Recent publications
Article
Elliot, TAE, Lecky, DAJ & Bending, D 2023, 'T-cell response to checkpoint blockade immunotherapies: from fundamental mechanisms to treatment signatures', Essays in Biochemistry, vol. 2023, EBC20220247. https://doi.org/10.1042/EBC20220247
Quintana, JF, Sinton, MC, Chandrasegaran, P, Kumar Dubey, L, Ogunsola, J, Al Samman, M, Haley, M, McConnell, G, Kuispond Swar, N-R, Ngoyi, DM, Bending, D, de Lecea, L, MacLeod, A & Mabbott, NA 2023, 'The murine meninges acquire lymphoid tissue properties and harbour autoreactive B cells during chronic Trypanosoma brucei infection', PLoS Biology, vol. 21, no. 11, e3002389. https://doi.org/10.1371/journal.pbio.3002389
Whyte, CE, Singh, K, Burton, OT, Aloulou, M, Kouser, L, Veiga, RV, Dashwood, A, Okkenhaug, H, Benadda, S, Moudra, A, Bricard, O, Lienart, S, Bielefeld, P, Roca, CP, Naranjo-Galindo, FJ, Lombard-Vadnais, F, Junius, S, Bending, D, Hochepied, T, Halim, TYF, Schlenner, S, Lesage, S, Dooley, J & Liston, A 2022, 'Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits', The Journal of Experimental Medicine, vol. 219, no. 7, e20212391. https://doi.org/10.1084/jem.20212391
Sheriff, L & Bending, D 2022, 'Flow cytometric analysis of CD4+ T cell re-activation following anti-PD1 immunotherapy in a transgenic mouse model', STAR Protocols, vol. 3, no. 1, 101161. https://doi.org/10.1016/j.xpro.2022.101161
Drummond, RA, Desai, JV, Ricotta, EE, Swamydas, M, Deming, C, Conlan, S, Quinones, M, Matei-Rascu, V, Sherif, L, Lecky, D, Lee, C-CR, Green, NM, Collins, N, Zelazny, AM, Prevots, DR, Bending, D, Withers, D, Belkaid, Y, Segre, JA & Lionakis, MS 2022, 'Long-term antibiotic exposure promotes mortality after systemic fungal infection by driving lymphocyte dysfunction and systemic escape of commensal bacteria', Cell Host & Microbe, vol. 30, no. 7, pp. 1020-1033.e6. https://doi.org/10.1016/j.chom.2022.04.013
Elliot, T, Jennings, E, Lecky, D, Rouvray, S, MacKie, G, Scarfe, L, Sheriff, L, Ono, M, Maslowski, K & Bending, D 2022, 'Nur77-Tempo mice reveal T cell steady state antigen recognition', Discovery Immunology, vol. 1, no. 1, kyac009. https://doi.org/10.1093/discim/kyac009
Gudgeon, N, Munford, H, Bishop, EL, Hill, J, Fulton-Ward, T, Bending, D, Roberts, J, Tennant, DA & Dimeloe, S 2022, 'Succinate uptake by T cells suppresses their effector function via inhibition of mitochondrial glucose oxidation', Cell Reports, vol. 40, no. 7, 111193. https://doi.org/10.1016/j.celrep.2022.111193
Elliot, T, Jennings, E, Lecky, D, Thawait, N, Flores-Langarica, A, Copland, A, Maslowski, K, Wraith, D & Bending, D 2021, 'Antigen and checkpoint receptor engagement recalibrates T cell receptor signal strength', Immunity, vol. 54, no. 11, pp. 2481-2496.e6. https://doi.org/10.1016/j.immuni.2021.08.020
Comment/debate
Sheriff, L, Copland, A & Bending, D 2023, 'T cell biomarkers come to the fore in cancer immunotherapy', Cell Reports Medicine, vol. 4, no. 4, 100989. https://doi.org/10.1016/j.xcrm.2023.100989
Preprint
Lecky, DAJ, Sheriff, L, Rouvray, ST, George, LS, Drummond, RA, Wraith, DC & Bending, D 2024 'Interferon-γ and IL-27 positively regulate type 1 regulatory T-cell development during adaptive tolerance' bioRxiv. https://doi.org/10.1101/2024.06.21.598825
Takahashi, M, Tsunoda, M, Aoki, H, Kurosu, M, Ogiwara, H, Shichino, S, Bending, D, Ishikawa, S, Thaventhiran, JED, Matsushima, K & Ueha, S 2024 'LAG-3 blockade reactivates the CD8+T cell expansion program to re-expand contracted clones in the tumor' bioRxiv. https://doi.org/10.1101/2024.07.05.601623
Sheriff, L, Copland, A, Lecky, D, Done, R, George, LS, Jennings, E, Rouvray, S, Elliot, T, Jinks, ES, Pallan, L & Bending, D 2024 'Lag3 and PD-L1 govern T cell receptor signal duration in adaptively tolerised CD4+ T cells' bioRxiv. https://doi.org/10.1101/2024.06.06.597762
Copland, A, Mackie, G, Scarfe, L, Lecky, D, Gudgeon, N, McQuade, R, Ono, M, Barthel, M, Hardt, W-D, Ohno, H, Dimeloe, S, Bending, D & Maslowski, K 2023 'Salmonella cancer therapy metabolically disrupts tumours at the collateral cost of T cell immunity' bioRxiv. https://doi.org/10.1101/2023.01.12.523780
Watt, HJ, Chawla, AS, Lamoliatte, F, Pryde, S, Knatko, E, Rasmussen, KD, Bending, D & Swamy, M 2023 'Rewiring of the TCR signalosome in natural intestinal Intraepithelial T lymphocytes drives non-deletional tolerance' bioRxiv. https://doi.org/10.1101/2023.09.01.555859
Review article
Bending, D & Zikherman, J 2023, 'Nr4a nuclear receptors: markers and modulators of antigen receptor signaling', Current Opinion in Immunology, vol. 81, 102285. https://doi.org/10.1016/j.coi.2023.102285
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