Cardiovascular Translational Group in Hypertension, Myocardial Infarction and Heart Failure

Cardiovascular Translational Research from Bench to Bedside

• Nitrite as a therapeutic intervention for cardiovascular disease

• Redox signalling of nitrite and persulfides in cardiovascular health and disease 

• Cardiovascular metabolism 

Please view a full list of Professor Madhani’s publications

'Cysteine hydropersulfide reduces lipid peroxidation and protects against myocardial ischaemia-reperfusion injury: - Are endogenous persulfides mediators of ischaemic preconditioning?'Griffiths, K, Ida, T, Morita, M, Lamb, RJ, Lee, JJ, Frenneaux, MP, Fukuto, JM, Akaike, T, Feelisch, M & Madhani, M 2023, , Redox Biology, vol. 60, 102605. 

Nitrite and myocardial ischaemia reperfusion injury. Where are we now? Griffiths, K, Lee, J, Frenneaux, M, Feelisch, M & Madhani, M Pharmacology & Therapeutics, 2021 vol. 223, 107819.

Long-lasting blood pressure lowering effects of nitrite are NO-independent and mediated by hydrogen peroxide, persulfides and oxidation of protein kinase G 1α redox signaling.Feelisch M, Akaike T, Griffiths K, Ida T, Prysyahna O, Goodwin JJ, Gollop ND, Fernandez BO, Minnion M, Cortese-Krott MM, Borgognone A, Hayes RM, Eaton P, Frenneaux MP, Madhani M. Cardiovasc Res. 2019 Jul 31.

A robust and versatile mass spectrometry platform for comprehensive assessment of the thiol redox metabolome. Sutton TR, Minnion M, Barbarino F, Koster G, Fernandez BO, Cumpstey AF, Wischmann P, Madhani M, Frenneaux MP, Postle AD, Cortese-Krott MM, Feelisch M. Redox Biol. 2018 Jun;16:359-380. doi: 10.1016/j.redox.2018.02.012. Epub 2018 Feb 19.

Nitrite circumvents platelet resistance to nitric oxide in patients with heart failure preserved ejection fraction and chronic atrial fibrillation. Borgognone A, Shantsila E, Worrall SM, Prompunt E, Loka T, Loudon BL, Chimen M, Rainger GE, Lord JM, Turner A, Nightingale P, Feelisch M, Kirchhof P, Lip GYH, Watson SP, Frenneaux MP, Madhani M. Cardiovasc Res. 2018 Apr 12.

Short-term intravenous sodium nitrite infusion improves cardiac and pulmonary hemodynamics in heart failure patients. J O M Ormerod, S Arif, MMukadam, J D W Evans, R Beadle, B O Fernandez RS Bonser, M Feelisch, M Madhani*,M P Frenneaux* - *joint last authors.   Circulation Heart Failure. 2015 May: 8(3): 565-71

Cardiac metabolism - A promising therapeutic target for heart failure.Noordali H, Loudon BL, Frenneaux MP, Madhani M. Pharmacol Ther. 2018 Feb;182:95-114. doi: 10.1016/j.pharmthera.2017.08.001. Epub 2017 Aug 15.

Present and future pharmacotherapeutic agents in heart failure: an evolving paradigm. Loudon BL, Noordali H, Gollop ND, Frenneaux MP, Madhani M. Br J Pharmacol. 2016 Jun;173(12):1911-24. doi: 10.1111/bph.13480. Epub 2016 May 6.

Pharmacology and therapeutic role of inorganic nitrite and nitrate in vasodilatation. J C Bailey, M Feelisch, J D Horowitz, M P Frenneaux, M Madhani.Pharmacol Ther. 2014 Jun 30.

Intravenous sodium nitrite in acute ST elevation myocardial infarction: a randomised controlled trial (NIAMI). N Siddiqi, M Bruce,CJ Neil,B Jagpal ,G Maclennon ,SC Cotton,SA Papadopoulo,N Bunce, L P, K Schwarz, S Singh ,D  Hildick-Smith, JD Horowitz, M Madhani, N Boon,JC Kaski,D Dawson,MP Frenneaux. European Heart Journal 2014 May 14; 35(19):1255-62

Research Fellows

• Dr Kayleigh Griffiths (BHF postdoctoral research fellow)

Students

• Mr Reece Lamb (PhD student)
• Mr Giovanni Guglielmi (PhD student)
• Mrs Fifi Ibrahim (PhD student)
• Mr Ross Keeler (MRes Student) 

External Collaborators

• Professor Michael Frenneaux (Qatar, Doha)
• Professor Hugh Montgomery (UCL)
• Professor Adrian Hobbs (QMUL, UK)
• Professor Philip Eaton (QMUL, UK)
• Professor Martin Feelisch (Southampton University, UK)
• Professor Jon Fukuto (Sonoma State, USA)
• Professor Takaaki Akaike (Tohoku University, Japan) 
• Professor Bryan Yang (Prince of Wales Hospital, Hong Kong)