1001/archpsyc.60.9.878 

2001

Kircher, T. T. J., Bulimore, E. T., Brammer, M. J., Williams, S. C. R., Broome, M. R., Murray, R. M., & McGuire, P. K. (2001). Differential activation of temporal cortex during sentence completion in schizophrenic patients with and without formal thought disorder. Schizophrenia Research50(1-2), 27-40. doi:10.1016/S0920-9964(00)00042-6 

1994

Broome, M. R., Collingridge, G. L., & Irving, A. J. (1994). Activation of the NO-cGMP signalling pathway depresses hippocampal synaptic transmission through an adenosine receptor-dependent mechanism. Neuropharmacology33(11), 1511-1513. doi:10.1016/0028-3908(94)90056-6 

Book chapters: 

Sullivan-Bissett, E.,  Bortolotti, L., Broome, M.,  Mameli, M., (2016). Moral and legal    implications of the continuity between delusional and non-delusional beliefs. In G. Keil, L. Keuk & R. Hauswald (Eds), Vagueness in Psychiatry. Oxford University Press.

Humpston, C., & Broome, M. R. (2016). Perplexity. In G. Stanghellini, & M. Aragona (Eds.), An Experiential Approach to Psychopathology (pp. 245-264). Springer.

Bluhm, R., Raczek, M., Broome, M. R., & Wall, M. B. (2015). Ethical issues in brain imaging in psychiatry. In J. Z. Sadler, C. W. Staden, & K. W. M. Fulford (Eds.), Oxford Handbook of Psychiatric Ethics. Oxford University Press, USA.

Sabbarton-Leary, N., Bortolotti, L., & Broome, M. R. (2015). Natural and Para-natural Kinds in Psychiatry.. In P. Zachar, D. S. Stoyanov, M. Aragona, & A. Jablensky (Eds.), Alternative Perspectives in Psychiatric Validation (pp. 76-93). Oxford: Oxford University Press.

Miyazono, K., Bortolotti, L., & Broome, M. R. (2014). Prediction-error and two-factor theories of delusion formation: competitors or allies?. In N. Galbraith (Ed.), Aberrant Beliefs and Reasoning (pp. 34-54). Psychology Press.

Broome, M. R., Fusar-Poli, P., & Wuyts, P. (2013). Conceptual and Ethical Issues in the Prodromal Phase of Psychosis. In K. W. M. Fulford, M. Davies, R. Gipps, G. Graham, J. Z. Sadler, G. Stanghellini, & T. Thornton (Eds.), The Oxford Handbook of Philosophy and Psychiatry (pp. 779-802). Oxford University Press.

Broome, M. R. (2013). Jaspers and Neuroscience. In G. Stanghellini, & T. Fuchs (Eds.), One Century of Karl Jaspers' General Psychopathology (pp. 121-132). Oxford: Oxford University Press.

Kamatchi, R., & Broome, M. R. (2013). Complexity and the Onset of Psychosis. In C. Martin, & J. P. Sturmberg (Eds.), Handbook of Systems and Complexity in Health (pp. 317-333). Springer Science & Business Media.

Bortolotti, L., Cox, R., Broome, M. R., & Mameli, M. (2012). Rationality and self-knowledge in delusions and confabulations: implications for autonomy as self-governance. In L. Radoiliska (Ed.), Autonomy and Mental Disorder (pp. 100-122). Oxford: Oxford University Press.

Ratcliffe, M., & Broome, M. (2012). Existential phenomenology, psychiatric illness, and the death of possibilities. In S. Crowell (Ed.), The Cambridge Companion to Existentialism (pp. 361-382). Cambridge, UK: Cambridge University Press. doi:10.1017/CCOL9780521513340.018

Broome, M. R., & McGuire, P. K. (2008). Imaging and Delusions. In D. Freeman, R. Bentall, & P. Garety (Eds.), Persecutory Delusions: Assessment, Theory, and Treatment (pp. 281-304). Oxford: Oxford University Press.

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Expertise

I am a psychiatrist interested in the onset of mental disorders in young people. I have worked largely in the area of early psychosis, and am also interested in mood instability, autism, bullying, suicide and self-harm, and the philosophy and ethics of mental health.

  • Mental illness
  • Mental illness in young people
  • Early psychosis (especially high-risk)
  • Philosophy and ethics in mental health
  • Mood instability
  • Autism
  • Suicide and self-harm
  • Cognitive neuropsychology

Policy experience