Mrs Catherine Moakes BSc (Hons), MSc

Mrs Catherine Moakes

Institute of Applied Health Research
Senior Medical Statistician

Contact details

Birmingham Clinical Trials Unit (BCTU)
Public Health Building
University of Birmingham
B15 2TT

Catherine Moakes has over 8 years’ experience in the design and analysis of clinical trials working as a Medical Statistician for the Birmingham Clinical Trials Unit (BCTU).

Catherine's main portfolios within BCTU are trials related to obstetrics and gynaecology with a special interest in pre-term birth.

Catherine has also worked in trials related to Respiratory, Gastroenterology and Hepatology, and is an experienced user of both major statistical analysis software packages SAS and STATA as required by MHRA for analysis of clinical trials.


MSc in Medical Statistics, University of Leicester, 2014

BSc (Hons) in Mathematics, University of Loughborough, 2013


Catherine graduated from the University of Loughborough in 2013 with a first class BSc (Hons) degree in Mathematics. She then went on to study for an MSc in Medical Statistics at the University of Leicester.

After finishing her Masters in September 2014, Catherine started work as a Trainee Statistician at the Birmingham Clinical Trials Unit (BCTU) at the University of Birmingham. Catherine progressed to a Trial Statistician role in December 2016 and later to a Senior Statistician in March 2020.

Catherine’s main portfolios within BCTU are trials related to women’s health (obstetrics and gynaecology), vascular surgery and physical activity. She has also worked in trials related to Respiratory, Gastroenterology and Hepatology, and is an experienced user of both major statistical analysis software packages SAS and STATA as required by MHRA for analysis of clinical trials.


  • Masters in Clinical Trials (lecturer on Rationale for Clinical Trials, Key Concepts and Features and Module Lead for Selection, Collection and Reporting of Outcomes module and statistical supervisor for the final research projects)
  • BCTU’s CPD approved “Introduction to Randomised Controlled Trials in Healthcare” course
  • Group tutor for the Masters in Public Health (Epidemiology Statistics and Research Methods - Stata Practical and Advanced Statistical Methods - Stata Practical)
  • Lecturer for the BSc Biomedical Science: Molecular and Integrative Pharmacology


Through her work on several successfully funded NIHR/EME/RfPB grants, Catherine has developed a wealth of practical experience in various clinical trial designs including: pilot and feasibility studies, surgical trials, non-inferiority approaches, cluster-randomised trials and cohort designs. She also has an interest in diagnostic studies, individual patient data meta-analysis, missing data methods and automated output methods.

Other activities

Independent statistician on numerous Trial Steering and Data Monitoring Committees contributing to the oversight and direction of externally run clinical trials.

Member of the pre-term birth CSG.

Statistical reviewer for trials.


Recent publications


Popplewell, MA, Meecham, L, Davies, HOB, Kelly, L, Ellis, T, Bate, GR, Moakes, CA & Bradbury, AW 2024, 'Editor's Choice - Bypass versus Angioplasty for Severe Ischaemia of the Leg (BASIL) Prospective Cohort Study and the Generalisability of the BASIL-2 Randomised Controlled Trial', European Journal of Vascular and Endovascular Surgery, vol. 67, no. 1, pp. 146-152.

Tripathi, D, Patch, D, Mehrzad, H, Yu, D, Aspinall, RJ, Armstrong, MJ, Stanley, AJ, Ireland, H, Travis, S, Hayes, P, Lomax, M, Roslund, N, Lam, E, Slinn, G, Jowett, S, Moakes, C, Maher, A, Brettell, E, Sehmi, S & REACT-AVB trial collaborative group 2024, 'Study protocol for a Randomised controlled trial of EArly transjugular intrahepatiC porTosystemic stent–shunt in Acute Variceal Bleeding (REACT-AVB trial)', BMJ Open Gastroenterology, vol. 11, no. 1, e001314.

Ashworth, D, Battersby, C, Bick, D, Green, M, Hardy, P, Leighton, L, Magee, LA, Maher, A, McManus, RJ, Moakes, C, Morris, RK, Nelson-Piercy, C, Sparkes, J, Rivero-Arias, O, Webb, A, Wilson, H, Myers, J & Chappell, LC 2023, 'A treatment strategy with nifedipine versus labetalol for women with pregnancy hypertension: study protocol for a randomised controlled trial (Giant PANDA)', Trials, vol. 24, no. 1, 584.

BASIL-2 Trial Investigators 2023, 'A vein bypass first versus a best endovascular treatment first revascularisation strategy for patients with chronic limb threatening ischaemia who required an infra-popliteal, with or without an additional more proximal infra-inguinal revascularisation procedure to restore limb perfusion (BASIL-2): an open-label, randomised, multicentre, phase 3 trial', The Lancet, vol. 401, no. 10390, pp. 1798-1809.

Horne, AW, Tong, S, Moakes, C, Middleton, L, Duncan, WC, Mol, B, Whitaker, LHR, Jurkovic, D, Coomarasamy, A, Nunes, N, Holland, T, Clarke, F, Doust, AM, Daniels, J & for the GEM3 collaborative 2023, 'Combination of gefitinib and methotrexate to treat tubal ectopic pregnancy (GEM3): a multicentre, randomised, double-blind, placebo-controlled trial', The Lancet.

Mackenzie, SC, Moakes, CA, Doust, AM, Mol, BW, Duncan, WC, Tong, S, Horne, AW & Whitaker, LHR 2023, 'Early (Days 1-4) post-treatment serum hCG level changes predict single-dose methotrexate treatment success in tubal ectopic pregnancy', Human Reproduction.

GEM3 Collaborative Group 2023, 'Gefitinib and methotrexate to resolve tubal ectopic pregnancy: the GEM3 RCT', Efficacy and Mechanism Evaluation, vol. 10, no. 1.

Daley, AJ, Griffin, RA, Moakes, CA, Sanders, JP, Skrybant, M, Ives, N, Maylor, B, Greenfield, SM, Gokal, K, Parretti, HM, Biddle, SJH, Greaves, C, Maddison, R, Mutrie, N, Esliger, DW, Sherar, L, Edwardson, CL, Yates, T, Frew, E, Tearne, S & Jolly, K 2023, 'Snacktivity™ to promote physical activity and reduce future risk of disease in the population: protocol for a feasibility randomised controlled trial and nested qualitative study', Pilot and Feasibility Studies, vol. 9, no. 1, 45.

WILL Trial Study Group 2023, 'WILL (When to induce labour to limit risk in pregnancy hypertension): Protocol for a multicentre randomised trial', Pregnancy Hypertension, vol. 32, pp. 35-42.

Morton, V, Toozs-Hobson, P, Moakes, C, Moakes, C, Middleton, L, Daniels, J, Simpson, NAB, Shennan, A, Israfil-Bayli, F, Ewer, A, Gray, J, Slack, M, Norman, JE, Lees, C, Tryposkiadis, K, Hughes, M, Brocklehurst, P & Morris, RK 2022, 'Monofilament suture versus braided suture thread to improve pregnancy outcomes after vaginal cervical cerclage (C-STICH): a pragmatic randomised, controlled, phase 3, superiority trial', The Lancet, vol. 400, no. 10361, pp. 1426-1436.

Gokal, K, Amos-Hirst, R, Moakes, C, Sanders, JP, Esliger, DW, Sherar, LB, Ives, N, Biddle, SJH, Edwardson, C, Frew, E, Yates, T, Greaves, C, Rowland, N, Greenfield, S, Jolly, K, Skrybant, M, Maddison, R, Mutrie, N, Parretti, H & Daley, A 2022, 'Views of the public about Snacktivity™: A small changes approach to promoting physical activity and reducing sedentary behaviour', BMC Public Health, vol. 22, no. 618, 618.

WILL Trial Study Group 2022, 'WILL (When to Induce Labour to Limit risk in pregnancy hypertension): a multicentre randomised controlled trial — adaptations to deliver a timing-of-birth trial during the COVID-19 international pandemic', Trials, vol. 23, no. 1, 884.

Jayne, D, Scholefield, J, Tolan, D, Gray, R, Senapati, A, Hulme, C, Sutton, A, Handley, K, Hewitt, C, Kaur, M, Magill, L & FIAT Trial Collaborative Group 2021, 'A multicentre randomised controlled trial comparing safety, efficacy, and cost-effectiveness of the Surgisis anal fistula plug versus surgeon’s preference for transsphincteric fistula-in-ano: the FIAT trial', Annals of surgery, vol. 273, no. 3, pp. 433-441.


Mackenzie, SC, Moakes, C, Duncan, WC, Tong, S & Horne, AW 2023, 'Subsequent pregnancy outcomes among women with tubal ectopic pregnancy treated with methotrexate', Reproduction and Fertility , vol. 4, no. 2, e230019.

Review article

Ahmed, SI, Ammerdorffer, A, Moakes, CA, Cheshire, J, Gülmezoglu, AM, Coomarasamy, A, Lissauer, D & Wilson, A 2022, 'Prophylactic antibiotics for uterine evacuation procedures to treat miscarriage', Cochrane Database of Systematic Reviews, vol. 2022, no. 1, CD014844.

View all publications in research portal