Recent publications
Article
Hain, S, Fu, MS, Wigg, L, George, L, Lecky, D, Whitehead, AJ, Clipston, E, Sato, K, Ono, M, Wuthrich, M, Klein, B, Kawakami, K, Rayes, J, Bending, D & Drummond, RA 2025, 'Brain-infiltrating CD4 T cells drive inflammatory microglia proliferation during cryptococcal meningitis in mice', Nature Communications, vol. 16, no. 1, 8995. https://doi.org/10.1038/s41467-025-64034-5
Perez-Toledo, M, Beristain-Covarrubias, N, Pillaye, J, Persaud, R, Marcial Juarez, E, Jossi, S, Hitchcock, J, Alshayea, A, Channell, W, Wiersma, N, Lamerton, R, Kavanagh, D, Carestia, A, Horsnell, W, Henderson, IR, Mackman, N, Clark, AR, Jenne, CN, Rayes, J, Watson, S & Cunningham, A 2025, 'Discrete and conserved inflammatory signatures drive thrombosis in different organs after Salmonella infection', Nature Communications, vol. 16, 2356. https://doi.org/10.1038/s41467-025-57466-6
Stapley, RJ, Sawkulycz, X, Da Mota Araujo, GHM, Englert, M, Garcia-Quintanilla, L, Smith, SRM, Ahmed, A, Haining, EJ, Kaur, N, Bacon, A, Pisarev, AV, Poulter, NS, Kavanagh, DPJ, Thomas, SG, Montague, SJ, Rayes, J, Nagy, Z & Morgan, NV 2025, 'Platelet-specific SLFN14 deletion causes macrothrombocytopenia and platelet dysfunction through dysregulated megakaryocyte and platelet gene expression', Journal of Clinical Investigation. https://doi.org/10.1172/JCI189100
El-awaisi, J, Perrella, G, Mayer, N, Tinkova, V, Simon, CJ, Grygielska, B, Watson, SP, Dimitrov, JD, Brill, A, Hassan, E, Nicolson, PLR, Kavanagh, D, Kalia, N & Rayes, J 2025, 'Spleen tyrosine kinase inhibition mitigates hemin-induced thromboinflammation in an organ-specific manner in sickle cell mice', Arteriosclerosis Thrombosis and Vascular Biology. https://doi.org/10.1161/ATVBAHA.124.32207
Sekar, R, Mimoun, A, Bou-Jaoudeh, M, Loyau, S, Delignat, S, Daventure, V, Bonilla, P, Bahle, AS, Venkataraman, K, Rayes, J, Boulaftali, Y, Jandrot-Perrus, M, Proulle, V & Lacroix-Desmazes, S 2024, 'High FVIII concentrations interfere with GPVI-mediated platelet activation in vitro', Journal of Thrombosis and Haemostasis. https://doi.org/10.1016/j.jtha.2024.01.021
Bourne, JH, Perrella, G, El-Awaisi, J, Terry, LV, Tinkova, V, Hogg, RL, Gant, P, Grygielska, B, Kalia, N, Kavanagh, D, Brill, A, Dimitrov, JD, Watson, SP & Rayes, J 2024, 'Hydroxychloroquine inhibits hemolysis-induced arterial thrombosis ex vivo and improves lung perfusion in hemin-treated mice', Journal of Thrombosis and Haemostasis, vol. 22, no. 7, pp. 2018-2026. https://doi.org/10.1016/j.jtha.2024.04.008
Reyat, J, Sommerfeld, L, O'Reilly, M, Roth Cardoso, V, Thiemann, E, Khan, A, O'Shea, C, Harder, S, Müller, C, Barlow, J, Stapley, R, Chua, WWL, Kabir, N, Grech, O, Hummel, O, Hübner, N, Kaab, S, Mont, L, Hatem, SN, Winters, J, Zeemering, S, Morgan, N, Rayes, J, Gehmlich, K, Stoll, M, Brand, T, Schweizer , M, Piasecki, A, Schotten, U, Gkoutos, G, Lorenz, K, Cuello, F, Kirchhof, P & Fabritz, L 2024, 'PITX2 deficiency leads to atrial mitochondrial dysfunction', Cardiovascular Research. https://doi.org/10.1093/cvr/cvae169
Roullet, S, Luc, N, Rayes, J, Solarz, J, Disharoon, D, Ditto, A, Gahagan, E, Pawlowski, C, Sefiane, T, Adam, F, Casari, C, Christophe, OD, Bruckman, M, Lenting, PJ, Sen Gupta, A & Denis, CV 2023, 'Efficacy of platelet-inspired hemostatic nanoparticles on bleeding in von Willebrand disease murine models', Blood, vol. 141, no. 23, pp. 2891-2900. https://doi.org/10.1182/blood.2022018956
Khan, AO, Rodriguez-Romera, A, Reyat, JS, Olijnik, AA, Colombo, M, Wang, G, Wen, WX, Sousos, N, Murphy, LC, Grygielska, B, Perrella, G, Mahony, CB, Ling, RE, Elliott, NE, Karali, CS, Stone, AP, Kemble, S, Cutler, EA, Fielding, AK, Croft, AP, Bassett, D, Poologasundarampillai, G, Roy, A, Gooding, S, Rayes, J, Machlus, KR & Psaila, B 2023, 'Human Bone Marrow Organoids for Disease Modeling, Discovery, and Validation of Therapeutic Targets in Hematologic Malignancies', Cancer Discovery, vol. 13, no. 2, pp. 364-385. https://doi.org/10.1158/2159-8290.CD-22-0199
Bourne, JH, Campos, J, Hopkin, SJ, Whitworth, K, Palis, J, Senis, YA, Rayes, J, Iqbal, AJ & Brill, A 2023, 'Megakaryocyte NLRP3 hyperactivation induces mild anemia and potentiates inflammatory response in mice', Frontiers in immunology, vol. 14, 1226196. https://doi.org/10.3389/fimmu.2023.1226196
Reyat, JS, di Maio, A, Grygielska, B, Pike, J, Kemble, S, Rodriguez-Romero, A, Simoglou Karali, C, Croft, AP, Psaila, B, Simões, F, Rayes, J & Khan, AO 2023, 'Modelling the pathology and treatment of cardiac fibrosis in vascularised atrial and ventricular cardiac microtissues', Frontiers in cardiovascular medicine, vol. 10. https://doi.org/10.3389/fcvm.2023.1156759
Bourne, J, Smith, C, Jooss, N, Di, Y, Brown, H, Montague, S, Thomas, M, Poulter, N, Rayes, J & Watson, SP 2022, 'CLEC-2 supports platelet aggregation in mouse but not human blood at arterial shear', Thrombosis and Haemostasis, vol. 122, no. 12, pp. 1988-2000. https://doi.org/10.1055/a-1896-6992
Editorial
Rayes, J 2022, 'It takes guts to boost platelet reactivity and inflammation', Blood, vol. 139, no. 12, pp. 1781-1783. https://doi.org/10.1182/blood.2021015118
Preprint
Brill, A, Bourne, J, Campos, J, Hopkin, S, Whitworth, K, Palis, J, Senis, Y, Rayes, J & Iqbal, A 2023 'Megakaryocyte NLRP3 hyperactivation induces anemia and potentiates inflammatory response in mice' Research Square. https://doi.org/10.21203/rs.3.rs-2616664/v1
Review article
Rayes, J & Brill, A 2024, 'Hot under the clot: venous thrombogenesis is an inflammatory process', Blood, vol. 144, no. 5, pp. 477-489. https://doi.org/10.1182/blood.2023022522
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