Professor Rachel Upthegrove MBBS, FRCPsych, PhD

Professor Rachel Upthegrove

School of Psychology
Professor of Psychiatry and Youth Mental Health
Consultant Psychiatrist Early Intervention in Psychosis

Contact details

School of Psychology
University of Birmingham
B15 2TT

Rachel is Professor of Psychiatry and Youth Mental Health at the University of Birmingham, and Consultant Psychiatrist in the Birmingham Early Intervention Services. Her research Interest is within the field of major mental illness; particularly schizophrenia and co-morbid depression in early phases of illness. Recent projects have developed the investigation of inflammatory models of psychosis and machine learning in prognostic indicators in early phases of developing mental ill health.


  • PhD Birmingham 2011
  • MPhil Birmingham 2001
  • FRCPsych 2017
  • MRCPsych 1999
  • MBBS University of London, Royal Free Hospital School of Medicine 1994


Postgraduate supervision

Professor Upthegrove's primary research interests and background encompass the investigation of schizophrenia and psychosis, with particular emphasis on translational research, transdiagnostic psychoimmunology and new treatments. She is happy to research doctoral projects on these themes.

Other activities

  • NIHR CRN Specialty Lead for the West Midlands
  • Council Member of the British Association for Psychopharmacology
  • Deputy Editor for the British Journal of Psychiatry


Recent publications


Sampson, K, Upthegrove, R, Abu-Akel, A, Haque, S, Wood, S & Reniers, R 2020, 'Co-occurrence of autistic an psychotic traits: implications for depression, self-harm and suicidality', Psychological Medicine.

McGinty, J & Upthegrove, R 2020, 'Depressive symptoms during first episode psychosis and functional outcome: a systematic review and meta-analysis', Schizophrenia Research.

Fisher, E, Wood, S, Upthegrove, R & Aldred, S 2020, 'Designing a feasible exercise intervention in first-episode psychosis: exercise quality, engagement and effect', Psychiatry Research, vol. 286, 112840.

Jones, R, MacCabe, J, Liu, X, Price, M & Upthegrove, R 2020, 'Effect of age on the relative efficacy of clozapine in schizophrenia', Acta Psychiatrica Scandinavica.

Salokangas, RKR, Hietala, J, Armio, RL, Laurikainen, H, From, T, Borgwardt, S, Riecher-Rössler, A, Brambilla, P, Bonivento, C, Meisenzahl, E, Schultze-Lutter, F, Haidl, T, Ruhrmann, S, Upthegrove, R, Wood, SJ, Pantelis, C, Kambeitz-Ilankovic, L, Ruef, A, Dwyer, DB, Kambeitz, J & Koutsouleris, N 2020, 'Effect of childhood physical abuse on social anxiety is mediated via reduced frontal lobe and amygdala-hippocampus complex volume in adult clinical high-risk subjects', Schizophrenia Research.

Barnes, TR, Drake, R, Paton, C, Cooper, S, Deakin, JFW, Ferrier, N, Lewis, S, Joyce, EM, Upthegrove, R & Yung, A 2020, 'Evidence-based guidelines for the pharmacological treatment of schizophrenia: updated recommendations from the British Association for Psychopharmacology', Journal of Psychopharmacology.

Aldred, S, Fisher, E, Upthegrove, R, Wood, S & Elsworthy, R 2020, 'Exercise as a protective mechanism against the negative effects of oxidative stress in first-episode psychosis: a biomarker led study.', Translational Psychiatry.

Heald, AH, Stedman, M, Davies, M, Farman, S, Upthegrove, R, Taylor, D & Gadsby, R 2020, 'Influences on the use of antidepressants in primary care: All England general practice-level analysis of demographic, practice-level and prescriber factors', Human Psychopharmacology.

Upthegrove, R, Lalousis, PA, Mallikarjun, P, Chisholm, K, Griffiths, L, Iqbal, M, Pelton, M, Reniers, R, Stainton, A, Rosen, M, Ruef, A, Dwyer, D, Marian, S, Penzal, N, Kambietz, L, Alessasandro, B, Brambillo, P, Borgwardt, S, Kambietz, J, Lencer, R, Pantelis, C, Ruhrmann, S, Schultze Lutter, F, Salokangas, RKR, Meisenzahl, E, Wood, S & Koutsouleris, N 2020, 'The psychopathology and neuroanatomical markers of depression in early psychosis', Schizophrenia bulletin.

David, P, Ruef, A, Chisholm, K, Wood, S, Upthegrove, R, Kambietz, L, Kambietz, J, Meisenzahl, E, Schultze Lutter, F, Brambillo, P, Borgwardt, S, Salokangas, RKR, Lencer, R, Ruhrmann, S & Koutsouleris, N 2020, 'Traces of trauma – a multivariate pattern analysis of childhood trauma, brain structure and clinical phenotypes', Biological Psychiatry.

Chisholm, K, Pelton, M, Duncan, N, Kidd, K, Wardenaar, KJ, Upthegrove, R, Broome, M, Lin, A & Wood, S 2019, 'A cross-sectional examination of the clinical significance of autistic traits in individuals experiencing a first episode of psychosis', Psychiatry Research, vol. 282, 112623.

Upthegrove, R & Khandaker, GM 2019, 'Cytokines, oxidative stress and cellular markers of inflammation in schizophrenia', Current Topics in Behavioral Neurosciences.

Leighton, S, Upthegrove, R, Krishnadas, R, Benros, M, Broome, M, Gkoutos, G, Liddle, P, Singh, S, Everard, L, Jones, P, Fowler, D, Sharma, V, Freemantle, N, Christensen, R, Albert, N, Nordentoft, M, Schwannnauer, M, Cavanagh, J, Gumley, A, Birchwood, M & Mallikarjun, P 2019, 'Development and validation of multivariable prediction models of remission, recovery and quality of life outcomes in people with first episode psychosis: a machine learning approach', The Lancet Digital Health, vol. 1, no. 6, pp. e261-e270.


Koutsouleris, N, Upthegrove, R & Wood, SJ 2019, 'Importance of variable selection in multimodal prediction models in patients at clinical high risk for psychosis and recent onset depression-reply', JAMA psychiatry, vol. 76, no. 3, pp. 339-340.

Review article

Grigoriou, M, Upthegrove, R & Bortolotti, L 2019, 'Instrumental rationality and suicide in schizophrenia: a case for rational suicide?', Journal of Medical Ethics, vol. 45, no. 12, pp. 802-805.

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