Dr Chris Weston BSc PhD

Dr Chris Weston

Institute of Immunology and Immunotherapy
Senior Research Fellow

Contact details

Address
NIHR Biomedical Research Unit and Centre for Liver Research
5th Floor Institute for Biomedical Research
The Medical School
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Chris Weston is a post-doctoral research fellow based in the Centre for Liver Research who has received grant funding from the MRC and the Wellcome Trust.

His research focus is the regulation of immune mediated injury and fibrosis in the human liver, with a view to establish the role that amine oxidases such as vascular adhesion protein-1 (VAP-1) and the lysyl oxidase family (LOX, LOXL1-4) play in this process. He is also interested in the development of therapeutic agents to target inflammatory liver disease and works closely with clinical colleagues to facilitate the transition from bench to bedside.

Qualifications

  • PhD Biochemistry, Birmingham 2001
  • BSc Biochemistry with Biotechnology, Birmingham 1998

Teaching

Postgraduate supervision

Dr Weston is interested in supervising doctoral research in the following areas:

The role of amine oxidases in liver disease and primary liver cancer
Lymphocyte recruitment to the human liver

Other activities

  • Membership of the British Association for the Study of the Liver
  • STEM ambassador to promote Science and Technology for children and young people

Publications

Recent publications

Article

Law, JP, Price, AM, Pickup, L, Radhakrishnan, A, Weston, C, Jones, AM, McGettrick, HM, Chua, W, Steeds, RP, Fabritz, L, Kirchhof, P, Pavlovic, D, Townend, JN & Ferro, CJ 2020, 'Clinical potential of targeting fibroblast growth factor‐23 and αKlotho in the treatment of uremic cardiomyopathy', Journal of the American Heart Association, vol. 9, no. 7, e016041. https://doi.org/10.1161/JAHA.120.016041

Hayer, M, Radhakrishnan, A, Price, A, Liu, B, Baig, S, Weston, C, Biasiolli, L, Ferro, C, Townend, J, Steeds, R & Edwards, NC 2020, 'Defining myocardial abnormalities across the stages of chronic kidney disease: a cardiac magnetic resonance imaging study', JACC: Cardiovascular Imaging, vol. 13, no. 11, pp. 2357-2367. https://doi.org/10.1016/j.jcmg.2020.04.021

Fromont, C, Atzori, A, Kaur, D, Hashmi, L, Greco, G, Cabanillas, A, Nguyen, HV, Jones, DH, Garzón, M, Varela, A, Stevenson, B, Iacobini, G, Lenoir, M, Rajesh, S, Box, C, Kumar, J, Grant, P, Novitskaia, V, Morgan, J, Sorrell, F, Redondo, C, Kramer, A, Harris, CJ, Leighton, B, Vickers, S, Cheetham, S, Kenyon, C, Grabowska, AM, Overduin, M, Berditchevski, F, Weston, CJ, Knapp, S, Fischer, PM & Butterworth, S 2020, 'Discovery of highly selective inhibitors of calmodulin-dependent kinases that restore insulin sensitivity in the diet-induced obese in vivo mouse model', Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.9b01803

Brenig, R, Pop, OT, Triantafyllou, E, Geng, A, Singanayagam, A, Perez-Shibayama, C, Besse, L, Cupovic, J, Künzler, P, Boldanova, T, Brand, S, Semela, D, Duong, FH, Weston, CJ, Ludewig, B, Heim, MH, Wendon, J, Antoniades, CG & Bernsmeier, C 2020, 'Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis', Life Science Alliance, vol. 3, no. 1, e201900465. https://doi.org/10.26508/lsa.201900465

Chauhan, A, Sheriff, L, Hussain, MT, Webb, GJ, Patten, DA, Shepherd, EL, Shaw, R, Weston, CJ, Haldar, D, Bourke, S, Bhandari, R, Watson, S, Adams, DH, Watson, SP & Lalor, PF 2020, 'The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure', Nature Communications, vol. 11, no. 1, 1939. https://doi.org/10.1038/s41467-020-15584-3

Chen, Y-Y, Arndtz, K, Webb, G, Corrigan, M, Akiror, S, Liaskou, E, Woodward, P, Adams, DH, Weston, CJ & Hirschfield, GM 2019, 'Intrahepatic macrophage populations in the pathophysiology of primary sclerosing cholangitis', JHEP Reports, vol. 1, no. 5, pp. 369-376. https://doi.org/10.1016/j.jhepr.2019.10.003

Patten, DA, Shepherd, EL, Weston, CJ & Shetty, S 2019, 'Novel targets in the immune microenvironment of the hepatic sinusoids for treating liver diseases', Seminars in Liver Disease, vol. 39, no. 2, pp. 111-123. https://doi.org/10.1055/s-0039-1678727

Parker, R, Kim, SJ, Im, GY, Nahas, J, Dhesi, B, Vergis, N, Sinha, A, Ghezzi, A, Rink, MR, McCune, A, Aithal, GP, Newsome, PN, Weston, CJ, Holt, A & Gao, B 2019, 'Obesity in acute alcoholic hepatitis increases morbidity and mortality', EBioMedicine, vol. 45, pp. 511-518. https://doi.org/10.1016/j.ebiom.2019.03.046

Parker, R, Kim, SJ, Im, GY, Nahas, J, Dhesi, B, Vergis, N, Sinha, A, Ghezzi, A, Rink, MR, McCune, A, Aithal, GP, Newsome, PN, Weston, CJ, Holt, A & Gao, B 2019, 'Obesity in acute alcoholic hepatitis increases morbidity and mortality.', EBioMedicine. https://doi.org/10.1016/j.ebiom.2019.03.046

Malehmir, M, Pfister, D, Gallage, S, Szydlowska, M, Inverso, D, Kotsiliti, E, Leone, V, Peiseler, M, Surewaard, BGJ, Rath, D, Ali, A, Wolf, MJ, Drescher, H, Healy, ME, Dauch, D, Kroy, D, Krenkel, O, Kohlhepp, M, Engleitner, T, Olkus, A, Sijmonsma, T, Volz, J, Deppermann, C, Stegner, D, Helbling, P, Nombela-Arrieta, C, Rafiei, A, Hinterleitner, M, Rall, M, Baku, F, Borst, O, Wilson, CL, Leslie, J, O'Connor, T, Weston, CJ, Adams, DH, Sheriff, L, Teijeiro, A, Prinz, M, Bogeska, R, Anstee, N, Bongers, MN, Notohamiprodjo, M, Geisler, T, Withers, DJ, Ware, J, Mann, DA, Augustin, HG, Vegiopoulos, A, Milsom, MD, Rose, AJ, Lalor, PF, Llovet, JM, Pinyol, R, Tacke, F, Rad, R, Matter, M, Djouder, N, Kubes, P, Knolle, PA, Unger, K, Zender, L, Nieswandt, B, Gawaz, M, Weber, A & Heikenwalder, M 2019, 'Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer', Nature Medicine, vol. 25, no. 4, pp. 641-655. https://doi.org/10.1038/s41591-019-0379-5, https://doi.org/10.1038/s41591-019-0379-5

Ramachandran, P, Dobie, R, Wilson-Kanamori, JR, Dora, EF, Henderson, BEP, Luu, NT, Portman, JR, Matchett, KP, Brice, M, Marwick, JA, Taylor, RS, Efremova, M, Vento-Tormo, R, Carragher, NO, Kendall, TJ, Fallowfield, JA, Harrison, EM, Mole, DJ, Wigmore, SJ, Newsome, PN, Weston, CJ, Iredale, JP, Tacke, F, Pollard, JW, Ponting, CP, Marioni, JC, Teichmann, SA & Henderson, NC 2019, 'Resolving the fibrotic niche of human liver cirrhosis at single-cell level', Nature, vol. 575, no. 7783, pp. 512-518. https://doi.org/10.1038/s41586-019-1631-3

Parker, R, Weston, CJ, Miao, Z, Corbett, C, Armstrong, M, Ertl, L, Ebsworth, K, Walters, M, Baumart, T, Newland, D, McMahon, J, Zhang, P, Singh, R, Campbell, J, Newsome, PN, Charo, I, Schall, T & Adams, DH 2018, 'CC Chemokine Receptor 2 Promotes Recruitment of Myeloid Cells Associated with Insulin Resistance in Non-Alcoholic Fatty Liver Disease', American journal of physiology. Gastrointestinal and liver physiology. https://doi.org/10.1152/ajpgi.00213.2017

Parker, R, Weston, CJ, Miao, Z, Corbett, C, Armstrong, M, Ertl, L, Ebsworth, K, Walters, M, Baumart, T, Newland, D, McMahon, J, Zhang, P, Singh, R, Campbell, J & Adams, DH 2018, 'CC Chemokine Receptor 2 Promotes Recruitment of Myeloid Cells Associated with Insulin Resistance in Non-Alcoholic Fatty Liver Disease.', American journal of physiology. Gastrointestinal and liver physiology. https://doi.org/10.1152/ajpgi.00213.2017

Wang, S-H, Yu, T-Y, Tsai, F-C, Weston, C, Lin, M-S, Hung, C-S, Kao, H-L, Li, Y-I, Solé, M, Unzeta, M, Chen, Y-L, Chuang, L-M & Li, H-Y 2018, 'Inhibition of semicarbazide-sensitive amine oxidase reduces atherosclerosis in apolipoprotein E-deficient mice', Translational Research. https://doi.org/10.1016/j.trsl.2018.03.001

Review article

Weston, CJ, Zimmermann, HW & Adams, DH 2019, 'The Role of Myeloid-Derived Cells in the Progression of Liver Disease', Frontiers in immunology, vol. 10, 893. https://doi.org/10.3389/fimmu.2019.00893

View all publications in research portal

Expertise

Immune mediated injury and fibrosis in the human liver