Highlight publications
PRONIA Consortium, Lalousis, PA, Schmaal, L, Wood, S, Reniers, R, Barnes, N, Chisholm, K, Griffiths, L, Stainton, A, Wen, J, Hwang, G, Davatzikos, C, Wenzel, J, Kambeitz-Ilankovic, L, Andreou, C, Bonivento, C, Dannlowski, U, Ferro, A, Liechtenstein, T, Riecher-Rössler, A, Romer, G, Rosen, M, Bertolino, A, Borgwardt, S, Brambilla, P, Kambeitz, J, Lencer, R, Pantelis, C, Ruhrmann, S, Salokangas, RKR, Schultze-Lutter, F, Schmidt, A, Meisenzahl, EM, Koutsouleris, N, Dwyer, D & Upthegrove, R 2022, 'Neurobiologically based stratification of recent-onset depression and psychosis: identification of two distinct transdiagnostic phenotypes', Biological Psychiatry, vol. 92, no. 7, pp. 552-562. https://doi.org/10.1016/j.biopsych.2022.03.021
Upthegrove, R, Marwaha, S & Birchwood, M 2017, 'Depression and schizophrenia: cause, consequence or trans-diagnostic issue?', Schizophrenia bulletin, vol. 43, no. 2, pp. 240-244. https://doi.org/10.1093/schbul/sbw097
PIMS collaboration 2022, 'Inflammation and brain structure in schizophrenia and other neuropsychiatric disorders: A Mendelian randomization study', JAMA psychiatry, vol. 2022, no. 5, pp. 1-11. https://doi.org/10.1001/jamapsychiatry.2022.0407
Morales-Munoz, I, Palmer, E, Mallikarjun, P, Marwaha, S & Upthegrove, R 2021, 'Persistent childhood and adolescent anxiety and risk for psychosis: a longitudinal birth cohort study', Biological Psychiatry. https://doi.org/10.1016/j.biopsych.2021.12.003
PRONIA Consortium 2020, 'The psychopathology and neuroanatomical markers of depression in early psychosis', Schizophrenia bulletin, vol. 2020, sbaa094. https://doi.org/10.1093/schbul/sbaa094
Recent publications
Article
Betz, LT, Penzel, N, Rosen, M, Bhui, K, Upthegrove, R & Kambeitz, J 2023, 'Disentangling heterogeneity of psychosis expression in the general population: Sex-specific moderation effects of environmental risk factors on symptom networks', Psychological Medicine, vol. 53, no. 5, pp. 1860-1869. https://doi.org/10.1017/S0033291721003470
Griffiths, SL, Bogatsu, T, Longhi, M, Butler, E, Alexander, B, Bandawar, M, Everard, L, Jones, PB, Fowler, D, Hodgekins, J, Amos, T, Freemantle, N, McCrone, P, Singh, SP, Birchwood, M & Upthegrove, R 2023, 'Five-year illness trajectories across racial groups in the UK following a first episode psychosis', Social Psychiatry and Psychiatric Epidemiology, vol. 58, no. 4, pp. 569-579. https://doi.org/10.1007/s00127-023-02428-w
Morales-Muñoz, I, Mallikarjun, PK, Chandan, JS, Thayakaran, R, Upthegrove, R & Marwaha, S 2023, 'Impact of anxiety and depression across childhood and adolescence on adverse outcomes in young adulthood: a UK birth cohort study', British Journal of Psychiatry , pp. 1-9. https://doi.org/10.1192/bjp.2023.23
Lalousis, PA, Schmaal, L, Wood, S, Reniers, R, Cropley, VL, Watson, A, Pantelis, C, Suckling, J, Barnes, N, Pariante, CM, Jones, P, Joyce, E, Barnes, TRE, Lawrie, SM, Husain, N, Dazzan, P, Deakin, B, Weickert, CS & Upthegrove, R 2023, 'Inflammatory subgroups of schizophrenia and their association with brain structure: A semi-supervised machine learning examination of heterogeneity', Brain, Behavior, and Immunity, vol. 113, pp. 166-175. https://doi.org/10.1016/j.bbi.2023.06.023
Herniman, SE, Wood, SJ, Khandaker, G, Dazzan, P, Pariante, CM, Barnes, NM, Krynicki, CR, Nikkheslat, N, Vincent, RC, Roberts, A, Giordano, A, Watson, A, Suckling, J, Barnes, TRE, Husain, N, Jones, PB, Joyce, E, Lawrie, SM, Lewis, S, Deakin, B & Upthegrove, R 2023, 'Network analysis of inflammation and symptoms in recent onset schizophrenia and the influence of minocycline during a clinical trial', Translational Psychiatry, vol. 13, no. 1, 297. https://doi.org/10.1038/s41398-023-02570-8
Altaweel, N, Upthegrove, R, Surtees, A, Durdurak, B & Marwaha, S 2023, 'Personality traits as risk factors for relapse or recurrence in major depression: a systematic review', Frontiers in Psychiatry, vol. 14, 1176355. https://doi.org/10.3389/fpsyt.2023.1176355
Osimo, EF, Perry, BI, Mallikarjun, P, Prichard, M, Lewis, J, Katunda, A, Murray , GK, Perez, J, Jones, P, Cardinal, RN, Howes, OD, Upthegrove, R & Khandaker, G 2023, 'Predicting treatment resistance from first-episode psychosis using routinely collected clinical information', Nature Mental Health, vol. 1, pp. 25-35. https://doi.org/10.1038/s44220-022-00001-z
Foley, EM, Griffiths, L, Murray, A, Rogers, J, Corsi-Zuelli, F, Hickinbotham, H, Warwick, E, Wilson, M, Kaser, M, Murray , GK, Deakin, B, Jadon, D, Suckling, J, Barnes, N, Upthegrove, R & Khandaker, GM 2023, 'Protocol for the Psychosis Immune Mechanism Stratified Medicine (PIMS) trial: a randomised double-blind placebo-controlled trial of single-dose tocilizumab in patients with psychosis', BMJ open, vol. 13, no. 3, e067944. https://doi.org/10.1136/bmjopen-2022-067944
Dwyer, DB, Chand, GB, Pigoni, A, Khuntia, A, Wen, J, Antoniades, M, Hwang, G, Erus, G, Doshi, J, Srinivasan, D, Varol, E, Kahn, RS, Schnack, HG, Meisenzahl, E, Wood, SJ, Zhuo, C, Sotiras, A, Shinohara, RT, Shou, H, Fan, Y, Schaulfelberger, M, Rosa, P, Lalousis, PA, Upthegrove, R, Kaczkurkin, AN, Moore, TM, Nelson, B, Gur, RE, Gur, RC, Ritchie, MD, Satterthwaite, TD, Murray, RM, Di Forti, M, Ciufolini, S, Zanetti, MV, Wolf, DH, Pantelis, C, Crespo-Facorro, B, Busatto, GF, Davatzikos, C, Koutsouleris, N & Dazzan, P 2023, 'Psychosis brain subtypes validated in first-episode cohorts and related to illness remission: results from the PHENOM consortium', Molecular Psychiatry. https://doi.org/10.1038/s41380-023-02069-0
PRONIA Consortium 2023, 'Structural and functional brain patterns predict formal thought disorder’s severity and its persistence in recent-onset psychosis: Results from the PRONIA Study', Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. https://doi.org/10.1016/j.bpsc.2023.06.001
Thomas, M, Rakesh, D, Whittle, S, Sheridan, M, Upthegrove, R & Cropley, V 2023, 'The neural, stress hormone and inflammatory correlates of childhood deprivation and threat in psychosis: a systematic review', Psychoneuroendocrinology. https://doi.org/10.1016/j.psyneuen.2023.106371
Morales-Muñoz, I, Upthegrove, R, Lawrence, K, Thayakaran, R, Kooij, S, Gregory, AM & Marwaha, S 2023, 'The role of inflammation in the prospective associations between early childhood sleep problems and ADHD at 10 years: findings from a UK birth cohort study', Journal of Child Psychology and Psychiatry. https://doi.org/10.1111/jcpp.13755
Comment/debate
Astle, DE, Moore, A, Marryat, L, Viding, E, Mansfield, KL, Fazel, M, Pierce, M, Abel, KM, Green, J, John, A, Broome, MR, Upthegrove, R, Bould, H, Minnis, H, Gajwani, R, Groom, MJ, Hollis, C, Liddle, E, Sayal, K, Berry, V, Collishaw, S, Dawes, H, Cortese, S, Violato, M, Pollard, J, MacCabe, JH, Blakemore, S-J, Simonoff, E, Watkins, E, Hiller, RM, Townsend, E, Armour, C, Geddes, JR, Thompson, L, Schwannauer, M, Nicholls, D, Hotopf, M, Downs, J, Rahman, A, Sharma, AN & Ford, TJ 2023, 'We need timely access to mental health data: implications of the Goldacre review', The Lancet Psychiatry, vol. 10, no. 4, pp. 242-244. https://doi.org/10.1016/S2215-0366(23)00030-5
Review article
Marwaha, S, Palmer, E, Suppes, T, Cons, E, Young, AH & Upthegrove, R 2023, 'Novel and emerging treatments for major depression', The Lancet, vol. 401, no. 10371, pp. 141-153. https://doi.org/10.1016/S0140-6736(22)02080-3
Alexandros Lalousis, P, Wood, S, Reniers, R, Schmaal, L, Azam, H, Mazziota, A, Saeed, H, Wragg, C & Upthegrove, R 2023, 'Transdiagnostic structural neuroimaging features in depression and psychosis: A systematic review', NeuroImage: Clinical, vol. 38, 103388. https://doi.org/10.1016/j.nicl.2023.103388
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