Dr Julie Rayes

Dr Julie Rayes

Institute of Cardiovascular Sciences
Researcher in Cardiovascular Sciences
British Heart Foundation Intermediate Fellow

Contact details

Address
Institute of Cardiovascular Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Julie Rayes is a researcher in Cardiovascular sciences. She holds a British Heart Foundation Intermediate Fellowship. She is interested in understanding the immunoregulatory functions of platelets beyond haemostasis. Her team focuses on the crosstalk between platelets, immune and endothelial cells to identify targets that limit thromboinflammation during infections and sterile inflammation.

Qualifications

  • PhD in biology and pharmacology of haemostasis and vessels (Denis Diderot university-Paris VII)
  • MA in biology and pharmacology of haemostasis and vessels (Denis Diderot university-Paris VII)

Biography

Julie Rayes completed her MA and PhD at the University of Denis Diderot-Paris VII in France (2003-2007) focusing on the role of Von Willebrand Factor and ADAMTS13 in thrombotic and bleeding disorders. During her first post doc (2008-2010), she established a mouse model of VWD type 2B using hydrodynamic injection. During her second post doc (2011-2014), she focused on the crosslink between coagulation and complement and the role of complement activation in the immune response against therapeutic FVIII in haemophilia A. Since 2014, Julie Rayes focuses on the crosstalk between platelets and immune cells in thromboinflammation.

In 2019, Julie was appointed as a lecturer in Cardiovascular Sciences at the University of Birmingham. In 2020, she received a British Heart Foundation Intermediate Fellowship to investigate novel mechanisms of thromboinflammation in haemolytic diseases, with both infectious and congenital origins.

Teaching

Postgraduate supervision

 Julie is interested in supervising doctoral research students in the following areas:

Research

Research Themes

The main aim of Julie's research is to investigate and target thromboinflammation in infection, haemolysis and sterile inflammation.

Her current research focuses on the role of Damage-Associated Molecular Patterns (DAMPs) and Pathogen-Associated Molecular Patterns (PAMPs) released during infections and haemolysis on the development and resolution of thromboinflammation focusing on platelet- innate immune cell interactions. She is also interested in understanding how the presence of comorbidities alter the response of platelets, endothelial cells and immune cells to DAMPs and PAMPs and identify potential targets to limit thromboinflammation in particular in the presence of cardiovascular diseases.

Publications

Recent publications

Article

Bourne, J, Beristain Covarrubias, N, Zuidscherwoude, M, Campos, J, Di, Y, Garlick, E, Colicchia, M, Terry, L, Thomas, S, Brill, A, Bayry, J, Watson, S & Rayes, J 2021, 'CLEC-2 Prevents Accumulation and Retention of Inflammatory Macrophages During Murine Peritonitis', Frontiers in immunology, vol. 12, 693974. https://doi.org/10.3389/fimmu.2021.693974

Haining, E, Lowe, K, Wichaiyo, S, Kataru, RP, Nagy, Z, Kavanagh, D, Lax, S, Di, Y, Nieswandt, B, Ho-Tin-Noé, B, Mehrara, BJ, Senis, Y, Rayes, J & Watson, S 2020, 'Lymphatic blood filling in CLEC-2-deficient mouse models', Platelets. https://doi.org/10.1080/09537104.2020.1734784

Khan, A, Slater, A, Maclachlan, A, Nicolson, P, Pike, J, Reyat, J, Yule, J, Stapley, R, Rayes, J, Thomas, S & Morgan, N 2020, 'Post-translational polymodification of β1-tubulin regulates motor protein localisation in platelet production and function', Haematologica, vol. 2020, no. 00, pp. 1-43. https://doi.org/10.3324/haematol.2020.270793

Delignat, S, Rayes, J, Dasgupta, S, Gangadharan, B, Denis, CV, Christophe, OD, Bayry, J, Kaveri, SV & Lacroix-Desmazes, S 2020, 'Removal of mannose-ending glycan at Asn2118 abrogates FVIII presentation by human monocyte-derived dendritic cells', Frontiers in immunology, vol. 11, 393. https://doi.org/10.3389/fimmu.2020.00393

Planchais, C, Rayes, J, Delignat, S, Pashova, S, Varthaman, A, Pashov, A, Bayry, J, Kaveri, SV, Dimitrov, JD & Lacroix-Desmazes, S 2020, 'Stimulation with FITC-labeled antigens confers B cells with regulatory properties', Cellular Immunology, vol. 355, 104151. https://doi.org/10.1016/j.cellimm.2020.104151

Wichaiyo, S, Lax-Williams, S, Montague, S, Li, Z, Grygielska, B, Pike, J, Haining, E, Brill, A, Watson, S & Rayes, J 2019, 'Platelet glycoprotein VI and C-type lectin-like receptor 2 deficiency accelerates wound healing by impairing vascular integrity in mice', Haematologica, vol. 104, no. 8, pp. 1648-1660. https://doi.org/10.3324/haematol.2018.208363

Rayes, J 2019, 'Platelets in Sepsis: An Update on Experimental Models and Clinical Data.', Frontiers in immunology.

Delignat, S, Russick, J, Gangadharan, B, Rayes, J, Ing, M, Voorberg, J, Kaveri, SV & Lacroix-Desmazes, S 2019, 'Prevention of the anti-factor VIII memory B-cell response by inhibition of bruton tyrosine kinase in experimental hemophilia A', Haematologica, vol. 104, no. 5, pp. 1046-1054. https://doi.org/10.3324/haematol.2018.200279

Bachelet, D, Albert, T, Mbogning, C, Hassler, S, Zhang, Y, Schultze-Strasser, S, Repesse, Y, Rayes, J, Pavlova, A, Pezeshkpoor, B, Liphardt, K, Davidson, JE, Hincelin-Mery, A, Donnes, P, Lacroix-Desmazes, S, Konigs, C, Oldenburg, J & Broet, P 2019, 'Risk stratification integrating genetic data for factor VIII inhibitor development in patients with severe hemophilia A', PLoS ONE, vol. 14, no. 6, e0218258. https://doi.org/10.1371/journal.pone.0218258

Beristain-Covarrubias, N, Perez-Toledo, M, Flores-langarica, A, Zuidscherwoude, M, Hitchcock, J, Channell, W, King, LDW, Thomas, MR, Henderson, I, Rayes, J, Watson, S & Cunningham, A 2019, 'Salmonella-induced thrombi in mice develop asynchronously in the spleen and liver and are not effective bacterial traps', Blood, vol. 133, no. 6, pp. 600–604. https://doi.org/10.1182/blood-2018-08-867267

Chapter

Haining, EJ, Nicolson, PLR, Onselaer, MB, Poulter, NS, Rayes, J, Thomas, MR & Watson, SP 2019, GPVI and CLEC-2. in Platelets. Elsevier Masson, pp. 213-226. https://doi.org/10.1016/B978-0-12-813456-6.00011-4

Review article

Bourne, J, Colicchia, M, Di, Y, Martin, E, Slater, A, Roumenina, LT, Dimitrov, JD, Watson, S & Rayes, J 2021, 'Heme induces human and mouse platelet activation through C-type-lectin-like receptor-2', Haematologica, vol. 106, no. 2, pp. 626-629. https://doi.org/10.3324/haematol.2020.246488

Rayes, J & Lacroix-Desmazes, S 2020, 'A molecular jewel for hemophilia A treatment', Blood, vol. 135, no. 17, pp. 1417-1419. https://doi.org/10.1182/BLOOD.2020005250

Rayes, J, Bourne, J, Brill, A & Watson, S 2020, 'The dual role of platelet-innate immune cell interactions in thrombo-inflammation', Research and Practice in Thrombosis and Haemostasis, vol. 4, no. 1, pp. 23-35. https://doi.org/10.1002/rth2.12266

Rayes, J, Watson, SP & Nieswandt, B 2019, 'Functional significance of the platelet immune receptors GPVI and CLEC-2', Journal of Clinical Investigation, vol. 129, no. 1, CI122955, pp. 12-23. https://doi.org/10.1172/JCI122955

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