Professor Rachel Upthegrove MBBS, FRCPsych, PhD

Professor Rachel Upthegrove

School of Psychology
Professor of Psychiatry and Youth Mental Health
Consultant Psychiatrist Early Intervention in Psychosis

Contact details

School of Psychology
University of Birmingham
B15 2TT

Rachel is Professor of Psychiatry and Youth Mental Health at the University of Birmingham, and Consultant Psychiatrist in the Birmingham Early Intervention Services. Her research Interest is within the field of major mental illness; particularly schizophrenia and co-morbid depression in early phases of illness. Recent projects have developed the investigation of inflammatory models of psychosis and machine learning in prognostic indicators in early phases of developing mental ill health.


  • PhD Birmingham 2011
  • MPhil Birmingham 2001
  • FRCPsych 2017
  • MRCPsych 1999
  • MBBS University of London, Royal Free Hospital School of Medicine 1994


Postgraduate supervision

Dr Upthegrove's primary research interests and background encompass the investigation of schizophrenia and psychosis, with particular emphasis on the importance of symptom dimensions and outcomes. She is happy to research doctoral projects on these themes.

Other activities

  • NIHR CRN Specialty Lead for the West Midlands
  • Council Member of the British Association for Psychopharmacology
  • Deputy Editor for the British Journal of Psychiatry


Recent publications


Leighton, S, Upthegrove, R, Krishnadas, R, Benros, M, Broome, M, Gkoutos, G, Liddle, P, Singh, S, Everard, L, Jones, P, Fowler, D, Sharma, V, Freemantle, N, Christensen, R, Albert, N, Nordentoft, M, Schwannnauer, M, Cavanagh, J, Gumley, A, Birchwood, M & Mallikarjun, P 2019, 'Development and validation of multivariable prediction models of remission, recovery and quality of life outcomes in people with first episode psychosis: a machine learning approach', The Lancet Digital Health.

Deakin, B, Suckling, J, Dazzan, P, Joyce, E, Lawrie, SM, Upthegrove, R, Husain, N, Chaudhry, IB, Dunn, G, Jones, PB, Lisiecka-ford, D, Lewis, S, Barnes, TR, Williams, SC, Pariante, CM, Knox, E, Drake, RJ, Smallman, R & Barnes, NM 2019, 'Minocycline for negative symptoms of schizophrenia and possible mechanistic actions: the BeneMin RCT', Efficacy and Mechanism Evaluation, vol. 6, no. 7, pp. 1-66.

Upthegrove, R & Khandaker, GM 2019, 'Cytokines, oxidative stress and cellular markers of inflammation in schizophrenia', Current Topics in Behavioral Neurosciences.

Perry, BI, Khandaker, G, Marwaha, S, Zammit, S, Andrew, T, Singh, S & Upthegrove, R 2019, 'Insulin resistance and obesity, and their association with depression in relatively young people: findings from a large U.K. birth cohort', Psychological Medicine. S0033291719000308

Qureshi, KL, Upthegrove, R, Toman, E, Sawlani, V, Davies, DJ & Belli, A 2019, 'Post-traumatic stress disorder in UK civilians with traumatic brain injury: an observational study of TBI clinic attendees to estimate PTSD prevalence and its relationship with radiological markers of brain injury severity', BMJ open, vol. 9, no. 2, e021675.

Bown, D, Belli, A, Qureshi, K, Davies, D, Toman, E & Upthegrove, R 2019, 'Post-traumatic stress disorder and self-reported outcomes after traumatic brain injury in victims of assault', PLoS ONE, vol. 14, no. 2, e0211684.

Kotecha, A & Upthegrove, R 2018, 'Celecoxib plus standard care for people with schizophrenia', Cochrane Database of Systematic Reviews, vol. 2018, no. 12, CD009205.

BeneMin Study team 2018, 'The benefit of minocycline on negative symptoms of schizophrenia in patients with recent-onset psychosis (BeneMin): a randomised, double-blind, placebo-controlled trial', The Lancet Psychiatry, vol. 5, no. 11, pp. 885-894.

Koutsouleris, N, Upthegrove, R, Wood, S & Chisholm, K 2018, 'Prediction models of functional outcomes for individuals in the clinical high risk state for psychosis or with recent onset depression: a multimodal, multisite machine learning analysis', JAMA psychiatry.

Dicapite, S, Upthegrove, R & Mallikarjun, P 2018, 'The relapse rate and predictors of relapse in patients with first-episode psychosis following discontinuation of antipsychotic medication', Early Intervention in Psychiatry, vol. 12, no. 5, pp. 893-899.

Rowland, T, Perry, B, Upthegrove, R, Barnes, N, Chatterjee, J, Gallacher, D & Marwaha, S 2018, 'Neurotrophins, cytokines and oxidative stress mediators, and mood state in bipolar disorder: systematic review and meta-analyses', British Journal of Psychiatry , vol. 213, no. 3, pp. 514-525.


Koutsouleris, N, Upthegrove, R & Wood, SJ 2019, 'Importance of variable selection in multimodal prediction models in patients at clinical high risk for psychosis and recent onset depression-reply', JAMA psychiatry.

Review article

Fisher, E, Gillam, J, Upthegrove, R, Aldred, S & Wood, SJ 2019, 'Role of magnetic resonance spectroscopy in cerebral glutathione quantification for youth mental health: A systematic review', Early Intervention in Psychiatry.

Zhuo, C, Xu, Y, Liu, S, Li, J, Zheng, Q, Gao, X, Li, S, Jing, R, Song, X, Yue, W, Zhou, C & Upthegrove, R 2018, 'Topiramate and metformin are effective add-on treatments in controlling antipsychotic-induced weight gain: a systematic review and network meta-analysis', Frontiers in Pharmacology, vol. 9, 1393.

Stainton, A, Chisholm, K, Kaiser, N, Rosen, M, Upthegrove, R, Ruhrmann, S & Wood, SJ 2018, 'Resilience as a multimodal dynamic process', Early Intervention in Psychiatry.

View all publications in research portal