How age alters our immune response to bereavement

Young people have a more robust immune response to the loss of a loved one, according to new research from the University of Birmingham, providing insight into how different generations cope with loss.

The study, published in the journal Immunity and Ageing, shows how the balance of our stress hormones during grief changes as we age – meaning elderly people are more likely to have reduced immune function and, as a result, suffer from infections.

It is the first research to compare different generations and display the relationship between stress hormones and immune function across different stages in our life.

Dr Anna Phillips, Reader in Behavioural Medicine at the University of Birmingham, explained, “During the difficult weeks and months after loss we can suffer from reduced neutrophil function. Neutrophils are the most abundant type of white blood cell and as such are essential at combating infections and illness, so we become vulnerable when this happens.”

The results of the study suggest a relationship between neutrophil function and the balance of our stress hormones. Two stress hormones in particular appear to display different responses to loss as we age; cortisol and dehydroepiandrosterone sulphate (DHEAS).

In younger participants, the ratio of cortisol and DHEAS was more balanced, whereas the cortisol:DHEAS ratio was significantly higher in the older study group.

Dr Phillips continued, “The effects of loss are poorly understood on the whole – we know that it affects the immune system amongst other things – but we don’t fully understand the role played by our stress hormones. We hope that this is a step towards that understanding, and being able to provide the best possible support.”

Professor Janet Lord, Professor of Immune Cell Biology at the University of Birmingham, added, “Cortisol is known to suppress elements of the immune system during times of high stress, so having an unbalanced ratio of cortisol and DHEAS is going to affect how able we are to ward of illness and infection when grieving. But, of course, it is also incredibly useful - particularly in activating some anti-stress and anti-inflammation pathways – so it’s not as simple as trying to suppress the cortisol in vulnerable people.”

The researchers, speaking at the British Science Festival in Birmingham, consider that hormonal supplements or similar products could be used to help people at an increased risk of stress but that this is not the only solution.

Dr Phillips concluded, “The changing ratio is something we need to learn much more about, and need to test whether altering that balance artificially could be a short-term help at times of stress. However, there is, quite simply, no substitute for a strong support network of family and friends to help manage the risks during a period of grieving.”

Participants were studied whilst grieving for the loss of a loved one; either a spouse or close family member.

Notes to editors

Full paper: ‘Bereavement reduces neutrophil oxidative burst only in older adults: role of the HPA axis and immunesenescence’ Ana Vitlic, Riyad Khanfer, Janet M Lord, Douglas Carroll and Anna C Phillips. Immunity & Ageing 2014, 11:13  doi:10.1186/1742-4933-11-13

The University of Birmingham has been named The Times and The Sunday Times University of the Year 2013/4. 

The University of Birmingham is ranked amongst the world’s top 100 institutions, its work brings people from across the world to Birmingham, including researchers and teachers and more than 4,000 international students from nearly 150 countries. 

About the British Science Festival

The British Science Festival is one of Europe’s largest science festivals and regularly attracts over 350 of the UK’s top scientists and speakers to discuss the latest developments in science with the public. Over 50,000 visitors attend the talks, discussions and workshops. Registration is free for journalists, and gets you access to hundreds of free events. The Festival takes place at a different location each year and was last held in Birmingham in 2010. The 2014 Festival will take place from 6 - 11 September hosted by the University of Birmingham. @BritishSciFest #BSF14

About the British Science Association

The British Science Association (BSA) believes that science should be part of – rather than set apart from – society and culture, and is owned by the wider community. Our programmes encourage people of all ages and backgrounds to engage with science, become ambassadors for science, and ultimately to be empowered to challenge and influence British science - whether they work in science or not.

Established in 1831, the BSA is a registered charity that organises major initiatives across the UK, including National Science & Engineering Week, the annual British Science Festival, regional and local events, the CREST Awards and other programmes for young people in schools and colleges. The BSA also organises specific activities for professional science communicators, including a specialist conference and training. 

For interview requests or for more information, please contact Luke Harrison, Media Relations Manager, University of Birmingham on +44 (0) 121 414 5134. 

For out of hours media enquiries, please call: +44 (0) 7789 921 165