Dr Chris Weston BSc PhD

Chris Weston

Institute of Immunology and Immunotherapy
Senior Research Fellow

Contact details

Address
NIHR Biomedical Research Unit and Centre for Liver Research
5th Floor Institute for Biomedical Research
The Medical School
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Chris Weston is a post-doctoral research fellow based in the Centre for Liver Research who has received grant funding from the MRC and the Wellcome Trust.

His research focus is the regulation of immune mediated injury and fibrosis in the human liver, with a view to establish the role that amine oxidases such as vascular adhesion protein-1 (VAP-1) and the lysyl oxidase family (LOX, LOXL1-4) play in this process. He is also interested in the development of therapeutic agents to target inflammatory liver disease and works closely with clinical colleagues to facilitate the transition from bench to bedside.

Qualifications

  • PhD Biochemistry, Birmingham 2001
  • BSc Biochemistry with Biotechnology, Birmingham 1998

Teaching

Postgraduate supervision

Dr Weston is interested in supervising doctoral research in the following areas:

The role of amine oxidases in liver disease and primary liver cancer
Lymphocyte recruitment to the human liver

If you are interesting in studying any of these subject areas please contact Dr Chris Weston directly, or for any general doctoral research enquiries, please email mds-gradschool@contacts.bham.ac.uk.

For a full list of available Doctoral Research opportunities, please visit our Doctoral Research programme listings.

Other activities

  • Membership of the British Association for the Study of the Liver
  • STEM ambassador to promote Science and Technology for children and young people

Publications

Recent publications

Article

Price, AM, Moody, WE, Stoll, VM, Vijapurapu, R, Hayer, MK, Biasiolli, L, Weston, CJ, Webster, R, Wesolowski, R, McGee, KC, Liu, B, Baig, S, Pickup, LC, Radhakrishnan, A, Law, JP, Edwards, NC, Steeds, RP, Ferro, CJ & Townend, JN 2021, 'Cardiovascular effects of unilateral nephrectomy in living kidney donors at 5 years', Hypertension, vol. 77, no. 4, pp. 1273-1284. https://doi.org/10.1161/HYPERTENSIONAHA.120.15398

Khamri, W, Gudd, C, Liu, T, Nathwani, R, Krasniqi, M, Azam, S, Barbera, T, Trovato, FM, Possamai, L, Triantafyllou, E, Seoane, RC, Lebosse, F, Singanayagam, A, Kumar, N, Bernsmeier, C, Mukherjee, S, McPhail, M, Weston, CJ, Antoniades, CG & Thursz, MR 2021, 'Suppressor CD4+ T cells expressing HLA-G are expanded in the peripheral blood from patients with acute decompensation of cirrhosis', Gut. https://doi.org/10.1136/gutjnl-2021-324071

Law, JP, Price, AM, Pickup, L, Radhakrishnan, A, Weston, C, Jones, AM, McGettrick, HM, Chua, W, Steeds, RP, Fabritz, L, Kirchhof, P, Pavlovic, D, Townend, JN & Ferro, CJ 2020, 'Clinical potential of targeting fibroblast growth factor‐23 and αKlotho in the treatment of uremic cardiomyopathy', Journal of the American Heart Association, vol. 9, no. 7, e016041. https://doi.org/10.1161/JAHA.120.016041

Hayer, M, Radhakrishnan, A, Price, A, Liu, B, Baig, S, Weston, C, Biasiolli, L, Ferro, C, Townend, J, Steeds, R & Edwards, NC 2020, 'Defining myocardial abnormalities across the stages of chronic kidney disease: a cardiac magnetic resonance imaging study', JACC: Cardiovascular Imaging, vol. 13, no. 11, pp. 2357-2367. https://doi.org/10.1016/j.jcmg.2020.04.021

Fromont, C, Atzori, A, Kaur, D, Hashmi, L, Greco, G, Cabanillas, A, Nguyen, HV, Jones, DH, Garzón, M, Varela, A, Stevenson, B, Iacobini, G, Lenoir, M, Rajesh, S, Box, C, Kumar, J, Grant, P, Novitskaia, V, Morgan, J, Sorrell, F, Redondo, C, Kramer, A, Harris, CJ, Leighton, B, Vickers, S, Cheetham, S, Kenyon, C, Grabowska, AM, Overduin, M, Berditchevski, F, Weston, CJ, Knapp, S, Fischer, PM & Butterworth, S 2020, 'Discovery of highly selective inhibitors of calmodulin-dependent kinases that restore insulin sensitivity in the diet-induced obese in vivo mouse model', Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.9b01803

Brenig, R, Pop, OT, Triantafyllou, E, Geng, A, Singanayagam, A, Perez-Shibayama, C, Besse, L, Cupovic, J, Künzler, P, Boldanova, T, Brand, S, Semela, D, Duong, FH, Weston, CJ, Ludewig, B, Heim, MH, Wendon, J, Antoniades, CG & Bernsmeier, C 2020, 'Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis', Life Science Alliance, vol. 3, no. 1, e201900465. https://doi.org/10.26508/lsa.201900465

Chauhan, A, Sheriff, L, Hussain, MT, Webb, GJ, Patten, DA, Shepherd, EL, Shaw, R, Weston, CJ, Haldar, D, Bourke, S, Bhandari, R, Watson, S, Adams, DH, Watson, SP & Lalor, PF 2020, 'The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure', Nature Communications, vol. 11, no. 1, 1939. https://doi.org/10.1038/s41467-020-15584-3

Gharanei, S, Fishwick, K, Peter Durairaj, R, Jin, T, Siamantouras, E, Liu, K-K, Straube, A, Lucas, ES, Weston, CJ, Rantakari, P, Salmi, M, Jalkanen, S, Brosens, JJ & Tan, BK 2020, 'Vascular Adhesion Protein-1 Determines the Cellular Properties of Endometrial Pericytes', Frontiers in cell and developmental biology, vol. 8, pp. 621016. https://doi.org/10.3389/fcell.2020.621016

Chen, Y-Y, Arndtz, K, Webb, G, Corrigan, M, Akiror, S, Liaskou, E, Woodward, P, Adams, DH, Weston, CJ & Hirschfield, GM 2019, 'Intrahepatic macrophage populations in the pathophysiology of primary sclerosing cholangitis', JHEP Reports, vol. 1, no. 5, pp. 369-376. https://doi.org/10.1016/j.jhepr.2019.10.003

Patten, DA, Shepherd, EL, Weston, CJ & Shetty, S 2019, 'Novel targets in the immune microenvironment of the hepatic sinusoids for treating liver diseases', Seminars in Liver Disease, vol. 39, no. 2, pp. 111-123. https://doi.org/10.1055/s-0039-1678727

Parker, R, Kim, SJ, Im, GY, Nahas, J, Dhesi, B, Vergis, N, Sinha, A, Ghezzi, A, Rink, MR, McCune, A, Aithal, GP, Newsome, PN, Weston, CJ, Holt, A & Gao, B 2019, 'Obesity in acute alcoholic hepatitis increases morbidity and mortality', EBioMedicine, vol. 45, pp. 511-518. https://doi.org/10.1016/j.ebiom.2019.03.046

Malehmir, M, Pfister, D, Gallage, S, Szydlowska, M, Inverso, D, Kotsiliti, E, Leone, V, Peiseler, M, Surewaard, BGJ, Rath, D, Ali, A, Wolf, MJ, Drescher, H, Healy, ME, Dauch, D, Kroy, D, Krenkel, O, Kohlhepp, M, Engleitner, T, Olkus, A, Sijmonsma, T, Volz, J, Deppermann, C, Stegner, D, Helbling, P, Nombela-Arrieta, C, Rafiei, A, Hinterleitner, M, Rall, M, Baku, F, Borst, O, Wilson, CL, Leslie, J, O'Connor, T, Weston, CJ, Adams, DH, Sheriff, L, Teijeiro, A, Prinz, M, Bogeska, R, Anstee, N, Bongers, MN, Notohamiprodjo, M, Geisler, T, Withers, DJ, Ware, J, Mann, DA, Augustin, HG, Vegiopoulos, A, Milsom, MD, Rose, AJ, Lalor, PF, Llovet, JM, Pinyol, R, Tacke, F, Rad, R, Matter, M, Djouder, N, Kubes, P, Knolle, PA, Unger, K, Zender, L, Nieswandt, B, Gawaz, M, Weber, A & Heikenwalder, M 2019, 'Platelet GPIb alpha is a mediator and potential interventional target for NASH and subsequent liver cancer', Nature Medicine. https://doi.org/10.1038/S41591-019-0379-5

Malehmir, M, Pfister, D, Gallage, S, Szydlowska, M, Inverso, D, Kotsiliti, E, Leone, V, Peiseler, M, Surewaard, BGJ, Rath, D, Ali, A, Wolf, MJ, Drescher, H, Healy, ME, Dauch, D, Kroy, D, Krenkel, O, Kohlhepp, M, Engleitner, T, Olkus, A, Sijmonsma, T, Volz, J, Deppermann, C, Stegner, D, Helbling, P, Nombela-Arrieta, C, Rafiei, A, Hinterleitner, M, Rall, M, Baku, F, Borst, O, Wilson, CL, Leslie, J, O'Connor, T, Weston, CJ, Adams, DH, Sheriff, L, Teijeiro, A, Prinz, M, Bogeska, R, Anstee, N, Bongers, MN, Notohamiprodjo, M, Geisler, T, Withers, DJ, Ware, J, Mann, DA, Augustin, HG, Vegiopoulos, A, Milsom, MD, Rose, AJ, Lalor, PF, Llovet, JM, Pinyol, R, Tacke, F, Rad, R, Matter, M, Djouder, N, Kubes, P, Knolle, PA, Unger, K, Zender, L, Nieswandt, B, Gawaz, M, Weber, A & Heikenwalder, M 2019, 'Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer', Nature Medicine, vol. 25, no. 4, pp. 641-655. https://doi.org/10.1038/s41591-019-0379-5

Review article

Pufal, K, Lawson, A, Hodson, J, Bangash, M, Patel, J, Weston, C, Gulik, TV & Dasari, BV 2021, 'Role of liver support systems in the management of post hepatectomy liver failure: a systematic review of the literature', Annals of hepato-biliary-pancreatic surgery, vol. 25, no. 2, pp. 171-178. https://doi.org/10.14701/ahbps.2021.25.2.171

Weston, CJ, Zimmermann, HW & Adams, DH 2019, 'The Role of Myeloid-Derived Cells in the Progression of Liver Disease', Frontiers in immunology, vol. 10, 893. https://doi.org/10.3389/fimmu.2019.00893

View all publications in research portal

Expertise

Immune mediated injury and fibrosis in the human liver

Culture and collections

Schools, institutes and departments

Services and facilities