Dr Ned Jenkinson PhD

Dr Ned Jenkinson

School of Sport, Exercise and Rehabilitation Sciences
Senior Lecturer in Human Movement Sciences

Contact details

Address
School of Sport, Exercise and Rehabilitation Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Ned’s research incorporates a range of techniques including non-invasive brain stimulation, electrophysiological recording, eye-tracking, neuroimaging and behavioural techniques. He uses these techniques to investigate how the brain controls movement and how it allows us to - seemingly effortlessly - learn new motor skills. His research is not only intended to help us understanding how the brain controls movements for its own sake, but to better comprehend how dysfunction of the brain produces the symptoms of movement disorders such as Parkinson's disease.

Biography

Ned has an undergraduate degree in Neuroscience from University College London, where he remained to complete a PhD in Neuroscience with Mitch Glickstein studying the role of the cerebellum in the sensory guidance of movement. After UCL he moved to Vanderbilt University, Tennessee, to learn electrophysiological techniques under Michael Armstrong-James in the laboratory of Ford Ebner. From there, he returned to the study of the cerebellum with Chris Miall at the University of Oxford. 

Later he worked in the Nuffield Departments of Surgery and then Clinical Neurosciences with Tipu Aziz studying deep brain stimulation (DBS). There he both developed new targets and the technique of DBS and took the unique opportunity to record electrical activity from deep within the brain’s of patients via the DBS electrodes to uncover how the Basal ganglia controls movements. During his time in Oxford he developed his own research group and left Oxford as associate professor to take a position as senior lecturer in Human Movement Sciences at the University of Birmingham.

Teaching

Module lead on third year module – Motor Learning and Neuroplasticity

Postgraduate supervision

  • Sarah Voets - Parkinson’s UK funded PhD student
  • Alice Day
  • Alison Hall
  • Matthew Weightman

Research

Research interests

  • Sensorimotor Neurocience
  • Plasticity in the motor system.
  • Motor learning in people with degenerative diseases i.e. Parkinson’s disease and cerebellar ataxia.
  • Mechanisms of non-invasive brain stimulation (such as transcranial magnetic and electrical stimulation) and its application to improving motor plasticity and motor leaning in people with degenerative brain disease and the elderly population.
  • The role of oscillatory brain activity in motor control.

Research identifiers

https://orcid.org/0000-0002-6803-486X

http://www.scopus.com/authid/detail.url?authorId=15925284700

https://scholar.google.co.uk/citations?user=I7h_dqwAAAAJ

Publications

Original research papers in peer-reviewed journals:

  • Panouillères, M.T.N., Joundi, R.A., Benitez-Riveiro, S., Cheeran, B., Butler, C.R., Németh, A.H., Chris Miall, R., Jenkinson, N. Sensorimotor adaptation as a behavioural biomarker of early spinocerebellar ataxia type (2017) Scientific Reports, 7 (1), art. no. 2366. https://dx.doi.org/10.1038/s41598-017-02469-7
  • Lago-Rodriguez, A., Ponzo, V., Jenkinson, N., Benitez-Rivero, S., Del-Olmo, M.F., Hu, M., Koch, G., Cheeran, B. Paradoxical facilitation after depotentiation protocol can precede dyskinesia onset in early Parkinson’s disease (2016) Experimental Brain Research, 234 (12), pp. 3659-3667. https://dx.doi.org/10.1007/s00221-016-4759-5
  • Wessel, J.R., Jenkinson, N., Brittain, J.-S., Voets, S.H.E.M., Aziz, T.Z., Aron, A.R. Surprise disrupts cognition via a fronto-basal ganglia suppressive mechanism (2016) Nature Communications, 7, art. no. 11195. https://dx.doi.org/10.1038/ncomms11195
  • Panouillères, M.T.N., Tofaris, G.K., Brown, P., Jenkinson, N. Intact acquisition and short-term retention of non-motor procedural learning in Parkinson's disease (2016) PLoS ONE, 11 (2), art. no. e0149224. https://dx.doi.org/10.1371/journal.pone.0149224
  • Panouillères, M.T.N., Joundi, R.A., Brittain, J.-S., Jenkinson, N. Reversing motor adaptation deficits in the ageing brain using non-invasive stimulation (2015) Journal of Physiology, 593 (16), pp. 3645-3655. https://dx.doi.org/10.1113/jp270484
  • Panouillères, M.T.N., Miall, R.C., Jenkinson, N. The role of the posterior cerebellum in saccadic adaptation: A transcranial direct current stimulation study (2015) Journal of Neuroscience, 35 (14), pp. 5471-5479. https://dx.doi.org/10.1523/jneurosci.4064-14.2015
  • Tan, H., Jenkinson, N., Brown, P. Dynamic neural correlates of motor error monitoring and adaptation during trial-to-trial learning (2014) Journal of Neuroscience, 34 (16), pp. 5678-5688. https://dx.doi.org/10.1523/jneurosci.4739-13.2014
  • Sitsapesan, H.A., Holland, P., Oliphant, Z., De Pennington, N., Brittain, J.-S., Jenkinson, N., Joint, C., Aziz, T.Z., Green, A.L. Deep brain stimulation for tremor resulting from acquired brain injury (2014) Journal of Neurology, Neurosurgery and Psychiatry, 85 (7), pp. 811-815. https://dx.doi.org/10.1136/jnnp-2013-305340
  • Zavala, B., Brittain, J.-S., Jenkinson, N., Ashkan, K., Foltynie, T., Limousin, P., Zrinzo, L., Green, A.L., Aziz, T., Zaghloul, K., Brown, P. Subthalamic nucleus local field potential activity during the eriksen flanker task reveals a novel role for theta phase during conflict monitoring (2013) Journal of Neuroscience, 33 (37), pp. 14758-14766. https://dx.doi.org/10.1523/jneurosci.1036-13.2013
  • Jenkinson, N., Kühn, A.A., Brown, P. Gamma oscillations in the human basal ganglia (2013) Experimental Neurology, 245, pp. 72-76. https://dx.doi.org/10.1016/j.expneurol.2012.07.005
  • McTaggart, J.S., Jenkinson, N., Brittain, J.-S., Greeley, S.A.W., Hattersley, A.T., Ashcroft, F.M. Gain-of-Function Mutations in the KATP Channel (KCNJ11) Impair Coordinated Hand-Eye Tracking (2013) PLoS ONE, 8 (4), art. no. e62646. https://dx.doi.org/10.1371/journal.pone.0062646
  • Joundi, R.A., Brittain, J.-S., Green, A.L., Aziz, T.Z., Brown, P., Jenkinson, N. Persistent suppression of subthalamic beta-band activity during rhythmic finger tapping in Parkinson's disease (2013) Clinical Neurophysiology, 124 (3), pp. 565-573. https://dx.doi.org/10.1016/j.clinph.2012.07.029
  • Joundi, R.A., Lopez-Alonso, V., Lago, A., Brittain, J.-S., Fernandez-Del-Olmo, M., Gomez-Garre, P., Mir, P., Jenkinson, N., Cheeran, B., Brown, P. The effect of BDNF val66met polymorphism on visuomotor adaptation (2012) Experimental Brain Research, 223 (1), pp. 43-50. https://dx.doi.org/10.1007/s00221-012-3239-9
  • Brittain, J.-S., Watkins, K.E., Joundi, R.A., Ray, N.J., Holland, P., Green, A.L., Aziz, T.Z., Jenkinson, N. A role for the subthalamic nucleus in response inhibition during conflict (2012) Journal of Neuroscience, 32 (39), pp. 13396-13401. https://dx.doi.org/10.1523/jneurosci.2259-12.2012
  • Joundi, R.A., Brittain, J.-S., Green, A.L., Aziz, T.Z., Jenkinson, N. High-frequency stimulation of the subthalamic nucleus selectively decreases central variance of rhythmic finger tapping in Parkinson's disease (2012) Neuropsychologia, 50 (10), pp. 2460-2466. https://dx.doi.org/10.1016/j.neuropsychologia.2012.06.017
  • Joundi, R.A., Brittain, J.-S., Green, A.L., Aziz, T.Z., Brown, P., Jenkinson, N. Oscillatory activity in the subthalamic nucleus during arm reaching in Parkinson's disease (2012) Experimental Neurology, 236 (2), pp. 319-326. https://dx.doi.org/10.1016/j.expneurol.2012.05.013
  • Bridge, H., Ragge, N., Jenkinson, N., Cowey, A., Watkins, K.E. The fate of the oculomotor system in clinical bilateral anophthalmia (2012) Visual Neuroscience, 29 (3), pp. 193-202. https://dx.doi.org/10.1017/s0952523812000119
  • Joundi, R.A., Brittain, J.-S., Punt, T.D., Green, A.L., Jenkinson, N., Aziz, T.Z. Stimulation of the subthalamic nucleus improves velocity of ballistic movements in Parkinson's disease (2012) NeuroReport, 23 (6), pp. 390-394. https://dx.doi.org/10.1097/wnr.0b013e3283525b39
  • Jenkinson, N., Brittain, J.-S., Hicks, S.L., Kennard, C., Aziz, T.Z. On the origin of oscillopsia during pedunculopontine stimulation (2012) Stereotactic and Functional Neurosurgery, 90 (2), pp. 124-129. https://dx.doi.org/10.1159/000335871
  • Joundi, R.A., Jenkinson, N., Brittain, J.-S., Aziz, T.Z., Brown, P. Driving oscillatory activity in the human cortex enhances motor performance (2012) Current Biology, 22 (5), pp. 403-407. https://dx.doi.org/10.1016/j.cub.2012.01.024
  • Ray, N.J., Brittain, J.-S., Holland, P., Joundi, R.A., Stein, J.F., Aziz, T.Z., Jenkinson, N. The role of the subthalamic nucleus in response inhibition: Evidence from local field potential recordings in the human subthalamic nucleus (2012) NeuroImage, 60 (1), pp. 271-278. https://dx.doi.org/10.1016/j.neuroimage.2011.12.035
  • Hyam, J.A., Owen, S.L.F., Kringelbach, M.L., Jenkinson, N., Stein, J.F., Green, A.L., Aziz, T.Z. Contrasting connectivity of the ventralis intermedius and ventralis oralis posterior nuclei of the motor thalamus demonstrated by probabilistic tractography (2012) Neurosurgery, 70 (1), pp. 162-169. https://dx.doi.org/10.1227/neu.0b013e3182262c9a
  • Thevathasan, W., Cole, M.H., Graepel, C.L., Hyam, J.A., Jenkinson, N., Brittain, J.-S., Coyne, T.J., Silburn, P.A., Aziz, T.Z., Kerr, G., Brown, P. A spatiotemporal analysis of gait freezing and the impact of pedunculopontine nucleus stimulation (2012) Brain, 135 (5), pp. 1446-1454. https://dx.doi.org/10.1093/brain/aws039
  • Thevathasan, W., Pogosyan, A., Hyam, J.A., Jenkinson, N., Foltynie, T., Limousin, P., Bogdanovic, M., Zrinzo, L., Green, A.L., Aziz, T.Z., Brown, P. Alpha oscillations in the pedunculopontine nucleus correlate with gait performance in parkinsonism (2012) Brain, 135 (1), pp. 148-160. https://dx.doi.org/10.1093/brain/awr315

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