Simon studied Mathematics and Music at the University of Birmingham. Prior to starting his PhD, Simon worked at University Hospitals Birmingham in a collaborative role with the European Association for Cardio-Thoracic Surgery (EACTS) chaired by Professor Domenico Pagano, providing technical and statistical support to Quality Improvement Programmes (QUIPs). Simon was also a member of a joint Cancer and Genomics-Health Informatics Research group chaired by Mr Prashant Patel, providing statistical support to projects, several of which have now been published.