Dr Paul Badenhorst PhD

Dr Paul Badenhorst

Institute of Cancer and Genomic Sciences
Associate Professor

Contact details

Institute of Cancer and Genomic Sciences
Institute of Biomedical Research
University of Birmingham
B15 2TT

Paul Badenhorst is an Associate Professor in the Institute of Cancer and Genomic Sciences.

Paul’s field of expertise is in Epigenetics and Development. Paul uses both the Drosophila model system and human cells to investigate how chromatin modifying complexes regulate gene expression to control developmental pathways. He has received major grant funding from Cancer Research UK, the Biotechnology and Biological Sciences Research Council and the Medical Research Council.


  • PhD, MRC Laboratory of Molecular Biology, University of Cambridge 1997
  • MSc Molecular Biology, 1993
  • BSc(Hons) Cell Biology, 1991
  • BSc Cell Biology and Chemistry, 1990


  • Cellular Biology and Biochemistry (Module co-ordinator)
  • Principles of Stem Cell Biology (Module co-ordinator)

Postgraduate supervision

Dr Badenhorst is interested in supervising doctoral research students in the following areas:

Regulation and function of chromatin remodelling enzymes.
Transcriptional regulation of immune cell differentiation and development

Other activities

BBSRC Panel of experts


Recent publications


Kwon, SY, Jang, B-Y & Badenhorst, P 2021, 'The ISWI chromatin remodelling factor NURF is not required for mitotic male X chromosome organisation', microPublication Biology, vol. 2021, no. 1. https://doi.org/10.17912/micropub.biology.000360

Kwon, SY, Massey, K, Watson, M, Hussain, T, Volpe, G, Buckley, C, Nicolaou, A & Badenhorst, P 2020, 'Oxidised metabolites of the omega-6 fatty acid linoleic acid activate dFOXO', Life Science Alliance, vol. 3, no. 2, e201900356. https://doi.org/10.26508/lsa.201900356

Roy Choudhury, S, Singh, A, McLeod, T, Blanchette , M, Jang, B, Badenhorst, P, Kanhere, A & Brogna, S 2016, 'Exon junction complex proteins bind nascent transcripts independently of pre-mRNA splicing in Drosophila melanogaster', eLife, vol. 5, e19881. https://doi.org/10.7554/eLife.19881

Kwon, SY, Grisan, V, Jang, B-Y, Herbert, J & Badenhorst, P 2016, 'Genome-wide mapping targets of the metazoan chromatin remodeling factor NURF reveals nucleosome remodeling at enhancers, core promoters and gene insulators', PLoS Genetics, vol. 12, no. 4, e1005969. https://doi.org/10.1371/journal.pgen.1005969

Zimmermann, HW, Bruns, T, Weston, CJ, Curbishley, SM, Liaskou, E, Li, K-K, Resheq, YJ, Badenhorst, PW & Adams, DH 2015, 'Bidirectional transendothelial migration of monocytes across hepatic sinusoidal endothelium shapes monocyte differentiation and regulates the balance between immunity and tolerance in liver', Hepatology. https://doi.org/10.1002/hep.28285

Bruns, T, Zimmermann, HW, Pachnio, A, Li, K-K, Trivedi, PJ, Reynolds, G, Hubscher, S, Stamataki, Z, Badenhorst, P, Weston, CJ, Moss, PA & Adams, DH 2015, 'CMV Infection of Human Sinusoidal Endothelium Regulates Hepatic T Cell Recruitment and Activation', Journal of Hepatology. https://doi.org/10.1016/j.jhep.2015.02.046

Walker, J, Kwon, SY, Badenhorst, P, East, P, McNeill, H & Svejstrup, JQ 2011, 'Role of Elongator Subunit Elp3 in Drosophila melanogaster Larval Development and Immunity', Genetics, vol. 187, no. 4, pp. 1067-U157. https://doi.org/10.1534/genetics.110.123893

Stofanko, M, Kwon, SY & Badenhorst, P 2010, 'Lineage Tracing of Lamellocytes Demonstrates Drosophila Macrophage Plasticity', PLoS ONE, vol. 5, no. 11, pp. e14051. https://doi.org/10.1371/journal.pone.0014051

Kwon, SY, Xiao, H, Wu, C & Badenhorst, P 2009, 'Alternative Splicing of NURF301 Generates Distinct NURF Chromatin Remodeling Complexes with Altered Modified Histone Binding Specificities', PLoS Genetics, vol. 5, no. 7, pp. e1000574. https://doi.org/10.1371/journal.pgen.1000574

Stofanko, M, Kwon, SY & Badenhorst, P 2008, 'A Misexpression Screen to Identify Regulators of Drosophila Larval Hemocyte Development', Genetics, vol. 180, no. 1, pp. 253-267. https://doi.org/10.1534/genetics.108.089094

Kwon, SY, Xiao, H, Glover, BP, Tjian, R, Wu, C & Badenhorst, P 2008, 'The nucleosome remodeling factor (NURF) regulates genes involved in Drosophila innate immunity', Developmental Biology, vol. 316, pp. 538-47. https://doi.org/10.1016/j.ydbio.2008.01.033

Bai, X, Larschan, E, Kwon, SY, Badenhorst, P & Kuroda, MI 2007, 'Regional control of chromatin organization by noncoding roX RNAs and the NURF remodeling complex in Drosophila melanogaster', Genetics, vol. 176, no. 3, pp. 1491-9. https://doi.org/10.1534/genetics.107.071571

Wysocka, J, Swigut, T, Xiao, H, Milne, TA, Kwon, SY, Landry, J, Kauer, M, Tackett, AJ, Chait, BT, Badenhorst, P, Wu, C & Allis, CD 2006, 'A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling', Nature, vol. 442, no. 7098, pp. 86-90. https://doi.org/10.1038/nature04815

Badenhorst, P, Xiao, H, Cherbas, L, Kwon, SY, Voas, M, Rebay, I, Cherbas, P & Wu, C 2005, 'The Drosophila nucleosome remodeling factor NURF is required for Ecdysteroid signaling and metamorphosis', Genes & Development, vol. 19, no. 21, pp. 2540-5. https://doi.org/10.1101/gad.1342605


Badenhorst, P 2014, What Can We Learn from Flies: Epigenetic Mechanisms Regulating Blood Cell Development in Drosophila: Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development. in C Bonifer & PN Cockerill (eds), Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development. Epigenetics and Human Health, Springer, pp. 15-47. https://doi.org/10.1007/978-3-642-45198-0_2

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