Research in the School of Dentistry

Research at the School of DentistryWelcome to the School of Dentistry Research. Our research programmes encompass Public Health and Epidemiology, Tissue Injury & Regeneration and Biomaterials and have strong translational focus. Our mission is to develop novel diagnostic and therapeutic solutions to important oral and general health problems to benefit the population as a whole. This translational research brings together world class clinical and experimental scientists with expertise in diverse aspects of dental and oral health research.

Oral infectious and inflammatory diseases are the most common human diseases worldwide and cause significant morbidity, impacting upon general health, wellbeing and mortality rates. Their impact on the economy is substantial. Our research is making significant inroads into understanding their pathobiology and translating this into novel treatments. Oral cancer is currently the 6th most common form of cancer with survival rates of only 60% and we aim to impact significantly upon these statistics through our collaborative research activities. Our interdisciplinary research excellence in the field of tissue repair, regeneration and rehabilitation draws upon multi-disciplinary expertise in the biological, physical and biological sciences to improve current, and develop future, therapeutic solutions.

Our clinician-basic science partnerships provide broad expertise and enable us to exploit our findings through clinical trials of novel diagnostics and therapeutics in collaboration with our NHS partners. While our state-of-the-art purpose built laboratories and associated clinics house cutting-edge technologies enabling us to explore disease mechanisms, improve our understanding of pathogenic processes, and formulate new healthcare solutions.

The strengths of our internationally-leading teams centre on developing a sound understanding of disease mechanisms to underpin novel diagnostic, tissue regenerative and engineering therapeutic strategies for periodontal diseases, caries and oral cancer; and are enhanced by strong local, national and international (Europe, North/South America, Far-East, Asia) collaborations.
Our focus on the scientific basis of oral and dental disease is providing innovative solutions to important problems significantly impacting the population and is helping us to deliver our vision for improving oral and general health.

Research themes in the School

Biomaterials

Description
This theme area seeks to develop novel biomaterials and tissue engineering approaches for application in dental and broader body organ contexts and to relate their clinical performance to studies of their mechanical and biological properties.

Public Health & Clinical Epidemiology

Description
In this research area, there is a strong focus on epidemiological oral health surveys of UK and international patient populations. This has helped identify disease trends and healthcare needs and thus strongly impacts upon healthcare policy and delivery. Importantly, our novel analyses have now identified significant relationships between oral and systemic diseases, including associations between periodontal diseases and cardiovascular disease and rheumatoid arthritis.

Tissue Injury & Regeneration

Description
This theme area seeks to understand molecular and cellular processes underlying tissue injury and health (periodontitis, endodontics & caries and oral cancer) to develop novel and improved approaches to diagnosis, prevention and therapy.