Professor Rachel Upthegrove MBBS, FRCPsych, PhD

Professor Rachel Upthegrove

School of Psychology
Professor of Psychiatry and Youth Mental Health
Consultant Psychiatrist Early Intervention in Psychosis

Contact details

School of Psychology
University of Birmingham
B15 2TT

Rachel is Professor of Psychiatry and Youth Mental Health at the University of Birmingham, and Consultant Psychiatrist in the Birmingham Early Intervention Services. Her research Interest is within the field of major mental illness; particularly schizophrenia and co-morbid depression in early phases of illness. Recent projects have developed the investigation of inflammatory models of psychosis and machine learning in prognostic indicators in early phases of developing mental ill health.


  • PhD Birmingham 2011
  • MPhil Birmingham 2001
  • FRCPsych 2017
  • MRCPsych 1999
  • MBBS University of London, Royal Free Hospital School of Medicine 1994


Postgraduate supervision

Professor Upthegrove's primary research interests and background encompass the investigation of schizophrenia and psychosis, with particular emphasis on translational research, transdiagnostic psychoimmunology and new treatments. She is happy to research doctoral projects on these themes.

Other activities

  • NIHR CRN Specialty Lead for the West Midlands
  • Council Member of the British Association for Psychopharmacology
  • Deputy Editor for the British Journal of Psychiatry


Recent publications


Penzel, N, Antonucci, LA, Betz, LT, Sanfelici, R, Weiske, J, Pogarell, O, Cumming, P, Quednow, BB, Howes, O, Falkai, P, Upthegrove, R, Bertolino, A, Borgwardt, S, Brambilla, P, Lencer, R, Meisenzahl, E, Rosen, M, Haidl, T, Kambeitz-Ilankovic, L, Ruhrmann, S, Salokangas, RRK, Pantelis, C, Wood, SJ, Koutsouleris, N, Kambeitz, J & PRONIA Consortium 2021, 'Association between age of cannabis initiation and gray matter covariance networks in recent onset psychosis', Neuropsychopharmacology, vol. 2021, no. 00, pp. 1-10.

Perry, BI, Osimo, E, Mallikarjun, P, Upthegrove, R, Perez, J, Stochl, J, Zammit, S, Howes, O, Jones, P & Khandaker, G 2021, 'Development and external validation of the Psychosis Metabolic Risk Calculator (PsyMetRiC): a cardiometabolic risk prediction algorithm for young people with psychosis', The Lancet Psychiatry.

Lalousis, PA, Wood, S, Schmaal, L, Chisholm, K, Griffiths, L, Reniers, R, Bertolino, A, Borgwardt, S, Brambilla, P, Kambeitz, J, Lencer, R, Pantelis, C, Ruhrmann, S, Salokangas, RKR, Schultze-Lutter, F, Bonivento, C, Dwyer, D, Ferro, A, Haidl, T, Rosen, M, Schmidt, A, Meisenzahl, E, Koutsouleris, N, Upthegrove, R & PRONIA Consortium 2021, 'Heterogeneity and classification of recent onset psychosis and depression: a multimodal machine learning approach', Schizophrenia bulletin.

Perry, BI, Stochl, J, Upthegrove, R, Zammit, S, Wareham, N, Langenberg, C, Winpenny, E, Dunger, DB, Jones, P & Khandaker, GM 2021, 'Longitudinal trends in insulin levels and BMI from childhood and their associations with risks of psychosis and depression in young adults', JAMA psychiatry, vol. 2021, no. 00, pp. 1-10.

Bashir, Z, Griffiths, L & Upthegrove, R 2021, 'Recognition and management of depression in early psychosis', BJPsych Bulletin, vol. 2021, no. 00, pp. 1-7.

Perry, BI, Burgess, S, Jones, HJ, Zammit, S, Upthegrove, R, Mason, AM, Day, FR, Langenberg, C, Wareham, NJ, Jones, PB & Khandaker, GM 2021, 'The potential shared role of inflammation in insulin resistance and schizophrenia: a bidirectional two-sample mendelian randomization study', PLoS Medicine, vol. 18, no. 3, e1003455.

Haas, SS, Antonucci, LA, Wenzel, J, Ruef, A, Biagianti, B, Paolini, M, Rauchmann, BS, Weiske, J, Kambeitz, J, Borgwardt, S, Brambilla, P, Meisenzahl, E, Salokangas, RKR, Upthegrove, R, Wood, SJ, Koutsouleris, N & Kambeitz-Ilankovic, L 2020, 'A multivariate neuromonitoring approach to neuroplasticity-based computerized cognitive training in recent onset psychosis', Neuropsychopharmacology, vol. 2020, pp. 1-8.

the PRONIA-consortium 2020, 'Basic Symptoms Are Associated With Age in Patients With a Clinical High-Risk State for Psychosis: Results From the PRONIA Study', Frontiers in Psychiatry, vol. 11, 552175.

Sampson, K, Upthegrove, R, Abu-Akel, A, Haque, S, Wood, S & Reniers, R 2020, 'Co-occurrence of autistic and psychotic traits: implications for depression, self-harm and suicidality', Psychological Medicine.

BeneMin Study team 2020, 'Deconstructing depression and negative symptoms of schizophrenia; differential and longitudinal immune correlates, and response to minocycline treatment', Brain, Behaviour, and Immunity, vol. 0, pp. 1-7.

McGinty, J & Upthegrove, R 2020, 'Depressive symptoms during first episode psychosis and functional outcome: a systematic review and meta-analysis', Schizophrenia Research, vol. 218, pp. 14-27.

Fisher, E, Wood, S, Upthegrove, R & Aldred, S 2020, 'Designing a feasible exercise intervention in first-episode psychosis: exercise quality, engagement and effect', Psychiatry Research, vol. 286, 112840.

Jones, R, MacCabe, J, Liu, X, Price, M & Upthegrove, R 2020, 'Effect of age on the relative efficacy of clozapine in schizophrenia', Acta Psychiatrica Scandinavica.

Review article

Grigoriou, M & Upthegrove, R 2020, 'Blunted affect and suicide in schizophrenia: A systematic review', Psychiatry Research, vol. 293, 113355.

Perry, BI, Upthegrove, R, Crawford, O, Jang, S, Lau, E, McGill, I, Carver, E, Jones, PB & Khandaker, GM 2020, 'Cardiometabolic risk prediction algorithms for young people with psychosis: a systematic review and exploratory analysis', Acta Psychiatrica Scandinavica, vol. 142, no. 3, pp. 215-232.

View all publications in research portal