Dr Dean Kavanagh BMedSc (Pharm), PhD, FRMS

Dr Dean Kavanagh

Institute of Cardiovascular Sciences
Assistant Professor of Cardiovascular Science

Contact details

Address
Institute of Cardiovascular Sciences
College of Medical and Dental Sciences
Institute of Biomedical Research
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Dr Dean Kavanagh is an Assistant Professor of Cardiovascular Sciences, based in the Institute of Cardiovascular Sciences. His interests are primarily the application and development of Intravital Microscopy imaging techniques, and their application in the context of microvascular imaging. In particular, he is interested in the mechanisms that drive microvascular inflammation and the identification, development and assessment of potential new inhibitors that may help to limit tissue damage following ischaemia-reperfusion injury. In addition, he has a keen interest in the development of technology around Intravital Microscopy, including development of analysis methodologies and software to help improve data analysis processes for this technique. In line with these interests, he is the designated Facility Manager for our state-of-the-art Intravital Imaging Facility in the Institute of Cardiovascular Sciences.

Dr Kavanagh contributes to teaching on a number of courses across Medical and Dental Sciences, as well as supporting both undergraduate and postgraduate project supervision.

Qualifications

  • 2009 - PhD (Medicine), University of Birmingham
  • 2005 – BMedSc (Hons) Pharmacology, University of Birmingham

Teaching

  • BDS Y1 Body Systems
  • BSc Y1 Fundamentals of Life Science
  • MBChB Y2 Foundations of Medical Science and Practice – CVS
  • MBChB Y2 Foundations of Medical Science and Practice – REN
  • MRes Cardiovascular Practical Skills Toolkit

Other activities

Honorary Treasurer of the British Microcirculation and Vascular Biology Society

Publications

Recent publications

Article

Hopkin, SJ, Pezhman, L, Begum, J, Kavanagh, D, McGettrick, HM, Iqbal, AJ & Chimen, M 2023, 'Aging modulates homeostatic leukocyte trafficking to the peritoneal cavity in a sex-specific manner', Journal of Leukocyte Biology, pp. 1-14. https://doi.org/10.1093/jleuko/qiad053

Alenazy, F, Harbi, M, Kavanagh, D, Price, J, Brady, P, Hargreaves, O, Harrison, P, Slater, A, Tiwari, A, Nicolson, P, Connolly, D, Kirchhof, P, Kalia, N, Jandrot-Perrus, M, Mangin, PH, Watson, S & Thomas, MR 2023, 'Amplified inhibition of atherosclerotic plaque-induced platelet activation by glenzocimab with dual antiplatelet therapy JTH', Journal of thrombosis and haemostasis : JTH. https://doi.org/10.1016/j.jtha.2023.07.018

El-awaisi, J, Kavanagh, D, Rink, M, Weston, C, Drury, N & Kalia, N 2022, 'Targeting IL-36 improves age-related coronary microcirculatory dysfunction and attenuates myocardial ischemia/ reperfusion injury in mice: ageing and the coronary microcirculation ', JCI Insight, vol. 7, no. 5, e155236. https://doi.org/10.1172/jci.insight.155236

Campos, J, Ponomaryov, T, De Prendergast, A, Whitworth, K, Smith, C, Khan, A, Kavanagh, D & Brill, A 2021, 'Neutrophil extracellular traps and inflammasomes cooperatively promote venous thrombosis in mice', Blood Advances, vol. 5, no. 9, pp. 2319–2324. https://doi.org/10.1182/bloodadvances.2020003377

Chimen, M, Evryviadou, A, Box, CL, Harrison, MJ, Hazeldine, J, Dib, LH, Kuravi, SJ, Payne, H, Price, JMJ, Kavanagh, D, Iqbal, AJ, Lax, S, Kalia, N, Brill, A, Thomas, SG, Belli, A, Crombie, N, Adams, RA, Evans, S-A, Deckmyn, H, Lord, JM, Harrison, P, Watson, SP, Nash, GB & Rainger, GE 2020, 'Appropriation of GPIbα from platelet-derived extracellular vesicles supports monocyte recruitment in systemic inflammation', Haematologica, vol. 105, no. 5, pp. 1248-1261. https://doi.org/10.3324/haematol.2018.215145

Haining, E, Lowe, K, Wichaiyo, S, Kataru, RP, Nagy, Z, Kavanagh, D, Lax, S, Di, Y, Nieswandt, B, Ho-Tin-Noé, B, Mehrara, BJ, Senis, Y, Rayes, J & Watson, S 2020, 'Lymphatic blood filling in CLEC-2-deficient mouse models', Platelets. https://doi.org/10.1080/09537104.2020.1734784

Du, M, Kavanagh, D, Kalia, N & Zhang, Z 2019, 'Characterising the mechanical properties of haematopoietic and mesenchymal stem cells using micromanipulation and atomic force microscopy', Medical Engineering & Physics, vol. 73, pp. 18-29. https://doi.org/10.1016/j.medengphy.2019.07.013

Du, M, Kavanagh, D, Zhang, Z & Kalia, N 2019, 'Designing microfluidic devices to sort haematopoietic stem cells based on their mechanical properties', Stem cells international, vol. 2019, 8540706. https://doi.org/10.1155/2019/8540706

Kavanagh, D, Lokman, A, Neag, G, Colley, A & Kalia, N 2019, 'Imaging the injured beating heart intravitally and the vasculoprotection afforded by haematopoietic stem cells', Cardiovascular Research, vol. 115, no. 13, pp. 1918-1932. https://doi.org/10.1093/cvr/cvz118

Kavanagh, D, Gallagher, MT & Kalia, N 2019, 'Tify: a quality-based frame selection tool for improving the output of unstable biomedical imaging', PLoS ONE, vol. 14, no. 3, e0213162. https://doi.org/10.1371/journal.pone.0213162

King, A, Houlihan, DD, Kavanagh, D, Haldar, D, Luu, N, Owen, A, Suresh, S, Than, NN, Reynolds, G, Penny, J, Sumption, H, Ramachandran, P, Henderson, NC, Kalia, N, Frampton, J, Adams, DH & Newsome, PN 2017, 'Sphingosine-1-phosphate prevents egress of hematopoietic stem cells from liver to reduce fibrosis', Gastroenterology, vol. 153, no. 1, pp. 233–248.e16. https://doi.org/10.1053/j.gastro.2017.03.022

Kavanagh, DPJ, Suresh, S, Newsome, PN, Frampton, J & Kalia, N 2015, 'Pretreatment of Mesenchymal Stem Cells Manipulates Their Vasculoprotective Potential While Not Altering Their Homing Within the Injured Gut', Stem Cells, vol. 33, no. 9, pp. 2785-97. https://doi.org/10.1002/stem.2061

Abstract

El-awaisi, J, Kavanagh, D, Rink, M, Weston, C, Drury, N & Kalia, N 2022, 'Intravital & laser speckle investigations of the role of interleukin-36 in myocardial ischaemia reperfusion injury – a new therapeutic target for the aged heart', Journal of Molecular and Cellular Cardiology, vol. 173, no. supplement, pp. 7. https://doi.org/10.1016/j.yjmcc.2022.08.017

El-awaisi, J, Kavanagh, D & Kalia, N 2021, 'BS13 Intravital investigations of the role of IL-36 in mediating age and gender specific changes in the injured beating coronary microcirculation', Heart, vol. 107, no. Suppl 1, A162. https://doi.org/10.1136/heartjnl-2021-BCS.211

Review article

Kavanagh, D & Kalia, N 2019, 'Live intravital imaging of cellular trafficking in the cardiac microvasculature – beating the odds', Frontiers in immunology, vol. 10, 2782. https://doi.org/10.3389/fimmu.2019.02782

View all publications in research portal