Dr Lisa J Hill PhD

Image of Lisa Hill

Institute of Clinical Sciences
Lecturer - Teaching & Research

Contact details

Address
Institute of Clinical Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Lisa Hill is a Lecturer based within the Neuroscience & Ophthalmology group and specialises in developing and translating new treatments for degenerative ocular diseases, including Age-related Macular Degeneration and Glaucoma. Lisa has a keen interest in developing novel methods for drug delivery into the eye. 

Qualifications

  • PhD in Medicine, 2015
  • BMedSc Neuroscience, 2010

Biography

Lisa has a background in Neuroscience and obtained her PhD at the University of Birmingham in 2015. Lisa’s PhD research investigated the role of cytokines and growth factors associated with ocular scarring diseases. After graduating she had a post-doctoral position with Professors Antonio Belli, Ann Logan and Liam Grover working in the fields of Neurotrauma, Ophthalmology and biomaterials science. As a lecturer (appointed February 2018) she now leads research in the fields of translational ophthalmology and ocular drug delivery and has a particular interest in developing new treatments for ocular scarring and degenerative diseases including, Glaucoma and Age-related Macular Degeneration.  Lisa has current collaborative projects with the University of Melbourne, the University of California Irvine, Queen’s University Belfast, Aston University and Moorfields Eye Hospital as well as international industrial partners.   

Teaching

Postgraduate supervision

  • Post-graduate supervisor
  • Clinical BSc supervisor

Research

Lisa has current funded projects related to the following projects:

  • Developing topical therapies for early interventions for AMD
  • Proteomic profiling of ocular inflammatory diseases
  • Investigating anti-scarring compounds to treat anterior segment fibrosis in Glaucoma
  • Tissue engineering/3D modelling of ocular microenvironments for evaluating novel therapies
  • Developing anti-scarring eye drops and slow release for anterior segment and retinal fibrosis
  • Understanding the role of autophagy in corneal scarring
  • Research affiliated with the National Institute for Health Research (NIHR) Surgical Reconstruction and Microbiology Research Centre (SRMRC) 

Read more about Lisa's research on her ResearchGate profile.

Other activities

Lisa is actively involved in organising and participating in public/patient events (e.g. Brain Awareness Week; Macular Society patient groups) and actively promote science via social media. Lisa is also organising and hosting the 4th Annual “Women in Vision UK” event in December 2020 at the University of Birmingham.

Memberships/Committee roles

  • Current member of
    • The Association for Research in Vision and Ophthalmology
    • The British Inflammation Research Association
    • Women In Vision UK.
  • Current academic lead for Postdoctoral/Early Researcher Career Development and Training at the University of Birmingham

Publications

  • Hill LJ, Moakes RM, Vareechon C, Butt G, Ng A, Brock K, Chouhan G, Vincent RC, Abbondante S, Williams R, Barnes NM, Pearlman E, Wallace GR, Rauz S, Logan A, Grover LM. Sustained release of decorin to the surface of the eye enables scarless corneal regeneration. npj Regenerative Medicine, Dec 21: 3: 23
  • Hill LJ, Mead B, Thomas CN, Foale S, Feinstein E, Berry M, Blanch RJ, Ahmed Z, Logan A. TGF-β-induced IOP elevations are mediated by RhoA in the early but not the late fibrotic phase of open angle glaucoma. Molecular Vision. 2018 Oct 29 (24): 712-726
  • Cooke ME, Jones SW, ter Horst B, Moiemen N, Snow M, Chouhan G, Hill LJ, Esmaeli M, Moakes RJ, Holton J, Nandra R. Structuring of Hydrogels across Multiple Length Scales for Biomedical Applications. Advanced Materials. 2018 Apr;30(14):1705013.
  • Di Pietro V, Lazzarino G, Amorini AM, Signoretti S, Hill LJ, Porto E, Tavazzi B, Lazzarino G, Belli A. Fusion or fission: the destiny of mitochondria in traumatic brain injury of different severities. Scientific Reports. 2017 Aug 23;7(1):9189.
  • Hill LJ, Pietro V, Hazeldine J, Davies D, Tomman E, Logan A, Belli A. Cystatin D (CST5): An ultra-early inflammatory biomarker of traumatic brain injury. Scientific reports. 2017 Jul 10;7(1):5002.
  • Hill LJ, de Cogan F, Lynch A, Morgan-Warren PJ, Lechner J, Berwick MR, Peacock AF, Chen M, Scott RA, Xu H, Logan A. Topical delivery of anti-VEGF drugs to the ocular posterior segment using cell-penetrating peptides. Investigative ophthalmology & visual science. 2017 May 1;58(5):2578-90.
  • Di Pietro V, Ragusa M, Davies D, Su Z, Hazeldine J, Lazzarino G, Hill LJ, Crombie N, Foster M, Purrello M, Logan A. MicroRNAs as novel biomarkers for the diagnosis and prognosis of mild and severe traumatic brain injury. Journal of neurotrauma. 2017 Jun 1;34(11):1948-56.
  • Hill LJ, Mead B, Blanch RJ, Ward K, Logan A, Berry M, Leadbeater W, Scheven BA. Mesenchymal stromal cell–mediated neuroprotection and functional preservation of retinal ganglion cells in a rodent model of glaucoma. Cytotherapy. 2016 Apr 1;18(4):487-96.
  • Hill LJ, Mead B, Blanch R J, Ahmed Z, De Cogan F, Morgan-Warren PJ, Mohamed S, Leadbeater W, Berry M, Logan, A. Decorin Reduces Intraocular Pressure and Retinal Ganglion Cell Loss in Rodents Through Fibrolysis of the Scarred Trabecular Meshwork. 2015. Investigative Ophthalmology & Visual Science, 56(6), 3743-3757

View all publications in research portal