Professor Rachel Upthegrove MBBS, FRCPsych, PhD

Professor Rachel Upthegrove

School of Psychology
Professor of Psychiatry and Youth Mental Health
Consultant Psychiatrist Early Intervention in Psychosis

Contact details

Address
School of Psychology
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Rachel is Professor of Psychiatry and Youth Mental Health at the University of Birmingham, and Consultant Psychiatrist in the Birmingham Early Intervention Services. Her research Interest is within the field of major mental illness; particularly schizophrenia and co-morbid depression in early phases of illness. Recent projects have developed the investigation of inflammatory models of psychosis and machine learning in prognostic indicators in early phases of developing mental ill health.

Qualifications

  • PhD Birmingham 2011
  • MPhil Birmingham 2001
  • FRCPsych 2017
  • MRCPsych 1999
  • MBBS University of London, Royal Free Hospital School of Medicine 1994

Postgraduate supervision

Professor Upthegrove's primary research interests and background encompass the investigation of schizophrenia and psychosis, with particular emphasis on translational research, transdiagnostic psychoimmunology and new treatments. She is happy to research doctoral projects on these themes.

Other activities

  • NIHR CRN Specialty Lead for the West Midlands
  • Council Member of the British Association for Psychopharmacology
  • Deputy Editor for the British Journal of Psychiatry

Publications

Recent publications

Article

Shields, GE, Buck, D, Varese, F, Yung, AR, Thompson, A, Husain, N, Broome, MR, Upthegrove, R, Byrne, R & Davies, LM 2022, 'A review of economic evaluations of health care for people at risk of psychosis and for first-episode psychosis', BMC Psychiatry, vol. 22, no. 1, 126. https://doi.org/10.1186/s12888-022-03769-7

Watson, AJ, Giordano, A, Suckling, J, Barnes, TRE, Husain, N, Jones, PB, Krynicki, CR, Lawrie, SM, Lewis, S, Nikkheslat, N, Pariante, CM, Upthegrove, R, Deakin, B, Dazzan, P & Joyce, EM 2022, 'Cognitive function in early-phase schizophrenia-spectrum disorder: IQ subtypes, brain volume and immune markers', Psychological Medicine. https://doi.org/10.1017/S0033291721004815

Perry, BI, Bowker, N, Burgess, S, Wareham, NJ, Upthegrove, R, Jones, P, Khandaker, GM & Langenberg, C 2022, 'Evidence for shared genetic aetiology between schizophrenia, cardiometabolic and inflammation related traits: genetic correlation and colocalization analyses', Schizophrenia Bulletin Open, vol. 3, no. 1, sgac001. https://doi.org/10.1093/schizbullopen/sgac001

PIMS collaboration 2022, 'Inflammation and brain structure in schizophrenia and other neuropsychiatric disorders: A Mendelian randomization study', JAMA psychiatry, vol. 2022, pp. 1-11. https://doi.org/10.1001/jamapsychiatry.2022.0407

PRONIA Consortium, Lalousis, PA, Schmaal, L, Wood, S, Reniers, R, Barnes, N, Chisholm, K, Griffiths, L, Stainton, A, Wen, J, Hwang, G, Davatzikos, C, Wenzel, J, Kambeitz-Ilankovic, L, Andreou, C, Bonivento, C, Dannlowski, U, Ferro, A, Liechtenstein, T, Riecher-Rössler, A, Romer, G, Rosen, M, Bertolino, A, Borgwardt, S, Brambilla, P, Kambeitz, J, Lencer, R, Pantelis, C, Ruhrmann, S, Salokangas, RKR, Schultze-Lutter, F, Schmidt, A, Meisenzahl, EM, Koutsouleris, N, Dwyer, D & Upthegrove, R 2022, 'Neurobiologically based stratification of recent onset depression and psychosis: identification of two distinct transdiagnostic phenotypes', Biological Psychiatry. https://doi.org/10.1016/j.biopsych.2022.03.021

Maidment, ID, Wong, G, Duddy, C, Upthegrove, R, Oduola, S, Robotham, D, Higgs, S, Ahern, A & Birdi, G 2022, 'REalist Synthesis Of non-pharmacologicaL interVEntions for antipsychotic-induced weight gain (RESOLVE) in people living with severe mental illness (SMI)', Systematic Reviews, vol. 11, no. 1, 42. https://doi.org/10.1186/s13643-022-01912-9

the PRONIA consortium 2022, 'Relationships between global functioning and neuropsychological predictors in subjects at high risk of psychosis or with a recent onset of depression', World Journal of Biological Psychiatry. https://doi.org/10.1080/15622975.2021.2014955

Antonucci, LA, Penzel, N, Sanfelici, R, Pigoni, A, Kambeitz-Ilankovic, L, Dwyer, D, Ruef, A, Sen Dong, M, Öztürk, ÖF, Haidl, T, Rosen, M, Ferro, A, Pergola, G, Andriola, I, Blasi, G, Ruhrmann, S, Schultze-Lutter, F, Falkai, P, Kambeitz, J, Lencer, R, Dannlowski, U, Upthegrove, R, Salokangas, RKR, Pantelis, C, Meisenzahl, E, Wood, SJ, Brambilla, P, Borgwardt, S, Bertolino, A & Koutsouleris, N 2022, 'Using combined environmental-clinical classification models to predict role functioning outcome in clinical high-risk states for psychosis and recent-onset depression', British Journal of Psychiatry, vol. 220, no. 4, pp. 229–245. https://doi.org/10.1192/bjp.2022.16

Penzel, N, Antonucci, LA, Betz, LT, Sanfelici, R, Weiske, J, Pogarell, O, Cumming, P, Quednow, BB, Howes, O, Falkai, P, Upthegrove, R, Bertolino, A, Borgwardt, S, Brambilla, P, Lencer, R, Meisenzahl, E, Rosen, M, Haidl, T, Kambeitz-Ilankovic, L, Ruhrmann, S, Salokangas, RRK, Pantelis, C, Wood, SJ, Koutsouleris, N, Kambeitz, J & PRONIA Consortium 2021, 'Association between age of cannabis initiation and gray matter covariance networks in recent onset psychosis', Neuropsychopharmacology, vol. 2021, no. 00, pp. 1-10. https://doi.org/10.1038/s41386-021-00977-9

Perry, BI, Upthegrove, R, Kappelmann, N, Jones, PB, Burgess, S & Khandaker, GM 2021, 'Associations of immunological proteins/traits with schizophrenia, major depression and bipolar disorder: a bi-directional two-sample mendelian randomization study', Brain, Behavior, and Immunity, vol. 97, pp. 176-185. https://doi.org/10.1016/j.bbi.2021.07.009

the PRONIA consortium 2021, 'Cognitive subtypes in recent onset psychosis: distinct neurobiological fingerprints?', Neuropsychopharmacology, vol. 46, no. 8, pp. 1475-1483. https://doi.org/10.1038/s41386-021-00963-1

Husain, MO, Chaudhry, IB, Khan, Z, Khoso, AB, Kiran, T, Bassett, P, Husain, MI, Upthegrove, R & Husain, N 2021, 'Depression and suicidal ideation in schizophrenia spectrum disorder: a cross-sectional study from a lower middle-income country', International Journal of Psychiatry in Clinical Practice, vol. 25, no. 3, pp. 245-251. https://doi.org/10.1080/13651501.2021.1914664

Review article

Dunleavy, C, Elsworthy, RJ, Upthegrove, R, Wood, SJ & Aldred, S 2022, 'Inflammation in first-episode psychosis: The contribution of inflammatory biomarkers to the emergence of negative symptoms, a systematic review and meta-analysis', Acta Psychiatrica Scandinavica. https://doi.org/10.1111/acps.13416

Maidment, I, Wong, G, Duddy, C, Upthegrove, R, Oduola, S, Allen, K, Jacklin, S, Howe, J & Macphee, M 2022, 'Medication optimisation in severe mental illness (MEDIATE): protocol for a realist review', BMJ open, vol. 12, no. 1, e058524. https://doi.org/10.1136/bmjopen-2021-058524

Barber, L, Reniers, R & Upthegrove, R 2021, 'A review of functional and structural neuroimaging studies to investigate the inner speech model of auditory verbal hallucinations in schizophrenia', Translational Psychiatry, vol. 11, no. 1, 582. https://doi.org/10.1038/s41398-021-01670-7

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