Professor Krish Nirantharakumar MBBS MPH MFPH MRCP(UK) MD

Professor Krish Nirantharakumar

Institute of Applied Health Research
Professor in Health Data Science and Public Health
Joint Director of the Centre for Health Data Science
Honorary Consultant in Public Health Medicine; Deputy Director IAHR

Contact details

IOEM Building
University of Birmingham
B15 2TT

Krish is the Joint-Director for the Centre for Health Data Science and Deputy Director for the Institute of Applied Health Research at University of Birmingham.

Krish is passionate to support junior staff, particularly from under-represented backgrounds to develop into self-sustaining leaders. His contribution was recognised and highlighted in BMJ as a role model. He has made significant achievements in three main research domains: 1) developing, implementing and evaluating digital technologies for learning health systems and real-world evidence research; 2) clinical and public health themes relating to diabetes epidemiology, women’s health and multimorbidity; and 3) global health.

Krish has gained large-scale external funding (over £15 million) and published over 100 peer-reviewed original research publications in the last three years and have gained recognition internationally for innovative automated methodological approaches for clinical epidemiology research.


  • MD University of Birmingham, UK 2013
  • Certificate of Completion of Training (CCT) in Public Health Medicine, West Midlands Deanery, UK 2012
  • MFPH Faculty of Public Health, UK 2010
  • PGDip. (Epidemiology) University of London, UK 2009
  • MPH University of Birmingham, UK 2008
  • MRCP (UK) Royal College of Physicians, UK 2007
  • MBBS University of Colombo, Sri Lanka 2002


Krish completed his medical degree in 2002 and trained in hospital medicine in a number of hospitals in UK. He was elected through exams as a Member of the Royal College of Physicians (MRCP) in 2007. Later he specialised in Public Health Medicine (2007 – 2012) completing a Masters in Public Health (MPH), Membership exams of the Faculty of Public Health (MFPH) and the certificate for completion of specialist training (CCT) in Public Health Medicine. He obtained his doctoral research degree (MD) studying the potential role of health informatics tools in improving the care of hospitalised patients with diabetes.

In March 2012 Krish was awarded a 3 year clinical research fellowship by the West Midlands Deanery. However in 2013 to gain experience in working in a cross disciplinary environment with computer scientists, mathematicians and engineers he joined the Institute of Digital Healthcare (IDH) at University of Warwick as a senior research fellow for one year and then returned to University of Birmingham to take on a Senior Clinical Lecturer post. In 2018 in recognition of his contribution to Real World Evidence (RWE) research and co-innovation of the DExtER tool for Automated Clinical Epidemiology Studies (ACES) he was awarded a prestigious MRC fellowship (UKRI Innovation Clinical Fellow). He was promoted to Professor of Health Data Science and Public Health in recognition of his international reputation for innovative methodology development for automated epidemiology studies and his clinical /public health research into epidemiology of diabetes/endocrinology, multimorbidity and women’s health.

Krish has vast experience in teaching and has led the MPH (Programme Lead) and post graduate taught courses (Director for PGT) at the Institute of Applied Health Research. He was awarded the prestigious vice chancellor's outstanding teaching award in 2016. 

Krish has honorary consultant in Public Health Medicine appointments with Public health England and University Hospitals Birmingham NHS Foundation Trust. He is the founder of the West Midlands Health Informatics Network (2013-2018) and Chief Scientific Officer and Founder of the DExtER Software start-up (2023- to date).


Postgraduate supervision

Krish has supervised ten doctoral students (9 PhDs and 1 MD) to completion, six of them as primary supervisor. He currently supervises eight students as primary supervisor.

Krish is interested in supervising doctoral research students in the following areas:

  • The role of informatics and digital technology in the management of diabetes and multiple morbidities.
  • Epidemiology of endocrinological disorders
  • Technologies for learning health systems (Automated Clinical Epidemiology, Computer Executable Guidelines and Electronic Health Record development)

If you are interested in studying any of these subject areas please contact Krish directly, or 
for any general doctoral research enquiries, please email


Methodology theme:

  • Developing, implementing and evaluating digital technologies for learning health systems (Automated Clinical Epidemiology Studies (ACES), Informatics Consult, Data/Electronic Health Record Driven Clinical Trials and Computable Clinical Guidelines): Innovative methodological approach to develop technologies that enable efficient research, quality improvement and decision making in health care has been the main focus of Krish’s current research and has led to the University of Birmingham gaining an international reputation for being one of the very few universities to have successfully researched and knowledge-engineered epidemiological study designs into computer executable formats. Krish was the first to implement such a platform (DExtER tool) in the United Kingdom and publish the methods in the European Journal of Epidemiology. The DExtER tool is now being trialled as a data driven clinical trials platform (RADIANT Trial). The tool is also part of developing AI based technologies for managing people living with multiple long term conditions (OPTIMAL project £2.5million). Krish is the medical director for OpenClinical, a social enterprise where he works with the technology lead (Dr Matthew South) to develop open-source tools for developing computable guidelines using the Proforma technology developed by Late Professor John Fox. Through funding from Midland Patient Safety Centre, BRC Data, Digital and Diagnostics theme and NHS organisations (Shrewsbury Maternity HospitaI and University Hospitals Birmingham), implementation of both DExtER and OpenClinical Platform as a learning health system within NHS organisation is currently being undertaken.
  • Real World Evidence Research (THIN-KING research group): Krish has established a research group to work with clinicians across the Midlands to provide rapid evidence using electronic medical record data. These research groups have contributed to over 50 publications, many in high impact general medical and specialty journals.

 Clinical and Public Health Themes:

  • Epidemiology of diabetes, endocrinology and metabolic disorders: Krish’s clinical research interest is focussed on diabetes and endocrinology. He leads the clinical epidemiology group at the centre for endocrinology, diabetes and metabolism (CEDAM). He has used electronic medical record, cohort, and clinical trials data to contribute to the understanding of the determinants, prognosis and therapeutic options for diabetes and endocrine disorders.
  • Women’s Health Research:  Focus include: 1) multiple long-term conditions in pregnancy (MuM-PreDiCT); 2) health conditions specific (e.g. polycystic ovarian syndrome) or dominant in women (e.g migraine, idiopathic intracranial hypertension) and their effect on pregnancy and long-term health conditions; and 3) the effect of domestic violence on health outcomes.
  • Multimorbidity Research: Krish leads two national consortiums in multimorbidity research with a grant income over £5 million. One as principal investigator (MuMPreDiCT as above) and the other as joint principal investigator (OPTIMAL: optimising therapies and tackling trajectories in people living with multiple long term conditions using AI methods).

Other activities

  • Honorary Consultant in Public Health Medicine: Diabetes Department, University Hospitals Birmingham NHS Foundation Trust. 2014 onwards
  • Honorary Consultant in Public Health Medicine: Public Health England. 2013 onwards
  • Medical Director: OpenClinical Community Interest Company, UK: 2020 onwards
  • Trustee of the charity: Network for Improving Care Services and Training (NICST): 2020 onwards
  • Panel Member: Medical Research Council, Methodology panel: 2020 onwards
  • Founder and Chief Scientific Officer: DEXTER Software Limited: 2023 onwards
  • Committee member: Acute care, Clinical Scientific Group (CSG), Diabetes UK: March 2017 to date
  • Founder and member: West Midlands Health Informatics Network (WIN): 2013-2017
  • Associate clinical fellow: Health Informatics Unit, Royal College of Physicians, UK: 2014-2019
  • Expert topic member: NICE guidelines update committee for diabetes prevention in high risk patients: 2016-2017
  • Expert topic member: NICE guidelines update committee for SGLT2 inhibitors and GLP1 agonists in diabetes management: 2017


  1. Thayakaran R, Adderley NJ, Sainsbury C, Torlinska B, Boelaert K, Sumilo D, Price M, Thomas GN, Toulis KA, Nirantharakumar K#*. Thyroid replacement therapy, thyroid stimulating hormone concentrations, and long term health outcomes in patients with hypothyroidism: longitudinal study. BMJ. 2019;366:l4892.
  2. Okoth K, Chandan JS, Marshall T, Thangaratinam S, Thomas GN, Nirantharakumar K#*, Adderley NJ. Association between the reproductive health of young women and cardiovascular disease in later life: umbrella review. BMJ. 2020;371:m3502.
  3. Adderley NJ, Nirantharakumar K*, Marshall T. Risk of stroke and transient ischaemic attack in patients with a diagnosis of resolved atrial fibrillation: retrospective cohort studies. BMJ. 2018;361:k1717.
  4. Šumilo D, Nirantharakumar K, Willis BH, Rudge GM, Martin J, Gokhale K, Thayakaran R, Adderley NJ, Chandan JS, Okoth K, Harris IM, Hewston R, Skrybant M, Deeks JJ, Brocklehurst P. Long term impact of prophylactic antibiotic use before incision versus after cord clamping on children born by caesarean section: longitudinal study of UK electronic health records. BMJ. 2022;377:e069704.
  5. Subramanian A, Nirantharakumar K*, Hughes S, Myles P et al. Symptoms and risk factors for long COVID in non-hospitalized adults. Nat Med. 2022;28(8):1706-14.
  6. Caleyachetty R, Thomas GN, Toulis KA, Mohammed N, Gokhale KM, Balachandran K, Nirantharakumar K#. Metabolically Healthy Obese and Incident Cardiovascular Disease Events among 3.5 Million Men and Women. Journal of the American College of Cardiology. 2017;70(12):1429-37.
  7. Adderley NJ, Subramanian A, Toulis K, Gokhale K, Taverner T, Hanif W, Haroon S, Thomas GN, Sainsbury C, Tahrani AA, Nirantharakumar K#. Obstructive Sleep Apnea, a Risk Factor for Cardiovascular and Microvascular Disease in Patients with Type 2 Diabetes: Findings from a Population-Based Cohort Study. Diabetes care. 2020;43(8):1868-77.
  8. Kumarendran B, O'Reilly MW, Subramanian A, Šumilo D, Toulis K, Gokhale KM, Wijeratne CN, Coomarasamy A, Tahrani AA, Azoulay L, Arlt W, Nirantharakumar K. Polycystic Ovary Syndrome, Combined Oral Contraceptives, and the Risk of Dysglycemia: A Population-Based Cohort Study With a Nested Pharmacoepidemiological Case-Control Study. Diabetes care. 2021;44(12):2758-66.
  9. Chandan JS, Thomas T, Gokhale KM, Bandyopadhyay S, Taylor J, Nirantharakumar K#. The burden of mental ill health associated with childhood maltreatment in the UK, using The Health Improvement Network database: a population-based retrospective cohort study. Lancet Psychiatry. 2019;6(11):926-34.
  10. Gooden TE, Gardner M, Wang J, Chandan JS, Beane A, Haniffa R, Taylor S, Greenfield S, Manaseki-Holland S, Thomas GN, Nirantharakumar K. The risk of mental illness in people living with HIV in the UK: a propensity score-matched cohort study. Lancet HIV. 2022;9(3):e172-e81.

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