Professor Dirk-Peter Herten

Professor Dirk-Peter Herten

Institute of Cardiovascular Sciences
School of Chemistry
Chair in Cell Biology of Membrane Proteins

Contact details

Address
Institute of Cardiovascular Sciences & School of Chemistry
College of Medical and Dental Sciences
Medical School
University of Birmingham
Edgbaston
B15 2TT

Dirk-Peter Herten is a Chair in Cell Biology of Membrane Proteins at the University of Birmingham shared by the Institute of Cardiovascular Sciences and the School of Chemistry with his labs located in the Institute of Biomedical Research (IBR).

Dirk’s interdisciplinary research spans from microscopy techniques over switchable fluorescent probes to biological applications, like T-cell signalling in the context of inflammation. He has specialized in single-molecule microscopy enabling quantitative studies of the composition and dynamics of cellular structures and enzymatic reactions in living cells.

ORCID ID: 0000-0002-3884-0262

Researcher ID: P-4836-2016

Qualifications

  • Venia legendi in Physical Chemistry 2008
  • PhD in Physical Chemistry 2000
  • Diploma in Chemistry, Heidelberg University 1996

Biography

Dirk graduated from the Heidelberg Department of Physical Chemistry in 2000 after studying Chemistry at the Heidelberg University, Germany.

After collecting experiences in industry at ATTO-TEC GmbH, Germany he returned to academia in 2002 by specializing in single-molecule spectroscopy at Heidelberg University where he was awarded the venia legendi in Physical Chemistry in 2008. In 2015 he became University Professor in Single-Molecule Spectroscopy at Heidelberg University until accepting a Chair in Cell Biology of Membrane Proteins at the University of Birmingham in 2019.

Postgraduate supervision

Dirk has openings for self-funded PhD students from biology, chemistry and physics in a variety of different areas related to single-molecule spectroscopy, quantitative microscopy, and fluorescent probes in the biomedical context:

  • Optimization and automation of optical microscopes for quantitative and super-resolution microscopy
  • Development of data analysis and evaluation procedures (also using machine learning)
  • Quantitative microscopy involving the development of fluorescent standards, quantification and labelling protocols
  • Fluorescent probes for single-molecule based super-resolution and multiplexing
  • Quantitative single-molecule studies of T-cell signaling in the context of inflammation and HIV-infection

Currently, Dirk has an opening for a funded PhD project in the area of data analysis procedures for quantitative single-molecule studies involving machine learning. Students with good skills in mathematics and programming interested in more theoretical work in optical microscopy are invited to read more about this project at findaphd.

Please email Professor Herten directly.

Research

Dirk researches tools to enable quantitative studies of the composition and dynamics of cellular structures and enzymatic reactions in living cells. This highly interdisciplinary research will improve our general understanding of intracellular functions and cellular responses to external stimuli in the context of various diseases by bridging biochemistry and cell biology. The design of fluorescent probes for live-cell single-molecule studies has potential for biomedical research and diagnostic applications.

Dirk is currently active in three areas in single-molecule research: single photon based molecular counting, switchable fluorescent probes for advanced fluorescence microscopy, e.g. super-resolution in living cells, and single-molecule studies of chemical reaction pathways.