Dr Samuel Lara Reyna BSc, MSc, PhD

Dr Samuel Lara Reyna

School of Biosciences
Postdoctoral Research Fellow

Contact details

Institute of Microbiology and Infection
School of Biosciences
University of Birmingham
B15 2TT

Samuel Lara is a researcher based in the College of Life and Environmental Sciences’ Institute of Microbiology and Infection. He is part of Dr Frickel’s laboratory which investigates mechanisms of human innate defence against pathogens, with a particular interest in Toxoplasma gondii and Salmonella typhimurium. 

Samuel’s research primarily focuses in innate immune cells and in studying intracellular mechanism involved in macrophage function. He studies IFNg-driven macrophage inflammation, metabolism and control of intracellular pathogens.


  • PhD in Medicine (Immunology), University of Leeds, 2020
  • MSc in Immunology and Immunotherapy, University of Birmingham, 2016
  • BSc in Molecular Biology, The University of Texas at San Antonio, 2014


Samuel started his medical training at the faculty of Medicine UJED in Mexico, where he developed an interest in immunology. He obtained his BSc in Biology with Highest Honours and International Distinction at the University of Texas at San Antonio, with a concentration in immunology & microbiology. During his studies in Texas, Samuel gain fundamental research insight at Dr LeBaron’s laboratory of molecular biology. 

He was awarded a CONACyT scholarship in 2015 and moved to Birmingham, UK, where he obtained his MSc in Immunology and Immunotherapy at the University of Birmingham. He obtained experience in innate immunity with Professor Andy Clark, where he completed his MSc research project investigating glucocorticoid effects in macrophage function at the Institute of inflammation and ageing. 

After his studies at the University of Birmingham, he was awarded the CONACyT/Leeds Graduate Fellowship to accomplish his doctoral studies in Medicine, at the University of Leeds. Samuel’s doctoral research focused on understanding the dysregulated molecular mechanisms of macrophages in autoinflammatory disorders. He studied cystic fibrosis and the dysregulated pathways affecting macrophages in this disease, with interest in inflammation, ER stress and cellular metabolism. He obtained his PhD in Medicine in 2020 at the University of Leeds under the supervisor of Dr Sinisa Savic, Professor Daniel Peckham, and Professor Michael McDermott.

Samuel is currently a postdoctoral research fellow working with Dr Eva Frickel at the Institute of Microbiology and Infection (IMI) at the University of Birmingham. His research focuses on understanding IFNg-driven innate immune responses, mainly in macrophages. He studies the function of guanylate binding proteins (GBPs) in macrophages and how these proteins defend immune cells against different pathogens.


  • Mechanisms of immune-mediated host protection against pathogens and other insults.
  • The role of guanylate binding proteins (GBPs) in innate immune cells.
  • Inflammation, metabolism and ubiquitination in innate immune cells.
  • The mechanisms driving sterile inflammation (autoinflammation) in macrophages.


Lara-Reyna S, Holbrook J, Jarosz-Griffiths H, Peckham D, McDermott MF: Dysregulated signalling pathways in innate immune cells with cystic fibrosis mutations. Cellular and molecular life Sciences: CMLS 2020. 

Jarosz-Griffiths HH, Scambler T, Wong CH, Lara-Reyna S, Holbrook J, Martinon F, Savic S, Whitaker P, Etherington C, Spoletini G et al: Different CFTR modulator combinations downregulate inflammation differently in cystic fibrosis. Elife 2020, 9. 

Scambler T, Jarosz-Griffiths HH, Lara-Reyna S, Pathak S, Wong C, Holbrook J, Martinon F, Savic S, Peckham D, McDermott MF: ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in cystic fibrosis. Elife 2019, 8. 

Lara-Reyna S, Scambler T, Holbrook J, Wong C, Jarosz-Griffiths HH, Martinon F, Savic S, Peckham D, McDermott MF: Metabolic Reprograming of Cystic Fibrosis Macrophages via the IRE1α Arm of the Unfolded Protein Response Results in Exacerbated Inflammation. Front Immunol 2019, 10. 

Jarosz-Griffiths HH, Holbrook J, Lara-Reyna S, McDermott MF: TNF receptor signalling in autoinflammatory diseases. Int Immunol 2019. 

Holbrook J, Lara-Reyna S, Jarosz-Griffiths H, McDermott M: Tumour necrosis factor signalling in health and disease. F1000Res 2019, 8. 

Lara-Reyna S, Scambler T, Holbrook J, Jarosz-Griffiths HH, Peckham D, McDermott MF: Regulation of the Unfolded Protein Response in Disease: Cellular Stress and microRNAs. Current Immunology Reviews 2018, 14(1):3-14.

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