Highlight publications
Middleton, G, Fletcher, P, Popat, S, Savage, J, Summers, Y, Greystoke, A, Gilligan, D, Cave, J, O’rourke, N, Brewster, A, Toy, E, Spicer, J, Jain, P, Dangoor, A, Mackean, M, Forster, M, Farley, A, Wherton, D, Mehmi, M, Sharpe, R, Mills, TC, Cerone, MA, Yap, TA, Watkins, TBK, Lim, E, Swanton, C & Billingham, L 2020, 'The National Lung Matrix Trial of personalized therapy in lung cancer', Nature, vol. 583, no. 7818, pp. 807-812. https://doi.org/10.1038/s41586-020-2481-8
Middleton, G, Brock, K, Savage, J, Mant, R, Summers, Y, Connibear, J, Shah, R, Ottensmeier, C, Shaw, P, Lee, SM, Popat, S, Barrie, C, Barone, G & Billingham, L 2020, 'Pembrolizumab in patients with non-small-cell lung cancer of performance status 2 (PePS2): a single arm, phase 2 trial', The Lancet Respiratory Medicine, vol. 8, no. 9, pp. 895-904. https://doi.org/10.1016/S2213-2600(20)30033-3
Williamson, SF, Grayling, MJ, Mander, AP, Noor, NM, Savage, JS, Yap, C & Wason, JMS 2022, 'Subgroup analyses in randomized controlled trials frequently categorized continuous subgroup information', Journal of Clinical Epidemiology, vol. 150, pp. 72-79. https://doi.org/10.1016/j.jclinepi.2022.06.017
Watts, C, Savage, J, Patel, A, Mant, R, Wykes, V, Pohl, U, Bulbeck, H, Apps, J, Sharpe, R, Thompson, G, Waldman, AD, Ansorge, O & Billingham, L 2022, 'Protocol for the Tessa Jowell BRAIN MATRIX Platform Study', BMJ open, vol. 12, no. 9, e067123. https://doi.org/10.1136/bmjopen-2022-067123
Menne, T, Slade, D, Savage, J, Johnson, S, Irving, J, Kearns, P, Plummer, R, Shenton, G, Veal, GJ, Vormoor, B, Vormoor, J & Billingham, L 2022, 'Selumetinib in combination with dexamethasone for the treatment of relapsed/refractory RAS-pathway mutated paediatric and adult acute lymphoblastic leukaemia (SeluDex): study protocol for an international, parallel-group, dose-finding with expansion phase I/II trial', BMJ open, vol. 12, no. 3, e059872. https://doi.org/10.1136/bmjopen-2021-059872
Recent publications
Article
Mitchell, E, Goodman, K, Wakefield, N, Cochran, C, Cockayne, S, Connolly, S, Desai, R, Hartley, S, Lawton, S, Oatey, K, Rhodes, S, Savage, J, Taylor, J & Youssouf, N 2022, 'Clinical trial management: a profession in crisis?', Trials, vol. 23, no. 1, 357. https://doi.org/10.1186/s13063-022-06315-8
Love, SB, Cafferty, F, Snowdon, C, Carty, K, Savage, J, Pallmann, P, McParland, L, Brown, L, Masters, L, Schiavone, F, Hague, D, Townsend, S, Amos, C, South, A, Sturgeon, K, Langley, R, Maughan, T, James, N, Hall, E, Kernaghan, S, Bliss, J, Turner, N, Tutt, A, Yap, C, Firth, C, Kong, A, Mehanna, H, Watts, C, Hills, R, Thomas, I, Copland, M, Bell, S, Sebag-Montefiore, D, Jones, R, Parmar, MKB & Sydes, MR 2022, 'Practical guidance for running late-phase platform protocols for clinical trials: lessons from experienced UK clinical trials units', Trials, vol. 23, no. 1, 757. https://doi.org/10.1186/s13063-022-06680-4
Veenith, T, Fisher, BA, Slade, D, Rowe, A, Sharpe, R, Thickett, DR, Whitehouse, T, Rowland, M, Scriven, J, Parekh, D, Bowden, SJ, Savage, JS, Richards, D, Bion, J, Kearns, P, Gates, S & CATALYST Trial Investigators 2021, 'CATALYST trial protocol: a multicentre, open-label, phase II, multiarm trial for an early and accelerated evaluation of the potential treatments for COVID-19 in hospitalised adults', BMJ open, vol. 11, no. 11, e050202. https://doi.org/10.1136/bmjopen-2021-050202
Kong, A, Good, JS, Kirkham, A, Savage, J, Mant, R, Llewellyn, L, Parish, J, Spruce, R, Forster, M, Schipani, S, Harrington, K, Sacco, JJ, Murray, P, Middleton, G, Yap, C & Mehanna, H 2020, 'Phase I trial of WEE1 inhibition with chemotherapy and radiotherapy as adjuvant treatment, and a window of opportunity trial with cisplatin in patients with head and neck cancer: the WISTERIA trial protocol', BMJ open, vol. 10, no. 3, e033009. https://doi.org/10.1136/bmjopen-2019-033009
Middleton, G, Fletcher, P, Popat, S, Savage, J, Summers, Y, Greystoke, A, Gilligan, D, Cave, J, O'Rourke, N, Brewster, A, Toy, E, Spicer, J, Jain, P, Dangoor, A, Mackean, M, Forster, M, Farley, A, Wherton, D, Mehmi, M, Sharpe, R, Mills, TC, Cerone, MA, Yap, TA, Watkins, TBK, Lim, E, Swanton, C & Billingham, L 2020, 'Publisher Correction: The National Lung Matrix Trial of personalized therapy in lung cancer', Nature. https://doi.org/10.1038/s41586-020-2656-3
Williams, CM, Savage, JS, Harper, MT, Moore, SF, Hers, I & Poole, AW 2016, 'Identification of roles for the SNARE-associated protein, SNAP29, in mouse platelets', Platelets, vol. 27, no. 4, pp. 286-294. https://doi.org/10.3109/09537104.2015.1100282
Golebiewska, EM, Harper, MT, Williams, CM, Savage, JS, Goggs, R, Von Mollard, GF & Poole, AW 2015, 'Syntaxin 8 regulates platelet dense granule secretion, aggregation, and thrombus stability', Journal of Biological Chemistry, vol. 290, no. 3, pp. 1536-1545. https://doi.org/10.1074/jbc.M114.602615
Moore, SF, Hunter, RW, Harper, MT, Savage, JS, Siddiq, S, Westbury, SK, Poole, AW, Mumford, AD & Hers, I 2013, 'Dysfunction of the PI3 kinase/Rap1/integrin aIIbb3 pathway underlies ex vivo platelet hypoactivity in essential thrombocythemia', Blood, vol. 121, no. 7, pp. 1209-1219. https://doi.org/10.1182/blood-2012-05-431288
Letter
Harper, MT, Savage, JS & Poole, AW 2013, 'Comment on "Platelet-Derived Nucleotides Promote Tumor Cell Transendothelial Migration and Metastasis via P2Y2 Receptor" by Schumacher etal.', Cancer Cell, vol. 24, no. 3. https://doi.org/10.1016/j.ccr.2013.08.016
Savage, JS, Williams, CM, Konopatskaya, O, Hers, I, Harper, MT & Poole, AW 2013, 'Munc13-4 is critical for thrombosis through regulating release of ADP from platelets', Journal of Thrombosis and Haemostasis, vol. 11, no. 4, pp. 771-775. https://doi.org/10.1111/jth.12138
Preprint
Love, SB, Cafferty, F, Snowdon, C, Carty, K, Savage, J, Pallmann, P, McParland, L, Brown, LJ, Masters, L, Schiavone, F, Hague, D, Townsend, S, Amos, C, South, A, Sturgeon, K, Langley, RE, Maughan, TS, James, N, Hall, E, Kernaghan, S, Bliss, J, Turner, NC, Yap, C, Firth, C, Kong, A, Mehanna, H, Watts, C, Hills, R, Thomas, I, Copland, M, Bell, SE, Tutt, ANJ, Sebag-Montefiore, D, Jones, R, Parmar, MKB & Sydes, MR 2022 'Practical guidance for running late-phase platform protocols for clinical trials: lessons from experienced UK clinical trials units' Research Square. https://doi.org/10.21203/rs.3.rs-1195468/v1
Watts, C, Savage, J, Patel, A, Mant, R, Wykes, V, Pohl, U, Bulbeck, H, Apps, J, Sharpe, R, Thompson, G, Waldman, A, Ansorge, O, Billingham, L & Watts, C 2022 'Protocol for the Tessa Jowell BRAIN MATRIX Platform Study' medRxiv. https://doi.org/10.1101/2022.07.29.22277991
Williamson, SF, Grayling, MJ, Mander, AP, Noor, N, Savage, J, Yap, C & Wason, JMS 2022 'Subgroup analyses in randomised controlled trials frequently categorise continuous subgroup information' SSRN Electronic Journal, SSRN. https://doi.org/10.2139/ssrn.4077740
Veenith, T, Fisher, BA, Slade, D, Rowe, A, Sharpe, R, Thickett, DR, Whitehouse, T, Rowland, M, Scriven, J, Parekh, D, Bowden, SJ, Savage, JS, Richards, D, Bion, J, Kearns, P & Gates, S 2021 'CATALYST trial protocol: a multicentre, open-label, phase II, multi-arm trial for an early and accelerated evaluation of the potential treatments for COVID-19 in hospitalised adults' medRxiv, pp. 1-15. https://doi.org/10.1101/2021.02.10.21251478
Menne, T, Slade, D, Savage, J, Johnson, S, Irving, JAE, Kearns, PR, Plummer, R, Shenton, G, Veal, GJ, Vormoor, B, Vormoor, J & Billingham, L 2021 'Selumetinib in combination with dexamethasone for the treatment of relapsed/refractory RAS-pathway mutated paediatric and adult acute lymphoblastic leukaemia (SeluDex): study protocol for an international, parallel-group, dose-finding with expansion phase I/II trial' medRxiv. https://doi.org/10.1101/2021.10.22.21265327
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