Dr Juma El-Awaisi

Dr Juma El-Awaisi

Institute of Cardiovascular Sciences
Research Fellow

Contact details

College of Medical and Dental Sciences
University of Birmingham
B15 2TT

Juma El-Awaisi is a research fellow based in the Microcirculation Research Group at the Institute of Cardiovascular Sciences.

Juma El-awaisi completed his PhD in cardiovascular sciences at the University of Birmigham and Master’s in Advanced Pharmacology at Strathclyde University. His focus is on identifying novel therapies for patients who have suffered from a heart attack. He is also investigating the effects of ageing, diabetes, and pulmonary disease on the heart, with a particular interest in the smallest blood vessels.


  • PhD in Cardiovascular Sciences 2019 - 2022
  • MSc in Advanced Pharmacology 2018 - 2019
  • BSc in Clinical Pharmacy 2008 - 2013


Juma El-awaisi is a researcher and health care professional with vast experience in business and management. After completing his undergraduate degree at the age of 20, Juma took a different path and moved towards business and marketing, where he co-founded a technology startup.

Juma is an advocate for merging scientific research with technology


Working under the supervision of Dr Neena Kalia, Dr El-Awaisi’s research is focused on myocardial ischemia-reperfusion injury (IRI). Following myocardial infarction (MI), diabetic and elderly patients have a poorer prognosis, which may be linked to increased coronary microvessel susceptibility to injury. Interleukin-36 (IL-36), a newly discovered proinflammatory member of the IL-1 superfamily, may mediate this injury, but its role in the injured heart is currently not known. Therefore, our research focuses on investigating the role of IL-36, age, and diabetes in myocardial IRI using intravital microscopy and laser speckle contrast imaging.

Using intravital microscopy in a beating heart environment, we are able to directly observe thromboinflammatory events within myocardial microvessels, particularly the trafficking, adhesion kinetics (rolling / adhesion / transmigration) and cross-talk between leukocytes and platelets with each other and vascular endothelium. We are combining this method with laser speckle contrast imaging of the beating heart to quantitate overall organ perfusion and correlate these events with those taking place at the microvascular level.

Research Groups and Centres

Microcirculation Research Group

Other activities

British microcirculation and vascular biology society committee member: 2020 – 2023


Recent publications


Bourne, JH, Perrella, G, El-Awaisi, J, Terry, LV, Tinkova, V, Hogg, RL, Gant, P, Grygielska, B, Kalia, N, Kavanagh, D, Brill, A, Dimitrov, JD, Watson, SP & Rayes, J 2024, 'Hydroxychloroquine inhibits hemolysis-induced arterial thrombosis ex vivo and improves lung perfusion in hemin-treated mice', Journal of Thrombosis and Haemostasis. https://doi.org/10.1016/j.jtha.2024.04.008

El-Awaisi, J, Kavanagh, DPJ & Kalia, N 2024, 'Monitoring coronary blood flow by laser speckle contrast imaging after myocardial ischaemia reperfusion injury in adult and aged mice', Frontiers in cardiovascular medicine, vol. 11, 1358472. https://doi.org/10.3389/fcvm.2024.1358472

Retzer, A, Ciytak, B, Khatsuria, F, El-awaisi, J, Harris, I, Chapman, L, Kelly, T, Richards, J, Lam, E, Newsome, P, Calvert, M & Gillett, C 2023, 'A toolkit for capturing a representative and equitable sample in health research', Nature Medicine, vol. 29, no. 12, pp. 3259–3267. https://doi.org/10.1038/s41591-023-02665-1

El-Awaisi, J, Mitchell, JL, Ranasinghe, A & Kalia, N 2023, 'Interleukin-36 is vasculoprotective in both sexes despite sex-specific changes in the coronary microcirculation response to IR injury', Frontiers in cardiovascular medicine, vol. 10, 1227499. https://doi.org/10.3389/fcvm.2023.1227499

El-awaisi, J, Kavanagh, D, Rink, M, Weston, C, Drury, N & Kalia, N 2022, 'Targeting IL-36 improves age-related coronary microcirculatory dysfunction and attenuates myocardial ischemia/ reperfusion injury in mice: ageing and the coronary microcirculation ', JCI Insight, vol. 7, no. 5, e155236. https://doi.org/10.1172/jci.insight.155236

El-awaisi, J 2016, 'Impact of Dermatologists’ Perceptions about Antibiotic Resistance on Antibiotic Prescribing for Acne.', Journal of Infectious Diseases and Therapy.


El-awaisi, J, Kavanagh, D, Rink, M, Weston, C, Drury, N & Kalia, N 2022, 'Intravital & laser speckle investigations of the role of interleukin-36 in myocardial ischaemia reperfusion injury – a new therapeutic target for the aged heart', Journal of Molecular and Cellular Cardiology, vol. 173, no. supplement, pp. 7. https://doi.org/10.1016/j.yjmcc.2022.08.017

El-awaisi, J, Kavanagh, D, Rink, M, Weston, C, Drury, N & Kalia, N 2022, 'Intravital & laser speckle investigations of the role of interleukin36 in myocardial ischaemia reperfusion injury; a new therapeutic target for the aged heart', Cardiovascular Research, vol. 118, no. Supplement_1, cvac066.051. https://doi.org/10.1093/cvr/cvac066.051

El-awaisi, J, Kavanagh, D & Kalia, N 2021, 'BS13 Intravital investigations of the role of IL-36 in mediating age and gender specific changes in the injured beating coronary microcirculation', Heart, vol. 107, no. Suppl 1, A162. https://doi.org/10.1136/heartjnl-2021-BCS.211

Doctoral Thesis

El-awaisi, J 2022, 'Investigating a Novel Role for the IL-36 / IL-36R Pathway in Mediating Inflammation in the Adult and Aged Murine Heart after Ischaemia-Reperfusion Injury', ???thesis.qualification.phd???. <https://etheses.bham.ac.uk//id/eprint/12701/>

Review article

Marriott, E, Singanayagam, A & El-Awaisi, J 2024, 'Inflammation as the nexus: exploring the link between acute myocardial infarction and chronic obstructive pulmonary disease', Frontiers in cardiovascular medicine, vol. 11, 1362564. https://doi.org/10.3389/fcvm.2024.1362564

View all publications in research portal