Dr Michael Newnham MBChB, MSc, MRCP, PGCE (MedEd), PhD

Dr Michael Newnham

Institute of Applied Health Research
Associate Professor & Respiratory Consultant

Contact details

Address
Murray Learning Centre
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Michael Newnham is an Associate Professor and Consultant in Respiratory Medicine.

Michael’s research interests are predominately focused on pulmonary vascular diseases including pulmonary embolism and chronic thromboembolic pulmonary hypertension. He has experience in research methods that include genomics, big data, biostatistics, clinical research trials and risk prediction modelling. 

Qualifications

  • PhD in Medicine 2019, University of Cambridge
  • PGCert in Medical Education 2011, University of Birmingham
  • MRCP 2009, Royal College of Physicians
  • MBChB 2006, University of Birmingham
  • MSc in Pathological Studies 2005, University of Birmingham

Biography

Michael graduated from the University of Birmingham in 2006 and then worked in the West Midlands and commenced Respiratory Medicine training in 2011. He undertook his PhD at Cambridge University from 2016-2019 investigating genetic associations in chronic thromboembolic pulmonary hypertension. He spent several years working in the pulmonary vascular disease’s unit at Papworth Hospital where he retains strong collaborative research links.

Michael has worked at the University of Birmingham since September 2018, as a Clinical Lecturer, Senior Lecturer and now Associate Professor as part of Professor Alice Turner’s research group.


Teaching

MBChB

  • 5th year academic lead for the Acutely Ill Patient module
  • 5th year Written Professional Communication module: teaching, marking and moderation
  • 4th year elective project supervisor
  • 3rd year evidence-based medicine teaching
  • 2nd year personal interest project supervisor: big data & artificial intelligence in medicine
  • 1st year research taster: subsegmental pulmonary embolism
  • Personal academic tutor
  • Senior invigilator

MSc Respiratory Medicine

  • Teaching

Postgraduate supervision

MPH

  • Dissertation supervisor

Research

Research Themes:

  • Diagnostic and prognostic studies in pulmonary vascular disease
  • Genetic associations of pulmonary vascular disease including chronic thromboembolic pulmonary hypertension
  • Utilising health data in research

Research studies: 

  • Co-investigator for STOP-APE (Stopping anticoagulation for isolated or incidental subsegmental pulmonary embolism) NIHR funded RCT

Other activities

BTS pulmonary embolism outpatient management quality standards committee: 2019

Publications

Recent publications

Article

Ellis, P, Bailey, E, Choate, R, Holm, KE, Sandhaus, RA, Turner, A & Newnham, M 2024, 'Prevalence of Cardiovascular Disease and Rate of Major Adverse Cardiovascular Events in Severe Alpha-1 Antitrypsin Deficiency COPD', International Journal of COPD, vol. 2024, no. 19, pp. 149-159. https://doi.org/10.2147/COPD.S419846

Lasserson, D, Gaddu, P, Mehta, S, Ignatowicz, A, Greenfield, S, Prince, C, Cummins, C, Robinson, G, Rodrigues, J, Noble, S, Jowett, S, Toshner, M, Newnham, M & Turner, A 2024, 'Stopping anticoagulation for isolated or incidental pulmonary embolism: the STOPAPE RCT protocol', Health Technology Assessment.

Armitage, MN, Mughal, AZ, Huntley, CC, Lasserson, D & Newnham, M 2023, 'Correction to: A multicentre observational study of the prevalence, management, and outcomes of subsegmental pulmonary embolism', Journal of Thrombosis and Thrombolysis, vol. 55, no. 3, pp. 584. https://doi.org/10.1007/s11239-023-02771-4

Newnham, M, Quinn, M & Turner, A 2023, 'Estimating the prevalence of AATD patients in the UK to identify underdiagnosis and determine the eligibility for potential augmentation therapy', International journal of chronic obstructive pulmonary disease, vol. 18, pp. 1197-1205. https://doi.org/10.2147/COPD.S395663

Spittle, D, Mansfield, A, Pye, A, Turner, A & Newnham, M 2023, 'Predicting Lung Function Using Biomarkers in Alpha-1 Antitrypsin Deficiency', Biomedicines, vol. 11, no. 7, 11072001. https://doi.org/10.3390/biomedicines11072001

Armitage, MN, Mughal, AZ, Huntley, C, Lasserson, D & Newnham, M 2022, 'A multicentre observational study of the prevalence, management, and outcomes of subsegmental pulmonary embolism', Journal of thrombosis and thrombolysis, vol. 55, no. 1, pp. 126-133. https://doi.org/10.1007/s11239-022-02714-5

Hadinnapola , CM, Southwood, M, Hernandez-Sanchez, J, Bunclark, K, Newnham, M, Swietlik, EM, Cannon, J, Preston , SD, Sheares, K, Taboada, D, Screaton, N, Jenkins, DP, Morrell, NW, Toshner, M & Pepke-Zaba, J 2022, 'Angiopoietin 2 and hsCRP are associated with pulmonary haemodynamics and long-term mortality respectively in CTEPH - results from a prospective discovery and validation biomarker study', The Journal of Heart and Lung Transplantation. https://doi.org/10.1016/j.healun.2022.08.021

Loo, J, Spittle, D & Newnham, M 2021, 'COVID-19, immunothrombosis and venous thromboembolism: biological mechanisms', Thorax, vol. 76, no. 4, pp. 412-420. https://doi.org/10.1136/thoraxjnl-2020-216243

Bunclark, K, Newnham, M, Chiu, Y-D, Ruggiero, A, Villar, SS, Cannon, JE, Coghlan, G, Corris, PA, Howard, L, Jenkins, D, Johnson, M, Kiely, DG, Ng, C, Screaton, N, Sheares, K, Taboada, D, Tsui, S, Wort, SJ, Pepke-Zaba, J & Toshner, M 2020, 'A multicenter study of anticoagulation in operable chronic thromboembolic pulmonary hypertension', Journal of Thrombosis and Haemostasis, vol. 18, no. 1, pp. 114-122. https://doi.org/10.1111/jth.14649

Newnham, M, Bunclark, K, Abraham, N, Ali, S, Amaral-Almeida, L, Cannon, JE, Doughty, N, Ng, C, Ponnaberanam, A, Sheares, K, Speed, N, Taboada, D, Toshner, M, Tsui, S, Jenkins, DP & Pepke-Zaba, J 2020, 'CAMPHOR score: patient-reported outcomes are improved by pulmonary endarterectomy in chronic thromboembolic pulmonary hypertension (CTEPH)', The European respiratory journal, vol. 56, no. 4, 1902096. https://doi.org/10.1183/13993003.02096-2019

Newnham, M, South, K, Bleda, M, Auger, W, Barberà, J, Bogaard, H, Bunclark, K, Cannon, J, Delcroix, M, Hadinnapola, C, Howard, L, Jenkins, D, Mayer, E, Ng, C, Rhodes, C, Screaton, N, Sheares, K, Simpson, M, Southwood, M, Su, L, Taboada, D, Traylor, M, Trembath, R, Villar, S, Wilkins, M, Wharton, J, Gräf, S, Pepe-Zaba, J, Laffan, M, Lane, D, Morrell, N & Toshner, M 2019, 'The ADAMTS13-VWF axis is dysregulated in chronic thromboembolic pulmonary hypertension.', European Respiratory Journal, vol. 53, no. 3, 1801805. https://doi.org/10.1183/13993003.01805-2018

Sofianopoulou, E, Kaptoge, S, Graf, S, Hadinnapola, C, Treacy, CM, Church, C, Coghlan, G, Gibbs, JSR, Haimel, M, Howard, L, Johnson, M, Kiely, DG, Lawrie, A, Lordan, J, MacKenzie Ross, RV, Martin, JM, Moledina, S, Newnham, M, Peacock, AJ, Price, L, Rhodes, CJ, Suntharalingam, J, Swietlik, EM, Toshner, MR, Wharton, J, Wilkins, MR, Wort, SJ, Pepke-Zaba, J, Condliffe, R, Corris, PA, Di Angelantonio, E, Provencher, S & Morrell, NW 2019, 'Traffic exposures, air pollution and outcomes in pulmonary arterial hypertension: a UK cohort study analysis', The European respiratory journal, vol. 53, no. 5, 1801429. https://doi.org/10.1183/13993003.01429-2018

Rhodes, CJ, K, B, Bleda, M, Haimel, M, Southgate, L, Germain, M, Pauciulo, MW, Hadinnapola, C, Aman, J, Girerd, B, Arora, A, Knight, J, Hanscombe, KB, Karnes, JH, Kaakinen, M, Gall, H, Ulrich, A, Harbaum, L, Cebola, I, Ferrer, J, Lutz, K, Swietlik, EM, Ahmad, F, Amouyel, P, Archer, SL, Argula, R, Austin, ED, Badesch, D, Bakshi, S, Barnett, C, Benza, R, Bhatt, N, Bogaard, HJ, Burger, CD, Chakinala, M, Church, C, Coghlan, JG, Condliffe, R, Corris, PA, Danesino, C, Debette, S, Elliot, CG, Elwing, J, Eyries, M, Fortin, T, Franke, A, Frantz, RP, Frost, A, Garcia, JGN, Ghio, S, Ghofrani, HA, Gibbs, JSR, Harley, J, He, H, Hill, NS, Hirsch, R, Houweling, AC, Howard, LS, Ivy, D, Kiely, DG, Klinger, J, Kovacs, G, Lahm, T, Laudes, M, Machado, RD, MacKenzie Ross, RV, Marsolo, K, Martin, LJ, Moledina, S, Montani, D, Nathan, SD, Newnham, M, Olschewski, A, Olschewski, H, Oudiz, RJ, Ouwehand, WH, Peacock, AJ, Pepke-Zaba, J, Rehman, Z, Robbins, I, Roden, DM, Rosenzweig, EB, Saydain, G, Scelsi, L, Schilz, R, Seeger, W, Shaffer, CM, Simms, RW, Simon, M, Sitbon, O, Suntharalingam, J, Tang, H, Tchourbanov, AY, Thenappen, T, Torres, F, Toshner, MR, Treacy, CM, Vonk Noordegraaf, A, Waisfisz, Q, Walsworth, AK, Walter, RE, Wharton, J, White, RJ, Wilt, J, Wort, SJ, Yung, D, Lawrie, A, Humbert, M, Humbert, M, Soubrier, F, Tregouet, DA, Prokopenko, I, Kittles, R, Graf, S, Nichols, WC, Trembath, RC, Desai, AA, Morrell, NW & Wilkins, MR 2018, 'Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis.', Lancet Respir Med, vol. 7, no. 3, pp. 227-238. https://doi.org/10.1016/S2213-2600(18)30409-0

Gräf, S, Haimel, M, Bleda, M, Hadinnapola, C, Southgate, L, Li, W, Hodgson, J, Liu, B, Salmon, RM, Southwood, M, Machado, RD, Martin, JM, Treacy, CM, Yates, K, Daugherty, LC, Shamardina, O, Whitehorn, D, Holden, S, Aldred, M, Bogaard, HJ, Church, C, Coghlan, G, Condliffe, R, Corris, PA, Danesino, C, Eyries, M, Gall, H, Ghio, S, Ghofrani, H, Gibbs, JSR, Girerd, B, Houweling, AC, Howard, L, Humbert, M, Kiely, DG, Kovacs, G, Mackenzie Ross, RV, Moledina, S, Montani, D, Newnham, M, Olschewski, A, Olschewski, H, Peacock, AJ, Pepke-zaba, J, Prokopenko, I, Rhodes, CJ, Scelsi, L, Seeger, W, Soubrier, F, Stein, DF, Suntharalingam, J, Swietlik, EM, Toshner, MR, Van Heel, DA, Vonk Noordegraaf, A, Waisfisz, Q, Wharton, J, Wort, SJ, Ouwehand, WH, Soranzo, N, Lawrie, A, Upton, PD, Wilkins, MR, Trembath, RC & Morrell, NW 2018, 'Identification of rare sequence variation underlying heritable pulmonary arterial hypertension', Nature Communications, vol. 9, no. 1, 1416. https://doi.org/10.1038/s41467-018-03672-4

Review article

Balbirsingh, V, Mohammed, AS, Turner, A & Newnham, M 2022, 'Cardiovascular disease in chronic obstructive pulmonary disease: a narrative review', Thorax, vol. 77, no. 9, pp. 939-945. https://doi.org/10.1136/thoraxjnl-2021-218333

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