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Don’t know which steroids are important or which method to use to analyse them?

Steroid biosynthesis and metabolism can be investigated in serum, urine, saliva, or other biological fluids. Each biofluid has advantages and problems. For example, serum is invasive to collect and only allows investigation at a single point in time that can be hampered by the diurnal rhythm of some steroids. Saliva is non-invasive and easy to collect, but only useful for high concentration steroids and again is hampered by diurnal rhythms. 24-hour urine samples overcome the problems of diurnal rhythm, permitting a fuller picture of flux through steroid pathways, however, a 24-hour urine sample is cumbersome to collect, and the data is complicated by the further metabolism steps required to covert steroids into their excretable conjugates.

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Contact Angela Taylor