Mrs Catherine Moakes BSc (Hons), MSc

Mrs Catherine Moakes

Birmingham Clinical Trials Unit
Senior Medical Statistician

Contact details

Address
Birmingham Clinical Trials Unit (BCTU)
Public Health Building
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Catherine Moakes has over 8 years’ experience in the design and analysis of clinical trials working as a Medical Statistician for the Birmingham Clinical Trials Unit (BCTU).

Catherine's main portfolios within BCTU are trials related to obstetrics and gynaecology with a special interest in pre-term birth.

Catherine has also worked in trials related to Respiratory, Gastroenterology and Hepatology, and is an experienced user of both major statistical analysis software packages SAS and STATA as required by MHRA for analysis of clinical trials.

Qualifications

MSc in Medical Statistics, University of Leicester, 2014

BSc (Hons) in Mathematics, University of Loughborough, 2013

Biography

Catherine graduated from the University of Loughborough in 2013 with a first class BSc (Hons) degree in Mathematics. She then went on to study for an MSc in Medical Statistics at the University of Leicester.

After finishing her Masters in September 2014, Catherine started work as a Trainee Statistician at the Birmingham Clinical Trials Unit (BCTU) at the University of Birmingham. Catherine progressed to a Trial Statistician role in December 2016 and later to a Senior Statistician in March 2020.

Catherine’s main portfolios within BCTU are trials related to women’s health (obstetrics and gynaecology), vascular surgery and physical activity. She has also worked in trials related to Respiratory, Gastroenterology and Hepatology, and is an experienced user of both major statistical analysis software packages SAS and STATA as required by MHRA for analysis of clinical trials.

Teaching

  • Masters in Clinical Trials (lecturer on Rationale for Clinical Trials, Key Concepts and Features and Module Lead for Selection, Collection and Reporting of Outcomes module and statistical supervisor for the final research projects)
  • BCTU’s CPD approved “Introduction to Randomised Controlled Trials in Healthcare” course
  • Group tutor for the Masters in Public Health (Epidemiology Statistics and Research Methods - Stata Practical and Advanced Statistical Methods - Stata Practical)
  • Lecturer for the BSc Biomedical Science: Molecular and Integrative Pharmacology

Research

Through her work on several successfully funded NIHR/EME/RfPB grants, Catherine has developed a wealth of practical experience in various clinical trial designs including: pilot and feasibility studies, surgical trials, non-inferiority approaches, cluster-randomised trials and cohort designs. She also has an interest in diagnostic studies, individual patient data meta-analysis, missing data methods and automated output methods.

Other activities

Independent statistician on numerous Trial Steering and Data Monitoring Committees contributing to the oversight and direction of externally run clinical trials.

Member of the pre-term birth CSG.

Statistical reviewer for trials.

Publications

Recent publications

Article

BASIL-2 Investigators, Abdali, Z, Kigozi, J, Moakes, CA, Bate, GR, Hall, J, Kelly, L, Meecham, L, Bradbury, AW & Popplewell, MA 2025, 'A vein bypass first versus a best endovascular treatment first revascularization strategy for patients with chronic limb-threatening ischaemia who require an infra-popliteal, with or without an additional more proximal infra-inguinal, revascularization procedure to restore limb perfusion: the BASIL-2 within-trial health economic analysis', British Journal of Surgery, vol. 112, no. 6, znaf119. https://doi.org/10.1093/bjs/znaf119

CALIBRE Trial, Tripathi, D, Handley, K, Holden, L, Abdali, Z, Jowett, S, Mathers, J, Poyner, C, Richardson, P, Ferguson, J & Rowe, IA 2025, 'Clinical Trial: A Multicentre Randomised Controlled Trial of Carvedilol Versus Variceal Band Ligation in Primary Prevention of Variceal Bleeding in Liver Cirrhosis (CALIBRE Trial)', Alimentary Pharmacology & Therapeutics, pp. 1-15. https://doi.org/10.1111/apt.70080

Popplewell, M, Hall, J, Meecham, L, Bate, G, Kelly, L, Deeks, JJ, Moakes, CA, Bradbury, A & BASIL-3 Investigators 2025, 'Long-term mortality rate and clinical outcomes associated with femoro-popliteal drug–coated balloon angioplasty and drug-eluting stents in chronic limb-threatening ischaemia: an analysis of the BASIL-3 RCT', British Journal of Surgery, vol. 112, no. 11, znaf251. https://doi.org/10.1093/bjs/znaf251

BASIL-3 Investigators, Bradbury, AW, Hall, JA, Popplewell, MA, Meecham, L, Bate, GR, Kelly, L, Deeks, JJ & Moakes, CA 2025, 'Plain versus drug balloon and stenting in severe ischaemia of the leg (BASIL-3): open label, three arm, randomised, multicentre, phase 3 trial', BMJ (Clinical research ed.), vol. 388, e080881. https://doi.org/10.1136/bmj-2024-080881

Daley, AJ, Griffin, RA, Sanders, JP, Gokal, K, Ives, N, Skrybant, M, Parretti, H, Edwardson, CL, Biddle, SJH, Jolly, K, Greaves, C, Greenfield, SM, Maddison, R, Esliger, DW, Sherar, LB, Frew, E, Mutrie, N, Maylor, B, Yates, T, Tearne, S & Moakes, CA 2025, 'Snacktivity™ to promote physical activity in primary care, community health and public health settings: A feasibility randomised controlled trial ', International Journal of Behavioral Medicine. https://doi.org/10.1007/s12529-025-10352-3

WILL Trial Study Group 2025, 'Women's Childbirth Experiences in the WILL Randomised Trial (When to Induce Labour to Limit Risk in Pregnancy Hypertension): A Mixed Methods Analysis', BJOG: An International Journal of Obstetrics & Gynaecology. https://doi.org/10.1111/1471-0528.18257

Bradbury, AW, Hall, J, Moakes, CA, Popplewell, M, Meecham, L, Bate, GR, Kelly, L, Diamantopoulos, A, Ganeshan, A, Houlind, K, Malmstedt, J, Patel, JV, Saratzis, A & Zayed, H 2024, 'Bypass versus Angioplasty in Severe Ischaemia of the Leg (BASIL)-2 Trial: Analysis of the Timing and Causes of Death in Participants Randomised to an Infrapopliteal Vein Bypass or Best Endovascular Treatment First Revascularisation Strategy', European Journal of Vascular and Endovascular Surgery. https://doi.org/10.1016/j.ejvs.2024.07.029

Hodgetts Morton, V, Moakes, CA, Daniels, J, Middleton, L, Shennan, A, Brocklehurst, P, Israfil-Bayli, F, Ewer, AK, Simpson, NA, Norman, JE, Lees, C, Tryposkiadis, K, Stubbs, C, Hughes, M, Morris, RK, Toozs-Hobson, P & Gray, J 2024, 'Cerclage suture type to prevent pregnancy loss in women requiring a vaginal cervical cerclage: the C-STICH RCT', Health Technology Assessment, vol. 28, no. 40, pp. 1-44. https://doi.org/10.3310/YKTW8402

the WILL Trial Study Group 2024, 'Determining optimal timing of birth for women with chronic or gestational hypertension at term: The WILL (When to Induce Labour to Limit risk in pregnancy hypertension) randomised trial', PLoS Medicine, vol. 21, no. 11, e1004481. https://doi.org/10.1371/journal.pmed.1004481

Popplewell, MA, Meecham, L, Davies, HOB, Kelly, L, Ellis, T, Bate, GR, Moakes, CA & Bradbury, AW 2024, 'Editor's Choice - Bypass versus Angioplasty for Severe Ischaemia of the Leg (BASIL) Prospective Cohort Study and the Generalisability of the BASIL-2 Randomised Controlled Trial', European Journal of Vascular and Endovascular Surgery, vol. 67, no. 1, pp. 146-152. https://doi.org/10.1016/j.ejvs.2023.09.041

Ives, N, Woolley, R, Saleem , MA, Moakes, C, Waters, A, Gilbert, RD, Jarrett, H, Brettell, E, Nash, S, Farmer, LK, Ourradi, K & Johnson, SA 2024, 'Efficacy and safety of eculizumab in children with Shiga-toxin-producing Escherichia coli haemolytic uraemic syndrome: the ECUSTEC RCT', Efficacy and Mechanism Evaluation, vol. 11, no. 11, pp. 1-78. https://doi.org/10.3310/RFTY4766

Tripathi, D, Patch, D, Mehrzad, H, Yu, D, Aspinall, RJ, Armstrong, MJ, Stanley, AJ, Ireland, H, Travis, S, Hayes, P, Lomax, M, Roslund, N, Lam, E, Slinn, G, Jowett, S, Moakes, C, Maher, A, Brettell, E, Sehmi, S & REACT-AVB trial collaborative group 2024, 'Study protocol for a Randomised controlled trial of EArly transjugular intrahepatiC porTosystemic stent–shunt in Acute Variceal Bleeding (REACT-AVB trial)', BMJ Open Gastroenterology, vol. 11, no. 1, e001314. https://doi.org/10.1136/bmjgast-2023-001314

BASIL-2 Investigators, Moakes, CA, Bradbury, AW, Abdali, Z, Bate, GR, Hall, J, Jarrett, H, Kelly, L, Kigozi, J, Lockyer, S, Meecham, L, Patel, S, Popplewell, M, Slinn, G & Deeks, JJ 2024, 'Vein bypass first vs. best endovascular treatment first revascularisation strategy for chronic limb-threatening ischaemia due to infra-popliteal disease: the BASIL-2 RCT', Health technology assessment (Winchester, England), vol. 28, no. 65, pp. 1-72. https://doi.org/10.3310/YTFV4524

Ashworth, D, Battersby, C, Bick, D, Green, M, Hardy, P, Leighton, L, Magee, LA, Maher, A, McManus, RJ, Moakes, C, Morris, RK, Nelson-Piercy, C, Sparkes, J, Rivero-Arias, O, Webb, A, Wilson, H, Myers, J & Chappell, LC 2023, 'A treatment strategy with nifedipine versus labetalol for women with pregnancy hypertension: study protocol for a randomised controlled trial (Giant PANDA)', Trials, vol. 24, no. 1, 584. https://doi.org/10.1186/s13063-023-07582-9

Review article

Ahmed, SI, Ammerdorffer, A, Moakes, CA, Cheshire, J, Gulmezoglu, AM, Coomarasamy, A, Lissauer, D & Wilson, A 2025, 'Prophylactic antibiotics for uterine evacuation procedures to manage miscarriage', Cochrane Library, vol. 2025, no. 4, CD014844. https://doi.org/10.1002/14651858.CD014844.pub2

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