Professor Rachel Upthegrove MBBS, FRCPsych, PhD

Professor Rachel Upthegrove

School of Psychology
Professor of Psychiatry and Youth Mental Health
Consultant Psychiatrist Early Intervention in Psychosis

Contact details

School of Psychology
University of Birmingham
B15 2TT

Rachel is Professor of Psychiatry and Youth Mental Health at the University of Birmingham, and Consultant Psychiatrist in the Birmingham Early Intervention Services. Her research Interest is within the field of major mental illness; particularly schizophrenia and co-morbid depression in early phases of illness. Recent projects have developed the investigation of inflammatory models of psychosis and machine learning in prognostic indicators in early phases of developing mental ill health.


  • PhD Birmingham 2011
  • MPhil Birmingham 2001
  • FRCPsych 2017
  • MRCPsych 1999
  • MBBS University of London, Royal Free Hospital School of Medicine 1994

Postgraduate supervision

Professor Upthegrove's primary research interests and background encompass the investigation of schizophrenia and psychosis, with particular emphasis on translational research, transdiagnostic psychoimmunology and new treatments. She is happy to research doctoral projects on these themes.

Other activities

  • NIHR CRN Specialty Lead for the West Midlands
  • Council Member of the British Association for Psychopharmacology
  • Deputy Editor for the British Journal of Psychiatry


Recent publications


Shields, GE, Buck, D, Varese, F, Yung, AR, Thompson, A, Husain, N, Broome, MR, Upthegrove, R, Byrne, R & Davies, LM 2022, 'A review of economic evaluations of health care for people at risk of psychosis and for first-episode psychosis', BMC Psychiatry, vol. 22, no. 1, 126.

the PRONIA consortium 2022, 'Clinical, brain, and multilevel clustering in early psychosis and affective stages', JAMA psychiatry, vol. 79, no. 7, pp. 677-689.

Watson, AJ, Giordano, A, Suckling, J, Barnes, TRE, Husain, N, Jones, PB, Krynicki, CR, Lawrie, SM, Lewis, S, Nikkheslat, N, Pariante, CM, Upthegrove, R, Deakin, B, Dazzan, P & Joyce, EM 2022, 'Cognitive function in early-phase schizophrenia-spectrum disorder: IQ subtypes, brain volume and immune markers', Psychological Medicine.

Rosen, M, Betz, LT, Kaiser, N, Penzel, N, Dwyer, D, Lichtenstein, TK, Schultze-Lutter, F, Kambeitz-Ilankovic, L, Bertolino, A, Borgwardt, S, Brambilla, P, Lencer, R, Meisenzahl, E, Pantelis, C, Salokangas, RKR, Upthegrove, R, Wood, S, Ruhrmann, S, Koutsouleris, N & Kambeitz, J 2022, 'Detailed clinical phenotyping and generalisability in prognostic models of functioning in at-risk populations', British Journal of Psychiatry, vol. 220, no. 6, pp. 318-321.

Jones, R, Upthegrove, R, Price, M, Pritchard, M, Chandan, J, Legge , S & MacCabe, J 2022, 'Duration of prior psychotic illness and clozapine response: a retrospective observational study using electronic health records', Therapeutic advances in psychopharmacology, vol. 12, pp. 1-12.

Perry, BI, Bowker, N, Burgess, S, Wareham, NJ, Upthegrove, R, Jones, P, Khandaker, GM & Langenberg, C 2022, 'Evidence for shared genetic aetiology between schizophrenia, cardiometabolic and inflammation related traits: genetic correlation and colocalization analyses', Schizophrenia Bulletin Open, vol. 3, no. 1, sgac001.

Haas, SS, Doucet, GE, Antoniades, M, Modabbernia, A, Corcoran, CM, Kahn, RS, Kambeitz, J, Kambeitz-Ilankovic, L, Borgwardt, S, Brambilla, P, Upthegrove, R, Wood, SJ, Salokangas, RKR, Hietala, J, Meisenzahl, E, Koutsouleris, N & Frangou, S 2022, 'Evidence of discontinuity between psychosis-risk and non-clinical samples in the neuroanatomical correlates of social function', Schizophrenia Research: Cognition, vol. 29, 100252.

Koutsouleris, N, Pantelis, C, Velakoulis, D, Mcguire, P, Dwyer, DB, Urquijo-Castro, MF, Paul, R, Dong, S, Popovic, D, Oeztuerk, O, Kambeitz, J, Salokangas, RKR, Hietala, J, Bertolino, A, Brambilla, P, Upthegrove, R, Wood, SJ, Lencer, R, Borgwardt, S, Maj, C, Nöthen, M, Degenhardt, F, Polyakova, M, Mueller, K, Villringer, A, Danek, A, Fassbender, K, Fliessbach, K, Jahn, H, Kornhuber, J, Landwehrmeyer, B, Anderl-Straub, S, Prudlo, J, Synofzik, M, Wiltfang, J, Riedl, L, Diehl-Schmid, J, Otto, M, Meisenzahl, E, Falkai, P & Schroeter, ML 2022, 'Exploring links between psychosis and frontotemporal dementia using multimodal machine learning: Dementia Praecox revisited', JAMA psychiatry, vol. 79, no. 9, pp. 907-919.

Upthegrove, R 2022, 'From co-morbidity to transdiagnostic potential and novel immunotherapies for psychosis', Psychiatry Research, vol. 317, 114866.

PIMS collaboration 2022, 'Inflammation and brain structure in schizophrenia and other neuropsychiatric disorders: A Mendelian randomization study', JAMA psychiatry, vol. 2022, pp. 1-11.

Maidment, I, Wong, G, Duddy, C, Upthegrove, R, Oduola, S, Allen, K, Jacklin, S, Howe, J & Macphee, M 2022, 'Medication optimisation in severe mental illness (MEDIATE): protocol for a realist review', BMJ open, vol. 12, no. 1, e058524.

PRONIA Consortium, Lalousis, PA, Schmaal, L, Wood, S, Reniers, R, Barnes, N, Chisholm, K, Griffiths, L, Stainton, A, Wen, J, Hwang, G, Davatzikos, C, Wenzel, J, Kambeitz-Ilankovic, L, Andreou, C, Bonivento, C, Dannlowski, U, Ferro, A, Liechtenstein, T, Riecher-Rössler, A, Romer, G, Rosen, M, Bertolino, A, Borgwardt, S, Brambilla, P, Kambeitz, J, Lencer, R, Pantelis, C, Ruhrmann, S, Salokangas, RKR, Schultze-Lutter, F, Schmidt, A, Meisenzahl, EM, Koutsouleris, N, Dwyer, D & Upthegrove, R 2022, 'Neurobiologically based stratification of recent-onset depression and psychosis: identification of two distinct transdiagnostic phenotypes', Biological Psychiatry, vol. 92, no. 7, pp. 552-562.

Sanfelici, R, Ruef, A, Antonucci, LA, Penzel, N, Sotiras, A, Dong, MS, Urquijo-Castro, M, Wenzel, J, Kambeitz-Ilankovic, L, Hettwer, MD, Ruhrmann, S, Chisholm, K, Riecher-Rössler, A, Falkai, P, Pantelis, C, Salokangas, RKR, Lencer, R, Bertolino, A, Kambeitz, J, Meisenzahl, E, Borgwardt, S, Brambilla, P, Wood, SJ, Upthegrove, R, Schultze-Lutter, F, Koutsouleris, N & Dwyer, DB 2022, 'Novel gyrification networks reveal links with psychiatric risk factors in early illness', Cerebral Cortex, vol. 32, no. 8, pp. 1625-1636.

Abu-Akel, A, Wood, SJ, Upthegrove, R, Chisholm, K, Lin, A, Hansen, PC, Gillespie, SM, Apperly, IA & Montag, C 2022, 'Psychosocial functioning in the balance between autism and psychosis: evidence from three populations', Molecular Psychiatry, vol. 27, no. 7, pp. 2976-2984.

Review article

Dunleavy, C, Elsworthy, RJ, Upthegrove, R, Wood, SJ & Aldred, S 2022, 'Inflammation in first-episode psychosis: The contribution of inflammatory biomarkers to the emergence of negative symptoms, a systematic review and meta-analysis', Acta Psychiatrica Scandinavica.

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