Professor Motonari Kondo, M.D., Ph.D.
Department of Molecular Immunology
Toho University School of Medicine
Ota-ku, Tokyo 143-8540
Clarification of regulatory mechanisms in lymphocyte development
All classes of blood cells are derived from bone marrow resident hematopoietic stem cells (HSCs) in adults. Hematopoietic cells can be broadly separated into two major lineages: the lymphoid lineage and the myeloid lineage. Dr. Kondo’s research mainly focuses on how lymphoid lineage specification and commitment are regulated in HSCs and/or hematopoietic multipotent progenitors (MPPs). Dr. Kondo’s laboratory is also investigating roles of cytokines in lymphocyte development and function. Finally, Dr. Kondo has started to elucidate the genes required for functional T cell formation to get insights into T cell specific gene networks. Results of the research in Dr. Kondo’s laboratory would help to understand not only the normal lymphocyte development process but also abnormal lymphocyte development, which may lead to immunodeficiency, autoimmune disease, or leukemia/lymphoma.