Dr Julie Rayes

Dr Julie Rayes

Institute of Cardiovascular Sciences
Associate Professor in Cardiovascular Sciences
British Heart Foundation Intermediate Fellow

Contact details

Address
Institute of Cardiovascular Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Julie Rayes is an Associate Professor in Cardiovascular sciences. She holds a British Heart Foundation Intermediate Fellowship. She is interested in understanding the immunoregulatory functions of platelets beyond haemostasis. Her team focuses on the crosstalk between platelets, immune and endothelial cells to identify targets that limit thromboinflammation during infections and sterile inflammation.

Qualifications

  • PhD in biology and pharmacology of haemostasis and vessels (Denis Diderot university-Paris VII)
  • MA in biology and pharmacology of haemostasis and vessels (Denis Diderot university-Paris VII)

Biography

Julie Rayes completed her MA and PhD at the University of Denis Diderot-Paris VII in France (2003-2007) focusing on the role of Von Willebrand Factor and ADAMTS13 in thrombotic and bleeding disorders. During her first post doc (2008-2010), she established a mouse model of VWD type 2B using hydrodynamic injection. During her second post doc (2011-2014), she focused on the crosslink between coagulation and complement and the role of complement activation in the immune response against therapeutic FVIII in haemophilia A. Since 2014, Julie Rayes focuses on the crosstalk between platelets and immune cells in thromboinflammation.

In 2019, Julie was appointed as a lecturer in Cardiovascular Sciences at the University of Birmingham. In 2020, she received a British Heart Foundation Intermediate Fellowship to investigate novel mechanisms of thromboinflammation in haemolytic diseases, with both infectious and congenital origins.

Teaching

Postgraduate supervision

 Julie is interested in supervising doctoral research students in the following areas:

Research

Research Themes

The main aim of Julie's research is to investigate and target thromboinflammation in infection, haemolysis and sterile inflammation.

Her current research focuses on the role of Damage-Associated Molecular Patterns (DAMPs) and Pathogen-Associated Molecular Patterns (PAMPs) released during infections and haemolysis on the development and resolution of thromboinflammation focusing on platelet- innate immune cell interactions. She is also interested in understanding how the presence of comorbidities alter the response of platelets, endothelial cells and immune cells to DAMPs and PAMPs and identify potential targets to limit thromboinflammation in particular in the presence of cardiovascular diseases.

Publications

Recent publications

Article

Sekar, R, Mimoun, A, Bou-Jaoudeh, M, Loyau, S, Delignat, S, Daventure, V, Bonilla, P, Bahle, AS, Venkataraman, K, Rayes, J, Boulaftali, Y, Jandrot-Perrus, M, Proulle, V & Lacroix-Desmazes, S 2024, 'High FVIII concentrations interfere with GPVI-mediated platelet activation in vitro', Journal of Thrombosis and Haemostasis. https://doi.org/10.1016/j.jtha.2024.01.021

Rayes, J & Brill, A 2024, 'Hot under the clot: venous thrombogenesis is an inflammatory process', Blood. https://doi.org/10.1182/blood.2023022522

Bourne, JH, Perrella, G, El-Awaisi, J, Terry, LV, Tinkova, V, Hogg, RL, Gant, P, Grygielska, B, Kalia, N, Kavanagh, D, Brill, A, Dimitrov, JD, Watson, SP & Rayes, J 2024, 'Hydroxychloroquine inhibits hemolysis-induced arterial thrombosis ex vivo and improves lung perfusion in hemin-treated mice', Journal of Thrombosis and Haemostasis. https://doi.org/10.1016/j.jtha.2024.04.008

Roullet, S, Luc, N, Rayes, J, Solarz, J, Disharoon, D, Ditto, A, Gahagan, E, Pawlowski, C, Sefiane, T, Adam, F, Casari, C, Christophe, OD, Bruckman, M, Lenting, PJ, Sen Gupta, A & Denis, CV 2023, 'Efficacy of platelet-inspired hemostatic nanoparticles on bleeding in von Willebrand disease murine models', Blood, vol. 141, no. 23, pp. 2891-2900. https://doi.org/10.1182/blood.2022018956

Khan, AO, Rodriguez-Romera, A, Reyat, JS, Olijnik, AA, Colombo, M, Wang, G, Wen, WX, Sousos, N, Murphy, LC, Grygielska, B, Perrella, G, Mahony, CB, Ling, RE, Elliott, NE, Karali, CS, Stone, AP, Kemble, S, Cutler, EA, Fielding, AK, Croft, AP, Bassett, D, Poologasundarampillai, G, Roy, A, Gooding, S, Rayes, J, Machlus, KR & Psaila, B 2023, 'Human Bone Marrow Organoids for Disease Modeling, Discovery, and Validation of Therapeutic Targets in Hematologic Malignancies', Cancer Discovery, vol. 13, no. 2, pp. 364-385. https://doi.org/10.1158/2159-8290.CD-22-0199

Bourne, JH, Campos, J, Hopkin, SJ, Whitworth, K, Palis, J, Senis, YA, Rayes, J, Iqbal, AJ & Brill, A 2023, 'Megakaryocyte NLRP3 hyperactivation induces mild anemia and potentiates inflammatory response in mice', Frontiers in immunology, vol. 14, 1226196. https://doi.org/10.3389/fimmu.2023.1226196

Reyat, JS, di Maio, A, Grygielska, B, Pike, J, Kemble, S, Rodriguez-Romero, A, Simoglou Karali, C, Croft, AP, Psaila, B, Simões, F, Rayes, J & Khan, AO 2023, 'Modelling the pathology and treatment of cardiac fibrosis in vascularised atrial and ventricular cardiac microtissues', Frontiers in cardiovascular medicine, vol. 10. https://doi.org/10.3389/fcvm.2023.1156759

Bourne, J, Smith, C, Jooss, N, Di, Y, Brown, H, Montague, S, Thomas, M, Poulter, N, Rayes, J & Watson, SP 2022, 'CLEC-2 supports platelet aggregation in mouse but not human blood at arterial shear', Thrombosis and Haemostasis, vol. 122, no. 12, pp. 1988-2000. https://doi.org/10.1055/a-1896-6992

Schrottmaier, WC, Pirabe, A, Pereyra, D, Heber, S, Hackl, H, Schmuckenschlager, A, Brunnthaler, L, Santol, J, Kammerer, K, Oosterlee, J, Pawelka, E, Treiber, SM, Khan, AO, Pugh, M, Traugott, MT, Schörgenhofer, C, Seitz, T, Karolyi, M, Jilma, B, Rayes, J, Zoufaly, A & Assinger, A 2022, 'Platelets and antiplatelet medication in COVID-19-related thrombotic complications', Frontiers in cardiovascular medicine, vol. 8, 802566. https://doi.org/10.3389/fcvm.2021.802566

Khan, A, Reyat, J, Hill, H, Bourne, J, Colicchia, M, Newby, ML, Allen, JD, Crispin, M, Youd, E, Murray, P, Taylor, G, Stamataki, Z, Richter, A, Cunningham, A, Pugh, M & Rayes, J 2022, 'Preferential uptake of SARS-CoV-2 by pericytes potentiates vascular damage and permeability in an organoid model of the microvasculature', Cardiovascular Research, pp. 1-12. https://doi.org/10.1093/cvr/cvac097

Colicchia, M, Schrottmaier, WC, Perrella, G, Reyat, JS, Begum, J, Slater, A, Price, J, Clark, JC, Zhi, Z, Simpson, M, Bourne, J, Poulter, NS, Khan, AO, Nicolson, PLR, Pugh, MR, Harrison, P, Iqbal, AJ, Rainger, GE, Watson, SP, Thomas, MR, Mutch, NJ, Assinger, A & Rayes, J 2022, 'S100A8/A9 drives the formation of procoagulant platelets through GPIbα', Blood. https://doi.org/10.1182/blood.2021014966

Lamerton, R, Marcial-Juarez, E, Faustini, S, Perez-Toledo, M, Goodall, M, Jossi, S, Newby, ML, Chapple, I, Dietrich, T, Veenith, T, Shields, A, Harper, L, Henderson, I, Rayes, J, Wraith, D, Watson, S, Crispin, M, Drayson, M, Richter, A & Cunningham, A 2022, 'SARS-CoV-2 spike- and nucleoprotein-specific antibodies induced after vaccination or infection promote classical complement activation', Frontiers in immunology, vol. 13, 838780. https://doi.org/10.3389/fimmu.2022.838780

Editorial

Rayes, J 2022, 'It takes guts to boost platelet reactivity and inflammation', Blood, vol. 139, no. 12, pp. 1781-1783. https://doi.org/10.1182/blood.2021015118

Preprint

Brill, A, Bourne, J, Campos, J, Hopkin, S, Whitworth, K, Palis, J, Senis, Y, Rayes, J & Iqbal, A 2023 'Megakaryocyte NLRP3 hyperactivation induces anemia and potentiates inflammatory response in mice' Research Square. https://doi.org/10.21203/rs.3.rs-2616664/v1

Review article

Raghunathan, S, Rayes, J & Sen Gupta, A 2022, 'Platelet-inspired nanomedicine in hemostasis thrombosis and thromboinflammation', Journal of Thrombosis and Haemostasis, vol. 20, no. 7, pp. 1535-1549. https://doi.org/10.1111/jth.15734

View all publications in research portal