Professor Andy Wilson FRSC, FHEA

School of Chemistry
Professor of Chemical Biology

Contact details

Email: a.j.wilson.1@bham.ac.uk
Twitter: @ajwilsongroup

Address: School of Chemistry
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Andy Wilson is a Professor in the School of Chemistry

The Wilson group are interested in the application of synthetic molecules to problems in Chemical Biology and Materials Science. We pursue both curiosity driven fundamental research and mission inspired research addressing societal challenges.

The group is currently supported by The University of Birmingham, EPSRC and BBSRC.

Our group is participating in several large-scale, multi-investigator programmes including SPIDR, a major BBSRC investment, and led on the EPSRC PoPPI Programme.

Qualifications

PhD in Synthetic Chemistry with Professor David A. Leigh FRS, “The Controlled Assembly of Interlocked Architectures”. University of Warwick 1998-2000, The University of Manchester Institute of Science and Technology (UMIST) 1997-1998. 2000

BSc (Hons) Chemistry 1st Class at UMIST 1997

Publications

A. M. Acevedo-Jake, B. Mylemans, D. F. Kay, P. Zhang, B. Korona, G. G. Rhys, A. C. Leney, D. T. Huang, T. A. Edwards, L. S. Itzhaki, D. N. Woolfson, A. J. Wilson*: Grafted Coiled-coil Peptides as Multivalent Scaffolds for Protein Recognition, ACS Chem. Biol, 2025, 6, 1309-1318. View Paper.

D. Gimenez, M. Walko, J. A. Miles, R. Bayliss*, M. H. Wright*, A. J. Wilson*: Constrained TACC3 peptidomimetics for a non-canonical protein-protein interface elucidate allosteric communication in Aurora-A Kinase, Chem. Sci. 2025, 16, 354-363.View Paper

J. Holder, J. A. Miles, M. Batchelor, H. Popple, M. Walko, W. Yeung, N. Kannan, A. J. Wilson, R. Bayliss,* F. Gergely*: CEP192 localises mitotic Aurora-A activity by priming its interaction with TPX2, EMBO J., 2024, 43, 5381-5420. View Paper.

E. E. Cawood, E. Baker, T. A. Edwards, D. N. Woolfson,* T. K. Karamanos,* A. J. Wilson*: Peptidomimetic inhibitors of β-strand-mediated protein-protein interactions: tuning binding affinity of intrinsically disordered sequences through backbone modification, Chem. Sci. 2024, 15, 10237-10245. View Paper.

S. Celis, F. Hobor, T. James, G. J. Bartlett, A. A. Ibarra, D. K. Shoemark, Z. Hegedus, K. Hetherington, D. N. Woolfson, R. B. Sessions, T. A. Edwards, D. M. Andrews,* A. Nelson,* A. J. Wilson*: Query-Guided Protein-Protein Interaction Inhibitor Discovery, Chem. Sci., 2021, 12, 4753-4762. View Paper.

Z. Hegedüs, F. Hobor, D. K Shoemark, L.-Y. Lian, C. Trinh, R. B. Sessions, T. A. Edwards, A. J. Wilson*: Identification of β-Strand Mediated Protein-Protein Interaction Inhibitors Using Ligand-Directed Fragment Ligation, Chem. Sci., 2021, 12, 2286-2293. View Paper.

E. E. Cawood, N. Guthertz, J. Ebo, T. K. Karamanos, S. E. Radford,* A. J. Wilson*: Modulation of amyloidogenic protein self-assembly using tethered small molecules, J. Am. Chem. Soc., 2020, 142, 20845-20854. View Paper.

A. A. Ibarra, G. J. Bartlett, Z. Hegedüs, S. Dutt, F. Hobor, K. A. Horner, K. Hetherington, K. Spence, A. Nelson, T. A Edwards, D. N. Woolfson, R. B. Sessions,* A. J. Wilson*: Predicting and Experimentally Validating Hot-spot Residues at Protein-Protein Interfaces, ACS Chem. Biol., 2019, 14, 2252-2263. View Paper.

J. E. Horne, M. Walko, A. N. Calabrese, M. A. Levenstein, D. J. Brockwell, N. Kapur, A. J. Wilson*, S. E. Radford*: Rapid Mapping of Protein Interactions Using Tag-Transfer Photocrosslinkers, Angew. Chemie. Int. Ed., 2018, 57, 16688–16692. View Paper.

J. A. Miles, D. J. Yeo, Philip Rowell, S. Rodriguez-Marin, C. M. Pask, S. L. Warriner, T. A. Edwards*, A. J. Wilson*: Hydrocarbon Constrained Peptides – Understanding Preorganization and Binding Affinity, Chem. Sci., 2016, 7, 3694-3702. View Paper.

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