Dr Jessica Douglas-Pugh BSc MSc PhD

Dr Jessica Douglas-Pugh

Institute of Cancer and Genomic Sciences
Trial Management Team Leader

Contact details

Cancer Research UK Clinical Trials Unit (CRCTU)
Institute of Cancer and Genomic Sciences
University of Birmingham
B15 2TT

Dr Jessica Douglas-Pugh is the Trial Management Team Leader for the Children’s Cancer Trials Team – C Team (CCTT-C) at the Cancer Research UK Clinical Trials Unit, Institute of Cancer and Genomic Sciences.


  • PhD in Exercise Physiology, Loughborough University, 2016
  • MSc in Sports and Exercise Nutrition, Loughborough University, 2012
  • BSc (Hons) in Sports and Exercise Sciences, University of Birmingham, 2011


Jessica Douglas-Pugh graduated with a first class BSc (Hons) in Sport and Exercise Science from the University of Birmingham in 2011 before moving to Loughborough University. Jessica graduated with a Distinction in MSc Sports and Exercise Nutrition in 2012, and completed her PhD in 2016. Jessica’s PhD investigated the acute effects of exercise on appetite, energy intake and appetite regulatory hormones.

Jessica returned to Birmingham and joined CRCTU as a Trial Coordinator within the Diagnostics, Drugs, Devices and Biomarker team in 2017 and was promoted to the role of Senior Trial Coordinator in 2018 (Diagnostics, Drugs, Devices and Biomarker/ Inflammation – Advanced and Cellular Therapy teams). Jessica was appointed as a Trial Management Team Leader in 2020 for one of the Children’s Cancer Trial Teams and is responsible for the paediatric brain cell portfolio.


Research interests

Contributing to the design, set-up and management of clinical trials within the paediatric brain tumour portfolio.


  1. Hirschfield, G., Arndtz, K., Kirkham, A., Chen, Y.Y., Rowe, A., Douglas-Pugh, J., Thorburn, D., Barnes, E., Aithal, G.P., Hull, D., Bhandal, K., McQuillan, K., Woodward, P., Lax, S., Newsome, P., Smith, D., Kallio, A., Adams, D., Homer, V., Weston, C.J. (2024) Vascular adhesion protein-1 blockade in primary sclerosing cholangitis: open-label, multi-centre, single arm, phase II trial, Hepatology Communications, [in press].
  2. Ma, Y., Kirkham, S., Curbishley, S., Rowe, A., Blahova, M., Mehrzad, H., Karkhanis, S., Punia, P., James, M., Rao, A.R., Stern, N., Palmer, D.H., Hull, D., Lowe, F., Douglas-Pugh, J., Bathurst, C., Wilkhu, M., Yap, C., Adams, D.H. (2022), A randomised phase II clinical trial of low-dose cyclophosphamide and transarterial chemoembolization (TACE) with or without vaccination with dendritic cells (DC) pulsed with HepG2 lysate ex vivo in patients with hepatocellular carcinoma (HCC): The ImmunoTACE trial. Journal of Clinical Oncology, 4(16_suppl): 4012-4012
  3. Arndtz, K., Chen, Y.Y., Rowe, A., Homer, V., Kirkham, A., Douglas-Pugh, J., Slade, D., Thorburn, D., Barnes, E., Aithal, G., Newsome, P., Smith, D., Adams, D., Weston, C., Hirschfield, G. (2022), Monoclonal antibody BTT1023 targeting vascular adhesion protein 1 for treating primary sclerosing cholangitis: BUTEO single-arm Phase II trial. Southampton (UK): NIHR Journals Library; 2022 Mar.
  4. Retzer, A., Aiyegbusi, O.L., Rowe, A., Newsome, P.N., Douglas-Pugh, J., Khan, S., Mittal, S., Wilson, R., O'Connor, D., Campbell, L., Mitchell, S.A., Calvert, M. (2022), The value of patient-reported outcomes in early-phase clinical trials. Nat Med, 28(1):18-20.
  5. Sargeant, J.A., Aithal, G.P., Takamura, T., Misu, H., Takayama, H., Douglas, J.A., Turner, M.C., Stensel, D.J., Nimmo, M.A., Webb, D.R., Yates, T., King, J.A. (2017), The influence of adiposity and acute exercise on circulating hepatokines in normal-weight and overweight/obese men. Applied Physiology, Nutrition, and Metabolism, 43: 482-90.
  6. Douglas, J.A., King, J.A., Clayton, D.J., Jackson, A.P., Sargeant, J.A., Thackray, A.E., Davies, M.J., Stensel, D.J. (2017), Acute effects of exercise on appetite, ad libitum energy intake and appetite-regulatory hormones in lean and overweight/obese men and women. International Journal of Obesity, 41(12):1737-1744.
  7. King, J.A., Deighton, K., Broom, D.R., Wasse, L.K., Douglas, J.A., Burns, S.F., Cordery, P.A., Petherick, E.S., Batterham, R.L., Goltz, F.R., Thackray, A.E., Yates, T., Stensel, D.J. (2017), Individual variation in hunger, energy intake and ghrelin responses to acute exercise. Medicine and Science in Sports and Exercise, 49(6): 1219-1228.
  8. Douglas, J.A., Deighton, K., Atkinson, J.M., Vahid, S.S., Stensel, D.J., Atkinson, G. (2016), Acute exercise and appetite–regulating hormones in overweight and obese individuals: A meta-analysis. Journal of Obesity.
  9. Douglas, J.A., King, J.A., Mc Farlane, E., Baker, L., Bradley, C., Crouch, N., Hill, D., Stensel, D.J. (2015), Appetite, appetite hormone and energy intake responses to two consecutive days of aerobic exercise in healthy young men. Appetite, 92: 57-65.
  10. Bailey, D.P., Smith, L.R., Chrismas, B.C., Taylor, L., Stensel, D.J., Deighton, K., Douglas, J.A., Kerr, C.J. (2015), Appetite and gut hormone responses to moderate-intensity continuous exercise versus high-intensity interval exercise, in normoxic and hypoxic conditions. Appetite, 89: 237-45.
  11. Atkinson, G., Douglas, J.A., Stensel, D.J. (2014), The meta-analysis of crossover studies on exercise and appetite related hormones. Sports Medicine, 44(8): 1165.