Dr Chris Weston BSc PhD

Dr Chris Weston

Institute of Immunology and Immunotherapy
Senior Research Fellow

Contact details

Address
NIHR Biomedical Research Unit and Centre for Liver Research
5th Floor Institute for Biomedical Research
The Medical School
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Chris Weston is a post-doctoral research fellow based in the Centre for Liver Research who has received grant funding from the MRC and the Wellcome Trust.

His research focus is the regulation of immune mediated injury and fibrosis in the human liver, with a view to establish the role that amine oxidases such as vascular adhesion protein-1 (VAP-1) and the lysyl oxidase family (LOX, LOXL1-4) play in this process. He is also interested in the development of therapeutic agents to target inflammatory liver disease and works closely with clinical colleagues to facilitate the transition from bench to bedside.

Qualifications

  • PhD Biochemistry, Birmingham 2001
  • BSc Biochemistry with Biotechnology, Birmingham 1998

Teaching

Postgraduate supervision

Dr Weston is interested in supervising doctoral research in the following areas:

The role of amine oxidases in liver disease and primary liver cancer
Lymphocyte recruitment to the human liver

Other activities

  • Membership of the British Association for the Study of the Liver
  • STEM ambassador to promote Science and Technology for children and young people

Publications

Recent publications

Article

Parker, R, Kim, SJ, Im, GY, Nahas, J, Dhesi, B, Vergis, N, Sinha, A, Ghezzi, A, Rink, MR, McCune, A, Aithal, GP, Newsome, PN, Weston, CJ, Holt, A & Gao, B 2019, 'Obesity in acute alcoholic hepatitis increases morbidity and mortality', EBioMedicine, vol. 45, pp. 511-518. https://doi.org/10.1016/j.ebiom.2019.03.046

Patten, DA, Shepherd, EL, Weston, CJ & Shetty, S 2019, 'Novel targets in the immune microenvironment of the hepatic sinusoids for treating liver diseases', Seminars in Liver Disease, vol. 39, no. 2, pp. 111-123. https://doi.org/10.1055/s-0039-1678727

Malehmir, M, Pfister, D, Gallage, S, Szydlowska, M, Inverso, D, Kotsiliti, E, Leone, V, Peiseler, M, Surewaard, BGJ, Rath, D, Ali, A, Wolf, MJ, Drescher, H, Healy, ME, Dauch, D, Kroy, D, Krenkel, O, Kohlhepp, M, Engleitner, T, Olkus, A, Sijmonsma, T, Volz, J, Deppermann, C, Stegner, D, Helbling, P, Nombela-Arrieta, C, Rafiei, A, Hinterleitner, M, Rall, M, Baku, F, Borst, O, Wilson, CL, Leslie, J, O'Connor, T, Weston, CJ, Adams, DH, Sheriff, L, Teijeiro, A, Prinz, M, Bogeska, R, Anstee, N, Bongers, MN, Notohamiprodjo, M, Geisler, T, Withers, DJ, Ware, J, Mann, DA, Augustin, HG, Vegiopoulos, A, Milsom, MD, Rose, AJ, Lalor, PF, Llovet, JM, Pinyol, R, Tacke, F, Rad, R, Matter, M, Djouder, N, Kubes, P, Knolle, PA, Unger, K, Zender, L, Nieswandt, B, Gawaz, M, Weber, A & Heikenwalder, M 2019, 'Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer', Nature Medicine, vol. 25, no. 4, pp. 641-655. https://doi.org/10.1038/s41591-019-0379-5, https://doi.org/10.1038/s41591-019-0379-5

Bhogal, R, Weston, C, Velduis, S, Henri GD, L, Reynolds, G, Davies, S, Luu, N-T, Alfaifi, M, Shepherd, E, Boteon, Y, Wallace, L, Oo, YH, Adams, D, Mirza, DF, Mergentel, H, Muirhead, G, Stephenson, B & Afford, S 2018, 'The ROS-Mitophagy Signalling Pathway regulates liver endothelial cell survival during ischaemia-reperfusion injury', Liver Transplantation. https://doi.org/10.1002/lt.25313

Wang, S-H, Yu, T-Y, Tsai, F-C, Weston, C, Lin, M-S, Hung, C-S, Kao, H-L, Li, Y-I, Solé, M, Unzeta, M, Chen, Y-L, Chuang, L-M & Li, H-Y 2018, 'Inhibition of semicarbazide-sensitive amine oxidase reduces atherosclerosis in apolipoprotein E-deficient mice', Translational Research. https://doi.org/10.1016/j.trsl.2018.03.001

Parker, R, Weston, CJ, Miao, Z, Corbett, C, Armstrong, M, Ertl, L, Ebsworth, K, Walters, M, Baumart, T, Newland, D, McMahon, J, Zhang, P, Singh, R, Campbell, J, Newsome, PN, Charo, I, Schall, T & Adams, DH 2018, 'CC Chemokine Receptor 2 Promotes Recruitment of Myeloid Cells Associated with Insulin Resistance in Non-Alcoholic Fatty Liver Disease', American journal of physiology. Gastrointestinal and liver physiology. https://doi.org/10.1152/ajpgi.00213.2017

Patten, DA, Kamarajah, SK, Rose, JM, Tickle, J, Shepherd, EL, Adams, DH, Weston, CJ & Shetty, S 2017, 'SCARF-1 promotes adhesion of CD4+ T cells to human hepatic sinusoidal endothelium under conditions of shear stress', Scientific Reports, vol. 7, 17600. https://doi.org/10.1038/s41598-017-17928-4

Cooke, ME, Pearson, M, Moakes, R, Weston, C, Davis, E, Jones, S & Grover, L 2017, 'Geometric confinement is required for recovery and maintenance of chondrocyte phenotype in alginate', APL Bioengineering, vol. 1, 016104. https://doi.org/10.1063/1.5006752

Liu, B, Edwards, N, Neil, D, Weston, C, Nash, G, Nikolaidis, N, Barker, T, Patel, R, Bhabra, M & Steeds, R 2017, 'A prospective study examining the role of myocardial Fibrosis in outcome following mitral valve repair IN DEgenerative mitral Regurgitation: rationale and design of the mitral FINDER study', BMC Cardiovascular Disorders, vol. 17, 282. https://doi.org/10.1186/s12872-017-0715-y

Resheq, YJ, Menzner, A-K, Bosch, J, Tickle, J, Li, K-K, Wilhelm, A, Hepburn, E, Murihead, G, Ward, ST, Curbishley, SM, Zimmermann, HW, Bruns, T, Gilbert, DF, Tripal, P, Mackensen, A, Adams, DH & Weston, CJ 2017, 'Impaired Transmigration of Myeloid-Derived Suppressor Cells across Human Sinusoidal Endothelium Is Associated with Decreased Expression of CD13', Journal of Immunology, vol. 199, no. 5, pp. 1672-1681. https://doi.org/10.4049/jimmunol.1600466

Wadkin, JCR, Patten, DA, Kamarajah, S, Shepherd, EL, Novitskaia, V, Berditchevski, F, Adams, DH, Weston, CJ & Shetty, S 2017, 'CD151 supports VCAM-1 mediated lymphocyte adhesion to liver endothelium and is upregulated in chronic liver diseases and hepatocellular carcinoma', American journal of physiology. Gastrointestinal and liver physiology, vol. 313, no. 2, pp. G138-G149. https://doi.org/10.1152/ajpgi.00411.2016

Bernsmeier, C, Triantafyllou, E, Brenig, R, Lebosse, FJ, Singanayagam, A, Patel, VC, Pop, OT, Khamri, W, Nathwani, R, Tidswell, R, Weston, CJ, Adams, DH, Thursz, MR, Wendon, JA & Antoniades, CG 2017, 'CD14+CD15-HLA-DR- myeloid-derived suppressor cells impair antimicrobial responses in patients with acute-on-chronic liver failure', Gut. https://doi.org/10.1136/gutjnl-2017-314184

Arndtz, K, Corrigan, M, Rowe, A, Kirkham, A, Barton, D, Fox, RP, Llewellyn, L, Athwal, A, Wilkhu, M, Chen, Y, Weston, C, Desai, A, Adams, DH & Hirschfield, GM 2017, 'Investigating the safety and activity of the use of BTT1023 (Timolumab), in the treatment of patients with primary sclerosing cholangitis (BUTEO): A single-arm, two-stage, open-label, multi-centre, phase II clinical trial protocol', BMJ open, vol. 7, no. 6, e015081. https://doi.org/10.1136/bmjopen-2016-015081

Triantafyllou, E, Pop, OT, Possamai, LA, Wilhelm, A, Liaskou, E, Singanayagam, A, Bernsmeier, C, Khamri, W, Petts, G, Dargue, R, Davies, SP, Tickle, J, Yuksel, M, Patel, VC, Abeles, RD, Stamataki, Z, Curbishley, SM, Ma, Y, Wilson, ID, Coen, M, Woollard, KJ, Quaglia, A, Wendon, J, Thursz, MR, Adams, DH, Weston, CJ & Antoniades, CG 2017, 'MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure', Gut. https://doi.org/10.1136/gutjnl-2016-313615

Review article

Weston, CJ, Zimmermann, HW & Adams, DH 2019, 'The Role of Myeloid-Derived Cells in the Progression of Liver Disease', Frontiers in immunology, vol. 10, 893. https://doi.org/10.3389/fimmu.2019.00893

View all publications in research portal

Expertise

Immune mediated injury and fibrosis in the human liver