Dr Samantha Montague

Dr Samantha Montague

Institute of Cardiovascular Sciences
Research Fellow

Contact details

Address
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Dr Samantha Montague is a research fellow in the Birmingham Platelet Group at the Institute of Cardiovascular Sciences. She is supported by the British Heart Foundation.

Dr Montague’s background is in exploring platelet activation and function in thromboinflammation. Her current research is investigating platelet activation and signalling of tyrosine kinase receptors, including the platelet receptor FcgRIIA. 

Qualifications

  • PhD in Cardiovascular Sciences, University of Birmingham, 2016
  • BSc Biomedical Sciences, Cardiff University, 2012

Other activities

Publications

Recent publications

Article

Martin, E, Clark, J, Montague, S, Moran, LA, Di, Y, Bull, LJ, Whittle, L, Raka, F, Buka, R, Zafar, I, Kardeby, C, Slater, A & Watson, S 2024, 'Trivalent nanobody-based ligands mediate powerful activation of GPVI, CLEC-2 and PEAR1 in human platelets whereas FcγRIIA requires a tetravalent ligand', Journal of Thrombosis and Haemostasis, vol. 22, no. 1, pp. 271-285. https://doi.org/10.1016/j.jtha.2023.09.026

Schönichen, C, Montague, SJ, Brouns, SLN, Burston, JJ, Cosemans, JMEM, Jurk, K, Kehrel, BE, Koenen, RR, Ní Áinle, F, O'Donnell, VB, Soehnlein, O, Watson, SP, Kuijpers, MJE, Heemskerk, JWM & Nagy, M 2023, 'Antagonistic Roles of Human Platelet Integrin αIIbβ3 and Chemokines in Regulating Neutrophil Activation and Fate on Arterial Thrombi Under Flow', Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/ATVBAHA.122.318767

Whyte, CS, Morrow, GB, Gauer, JS, Montague, S & Nicolson, P 2023, 'Novel therapeutics and emerging technology in haemostasis and thrombosis: highlights from the British society for haemostasis and thrombosis annual meeting', Front Cardiovasc Med, vol. 10, 1225243. https://doi.org/10.3389/fcvm.2023.1225243

Buka, R, Montague, S, Moran, LA, Martin, E, Slater, A, Watson, S & Nicolson, P 2023, 'PF4 activates the c-Mpl-Jak2 pathway in platelets', Blood. https://doi.org/10.1182/blood.2023020872

Jooss, NJ, Smith, CW, Slater, A, Montague, SJ, Di, Y, O'shea, C, Thomas, MR, Henskens, YMC, Heemskerk, JWM, Watson, SP & Poulter, NS 2022, 'Anti-GPVI nanobody blocks collagen- and atherosclerotic plaque-induced GPVI clustering, signaling and thrombus formation', Journal of Thrombosis and Haemostasis, vol. 20, no. 11, pp. 2617-2631. https://doi.org/10.1111/jth.15836

Montague, S, Smith, C, Lodwick, CS, Stoneley, C, Roberts, M, Lowe, G, Lester, W, Watson, S & Nicolson, P 2022, 'Anti-platelet factor 4 immunoglobulin G levels in vaccine-induced immune thrombocytopenia and thrombosis: persistent positivity through 7 months', Research and Practice in Thrombosis and Haemostasis, vol. 6, no. 3, e12707. https://doi.org/10.1002/rth2.12707

Bourne, J, Smith, C, Jooss, N, Di, Y, Brown, H, Montague, S, Thomas, M, Poulter, N, Rayes, J & Watson, SP 2022, 'CLEC-2 supports platelet aggregation in mouse but not human blood at arterial shear', Thrombosis and Haemostasis, vol. 122, no. 12, pp. 1988-2000. https://doi.org/10.1055/a-1896-6992

Perrella, G, Montague, SJ, Brown, HC, Garcia Quintanilla, L, Slater, A, Stegner, D, Thomas, M, Heemskerk, JWM & Watson, SP 2022, 'Role of Tyrosine Kinase Syk in Thrombus Stabilisation at High Shear', International Journal of Molecular Sciences, vol. 23, no. 1, 493. https://doi.org/10.3390/ijms23010493

Zheng, Y, Montague, SJ, Lim, YJ, Xu, T, Xu, T, Gardiner, EE & Lee, WM 2021, 'Label-free multimodal quantitative imaging flow assay for intrathrombus formation in vitro', Biophysical Journal, vol. 120, no. 5, pp. 791-804. https://doi.org/10.1016/j.bpj.2021.01.015

Montague, SJ, Patel, P, Martin, EM, Slater, A, Quintanilla, LG, Perrella, G, Kardeby, C, Nagy, M, Mezzano, D, Mendes, PM & Watson, SP 2021, 'Platelet activation by charged ligands and nanoparticles: platelet glycoprotein receptors as pattern recognition receptors', Platelets, vol. 32, no. 8, pp. 1-13. https://doi.org/10.1080/09537104.2021.1945571

Montague, SJ, Hicks, SM, Lee, CSM, Coupland, LA, Parish, CR, Lee, WM, Andrews, RK & Gardiner, EE 2020, 'Fibrin exposure triggers αIIbβ3-independent platelet aggregate formation, ADAM10 activity and glycoprotein VI shedding in a charge-dependent manner', Journal of Thrombosis and Haemostasis, vol. 18, no. 6, pp. 1447-1458. https://doi.org/10.1111/jth.14797

Conference contribution

Zheng, Y, Montague, SJ, Lim, YJ, Gardiner, EE & Lee, WM 2021, QUANTIFICATION OF THROMBUS KINETICS THROUGH INHIBITING RECEPTOR SHEDDING WITH LABEL-FREE IMAGING FLOW ASSAY. in 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2021) . Chemical and Biological Microsystems Society, pp. 1533-1534, 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021, Palm Springs, Virtual, United States, 10/10/21. <https://www.proceedings.com/64786.html>

Zheng, Y, Montague, SJ, Lim, YJ, Xu, T, Gardiner, EE & Lee, WM 2020, Coherent Optical Scattering and Interferometry (COSI) microscopy for morphological imaging of thrombus. in CLEO: Applications and Technology, CLEO_AT 2020., AM1I.4, Optics InfoBase Conference Papers, vol. Part F181-CLEO-AT 2020, Optica Publishing Group (formerly OSA), CLEO: Applications and Technology, CLEO_AT 2020, Washington, United States, 10/05/20. https://doi.org/10.1364/CLEO_AT.2020.AM1I.4

Zheng, Y, Lim, YJ, Montague, SJ, Gardiner, EE & Lee, WM 2020, Coherent optical scattering and interferometry microscopy for functional imaging of thrombus. in Microscopy Histopathology and Analytics, Microscopy 2020. Optics InfoBase Conference Papers, vol. Part F177-Microscopy-2020, Optica Publishing Group (formerly OSA), Microscopy Histopathology and Analytics, Microscopy 2020, Washington, United States, 20/04/20. https://doi.org/10.1364/MICROSCOPY.2020.MTh3A.3

Letter

Smith, C, Montague, S, Kardeby, C, Di, Y, Lowe, G, Lester, W, Watson, S & Nicolson, P 2021, 'Anti-platelet drugs block platelet activation by vaccine-induced immune thrombocytopenia and thrombosis patient serum', Blood. https://doi.org/10.1182/blood.2021012277

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