Dr Melanie Madhani

Dr Melanie Madhani

Institute of Cardiovascular Sciences
Associate Professor in Cardiovascular Medicine

Contact details

Address
Institute of Cardiovascular Sciences
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Dr Melanie Madhani leads a translational research group to understand the mechanism of hypertension, myocardial infarction and heart failure. Her research group is assessing novel pharmacological strategies to protect against these diseases with scientists and clinicians working together from “bench to bedside, and back again”. 

Biography

Dr Melanie Madhani graduated from the University of Wales College of Medicine in 1998 and obtained a PhD in Cardiovascular Sciences from the Ivy League School, Dartmouth College, New Hampshire, USA and University of Wales in 2002. She then joined University College London (UCL) as a British Heart Foundation research fellow, to work under Dr Adrian Hobbs. Here, she investigated the role of nitric oxide (NO) in cardiovascular diseases. Dr Madhani was awarded a UCL Bogue Fellowship to work with Nobel Laureate Dr Louis Ignarro, University of California, LA, USA. In 2005, she joined Dr Philip Eaton's research group at St Thomas’ Hospital, King's College London, where she broadened her experience in cardiac physiology in order to complement her vascular knowledge and skills into NO regulation during myocardial ischaemia reperfusion injury. In 2009, the University of Birmingham appointed Dr Madhani and is an Associate Professor in Cardiovascular Medicine. Here, she continues with her research in this field and collaborates with Prof Frenneaux (Doha, Qatar), Prof Feelisch (University of Southampton), Prof Horowitz (Queen Elizabeth Hospital, University of Adelaide, Australia), and Prof Hugh Montgomery (UCL), Prof Bryan Yan (Prince of Wales Hospital, Chinese University of Hong Kong). Dr Madhani was the Treasurer for the British Society for Cardiovascular Research (2014-2019) and currently holds an Adjunct Honorary Associate Professor position at the Department of Medicine and Therapeutics, Chinese University of Hong Kong.

Teaching

Dr Madhani makes substantial contributions to teaching within her specialised field of hypertension, ischaemic heart disease and heart failure at the University of Birmingham. She was previously a Deputy Module Leader for BMed Sci Cardiovascular Cellular Mechanism and has contributed to the development of the new module Cardiovascular Integrated Regulation in Health and Disease. 

Postgraduate supervision

Dr Madhani has openings for self-funded MRes and PhD (basic science and clinical) in the area of:

  • Nitric oxide and nitrite in health and disease
  • Cardiometabolism in ischaemic heart disease and heart failure 

Research

Research Themes

Dr Madhani’s research programme identifies novel targets and intervention for hypertension, myocardial infarction and heart failure. Her internationally renowned research team focusses on:

  • Novel protective strategies against ischaemia reperfusion injury in patients undergoing coronary artery bypass grafting surgery
  • Assessing the protective role of nitrite and novel redox mediators (e.g sulfur metabolome) against wound healing, hypertension, ischaemic heart disease and heart failure
  • Perhexiline and novel cardiac metabolic agents to treat against pulmonary hypertension and heart failure

Research Groups and Centres

Madhani Lab

Other activities

She currently holds:

  • Adjunct Associate Professor position at the Department of Medicine and Therapeutics, Chinese University of Hong Kong.
  • Grant Advisory Panel for the NCR3s
  • Review Editor for Frontiers in Clinical & Translational Physiology
  • Head of Global Engagement at the Institute of Cardiovascular Sciences, University of Birmingham
  • Member of the Medical & Dental Sciences Global Engagement for University of Birmingham
  • British Society for Cardiovascular Research Ambassador

In addition, she has previously held a number of important appointments:

  • Treasurer for the British Society for Cardiovascular Research (2014-2019)
  • Associate Editor for International Journal for Pharmacology & Therapeutics (2006-2013)
  • Bulletin Editor for the British Society for Cardiovascular Research (2009-2013)

Publications

Recent publications

Article

Griffiths, K, Lee, J, Frenneaux, M, Feelisch, M & Madhani, M 2021, 'Nitrite and myocardial ischaemia reperfusion injury. Where are we now?', Pharmacology & Therapeutics, vol. 223, 107819. https://doi.org/10.1016/j.pharmthera.2021.107819

Drury, N, Bi, R, Woolley, R, Stickley, J, Morris, KP, Montgomerie, J, Doorn, CV, Dunn, W, Madhani, M, Ives, N, Kirchhof, P & Jones, T 2020, 'Bilateral Remote Ischaemic Conditioning in Children (BRICC) trial: protocol for a two-centre, double-blind, randomised controlled trial in young children undergoing cardiac surgery', BMJ open, vol. 10, no. 10, e042176. https://doi.org/10.1136/bmjopen-2020-042176

Feelisch, M, Akaike, T, Griffiths, K, Ida, T, Prysyahna, O, Goodwin, JJ, Gollop, ND, Fernandez, BO, Minnion, M, Cortese-Krott, MM, Borgognone, A, Hayes, RM, Eaton, P, Frenneaux, MP & Madhani, M 2020, 'Long-lasting blood pressure lowering effects of nitrite are NO-independent and mediated by hydrogen peroxide, persulfides, and oxidation of protein kinase G1α redox signalling', Cardiovascular Research, vol. 116, no. 1, pp. 51-62. https://doi.org/10.1093/cvr/cvz202

Sutton, TR, Minnion, M, Barbarino, F, Koster, G, fernandez, BO, Cumpstey, AF, Wischmann, P, Madhani, M, Frenneaux, MP, Postle, AD, Cortese-Krott, MM & Feelisch, M 2018, 'A robust and versatile mass spectrometry platform for comprehensive assessment of the thiol redox metabolome', Redox Biology, vol. 16, pp. 359-380. https://doi.org/10.1016/j.redox.2018.02.012

Borgognone, A, Shantsila, E, Worrall, S, Prompunt, E, Loka, T, Loudon, BL, Chimen, M, Rainger, GE, Lord, JM, Turner, A, Nightingale, P, Feelisch, M, Kirchhof, P, Lip, G, Watson, SP, Frenneaux, MP & Madhani, M 2018, 'Nitrite circumvents platelet resistance to nitric oxide in patients with heart failure preserved ejection fraction and chronic atrial fibrillation', Cardiovascular Research, vol. 114, pp. 1313–1323. https://doi.org/10.1093/cvr/cvy087

Noordali, H, Loudon, B, Frenneaux, M & Madhani, M 2017, 'Cardiac metabolism - a promising therapeutic target for heart failure', Pharmacology & Therapeutics. https://doi.org/10.1016/j.pharmthera.2017.08.001

Madhani, M 2017, 'Development of Fluorinated Analogues of Perhexiline with Improved Pharmacokinetic Properties and Retained Efficacy', Journal of Medicinal Chemistry, vol. 60, no. 7, pp. 2780-2789. https://doi.org/10.1021/acs.jmedchem.6b01592

Madhani, M 2017, 'Inorganic Nitrate in Angina Study: A Randomized Double-Blind Placebo-Controlled Trial', Journal of the American Heart Association, vol. 6, no. 9, e006478. https://doi.org/10.1161/JAHA.117.006478

Madhani, M, Noordali, H, Frenneaux, M, Loudon, B & Gollop, ND 2016, 'Present and future pharmacotherapeutic agents in heart failure: An evolving paradigm', British Journal of Pharmacology, vol. 173 , no. 12, pp. 1911-1924. https://doi.org/10.1111/bph.13480

Arif, S, Borgognone, A, Lin, EL, O'sullivan, AG, Sharma, V, Drury, NE, Menon, A, Nightingale, P, Mascaro, J, Bonser, RS, Horowitz, JD, Feelisch, M, Frenneaux, MP & Madhani, M 2015, 'Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans', British Journal of Pharmacology, vol. 172, no. 13, pp. 3341-3352. https://doi.org/10.1111/bph.13122

Ormerod, JOM, Arif, S, Mukadam, M, Evans, JDW, Beadle, R, Fernandez, BO, Bonser, RS, Feelisch, M, Madhani, M & Frenneaux, MP 2015, 'Short-term intravenous sodium nitrite infusion improves cardiac and pulmonary hemodynamics in heart failure patients', Circulation. Heart failure, vol. 8, no. 3, pp. 565-571. https://doi.org/10.1161/CIRCHEARTFAILURE.114.001716

Borgognone, A, Navarro-Nunez, L, Correia, JN, Pollitt, AY, Thomas, SG, Eble, JA, Pulcinelli, FM, Madhani, M & Watson, SP 2014, 'CLEC-2-dependent activation of mouse platelets is weakly inhibited by cAMP but not by cGMP', Journal of Thrombosis and Haemostasis, vol. 12, no. 4, pp. 550-559. https://doi.org/10.1111/jth.12514

Dautov, RF, Stafford, I, Liu, S, Cullen, H, Madhani, M, Chirkov, YY & Horowitz, JD 2014, 'Hypoxic potentiation of nitrite effects in human vessels and platelets', Nitric Oxide, vol. 40, pp. 36-44. https://doi.org/10.1016/j.niox.2014.05.005

Siddiqi, N, Neil, C, Bruce, M, MacLennan, G, Cotton, S, Papadopoulou, S, Feelisch, M, Bunce, N, Lim, PO, Hildick-Smith, D, Horowitz, J, Madhani, M, Boon, N, Dawson, D, Kaski, JC, Frenneaux, M & NIAMI investigators 2014, 'Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI)', European Heart Journal, vol. 35, no. 19, pp. 1255-62. https://doi.org/10.1093/eurheartj/ehu096

Borgognone, A, Lowe, KL, Watson, SP & Madhani, M 2014, 'Natriuretic peptides induce weak VASP phosphorylation at Serine 239 in platelets', Platelets, vol. 25, no. 1, pp. 1-7. https://doi.org/10.3109/09537104.2013.773969

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