Dr Alexandre Slater MSci (Hons), PhD

Dr Alexandre Slater

Institute of Cardiovascular Sciences
Research Fellow

Contact details

University of Birmingham
B15 2TT

Dr Slater is a British Heart Foundation research fellow at the Institute of Cardiovascular Sciences at the University of Birmingham.

Dr Slater’s background is in structural biology and protein-protein interactions. His current interests involve using a mixture of x-ray crystallography and cryo-electron microscopy to study the structure of platelet receptors in complex with inhibitory and activating ligands. This knowledge is then used for the development and characterization of novel anti-thrombotic therapies.


  • PhD in Biological chemistry (2017)
  • MSci in Biochemistry and Biological chemistry (2013)


Birmingham Platelet Group - Alexandre Slater

Other activities

  • Member of the British Society for Haemostasis and Thrombosis (BSHT)
  • Member of Biochemical society
  • Reviewer for numerous journals


Recent publications


Wang, X, Slater, A, Lee, SC, Harrison, N, Pollock, NL, Bakker, SE, Navarro, S, Nieswandt, B, Dafforn, TR, García, Á, Watson, SP & Tomlinson, MG 2024, 'Purification and characterisation of the platelet-activating GPVI/FcRγ complex in SMALPs', Archives of Biochemistry and Biophysics, vol. 754, 109944. https://doi.org/10.1016/j.abb.2024.109944

Martin, E, Clark, J, Montague, S, Moran, LA, Di, Y, Bull, LJ, Whittle, L, Raka, F, Buka, R, Zafar, I, Kardeby, C, Slater, A & Watson, S 2024, 'Trivalent nanobody-based ligands mediate powerful activation of GPVI, CLEC-2 and PEAR1 in human platelets whereas FcγRIIA requires a tetravalent ligand', Journal of Thrombosis and Haemostasis, vol. 22, no. 1, pp. 271-285. https://doi.org/10.1016/j.jtha.2023.09.026

Alenazy, F, Harbi, M, Kavanagh, D, Price, J, Brady, P, Hargreaves, O, Harrison, P, Slater, A, Tiwari, A, Nicolson, P, Connolly, D, Kirchhof, P, Kalia, N, Jandrot-Perrus, M, Mangin, PH, Watson, S & Thomas, MR 2023, 'Amplified inhibition of atherosclerotic plaque-induced platelet activation by glenzocimab with dual antiplatelet therapy JTH', Journal of thrombosis and haemostasis : JTH, vol. 21, no. 11, pp. 3236-3251. https://doi.org/10.1016/j.jtha.2023.07.018

Damaskinaki, F-N, Jooss, NJ, Martin, EM, Clark, JC, Thomas, MR, Poulter, NS, Emsley, J, Kellam, B, Watson, SP & Slater, A 2023, 'Characterizing the binding of glycoprotein VI with nanobody 35 reveals a novel monomeric structure of glycoprotein VI where the conformation of D1+D2 is independent of dimerization', Journal of thrombosis and haemostasis : JTH, vol. 21, no. 2, pp. 317-328. https://doi.org/10.1016/j.jtha.2022.11.002

Kardeby, C, Evans, A, Campos, J, Al-Wahaibi, AM, Smith, C, Slater, A, Martin, E, Severin, S, Brill, A, Pejler, G, Sun, Y & Watson, S 2023, 'Heparin and heparin proteoglycan-mimetics activate platelets via PEAR1 and PI3Kβ', Journal of Thrombosis and Haemostasis, vol. 21, no. 1, pp. 101-116. https://doi.org/10.1016/j.jtha.2022.10.008

Buka, R, Montague, S, Moran, LA, Martin, E, Slater, A, Watson, S & Nicolson, P 2023, 'PF4 activates the c-Mpl-Jak2 pathway in platelets', Blood. https://doi.org/10.1182/blood.2023020872

Jooss, NJ, Smith, CW, Slater, A, Montague, SJ, Di, Y, O'shea, C, Thomas, MR, Henskens, YMC, Heemskerk, JWM, Watson, SP & Poulter, NS 2022, 'Anti-GPVI nanobody blocks collagen- and atherosclerotic plaque-induced GPVI clustering, signaling and thrombus formation', Journal of Thrombosis and Haemostasis, vol. 20, no. 11, pp. 2617-2631. https://doi.org/10.1111/jth.15836

Maqsood, Z, Clark, JC, Martin, EM, Cheung, YFH, Morán, LA, Watson, SET, Pike, JA, Di, Y, Poulter, NS, Slater, A, Lange, BMH, Nieswandt, B, Eble, JA, Tomlinson, MG, Owen, DM, Stegner, D, Bridge, LJ, Wierling, C & Watson, SP 2022, 'Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins', PLoS Computational Biology, vol. 18, no. 11, e1010708. https://doi.org/10.1371/journal.pcbi.1010708

Perrella, G, Montague, SJ, Brown, HC, Garcia Quintanilla, L, Slater, A, Stegner, D, Thomas, M, Heemskerk, JWM & Watson, SP 2022, 'Role of Tyrosine Kinase Syk in Thrombus Stabilisation at High Shear', International Journal of Molecular Sciences, vol. 23, no. 1, 493. https://doi.org/10.3390/ijms23010493

Colicchia, M, Schrottmaier, WC, Perrella, G, Reyat, JS, Begum, J, Slater, A, Price, J, Clark, JC, Zhi, Z, Simpson, M, Bourne, J, Poulter, NS, Khan, AO, Nicolson, PLR, Pugh, MR, Harrison, P, Iqbal, AJ, Rainger, GE, Watson, SP, Thomas, MR, Mutch, NJ, Assinger, A & Rayes, J 2022, 'S100A8/A9 drives the formation of procoagulant platelets through GPIbα', Blood. https://doi.org/10.1182/blood.2021014966

Billiald, P, Slater, A, Welin, M, Clark, J, Loyau, S, Pugnière, M, Jiacomini , IG, Rose, N, Lebozec, K, Toledano, E, François, D, Watson, S & Jandrot-Perrus, M 2022, 'Targeting platelet GPVI with glenzocimab: a novel mechanism for inhibition', Blood Advances. https://doi.org/10.1182/bloodadvances.2022007863

Clark, J, Neagoe, RAI, Zuidscherwoude, M, Kavanagh, D, Slater, A, Martin, E, Soave, M, Stegner, D, Nieswandt, B, Poulter, N, Hummert, J, Herten, D-P, Tomlinson, M, Hill, SJ & Watson, S 2021, 'Evidence that GPVI is expressed as a mixture of monomers and dimers, and that the D2 domain is not essential for GPVI activation: GPVI dimerisation is not critical for ligand binding', Thrombosis and Haemostasis, vol. 2021, no. 00, pp. 1-26. https://doi.org/10.1055/a-1401-5014

Xu, R-G, Gauer, J, Baker, S, Slater, A, Martin, E, McPherson, H, Duval, C, Manfield, I, Bonna, A, Watson, S & Ariëns, RAS 2021, 'GPVI (Glycoprotein VI) interaction with fibrinogen is mediated by avidity and the fibrinogen αC-region', Arteriosclerosis Thrombosis and Vascular Biology, vol. 41, no. 3, pp. 1092-1104. https://doi.org/10.1161/ATVBAHA.120.315030

Zhi, Z, Jooss, NJ, Sun, Y, Colicchia, M, Slater, A, Moran, LA, Cheung, HYF, Di, Y, Rayes, J, Poulter, NS, Watson, SP & Iqbal, AJ 2021, 'Galectin-9 activates platelet ITAM receptors glycoprotein VI and C-type lectin-like receptor-2', Journal of thrombosis and haemostasis : JTH. https://doi.org/10.1111/jth.15625


Slater, A & Jandrot-Perrus, M 2022, 'GPVI and collagen: the final word?', Blood, vol. 139, no. 20, pp. 3005–3007. https://doi.org/10.1182/blood.2022015962

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