Dr Andy Chetwynd PhD

Dr Andy Chetwynd

School of Biosciences
Research Fellow

Contact details

Address
School of Biosciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Dr Andy Chetwynd is an analytical chemist with mass spectrometry experience in metabolomic, proteomics and inorganic analysis in clinical and environmental applications.

Qualifications

  • BSc Biochemistry (Toxicology) University of Surrey
  • PhD Analytical Chemistry University of Sussex

Biography

Dr Chetwynd carried out his undergraduate degree in Biochemistry (Toxicology) at the University of Surrey incorporating a year in industry and GSK. Following this he embarked on his PhD at Sussex where he developed nLC-nESI-MS methods for metabolomics and investigated the metabolomic consequences of HIV anti-retroviral therapy. He subsequently moved to the Birmingham Phenome Centre to perform high-through put clinical metabolomics studies before moving to an industrial post doc with Sciex on the Horizon 2020 project ACEnano. He now continues to work on ACEnano developing CE-MS based methods for protein and metabolite corona characterization.

Research

Research Interests

 

  • Development of novel mass spectrometry methods
  • Development of chromatographic and electrophoretic methodologies
  • Trace analysis of compounds from small sample volumes
  • Nanoparticle characterization

Research GroupEnvironmental Nanoscience

Scopus Reearch ID: 56406310900 https://www.scopus.com/authid/detail.uri?origin=resultslist&authorId=56406310900&zone=

Other activities

  • Member of American Chemical Society
  • Member of Metabolomics Society

Publications

Chetwynd, A.J.; Ogilvie, L.A.; Nzakizwanayo, J.; Pazdirek, F.; Hoch, J.; Dedi, C, Gilbert, D.; Abdul-Sada, A.; Hill, E.M. The potential of nanoflow liquid chromatography-nano electrospray ionisation-mass spectrometry for profiling trace molecules in the faecal metabolome, Journal of Chromatography A, In Press

Jiménez, b.; Holmes, H.; Heude, C.; Tolson, R.F.; Harvey, N.; Lodge, S.L.; Chetwynd, A.J.; Cannet, C.; Fang, F.; Pearce, J.T.M.; Lewis, M.R.; Viant, M.R.; Lindon, J.C.; Spraul, M.; Schäfer, H.; Nicholson, J.K. Quantitative Lipoprotein subclass and low molecular weight metabolite analysis in human serum and plasma by 1H NMR spectroscopy in a multilaboratory trial, Analytical Chemistry, 2018, 90, 11962-11971.

*Chetwynd, A.J.; Guggenheim, E.J.; Briffa, S.M.; Thorn, J.J.; Lynch, I.; Valsami-Jones, E. Current application of capillary electrophoresis in nanomaterial characterisation and its potential to characterise the protein and small molecule corona, Nanomaterials, 2018, 8, Article number 99

Chetwynd, A.J.; David, A. A review of nanoscale LC-ESI for metabolomics and its potential to improve the (xeno)metabolome coverage, Talanta, 2018, 182, 380-390

Lawson, TN.; Weber, RJM.; Jones, MR.; Chetwynd, AJ.; Rodriguez-Blanco, G.; Di Guida, R.; Viant, MR.; Dunn, WB. msPurity: Automated Evaluation of Precursor Ion Purity for Mass Spectrometry Based Fragmentation in Metabolomics, Analytical Chemistry, 2017, 84, 2432-2439

Chetwynd, AJ.; Samarawickrama, A.; Vera, J.; Bremner, SA.; Abdul-Sada, A.; Gilleece, Y.; Holt, S.; Hill, E.M. Disruption of the urinary metabolome of HIV-positive patients on combination antiretroviral therapy, Journal of Acquired Immune Deficiency Syndromes, 2017, 74, e45-53

*Chetwynd, A.J.; Abdul-Sada, A.; Holt. S.G.; Hill, E.M. Use of a pre-analysis osmolality normalisation method to correct for variable urine concentrations and for improved metabolomic analyses, Journal of Chromatography A, 2016, 1431, 103-110.

Chetwynd, A.J.; Abdul-Sada, A.; Hill, E.M. Solid phase extraction and nanoflow liquid chromatography-nanoelectrospray ionisation mass spectrometry for improved global urine metabolomics, Analytical Chemistry, 2015, 87, 1158-1165.

Chetwynd, A.J.; David, A.; Hill, E.M.; Abdul-Sada, A. Evaluation of sensitivity and reliability of direct nanoLC-nanoESI-high resolution mass spectrometry for metabolomic profiling. Journal of Mass Spectrometry, 2014, 49, 1063-1069.

*Denotes corresponding author

Book Chapters

Chetwynd, A.J.; Dunn, W.B.; Rodriguez-Blanco, G. Chapter 2: Collection and preparation of clinical samples for metabolomics. Metabolomics: From Fundamentals to Clinical Applications, 2017, 19-44, DOI: 10.1007/978-3-319-47656-8

Conference Preceedings

Chetwynd, AJ.; Abdul-Sada, A.; Hill, E.; Vera, J.; Fisher, M.; Samarawickrama, A.; Holt, S.; Gilleece, Y. Differences in urine metabolomes with HIV infection and antiretroviral drug exposure, HIV Medicine, 2016, 17, 35-37

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