Mrs Natalie Rowland (née Ives) BSc (Hons), MSc

Mrs Natalie Rowland

Institute of Applied Health Research
Reader in Clinical Trials, BCTU Director of Statistics and Research Strategy

Contact details

Birmingham Clinical Trials Unit (BCTU)
College of Medical and Dental Sciences
Public Health Building
University of Birmingham
B15 2TT

Natalie Rowland (née Ives) is a Reader in Clinical Trials. She is the Director of Statistics & Research Strategy, and a member of the Senior Management Team at the Birmingham Clinical Trials Unit (BCTU) in the Institute of Applied Health Research

Natalie is interested in the design, conduct and analysis of large scale late phase randomised controlled clinical trials.  She is the Lead Methodologist and Senior Statistician on a substantial and diverse portfolio of high quality clinical trials in the areas of Neuroscience and Parkinson’s Disease, Renal Disease, Coloproctology, Critical Care, Trauma and Primary Care assessing medical, surgical and complex interventions in both adults and children. 

Her research has been published in various high impact scientific journals (NEJM, Lancet, BMJ) and she is a co-applicant on a number of grants funded by the National Institute for Health Research (NIHR) funding streams (HTA, EME and RfPB). 


  • MSc in Statistics, University of Sheffield, 1997
  • BSc (Hons) in Mathematics (1st), University of Leicester, 1995


Teaching Programmes

Other activities

  • Member of the NIHR Incubator for Methodology (2020-present), and lead for the Incubator Awareness Raising Workstream
  • Member of the UKCRC Statistics Operational Group committee (2019-present). Deputy Chair since 2021.
  • Reviewer for various scientific journals
  • Statistical reviewer for the National Institute for Health Research (HTA, EME, RfPB) 
  • Independent statistician on several Trial Steering and Data Monitoring Committees contributing to the oversight and direction of externally run clinical trials


Recent publications


Krouwel, M, Greenfield, SM, Chalkley, A, Sanders, JP, Parretti, HM, Gokal, K, Jolly, K, Skrybant, M, Biddle, SJH, Greaves, C, Maddison, R, Mutrie, N, Ives, N, Esliger, DW, Sherar, L, Edwardson, CL, Yates, T, Frew, E, Tearne, S, Daley, AJ & Kwaghe, AV (ed.) 2023, 'Promoting participation in physical activity through Snacktivity: A qualitative mixed methods study', PLOS One, vol. 18, no. 9, e0291040.

Daley, AJ, Griffin, RA, Moakes, CA, Sanders, JP, Skrybant, M, Ives, N, Maylor, B, Greenfield, SM, Gokal, K, Parretti, HM, Biddle, SJH, Greaves, C, Maddison, R, Mutrie, N, Esliger, DW, Sherar, L, Edwardson, CL, Yates, T, Frew, E, Tearne, S & Jolly, K 2023, 'Snacktivity™ to promote physical activity and reduce future risk of disease in the population: protocol for a feasibility randomised controlled trial and nested qualitative study', Pilot and Feasibility Studies, vol. 9, no. 1, 45.

PREDNOS Collaborative Group, NIHR Medicines for Children Research Network Nephrology Clinical Studies Group, Afentou, N, Frew, E, Mehta, S, Rowland, N, Woolley, R, Brettell, E, Khan, A, Milford, D, Bockenhauer, D, Saleem , MA, Hall, AS, Koziell, A, Maxwell, H, Hegde , S, Finlay, ER, Gilbert, RD, Jones, C, McKeever, K, Cook, W, Webb, NJA & Christian, MT 2022, 'Economic evaluation of using daily prednisolone versus placebo at the time of an upper respiratory tract infection for the management of children with steroid-sensitive nephrotic syndrome: a model-based analysis', PharmacoEconomics, vol. 6, no. 4, pp. 605-617.

STOP ACEi Trial Investigators 2022, 'Renin-angiotensin system inhibition in advanced chronic kidney disease', The New England Journal of Medicine.

Kyte, D, Anderson, N, Bishop, J, Bissell, A, Brettell, E, Calvert, M, Chadburn, M, Cockwell, P, Dutton, M, Eddington, H, Forster, E, Hadley, G, Rowland, N, Jackson, L, O’Brien, S, Price, G, Sharpe, K, Stringer, S, Verdi, R, Waters, J & Wilcockson, A 2022, 'Results of a pilot feasibility randomised controlled trial exploring the use of an electronic patient-reported outcome measure in the management of UK patients with advanced chronic kidney disease', BMJ open, vol. 12, no. 3, e050610.

RePHILL collaborative group 2022, 'Resuscitation with blood products in patients with trauma-related haemorrhagic shock receiving prehospital care (RePHILL): a multicentre, open-label, randomised, controlled, phase 3 trial', The Lancet Haematology, vol. 9, no. 4, pp. e250-e261.

Gokal, K, Amos-Hirst, R, Moakes, C, Sanders, JP, Esliger, DW, Sherar, LB, Ives, N, Biddle, SJH, Edwardson, C, Frew, E, Yates, T, Greaves, C, Rowland, N, Greenfield, S, Jolly, K, Skrybant, M, Maddison, R, Mutrie, N, Parretti, H & Daley, A 2022, 'Views of the public about Snacktivity™: A small changes approach to promoting physical activity and reducing sedentary behaviour', BMC Public Health, vol. 22, no. 618, 618.

The SUNRRISE Study Group on behalf of the Northwest Research Collaborative and the West Midlands Research Collaborative 2021, 'An international pragmatic randomised controlled trial to compare a single use negative pressure dressing versus a surgeon’s preference of dressing to reduce the incidence of surgical site infection following emergency laparotomy: the SUNRRISE Trial Protocol', Colorectal Disease, vol. 23, no. 4, pp. 989-1000.

Edwards, N, Price, A, Mehta, S, Hiemstra, TF, Kaur, A, Greasley , PJ, Webb, DJ, Dhaun, N, MacIntyre, IM, Farrah , T, Melville , V, Herrey , A, Slinn, G, Wale, B, Rowland, N, Wheeler, D, Wilkinson, I, Steeds, R, Ferro, C & Townend, J 2021, 'Effects of spironolactone and chlorthalidone on cardiovascular structure and function in chronic kidney disease', Clinical Journal of the American Society of Nephrology, vol. 16, no. 8, CJN.01930221.

Christian, M, Webb, NJA, Mehta, S, Woolley, R, Afentou, N, Frew, E, Brettell, E, Khan, A, Milford, D, Bockenhauer, D, Saleem , MA, Hall, AS, Koziell, A, Maxwell, H, Hegde , S, Prajapati , H, Gilbert, RD, Jones, C, McKeever, K, Cook, W & Rowland, N 2021, 'Evaluation of daily low-dose prednisolone during upper respiratory tract infection to prevent relapse in children with relapsing steroid-sensitive nephrotic syndrome: the PREDNOS 2 randomized clinical trial', JAMA Pediatrics.

Scobie , S, Jowett, S, Lambe, T, Patel, S, Woolley, R, Rowland, N, Rick, C, Smith, C, Brady , M, Clarke, CE & Sackley, C 2021, 'Lee Silverman voice treatment versus standard speech and language therapy versus control in Parkinson’s disease: preliminary cost-consequence analysis of the PD COMM pilot randomised controlled trial', Pilot and Feasibility Studies, vol. 7, no. 1, 154.

Gray, R, Patel, S, Rowland, N, Rick, C, Woolley, R, Muzerengi, S, Gray, A, Jenkinson, C, McIntosh, E, Wheatley, K, Williams, A, Clarke, CE & PD Med Collaborative Group 2021, 'Long-term effectiveness of adjuvant treatment with catechol-O-methyltransferase or monoamine oxidase B inhibitors compared with dopamine agonists among patients with Parkinson disease uncontrolled by Levodopa Therapy: the PD MED randomized clinical trial', JAMA Neurology.

Harper, L, Hewitt, C, Litchfield, I, Morgan, M, Chanouzas, D, Caulfield, H, Coughlan, L, Dean, C, Fletcher, K, Cramp, F, Greenfield, S, Rowland, N, Jowett, S, Kodabuckus, S, Tearne, S, Sehmi, S, Edwardson, C, Dawkins, NP & Daley, A 2021, 'Management of fatigue with physical activity and behavioural change support in vasculitis: a feasibility study', Rheumatology, vol. 60, no. 9, pp. 4130-4140.

Snacktivity Study Team 2021, '‘Snacktivity™’ to increase physical activity: time to try something different?', Preventive Medicine, vol. 153, 106851.

Markey, K, Mitchell, J, Botfield, H, Ottridge, R, Matthews, T, Krishnan, A, Woolley, R, Westgate, C, Yiangou, A, Alimajstorovic, Z, Shah, P, Rick, C, Ives, N, Taylor, A, Gilligan, L, Jenkinson, C, Arlt, W, Scotton, W, Fairclough, RJ, Singhal, R, Stewart, PM, Tomlinson, JW, Lavery, G, Mollan, S & Sinclair, A 2020, '11β-hydroxysteroid dehydrogenase type 1 inhibition in idiopathic intracranial hypertension: a double-blind randomized controlled trial', Brain Communications, vol. 2, no. 1, fcz050.

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