Professor Rachel Upthegrove MBBS, FRCPsych, PhD

Professor Rachel Upthegrove

School of Psychology
Professor of Psychiatry and Youth Mental Health
Consultant Psychiatrist Early Intervention in Psychosis

Contact details

School of Psychology
University of Birmingham
B15 2TT

Rachel is Professor of Psychiatry and Youth Mental Health at the University of Birmingham, and Consultant Psychiatrist in the Birmingham Early Intervention Services. Her research Interest is within the field of major mental illness; particularly schizophrenia and co-morbid depression in early phases of illness. Recent projects have developed the investigation of inflammatory models of psychosis and machine learning in prognostic indicators in early phases of developing mental ill health.


  • PhD Birmingham 2011
  • MPhil Birmingham 2001
  • FRCPsych 2017
  • MRCPsych 1999
  • MBBS University of London, Royal Free Hospital School of Medicine 1994


Postgraduate supervision

Professor Upthegrove's primary research interests and background encompass the investigation of schizophrenia and psychosis, with particular emphasis on translational research, transdiagnostic psychoimmunology and new treatments. She is happy to research doctoral projects on these themes.

Other activities

  • NIHR CRN Specialty Lead for the West Midlands
  • Council Member of the British Association for Psychopharmacology
  • Deputy Editor for the British Journal of Psychiatry


Recent publications


Penzel, N, Antonucci, LA, Betz, LT, Sanfelici, R, Weiske, J, Pogarell, O, Cumming, P, Quednow, BB, Howes, O, Falkai, P, Upthegrove, R, Bertolino, A, Borgwardt, S, Brambilla, P, Lencer, R, Meisenzahl, E, Rosen, M, Haidl, T, Kambeitz-Ilankovic, L, Ruhrmann, S, Salokangas, RRK, Pantelis, C, Wood, SJ, Koutsouleris, N, Kambeitz, J & PRONIA Consortium 2021, 'Association between age of cannabis initiation and gray matter covariance networks in recent onset psychosis', Neuropsychopharmacology, vol. 2021, no. 00, pp. 1-10.

Perry, BI, Upthegrove, R, Kappelmann, N, Jones, PB, Burgess, S & Khandaker, GM 2021, 'Associations of immunological proteins/traits with schizophrenia, major depression and bipolar disorder: a bi-directional two-sample mendelian randomization study', Brain, Behavior, and Immunity.

the PRONIA consortium 2021, 'Cognitive subtypes in recent onset psychosis: distinct neurobiological fingerprints?', Neuropsychopharmacology, vol. 46, no. 8, pp. 1475-1483.

Husain, MO, Chaudhry, IB, Khan, Z, Khoso, AB, Kiran, T, Bassett, P, Husain, MI, Upthegrove, R & Husain, N 2021, 'Depression and suicidal ideation in schizophrenia spectrum disorder: a cross-sectional study from a lower middle-income country', International Journal of Psychiatry in Clinical Practice.

Perry, BI, Osimo, E, Mallikarjun, P, Upthegrove, R, Perez, J, Stochl, J, Zammit, S, Howes, O, Jones, P & Khandaker, G 2021, 'Development and external validation of the Psychosis Metabolic Risk Calculator (PsyMetRiC): a cardiometabolic risk prediction algorithm for young people with psychosis', The Lancet Psychiatry.

Lalousis, PA, Wood, S, Schmaal, L, Chisholm, K, Griffiths, L, Reniers, R, Bertolino, A, Borgwardt, S, Brambilla, P, Kambeitz, J, Lencer, R, Pantelis, C, Ruhrmann, S, Salokangas, RKR, Schultze-Lutter, F, Bonivento, C, Dwyer, D, Ferro, A, Haidl, T, Rosen, M, Schmidt, A, Meisenzahl, E, Koutsouleris, N, Upthegrove, R & PRONIA Consortium 2021, 'Heterogeneity and classification of recent onset psychosis and depression: a multimodal machine learning approach', Schizophrenia bulletin.

Perry, BI, Stochl, J, Upthegrove, R, Zammit, S, Wareham, N, Langenberg, C, Winpenny, E, Dunger, DB, Jones, P & Khandaker, GM 2021, 'Longitudinal trends in insulin levels and BMI from childhood and their associations with risks of psychosis and depression in young adults', JAMA psychiatry, vol. 2021, no. 00, pp. 1-10.

Bashir, Z, Griffiths, L & Upthegrove, R 2021, 'Recognition and management of depression in early psychosis', BJPsych Bulletin, pp. 1-7.

Haidl, TK, Hedderich, DM, Rosen, M, Kaiser, N, Seves, M, Lichtenstein, T, Penzel, N, Wenzel, J, Kambeitz-Ilankovic, L, Ruef, A, Popovic, D, Schultze-Lutter, F, Chisholm, K, Upthegrove, R, Salokangas, RKR, Pantelis, C, Meisenzahl, E, Wood, SJ, Brambilla, P, Borgwardt, S, Ruhrmann, S, Kambeitz, J & Koutsouleris, N 2021, 'The non-specific nature of mental health and structural brain outcomes following childhood trauma', Psychological Medicine.

Perry, BI, Burgess, S, Jones, HJ, Zammit, S, Upthegrove, R, Mason, AM, Day, FR, Langenberg, C, Wareham, NJ, Jones, PB & Khandaker, GM 2021, 'The potential shared role of inflammation in insulin resistance and schizophrenia: a bidirectional two-sample mendelian randomization study', PLoS Medicine, vol. 18, no. 3, e1003455.

Haas, SS, Antonucci, LA, Wenzel, J, Ruef, A, Biagianti, B, Paolini, M, Rauchmann, BS, Weiske, J, Kambeitz, J, Borgwardt, S, Brambilla, P, Meisenzahl, E, Salokangas, RKR, Upthegrove, R, Wood, SJ, Koutsouleris, N & Kambeitz-Ilankovic, L 2020, 'A multivariate neuromonitoring approach to neuroplasticity-based computerized cognitive training in recent onset psychosis', Neuropsychopharmacology, vol. 2020, pp. 1-8.

the PRONIA-consortium 2020, 'Basic Symptoms Are Associated With Age in Patients With a Clinical High-Risk State for Psychosis: Results From the PRONIA Study', Frontiers in Psychiatry, vol. 11, 552175.

Review article

PRONIA Consortium 2021, 'Towards clinical application of prediction models for transition to psychosis: a systematic review and external validation study in the PRONIA Sample', Neuroscience and biobehavioral reviews, vol. 125, pp. 478-492.

Grigoriou, M & Upthegrove, R 2020, 'Blunted affect and suicide in schizophrenia: A systematic review', Psychiatry Research, vol. 293, 113355.

Perry, BI, Upthegrove, R, Crawford, O, Jang, S, Lau, E, McGill, I, Carver, E, Jones, PB & Khandaker, GM 2020, 'Cardiometabolic risk prediction algorithms for young people with psychosis: a systematic review and exploratory analysis', Acta Psychiatrica Scandinavica, vol. 142, no. 3, pp. 215-232.

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