Recent publications
Article
Shen, Y, Benlabiod, C, Watson, E, Gurashi, K, Fower, A, Rodriguez-Romera, A, Reyat, JS, Adnan-Awad, S, Hargreaves, R, Kemble, S, Smith, CG, Croft, AP, Oppermann, U, Welsh, A, Murphy, L, Murphy, E, Moetazedian, A, Jooss, N, Wong, ZC, Rayes, J, Mead, AJ, Roy, A, Gooding, S, Psaila, B & Khan, AO 2026, 'comBO: A combined human bone and lympho-myeloid bone marrow organoid for preclinical modeling of hematopoietic disorders', Cell stem cell. https://doi.org/10.1016/j.stem.2026.01.010
Rayes, J & Bayry, J 2026, 'Solving the mystery of vaccine-induced immune thrombocytopenia and thrombosis', Nature Reviews Cardiology. https://doi.org/10.1038/s41569-026-01279-7
Hain, S, Fu, MS, Wigg, L, George, L, Lecky, D, Whitehead, AJ, Clipston, E, Sato, K, Ono, M, Wuthrich, M, Klein, B, Kawakami, K, Rayes, J, Bending, D & Drummond, RA 2025, 'Brain-infiltrating CD4 T cells drive inflammatory microglia proliferation during cryptococcal meningitis in mice', Nature Communications, vol. 16, no. 1, 8995. https://doi.org/10.1038/s41467-025-64034-5
Perez-Toledo, M, Beristain-Covarrubias, N, Pillaye, J, Persaud, R, Marcial Juarez, E, Jossi, S, Hitchcock, J, Alshayea, A, Channell, W, Wiersma, N, Lamerton, R, Kavanagh, D, Carestia, A, Horsnell, W, Henderson, IR, Mackman, N, Clark, AR, Jenne, CN, Rayes, J, Watson, S & Cunningham, A 2025, 'Discrete and conserved inflammatory signatures drive thrombosis in different organs after Salmonella infection', Nature Communications, vol. 16, 2356. https://doi.org/10.1038/s41467-025-57466-6
Stapley, RJ, Sawkulycz, X, Da Mota Araujo, GHM, Englert, M, Garcia-Quintanilla, L, Smith, SRM, Ahmed, A, Haining, EJ, Kaur, N, Bacon, A, Pisarev, AV, Poulter, NS, Kavanagh, DPJ, Thomas, SG, Montague, SJ, Rayes, J, Nagy, Z & Morgan, NV 2025, 'Platelet-specific SLFN14 deletion causes macrothrombocytopenia and platelet dysfunction through dysregulated megakaryocyte and platelet gene expression', Journal of Clinical Investigation. https://doi.org/10.1172/JCI189100
El-awaisi, J, Perrella, G, Mayer, N, Tinkova, V, Simon, CJ, Grygielska, B, Watson, SP, Dimitrov, JD, Brill, A, Hassan, E, Nicolson, PLR, Kavanagh, D, Kalia, N & Rayes, J 2025, 'Spleen tyrosine kinase inhibition mitigates hemin-induced thromboinflammation in an organ-specific manner in sickle cell mice', Arteriosclerosis Thrombosis and Vascular Biology. https://doi.org/10.1161/ATVBAHA.124.32207
Olijnik, A-A, Rodriguez-Romera, A, Wong, ZC, Shen, Y, Reyat, JS, Jooss, NJ, Rayes, J, Psaila, B & Khan, AO 2024, 'Generating human bone marrow organoids for disease modeling and drug discovery', Nature protocols, vol. 19, no. 7, pp. 2117-2146. https://doi.org/10.1038/s41596-024-00971-7
Sekar, R, Mimoun, A, Bou-Jaoudeh, M, Loyau, S, Delignat, S, Daventure, V, Bonilla, P, Bahle, AS, Venkataraman, K, Rayes, J, Boulaftali, Y, Jandrot-Perrus, M, Proulle, V & Lacroix-Desmazes, S 2024, 'High FVIII concentrations interfere with GPVI-mediated platelet activation in vitro', Journal of Thrombosis and Haemostasis. https://doi.org/10.1016/j.jtha.2024.01.021
Bourne, JH, Perrella, G, El-Awaisi, J, Terry, LV, Tinkova, V, Hogg, RL, Gant, P, Grygielska, B, Kalia, N, Kavanagh, D, Brill, A, Dimitrov, JD, Watson, SP & Rayes, J 2024, 'Hydroxychloroquine inhibits hemolysis-induced arterial thrombosis ex vivo and improves lung perfusion in hemin-treated mice', Journal of Thrombosis and Haemostasis, vol. 22, no. 7, pp. 2018-2026. https://doi.org/10.1016/j.jtha.2024.04.008
Reyat, J, Sommerfeld, L, O'Reilly, M, Roth Cardoso, V, Thiemann, E, Khan, A, O'Shea, C, Harder, S, Müller, C, Barlow, J, Stapley, R, Chua, WWL, Kabir, N, Grech, O, Hummel, O, Hübner, N, Kaab, S, Mont, L, Hatem, SN, Winters, J, Zeemering, S, Morgan, N, Rayes, J, Gehmlich, K, Stoll, M, Brand, T, Schweizer , M, Piasecki, A, Schotten, U, Gkoutos, G, Lorenz, K, Cuello, F, Kirchhof, P & Fabritz, L 2024, 'PITX2 deficiency leads to atrial mitochondrial dysfunction', Cardiovascular Research. https://doi.org/10.1093/cvr/cvae169
Roullet, S, Luc, N, Rayes, J, Solarz, J, Disharoon, D, Ditto, A, Gahagan, E, Pawlowski, C, Sefiane, T, Adam, F, Casari, C, Christophe, OD, Bruckman, M, Lenting, PJ, Sen Gupta, A & Denis, CV 2023, 'Efficacy of platelet-inspired hemostatic nanoparticles on bleeding in von Willebrand disease murine models', Blood, vol. 141, no. 23, pp. 2891-2900. https://doi.org/10.1182/blood.2022018956
Comment/debate
Perrella, G & Rayes, J 2026, 'Tethered platelets in severe infection', Science (New York, N.Y.), vol. 391, no. 6783, pp. 349-350. https://doi.org/10.1126/science.aed1243
Letter
Reyat, JS, Shen, Y, Poologasundarampillai, G, Moetazedian, A, Rayes, J & Khan, AO 2025, 'Human Multi-Organoid Platform to Model Immune Dynamics in Cardiac Injury and Disease', Circulation Research, vol. 137, no. 8, pp. 1133-1136. https://doi.org/10.1161/CIRCRESAHA.125.326823
Review article
Rayes, J & Brill, A 2024, 'Hot under the clot: venous thrombogenesis is an inflammatory process', Blood, vol. 144, no. 5, pp. 477-489. https://doi.org/10.1182/blood.2023022522
Dimitrov, JD, Roumenina, LT, Perrella, G & Rayes, J 2023, 'Basic Mechanisms of Hemolysis-Associated Thrombo-Inflammation and Immune Dysregulation', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 43, no. 8, pp. 1349-1361. https://doi.org/10.1161/ATVBAHA.123.318780
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