Mr Prashant Patel MBBS, MS, FRCSEd, FRCSEd (Urol), PhD, FEBU

Mr Prashant Patel

Institute of Cancer and Genomic Sciences
Senior Lecturer In Urology
Honorary Consultant Urological Surgeon (University Hospitals Birmingham)
Clinical Service Lead (Urology)

Contact details

Address
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Prashant Patel qualified in 1993 from India and then trained to qualify as a General Surgeon with special interest in pelvic surgery. He was awarded a PhD from the University of Birmingham whilst training as a Urologist. His research explored gene and immunotherapy for prostate cancer. He travelled to Perth, Australia to complete a fellowship in urological cancer surgery where he had exposure to laparoscopic  and robotic surgery.

Upon Mike Wallace's retirement, he took up the appointment as a Senior Lecturer in Urology at the University of Birmingham and Consultant Urological Surgeon at QE Hospital (UHB), Birmingham (2010) to pursue a joint career in academic and clinical urology. His academic interests are to explore molecular markers in bladder cancer, immunotherapeutic approaches in all urological cancers and informatics. His clinical interests are in pelvic cancers (bladder and prostate) and retro-peritoneal node surgery for metastatic testicular cancer, developing a program in Robotic surgery at UHB and conduct clinical trials in urological cancers.

Prashant is also the theme lead in Clinical Research and Epidemiology for the Bladder Cancer Research Centre in the Institute of Cancer and Genomic Sciences.

Qualifications

  • FRCSEd (Urol) Fellow of the Royal College of Surgeons in Urology, 2009
  • PhD in Gene and Immunotherapy, University of Birmingham, 2008
  • FRCSEd, Fellow of the Royal College of Surgeons in Surgery, 2001
  • MS (General Surgery), University of Karnataka, 1998
  • MBBS, University of Poona, 1993

Teaching

  • Surgical Oncology (Module Lead and Tutor)
  • Cancer Therapy and Management (Module Tutor)
  • Translational Research (Module Tutor)
  • FRCS (Urol) Revision Course (BAUS) Faculty

Postgraduate supervision

Prashant has supervised the following students:

MD

  • 2020-2022 - Umair Kamran - POUGIC – Quality Indicators of Upper GI Endoscopy (Funding: Joint with Dr Nigel Trudgill and SWBHT)
  • 2017 - 2020 - Omar Abdullah - VTE in Bladder Cancer (Funding: Joint with Professor Annie Young and Warwick University)
  • 2018 - 2020 - Dominic King - Outcomes of PTC and EUS biopsy for Pancreatic malignancies (Funding: Joint with Dr Nigel Trudgill and SWBHT)
  • 2018 - 2019 - Amandeep Dosanjh - Validation of Algorithms to predict an event using HES data in Urological cancers (Funding: Joint with Professor Nick James)
  • 2016 - 2018 - Phillip Harvey - Achalasia Cardia outcomes (Funding: Joint with Dr Nigel Trudgill and SWBHT)
  • 2015 - 2017 - Julien Al Shakarchi - Natural History of Vascular Access and pre-operative predictors of outcome (Funding: Joint with Mr Nick Inston and UHBFT)
  • 2014 - 2016 - James Rees - Changing outcomes for emergency Inflammatory Bowel Disease admissions in England (Funding: Joint with Dr Nigel Trudgill and SWBHT)
  • 2014 - 2015 - David Muthuveloe - Urological Cancer Outcomes on HES (Funding: UHBFT)
  • 2013 - 2015 - Vinney During - Immune responses in Bladder Cancer (Funding: Joint with Dr Graham Taylor and UHBFT)
  • 2012 - 2014 - Danny Cheung - Missed cancers in Endoscopy (Funding: Joint with Dr Nigel Trudgill and SWBHT)
  • 2011 - 2013 - Jane Anderson -  Role of Autotaxins in Urological cancers (Funding: Joint with Professor Paul Murray and UHBFT)

ChM (Urology)

  • 2016 -2017 - Ishtiakul Rizvi - Accuracy of Choline-PET CT to detect prostate cancer metastasis at low levels of PSA (Funding: Self)
  • 2016 -2017 - Sachin Yallapa - Role of Renal Nephrometry score in predicting renal dysfunction (Funding: Self – Gold Medal for the project

MSc

  • 2014 - 2016 - Yakhub Khan - Assessment of late radiotherapy toxicity in patients treated radically for prostate cancer: a comparison between different image verification techniques (Funding: Self)

BMedSci

  • 2014 - 2015 - Robert Telford - Correlation of template biopsy with MRI and prostatectomy (Funding: Self)

Research

Currently, Investigator on the following grants:

  • Targeted-Amplicon sequencing of Urinary DNA for the detection of bladder cancer: AmpseqUr
  • NIHR-HTA: BladderPath: Image Directed Redesign of Bladder Cancer Treatment Pathways
  • NIHR-RfPB:Partnership in prostate cancer care: the feasibility of an integrated system to improve patient outcomes and experience
  • MSD: IBD study
  • RDF UHB: Urinary biomarkers for Bladder Cancer surveillance
  • CDF UoB: The molecular and cellular immunology of bladder cancer and disease responses to BCG therapy.
  • MRC: A Phase I Clinical Trial of a replication defective type 5 adenovirus vector expressing nitroreductase and GMCSF (AdNRGM) Gene therapy in Prostate Cancer

Principal Investigator on the following Open Clinical Trials:

  • WOCBP – ImVIGOR trial, A Phase III, Open-Label, Multicenter, Randomized Study Of Atezolizumab (Anti−Pd-L1 Antibody) Versus Observation As Adjuvant Therapy In Patients With Pd-L1−Selected, High-Risk Muscle-Invasive Bladder Cancer After Cystectomy
  • AdUP - A Phase I Clinical Trial of a replication defective type 5 adenovirus vector expressing nitroreductase and GMCSF (AdNRGM) given via trans-perineal, template guided, intra-prostatic injection, followed by intravenous CB1954, in patients with locally relapsed hormone refractory Prostate Cancer.
  • Bladder-Path Trial

Co-Investigator on the following Clinical Trials:

  • POUT – Co-Investigator
  • Phase I/II feasibility study of cetuximab with 5FU and mitomycin C or cisplatin with concurrent radiotherapy in muscle invasive bladder cancer (TUXEDO)

Find out more:

Other activities

  • EAU Chair and Abstract reviewer: Bladder Cancer, Perioperative Chemotherapy & Advanced Disease: Mar. 2017 (Lon), Mar 2018 (Copenhagen), Mar 2019 (Barcelona), Mar 2020 (Virtual), July 21 (Virtual)
  • Frontiers. Guest Associate Editor in Genitourinary Oncology: 2018
  • French National Cancer Institute: Scientific Evaluation Committee, Translational Cancer Research: 2019, 2020
  • National Committee of Selectors: Urology Interview Panel Member (2011 - Present)
  • BAUS: FRCS Urol Course examiner
  • Cancer Informatics – Clinical Lead (UoB + UHB) 2012 - Present
  • Bladder Cancer – Clinical Lead (UHB)
  • ARCP – Academic representative (West Midlands Deanery)
  • West Midlands Collaborative Audit (Jan 2009 – Present) – Lead
  • 9th  Uro-Oncology Symposium: Course Organiser and Session Chair
  • UHB Radiology Systems Procurement Committee for PACS, RIS and LTA
  • National Consensus Panellist for ‘Beyond TME’ in advanced rectal cancer
  • Urological Cancer Lead: ‘myhealth@UHB’ Clinical Portal
  • BAUS: Joint Audit lead for RPLND surgery

Publications

Recent publications

Article

Bryan, R, Liu, W, Pirrie, S, Amir, R, Gallagher, J, Hughes, A, Jefferson, K, Knight, A, Nanton, V, Mintz, H, Pope, A, Catto, J, Patel, P & James, N 2021, 'Comparing an imaging-guided pathway with the standard pathway for staging muscle-invasive bladder cancer: preliminary data from the BladderPath study', European urology. https://doi.org/10.1016/j.eururo.2021.02.021

King, D, Coupland, B, Dosanjh, A, Cole, A, Adderley, N, Reulen, R, Patel, P & Trudgill, N 2021, 'The risk of later surgery at the anastomotic site following right hemicolectomy for Crohn’s disease in a national cohort of 12 230 patients', Alimentary Pharmacology & Therapeutics, vol. 53, no. 1, pp. 114-127. https://doi.org/10.1111/apt.16114

Mintz, H, Dosanjh, A, Parsons, H, Hughes, A, Jakeman, A, Pope, A, Bryan, R, James, N & Patel, P 2020, 'Development and validation of a follow-up methodology for a randomised controlled trial, utilising routine clinical data as an alternative to traditional designs: a pilot study to assess the feasibility of use for the BladderPath trial', Pilot and Feasibility Studies, vol. 6, 165. https://doi.org/10.1186/s40814-020-00713-y

Rees, J, Mytton, J, Evison, F, Mangat, KS, Patel, P & Trudgill, N 2020, 'The outcomes of biliary drainage by percutaneous transhepatic cholangiography for the palliation of malignant biliary obstruction in England between 2001 and 2014: a retrospective cohort study', BMJ open, vol. 10, no. 1, e033576. https://doi.org/10.1136/bmjopen-2019-033576

Dosanjh, A, Baldwin, S, Mytton, J, King, D, Trudgill, N, Belal, M & Patel, P 2019, 'A national study of artificial urinary sphincter and male sling implantation after radical prostatectomy in England', BJU International , pp. 1-9. https://doi.org/10.1111/bju.14955

Afshar, M, Patel, HRH, Jain, A, Kumar, A, Patel, P, James, N & Porfiri, E 2019, 'Chronic tyrosine kinase inhibitor (TKI) use in metastatic renal cell carcinoma (mRCC): can this lead to the adverse effect of hypogonadism?', Expert Review of Anticancer Therapy, vol. 19, no. 6, pp. 529-532. https://doi.org/10.1080/14737140.2019.1609355

Harvey, P, Rees, J, Baldwin, S, Waheed, H, Tanner, J-R, Evison, F, Patel, P & Trudgill, N 2019, 'Outcomes of colorectal stents when used as a bridge to curative resection in obstruction secondary to colorectal cancer', International journal of colorectal disease, vol. 34, no. 7, pp. 1295-1302. https://doi.org/10.1007/s00384-019-03302-5

King, D, Rees, J, Mytton, J, Harvey, P, Thomas, T, Cooney, R, Patel, P & Trudgill, N 2019, 'The outcomes of emergency admissions with ulcerative colitis between 2007 and 2017 in England', Journal of Crohn's & Colitis. https://doi.org/10.1093/ecco-jcc/jjz185

Snell, K, Ward, D, Gordon, N, Goldsmith, J, Sutton, A, Patel, P, James, N, Zeegers, M, Cheng, K & Bryan, R 2018, 'Exploring the roles of urinary HAI-1, EpCAM & EGFR inbladder cancer prognosis & risk stratification', OncoTarget, vol. 9, pp. 25244-25253. https://doi.org/10.18632/oncotarget.25397

Afshar, M, Goodfellow, H, Jackson-spence, F, Evison, F, Parkin, J, Bryan, R, Parsons, H, James, N & Patel, P 2017, 'Centralisation of radical cystectomies for bladder cancer in England, a decade on from the ‘Improving Outcomes Guidance’: The case for super centralisation', BJU international. https://doi.org/10.1111/bju.13929

Afshar, M, Giles, S, Viney, R, Patel, P, Foster, M, James, N, Bryan, R & Porfiri, E 2016, 'An evaluation of available therapies for recurrent and refractory testicular tumours', Oncology Letters.

Ward, D, Baxter, L, Gordon, N, Ott, S, Savage, R, Beggs, A, James, J, Lickiss, J, Grren, S, Wallis, Y, Wei, W, James, N, Zeegers, M, Cheng, K, Matthews, G, Patel, P, Griffiths, M & Bryan, R 2016, 'Multiplex PCR and next generation sequencing for the non-invasive detection of bladder cancer', PLoS ONE. https://doi.org/10.1371/journal.pone.0149756

Muthuveloe, D, Nkwam, N, Hutton, P, Wallace, DMA, Viney, R & Patel, P 2016, 'Urologist led one-stop testicular clinic: the UK 'gold standard'', SpringerPlus, vol. 5, 95. https://doi.org/10.1186/s40064-016-1722-7

Comment/debate

Bryan, RT, Arnold, R, Khanim, FL, Shepherd, DE, Patel, P & Ward, DG 2021, 'Establishing the Bladder Cancer Research Centre at the University of Birmingham', Nature Reviews Urology, vol. 2021. https://doi.org/10.1038/s41585-021-00448-2

BladderPath Trial Management Group 2021, 'Reply to Trey Durdin, Alvin Goh, and Eugene Pietzak. Can an imaging-guided pathway replace the current paradigm for muscle-invasive bladder cancer?', European urology. https://doi.org/10.1016/j.eururo.2021.04.034

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