Professor Rachel Upthegrove MBBS, FRCPsych, PhD

Professor Rachel Upthegrove

School of Psychology
Professor of Psychiatry and Youth Mental Health
Consultant Psychiatrist Early Intervention in Psychosis

Contact details

School of Psychology
University of Birmingham
B15 2TT

Rachel is Professor of Psychiatry and Youth Mental Health at the University of Birmingham, and Consultant Psychiatrist in the Birmingham Early Intervention Services. Her research Interest is within the field of major mental illness; particularly schizophrenia and co-morbid depression in early phases of illness. Recent projects have developed the investigation of inflammatory models of psychosis and machine learning in prognostic indicators in early phases of developing mental ill health.


  • PhD Birmingham 2011
  • MPhil Birmingham 2001
  • FRCPsych 2017
  • MRCPsych 1999
  • MBBS University of London, Royal Free Hospital School of Medicine 1994


Postgraduate supervision

Dr Upthegrove's primary research interests and background encompass the investigation of schizophrenia and psychosis, with particular emphasis on the importance of symptom dimensions and outcomes. She is happy to research doctoral projects on these themes.

Other activities

  • NIHR CRN Specialty Lead for the West Midlands
  • Council Member of the British Association for Psychopharmacology
  • Deputy Editor for the British Journal of Psychiatry


Recent publications


Haidl, T, Schneider, N, Ruhrmann, S, Kaiser, N, Rosen, M, Thorsten, L, Salokangas, R, Upthegrove, R, Wood, S, Pantelis, C, Meisenzahl, E, Brambillo, P, Borgwardt, S, Lencer, R, Kambeitz, J & Koutsouleris, N 2020, 'Validation of the Bullying Scale for Adults - Results of the PRONIA-study', Journal of Psychiatric Research.

Fisher, E, Wood, S, Upthegrove, R & Aldred, S 2020, 'Designing a feasible exercise intervention in first-episode psychosis: exercise quality, engagement and effect', Psychiatry Research, vol. 286, 112840.

McGinty, J & Upthegrove, R 2020, 'Depressive symptoms during first episode psychosis and functional outcome: a systematic review and meta-analysis', Schizophrenia Research.

Sampson, K, Upthegrove, R, Abu-Akel, A, Haque, S, Wood, S & Reniers, R 2020, 'Co-occurrence of autistic an psychotic traits: implications for depression, self-harm and suicidality', Psychological Medicine.

Jones, R, MacCabe, J, Liu, X, Price, M & Upthegrove, R 2020, 'Effect of age on the relative efficacy of clozapine in schizophrenia', Acta Psychiatrica Scandinavica.

Barnes, TR, Drake, R, Paton, C, Cooper, S, Deakin, JFW, Ferrier, N, Lewis, S, Joyce, EM, Upthegrove, R & Yung, A 2020, 'Evidence-based guidelines for the pharmacological treatment of schizophrenia: updated recommendations from the British Association for Psychopharmacology', Journal of Psychopharmacology.

Chisholm, K, Pelton, M, Duncan, N, Kidd, K, Wardenaar, KJ, Upthegrove, R, Broome, M, Lin, A & Wood, S 2019, 'A cross-sectional examination of the clinical significance of autistic traits in individuals experiencing a first episode of psychosis', Psychiatry Research, vol. 282, 112623.

Leighton, S, Upthegrove, R, Krishnadas, R, Benros, M, Broome, M, Gkoutos, G, Liddle, P, Singh, S, Everard, L, Jones, P, Fowler, D, Sharma, V, Freemantle, N, Christensen, R, Albert, N, Nordentoft, M, Schwannnauer, M, Cavanagh, J, Gumley, A, Birchwood, M & Mallikarjun, P 2019, 'Development and validation of multivariable prediction models of remission, recovery and quality of life outcomes in people with first episode psychosis: a machine learning approach', The Lancet Digital Health, vol. 1, no. 6, pp. e261-e270.

Deakin, B, Suckling, J, Dazzan, P, Joyce, E, Lawrie, SM, Upthegrove, R, Husain, N, Chaudhry, IB, Dunn, G, Jones, PB, Lisiecka-ford, D, Lewis, S, Barnes, TR, Williams, SC, Pariante, CM, Knox, E, Drake, RJ, Smallman, R & Barnes, NM 2019, 'Minocycline for negative symptoms of schizophrenia and possible mechanistic actions: the BeneMin RCT', Efficacy and Mechanism Evaluation, vol. 6, no. 7, pp. 1-66.

Upthegrove, R & Khandaker, GM 2019, 'Cytokines, oxidative stress and cellular markers of inflammation in schizophrenia', Current Topics in Behavioral Neurosciences.

Perry, BI, Khandaker, G, Marwaha, S, Zammit, S, Andrew, T, Singh, S & Upthegrove, R 2019, 'Insulin resistance and obesity, and their association with depression in relatively young people: findings from a large U.K. birth cohort', Psychological Medicine. S0033291719000308

Qureshi, KL, Upthegrove, R, Toman, E, Sawlani, V, Davies, DJ & Belli, A 2019, 'Post-traumatic stress disorder in UK civilians with traumatic brain injury: an observational study of TBI clinic attendees to estimate PTSD prevalence and its relationship with radiological markers of brain injury severity', BMJ open, vol. 9, no. 2, e021675.

Bown, D, Belli, A, Qureshi, K, Davies, D, Toman, E & Upthegrove, R 2019, 'Post-traumatic stress disorder and self-reported outcomes after traumatic brain injury in victims of assault', PLoS ONE, vol. 14, no. 2, e0211684.

Review article

Grigoriou, M, Upthegrove, R & Bortolotti, L 2019, 'Instrumental rationality and suicide in schizophrenia: a case for rational suicide?', Journal of Medical Ethics, vol. 45, no. 12, pp. 802-805.

Fisher, E, Gillam, J, Upthegrove, R, Aldred, S & Wood, SJ 2019, 'Role of magnetic resonance spectroscopy in cerebral glutathione quantification for youth mental health: A systematic review', Early Intervention in Psychiatry.

View all publications in research portal