Outputs

Our students are highly productive and many publish in peer-reviewed journals and speak at national and international conferences each year. Since 2008 students from the PSIBS and Sci-Phy programmes have given 165 conference presentations (posters and oral presentations) and published as first and named authors on 90+ peer reviewed papers.

2019

Owen G. Davies, Sophie Cox, Ioannis Azoidis, Adam McGuinness, Megan Cooke, Liam Heaney, Liam Grover, “Osteoblast-Derived Vesicle Protein Content Is Temporally Regulated During Osteogenesis: Implications for Regenerative Therapies” Front. Bioeng. Biotechnol May 2019, DOI:10.3389/fbioe.2019.00092

Nathaniel Wand, Darren Smith, Andrew Wilkinson, Ashleigh Rushton, Stephen Busby, Iain Styles, Rob Neely, “DNA barcodes for rapid, whole genome, single-molecule analyses”, Nucleic Acids Research, 28 March 2019 DOI: 10.1093/nar/gkz212

Christopher O’Shea, Andrew Holmes, James Winter, Joao Correia, Xianhong Ou, Ruirui Dong, Shicheng He, Paulus Kirchhof, Larissa Fabritz, Kashif Rajpoot, Davor Pavlovic, “Cardiac Optogenetics and Optical Mapping - Overcoming Spectral Congestion in All-Optical Cardiac Electrophysiology”, Front. Physiol., 07 March 2019, DOI: 10.3389/fphys.2019.00182

Christopher O’Shea, Andrew Holmes, Ting Y. Yu, James Winter, Simon Wells, Joao Correia, Bastiaan Boukens, Joris De Groot, Gavin Chu, Xin Li, G. Andre Ng, Paulus Kirchhof, Larissa Fabritz, Kashif Rajpoot, Davor Pavlovic, “ElectroMap: High-throughput open-source software for analysis and mapping of cardiac electrophysiology”, Scientific Reports 9, Feb 2019, DOI: 10.1038/s41598-018-38263-2

Emma Metcalfe-Smith, Emma Meeus, Jan Novak, Hamid Dehghani, Andrew Peet, Niloufar Zarinabad, “Auto-regressive Discrete Acquisition Points Transformation for Diffusion Weighted MRI Data”, IEEE Transactions on Biomedical Engineering, Jan 2019, DOI:10.1109/TBME.2019.2893523

2018

Mark Pearson, Megan Cooke, Liam Grover, Simon Jones, Ashleigh Philip, Thomas Nicholson, Matthew Newton Ede, “Evidence of Intrinsic Impairment of Osteoblast Phenotype at the Curve Apex in Girls With Adolescent Idiopathic Scoliosis”, Spine Deformity, Nov 18, DOI: 10.1016/j.jspd.2018.11.016.

Megan Cooke, Bernard Lawless, Simon W. Jones, Liam M. Grover "Matrix degradation in osteoarthritis primes the superficial region of cartilage for mechanical damage." Acta Biomaterialia , Sept 2018, DOI:10.1016/j.actbio.2018.07.037

Emma M. McCarthy , Hayley Floyd, Owen Addison∥, Zhenyu J. Zhang , Pola Goldberg Oppenheimer, Liam M. Grover, ”Influence of Cobalt Ions on Collagen Gel Formation and Their Interaction with Osteoblasts”, American Chemical Society, Aug 2018, DOI: 10.1021/acsomega.8b01048

Megan Cooke, Simon W. Jones, Britt ter Horst, Naiem Moiemen, Martyn Snow, Gurpreet Chouhan, Lisa Hill, Maryam Esmaeli, Richard Moakes, James Holton, Rajpal Nandra, Richard Williams, Alan Smith, Liam Grover, "Structuring of Hydrogels across Multiple Length Scales for Biomedical Applications." 30(14): 1705013. Advanced Materials, Apr 2018, DOI: 10.1002/adma.201705013

Megan Cooke, B Lawless, S.W. Jones, L.M. Grover "Loss of proteoglycan content primes articular cartilage for mechanically induced damage." Osteoarthritis and Cartilage, Apr 2018, DOI: 10.1016/j.joca.2018.02.731

Trina Majumdar, Megan Cooke, Bernard Lawless, Francis Bellier, Erik Hughes, Liam Grover, Simon W Jones, Sophie Cox ”Formulation and viscoelasticity of mineralised hydrogels for use in bone-cartilage interfacial reconstruction” Journal of the Mechanical Behavior of Biomedical Materials, Apr 2018, DOI: 10.1016/jmbbm.2018.01.016

Erik Hughes, Sophie Cox, Megan Cooke, Owen Davies, Richard Williams, Thomas Hall, Liam Grover "Interfacial Mineral Fusion and Tubule Entanglement as a Means to Harden a Bone Augmentation Material." Advanced Healthcare Materials, Jan 2018, DOI: 10.1002/adhm.201701166

2017

Zoe Schofield, Michelle AC Reed, Philip N Newsome, David H Adams, Ulrich L Günther, Patricia F Lalor, "Changes in human hepatic metabolism in steatosis and cirrhosis". World Journal of Gastroenterology. Apr 2017; vol 23, issue 15: pp. 2685-2695. DOI: 10.3748/wjg.v23.i15.2685
Milena Helmer Lauer, Charlotte Vranken, Jochem Deen, Nathaniel Wand, Wout Frederickx, Willem Vanderlinden, Volker Leen, Marcelo Henrique Gehlen, Johan Hofkens and Robert Kenneth Neely, "Methyltransferase-directed covalent coupling of fluorophores to DNA". Chemical Science, 2017, DOI: 10.1039/C6SC04229E
Emily J Guggenheim, Iseult Lynch, Joshua Z. Rappoport, “Imaging In focus: Reflected light imaging: Techniques and applications”. The International Journal of Biochemistry and Cell Biology, vol 83, Feb 2017, pp. 65–70
Samuel R. Moxon, Megan E. Cooke, Sophie C. Cox, Martyn Snow, Lee Jeys, Simon W. Jones, Alan M. Smith, Liam M. Grover, “Suspended Manufacture of Biological Structures”. Advanced Materials, Jan 2017, DOI: 10.1002/adma.201605594
N. Vyas, R.L. Sammons, Z. Pikramenou, W.M. Palin, H. Dehghani, A.D. Walmsley, “Penetration of sub-micron particles into dentinal tubules using ultrasonic cavitation”. Journal of Dentistry, vol 56, Jan 2017, pp. 112–120
Jeremy A. Pike, Iain B. Styles, Joshua Z. Rappoport, John K. Heath, “Quantifying receptor trafficking and colocalization with confocal microscopy”. Methods, vol 115, 15 Feb 2017, pp. 42–54
Roya Jalali, R.Christopher Miall, Joseph M. Galea, "No consistent effect of cerebellar transcranial direct current stimulation (tDCS) on visuomotor adaptation". Journal of Neurophysiology, March 2017, DOI: 10.1152/jn.00896.2016

2016

Meeus EM, Novak J, Withey SB, Zarinabad N, Dehghani H, Peet AC, "Evaluation of intravoxel incoherent motion fitting methods in low-perfused tissue". Journal of Magnetic Resonance Imaging, 2016, DOI: 10.1002/jmri.25411
Birch R, Peet AC, Dehghani H, Wilson M, "Influence of macromolecule baseline on 1 H MR spectroscopic imaging reproducibility". Magnetic Resonance in Medicine. 2016 Jan 22, DOI: 10.1002/mrm.26103
Brown RM, Meah CJ, Heath VL, Styles IB, Bicknell R., “Tube-Forming Assays”. Methods in Molecular Biology, 2016, pp. 149-157, DOI: 10.1007/978-1-4939-3628-1_9
Clancy M, Belli A, Davies D, Lucas SJ, Su Z, Dehghani H, "Improving the quantitative accuracy of cerebral oxygen saturation in monitoring the injured brain using atlas based Near Infrared Spectroscopy models". Journal of Biophotonics, 9: 812–826. doi:10.1002/jbio.201500302
Davies DJ, Clancy M, Lighter D, Balanos GM, Lucas SJ, Dehghani H, Su Z, Forcione M, Belli A., "Frequency-domain vs continuous-wave near-infrared spectroscopy devices: a comparison of clinically viable monitors in controlled hypoxia". Journal of Clinical Monitoring and Computing. 2016 Oct 24. DOI: doi:10.1007/s10877-016-9942-5
Guggenheim EJ, Khan A, Pike J, Chang L, Lynch I, Rappoport JZ, "Comparison of Confocal and Super-Resolution Reflectance Imaging of Metal Oxide Nanoparticles". PLoS One. 2016 Oct 3;11(10):e0159980.
Mazzolini J, Weber R, Chen HS, Khan A, Guggenheim E, Shaw R, Chipman J, Viant M, Rappoport JZ. “Protein corona modulates uptake and toxicity of nanoceria via clathrin mediated endocytosis”. The Biological Bulletin 231, no. 1 (August 2016): 40-60. DOI: 10.1086/689590
Bailey, M. J., et al. (2016). "Analysis of urine, oral fluid and fingerprints by liquid extraction surface analysis coupled to high resolution MS and MS/MS - opportunities for forensic and biomedical science." Analytical Methods 8(16): 3373-3382.
Cutter, J. R., et al. (2016). "Image-based Registration for a Neurosurgical Robot: Comparison Using Iterative Closest Point and Coherent Point Drift Algorithms." Procedia Computer Science 90: 28-34.
Davies, D., et al. (2016). "Comparison of near infrared spectroscopy with functional MRI for detection of physiological changes in the brain independent of superficial tissue." The Lancet 387, Supplement 1: S34.
Guggenheim, J. A., et al. (2016). "Time resolved diffuse optical spectroscopy with geometrically accurate models for bulk parameter recovery." Biomedical Optics Express 7(9): 3784-3794.
Holmes, A. P., et al. (2016). "A Regional Reduction in Ito and IKACh in the Murine Posterior Left Atrial Myocardium Is Associated with Action Potential Prolongation and Increased Ectopic Activity." PLoS One 11(5): e0154077.
Lighter, D., et al. (2016). "Assessing the quantitative accuracy of continuous wave and frequency domain near infrared spectroscopy for detecting hypoxia in patients with traumatic brain injury". Clinical and Translational Biophotonics, Optical Society of America.
M. Race, A. T. S., Rory; Palmer, Andrew D.; B. Styles, Iain; Bunch, Josephine (2016). "Memory Efficient Principal Component Analysis for the Dimensionality Reduction of Large Mass Spectrometry Imaging Data Sets." ACS Publications.
Mason, S., et al. (2016). "Cherenkov Radiation Portal Imaging during Photon Radiotherapy". Optical Tomography and Spectroscopy, Optical Society of America.
Randall, E. C., et al. (2016). "MALDI imaging of LESA sampled tissue." Analytical Chemistry 88 (17), pp 8433–8440
Rassul, S. M., et al. (2016) "Live-imaging in the CNS: New insights on oligodendrocytes, myelination, and their responses to inflammation." Neuropharmacology. Volume 110, Part B, November 2016, Pages 594–604
Sarsby, J., et al. (2015). "Liquid Extraction Surface Analysis Mass Spectrometry Coupled with Field Asymmetric Waveform Ion Mobility Spectrometry for Analysis of Intact Proteins from Biological Substrates." Anal Chem 87(13): 6794-6800.
Taylor, S. L., et al. (2016). Development of a Multi-Modal Optical Imaging System. Biomedical Optics 2016, Fort Lauderdale, Florida, Optical Society of America.
Vyas, N., et al. (2016). "High Speed Imaging of Cavitation around Dental Ultrasonic Scaler Tips." PLoS One 11(3): e0149804.
Vyas, N., et al. (2016). "A quantitative method to measure biofilm removal efficiency from complex biomaterial surfaces using SEM and image analysis." Scientific Reports 6: 32694.

2015

Marshall, R. J., et al. (2015). "Optimisation of patterned illumination to improve depth estimation from a plenoptic camera". Imaging and Applied Optics 2015, Arlington, Virginia, Optical Society of America.
Marshall, R. J., et al. (2015). "Improving depth estimation from a plenoptic camera by patterned illumination". Proc. SPIE 9528, Videometrics, Range Imaging, and Applications XIII, 952815 (21 June 2015); doi: 10.1117/12.2184742
Meah, C., et al. (2015). "Towards Plenoptic Multi-View Imaging". Imaging and Applied Optics 2015, Arlington, Virginia, Optical Society of America.
Poulter, N. S., et al. (2015). "The Physical Basis of Total Internal Reflection Fluorescence (TIRF) Microscopy and Its Cellular Applications". Advanced Fluorescence Microscopy: Methods and Protocols. J. P. Verveer. New York, NY, Springer New York: 1-23.
Poulter, N. S., et al. (2015). "Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich syndrome protein and ARP2/3 complex." Nat Commun 6.
Race, A. M. and J. Bunch (2015). "Optimisation of colour schemes to accurately display mass spectrometry imaging data based on human colour perception." Analytical and Bioanalytical Chemistry 407(8): 2047-2054.
Roussakis, Y. G., et al. (2015). "Validation of a dose warping algorithm using clinically realistic scenarios." The British Journal of Radiology 88(1049): 20140691.
Taylor, S. L., et al. (2015). "Accounting for filter bandwidth improves the quantitative accuracy of bioluminescence tomography." J Biomed Opt 20(9): 096001.
Taylor, S. L., et al. (2015). Optimisation of acquisition time in bioluminescence imaging. Proc. SPIE 9319, Optical Tomography and Spectroscopy of Tissue XI, 93191T (March 5, 2015); doi:10.1117/12.2075661
Taylor, S. L., et al. (2015). "Accounting for filter bandwidth improves the quantitative accuracy of bioluminescence tomography." Journal of Biomedical Optics 20(9): 096001-096001.
Taylor, S. L., et al. (2015). Accounting for systematic errors in bioluminescence imaging to improve quantitative accuracy. Biomedical Optics 2015, Munich, Germany. Optical Society of America
Turola, M., et al. (2015). Effect of wavefront aberrations on a focused plenoptic imaging system: a wave optics simulation approach. Proc. SPIE 9526, Modeling Aspects in Optical Metrology V, 95260X (June 21, 2015); doi:10.1117/12.2184621
Waterman, N., et al. (2015). Super-resolution Imaging with Metamaterials for Cardiovascular Disease. Optics in the Life Sciences, Vancouver, Optical Society of America.
Wudebwe, U. N., et al. (2015). "Exploiting cell-mediated contraction and adhesion to structure tissues in vitro." Philos Trans R Soc Lond B Biol Sci 370(1661): 20140200.
Yiannis, R., et al. (2015). "Real-time Cherenkov emission portal imaging during CyberKnife ® radiotherapy." Physics in Medicine and Biology 60(22): N419.
Yu, T. Y., et al. (2015). "Optical mapping design for murine atrial electrophysiology." Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization: 1-9.

2014

Bamford, R. A., et al. (2014) "Electroporation and microinjection successfully deliver single-stranded and duplex DNA into live cells as detected by FRET measurements". PloS one 9, e95097
Basevi, H. R., et al. (2014). "Towards Bayesian Reconstruction and Analysis in Bioluminescence Tomography via Markov Chain Monte Carlo Techniques". Biomedical Optics 2014, Miami, Florida, Optical Society of America.
Clancy, M., et al. (2014). "Quantitative Evaluation of NIRS Probes and Imaging Protocol for Traumatic Brain Injury (TBI)". Biomedical Optics 2014, Miami, Florida, Optical Society of America.
Koburger, S., et al. (2014). "A novel method for monitoring mineralisation in hydrogels at the engineered hard-soft tissue interface." Biomaterials Science 2(1): 41-51.
Macedo, R. G., et al. (2014). "A novel methodology providing insights into removal of biofilm-mimicking hydrogel from lateral morphological features of the root canal during irrigation procedures." International Endodontic Journal 47(11): 1040-1051.
Marshall, R., et al. (2014). "Plenoptic imaging of the retina: can it resolve depth in scattering tissues?". Biomedical Optics 2014, Miami, Florida, Optical Society of America.
Palmer, A. D., et al. (2014). "The Use of Random Projections for the Analysis of Mass Spectrometry Imaging Data." Journal of The American Society for Mass Spectrometry 26(2): 315-322.
Randall, E. C., et al. (2014). "Direct Analysis of Intact Proteins from Escherichia coli Colonies by Liquid Extraction Surface Analysis Mass Spectrometry." Analytical Chemistry 86(21): 10504-10510.
Rogers, N. J., et al. (2014). "High coating of Ru(ii) complexes on gold nanoparticles for single particle luminescence imaging in cells." Chemical Communications 50(5): 617-619.
Sarsby, J., et al. (2014). "Top-down and bottom-up identification of proteins by liquid extraction surface analysis mass spectrometry of healthy and diseased human liver tissue." Journal of the American Society for Mass Spectrometry 25(11): 1953-1961.
Taylor, S., et al. (2014). Importance of Free Space Modelling on Quantitative Non-Contact Imaging. Biomedical Optics 2014, Miami, Florida, Optical Society of America.
Wu, H. Y., et al. (2014). Development of Multispectral Diffuse Optical Tomography System for Early Diagnosis of Rheumatoid Arthritis. Biomedical Optics 2014, Miami, Florida, Optical Society of America.
Quantitative evaluation of registration methods for atlas-based diffuse optical tomography.u, X., et al. (2013).
Yu, T. Y., et al. (2014). "191 Advancement of Optical Mapping through Automated Algorithms and Second Generation CMOS Detectors to Reveal Murine Atrial Activation Patterns and Regional Variation of Action Potential Duration." Heart 100(Suppl 3): A106.
Yu, T. Y., et al. (2014). "An automated system using spatial oversampling for optical mapping in murine atria. Development and validation with monophasic and transmembrane action potentials." Progress in Biophysics and Molecular Biology 115(2–3): 340-348.

2013

Bannerman, A., et al. (2014). "Imaging the hard/soft tissue interface." Biotechnology Letters 36(3): 403-415.
Basevi, H. R. A., et al. (2013). "Information-theoretic method for wavelength selection in bioluminescence tomography". Biomedical Optics 2013, Munich, Germany, Optical Society of America.
Basevi, H. R. A., et al. (2013). "Simultaneous multiple view high resolution surface geometry acquisition using structured light and mirrors." Optics Express 21(6): 7222-7239.
Calcagni, A., et al. (2013). "Multispectral retinal image analysis (MRIA) for the assessment of subretinal fibrosis in neovascular age-related macular degeneration (nAMD)." Acta Ophthalmologica 91: 0-0.
Fonville, J. M., et al. (2013). "Hyperspectral Visualization of Mass Spectrometry Imaging Data." Analytical Chemistry 85(3): 1415-1423.
Garcia, A., et al. (2013). "Differences in the time course of learning for hard compared to easy training." Frontiers in Psychology 4.
Griffiths, R. L., et al. (2013). "Formal lithium fixation improves direct analysis of lipids in tissue by mass spectrometry." Anal Chem 85(15): 7146-7153.
Guggenheim, J. A., et al. (2013). "Bioluminescence tomography improves quantitative accuracy for pre-clinical imaging". Proc. SPIE 8799, Diffuse Optical Imaging IV, 87990G (June 14, 2013); doi:10.1117/12.2033317
Guggenheim, J. A., et al. (2013). "Quantitative surface radiance mapping using multiview images of light-emitting turbid media." Journal of the Optical Society of America A 30(12): 2572-2584.
James, A. G., et al. (2013). "Multi-modal molecular diffuse optical tomography system for small animal imaging." Measurement Science and Technology 24(10): 105405.
Palmer, A. D., et al. (2013). Faster tissue interface analysis from Raman microscopy images using compressed factorisation. Biomedical Optics 2013, Munich, Germany, Optical Society of America.
Palmer, A. D., et al. (2013). "Randomized Approximation Methods for the Efficient Compression and Analysis of Hyperspectral Data." Analytical Chemistry 85(10): 5078-5086.
Race, A. M., et al. (2013). "Memory Efficient Principal Component Analysis for the Dimensionality Reduction of Large Mass Spectrometry Imaging Data Sets." Analytical Chemistry 85(6): 3071-3078.
Robinson, J. P., et al. (2013). "Reciprocating root canal technique induces greater debris accumulation than a continuous rotary technique as assessed by 3-dimensional micro-computed tomography." J Endod 39(8): 1067-1070.
Steven, R. T. and J. Bunch (2013). "Repeat MALDI MS imaging of a single tissue section using multiple matrices and tissue washes." Analytical and Bioanalytical Chemistry 405(14): 4719-4728.
Steven, R. T., et al. (2013). "Fluorometric Beam Profiling of UV MALDI Lasers." Journal of The American Society for Mass Spectrometry 24(7): 1146-1152.
Steven, R. T., et al. (2013). "para-Nitroaniline is a Promising Matrix for MALDI-MS Imaging on Intermediate Pressure MS Systems." Journal of The American Society for Mass Spectrometry 24(5): 801-804.
Styles, I. B., et al. (2013). Random matrix-based dimensionality reduction for bioluminescence tomography reconstruction. Biomedical Optics 2013, Munich, Germany, Optical Society of America.
Williams, R. L., et al. (2013). "Thiol modification of silicon-substituted hydroxyapatite nanocrystals facilitates fluorescent labelling and visualisation of cellular internalisation." Journal of Materials Chemistry B 1(35): 4370-4378.
Wu, X., et al. (2013). Quantitative evaluation of registration methods for atlas-based Diffuse Optical Tomography. Diffuse Optical Imaging IV, Munich, Optical Society of America.

2012

Basevi, H. R., et al. (2012). "Application of Compressive Sensing to Bioluminescence Tomography. Biomedical Optics and 3-D Imaging", Miami, Florida, Optical Society of America.
Basevi, H. R. A., et al. (2012). "Compressive sensing based reconstruction in bioluminescence tomography improves image resolution and robustness to noise." Biomedical Optics Express 3(9): 2131-2141.
Claire, S., et al. (2012). "Characterisation of bone following ultrasonic cutting." Clinical Oral Investigations 17(3): 905-912.
Davies, A., et al. (2012). "pH-controlled delivery of luminescent europium coated nanoparticles into platelets." Proc Natl Acad Sci U S A 109(6): 1862-1867.
Dowle, M., KP Arkill, ZW Wang, Richard Palmer (2012). "Mass spectrometry of individual ferritin cores using size-selected gold clusters as mass standards in the electron microscope."
Fabritz, L., et al. (2012). "Can preload-reducing therapy prevent disease progression in arrhythmogenic right ventricular cardiomyopathy? Experimental evidence and concept for a clinical trial." Progress in Biophysics and Molecular Biology 110(2–3): 340-346.
Guggenheim, J. A., et al. (2012). "Multi-View, Multi-Spectral Bioluminescence Tomography". Biomedical Optics and 3-D Imaging, Miami, Florida, Optical Society of America.
Palmer, A. D. G., Rian; Styles, Iain; Claridge, Ela; Calcagni, Antonio; Bunch, Josephine (2012). "Sucrose cryo-protection facilitates imaging of whole eye sections by MALDI mass spectrometry." Journal of Mass Spectrometry 47(2): 237-241.
Pitkeathly, W. T. E., et al. (2012). "Auto-Align – Multi-Modality Fluorescence Microscopy Image Co-registration." Traffic 13(2): 204-217.
Race, A. M., et al. (2012). "Inclusive sharing of mass spectrometry imaging data requires a converter for all." Journal of Proteomics 75(16): 5111-5112.
Robinson, J. P., et al. (2012). "An analytical Micro CT methodology for quantifying inorganic dentine debris following internal tooth preparation." Journal of Dentistry 40(11): 999-1005.
Smith, P. J., et al. (2012). "Cellular entry of nanoparticles via serum sensitive clathrin-mediated endocytosis, and plasma membrane permeabilization." International Journal of Nanomedicine 7: 2045-2055.

2011

Guggenheim, J. A., et al. (2011). "Development of a multi-view, multi-spectral bioluminescence tomography small animal imaging system". Diffuse Optical Imaging III, Munich, Optical Society of America.

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