Dr Niharika Duggal

Dr Niharika Duggal

Department of Inflammation and Ageing
Associate Professor in Immunity and Ageing

Contact details

Address
Department of Inflammation and Ageing
University of Birmingham Research Labs
Queen Elizabeth Hospital
Mindelsohn Way
Birmingham
B15 2WB

Dr Niharika Duggal is an Associate Professor embedded in the Department of Inflammation and Ageing and the Biomedical Research Centre (BRC) and Multimorbidity (https://www.birminghambrc.nihr.ac.uk/our-research/sarcopenia-and-multimorbidity) at the University of Birmingham and a trustee for the British Society of Research in Ageing (BSRA) with a long-standing interest in the field of immunesenescence.

Her research group investigates the gut–immune–muscle axis, immunometabolism resilience, and the development of translational interventions to support healthy ageing. This work spans mechanistic discovery through to human trials, integrating multi‑omics, immune profiling, and nutritional science. Her broader vision is to develop scalable, equitable, and evidence‑based strategies that enhance immune and physiological function across diverse ageing populations, bridging fundamental biology with real‑world interventions.

Qualifications

  • Postgraduate Certificate in Higher Education – University of Birmingham 2021
  • PhD in Immunology: University of Birmingham 2014
  • BSc (Hons) in Biological Sciences: University of Birmingham 2009

Biography

Niharika obtained her PhD in 2014 in Professor Janet Lord’s laboratory, where she investigated how chronic stress, specifically hip fracture and depression accelerate immune ageing. Following her doctorate, she continued her research at the University of Birmingham, focusing on the potential for lifelong physical activity to slow or reverse immunosenescence. In recognition of this work, she received the Korenchevsky Award from the British Society for Research in Ageing in 2017.

In 2019, Niharika was appointed Assistant Professor in the Department of Inflammation and Ageing, marking the beginning of her independent academic career and the establishment of her research programme investigating the gut–immune axis across the life course. Shortly thereafter, she was awarded a Springboard Award from the Academy of Medical Sciences (2020), supporting the development of this work.

Now an Associate Professor, her research spans mechanistic discovery through to early‑phase human trials, integrating multi‑omics, immune profiling and nutritional science. Her broader vision is to develop scalable, equitable and evidence‑based strategies that enhance immune and physiological function across diverse ageing populations, bridging fundamental biology with real‑world interventions. Her programme is supported by major funders including the BBSRC, the Ageing Biology Foundation, the Wellcome Trust, Marie Curie and Industry partners such as AstraZeneca and Yakult.

Niharika’s long‑term vision for ageing research is to build on the mechanistic insights gained over the past and translating her laboratory discoveries into early‑phase clinical trials, particularly those exploring microbiome‑based strategies to improve health in later life. Alongside this, she aims to identify new avenues for “anti‑ageing” interventions through strategic collaborations with industrial partners, ensuring that future solutions are scalable, equitable and grounded in robust science.

Teaching

Undergraduate

  • BSc Biomedical Science – Academic Lead for Year 3 Module ‘ Biology of Ageing’
  • Year 3 Modules; Immunity and Inflammatory Diseases and Experimental Immunology
  • Academic mentor for Year 3 Module 'Global Challenges'
  • BSc Biomedical Science Year 2 – 'Immunity and Infection'
  • BSc Biomedical Science Academic Lead Year 2 – ‘Student Science Selected Project'
  • MBChB Year 2 – Academic lead for ‘Personal Interest Project: Ageing of the immune system’

Postgraduate 

Postgraduate supervision

Niharika currently supervises doctoral researchers working on the following projects:

  • Gut microbiome dysbiosis and immunesenescence: investigating associations and potential beneficial effects of physical activity
  • Unravelling the role of Bacteria outer membrane vesicles in driving features of B cell Immunesenescence.

  • Pneumonia after major trauma: clinical diagnosis, predictive biomarkers and long-term outcomes.

  • Exploration of pro-inflammatory and injury biomarkers, acute brain injury and long-term neurocognitive dysfunction after trauma.

For researchers who are considering undertaking a PhD, Niharika has a funded PhD studentship available: Unravelling the potential of microbiome-based therapies for rejuvenating aged T cells and combating frailty in old age.

Research

Research in Niharika’s lab aims to uncover new mechanisms of ageing alongside the development and translation of biomarker panels. We answer research questions through the application of three inter-related research themes:

  • Employ immunophenotypic analysis, alongside cell-based assays and genomic analysis to identify immunesenescence features with biomarker potential in inflammatory conditions [such as Rheumatoid Arthritis, Ulcerative Colitis and critically ill cohorts].
  • Dissecting novel mechanisms of immune-microbiome cross-talk across lifespan and to develop a better understanding of how an individual’s lifestyle choices [ such as physical activity levels, diet,] contribute to an individual’s immune health status.
  • Development of a portfolio of pharmacological and nutritional supplementation targets [targeting the microbiome] with anti-immunesenescence potential that can be used to boost health span in healthy and frail older adults in clinical trials.

Podcasts

A podcast discussing her research on the impact of gut health on T cell ageing can be found on YouTube: Gut Health Impacts The Thymus And Immune System During Aging: Niharika Duggal, PhD

She was also invited to be a part of the Healthy Ageing Podcasts to discuss the impact of physical activity on immunity: Science and Technology - An Introduction to Healthy Ageing Podcast (Nottingham Trent University)

In the news

Your gut microbiome could add years to your life. Here's how to help it - BBC Science Focus Magazine

 I'm a scientist - could these longevity diets slow my ageing? - Sunday Times

Niharika has also been featured in the Telegraph Daily and on BBC Woman's Hour Radio interview on healthy living for longer. 

She is dedicated to promoting healthy ageing through public engagement and regularly delivers public lectures and webinars on the importance of maintaining immune health in later life. Read more on her contributions to the biology of ageing via Club Vita's website.

Other activities

  • Niharika serves on the Board of Trustees of the British Society of Research in Ageing (BSRA), a charity which promotes widening participation, social mobility and diversity in Ageing Research [2022 – 2027].
  • She is currently a member of the RIPEN scientific advisory committee. Translational Innovation Hub for Population Health using Food and Nutrition approaches to enhance Positive Physiology (RIPEN) is a BBSRC-funded network for UK focused on uncovering the complex relationship between food components and human physiology through the support of grant applications, organisation of meetings/workshops [ 2022 – 2027].
  • Member of the steering committee for the project on ‘Recognizing immunosenescence in ICD coding to guide clinical care’ for developing a guidance document unifying current research on the immune ageing, by developing a comprehensive system for classifying and staging age-related pathology, to complement the WHO’s International Classification of Diseases (ICD).
  • Associate Editor Journal of Gerontology: Medical Sciences (2023 - 2025)
  • Associated Editor Frontier of Ageing (2024 - present)
  • Early Career Researcher (ECR) Lead and member of the management board of the Food4Years Ageing Network
  • UK Coronavirus Immunology Consortium Dr Niharika A Duggal | UK-CIC

Publications

Selected recent publications

Review articles

Allen S L , Breen L, Lord J M , Duggal NA (2026) Age-related sarcopenia and the gut microbiome:mechanistic insights into the gut-muscle axis and potential microbiome based therapeutic interventions. Ageing Res Reviews 118:103065

Short E, ICCARP group, Calimport S, Bentley B (2024) Defining an ageing-related pathology, disease or syndrome: International consensus statement. Geroscience [ member of the ICCARP working group]

Clegg M, Methven L, Lanham-Nue S, Green M, Duggal NA, Hetherington (2023). The Food4Years Ageing Network: Improving foods and diets as a strategy for supporting quality of life, independence, and health-span in older adults. Nutrition Bulletin https://doi.org/10.1111/nbu.12599

Dugan B, Conway J, Duggal NA (2023) Inflammaging as a target for healthy Ageing. Age and Ageing 52:afac328 https://doi.org/10.1093/ageing/afac328

Almeida H M, Sardeli AV, Conway J, Duggal NA,Cavagleiri CR (2022) Comparison between frail and non-frail older adults gut microbiota: a systemic review and meta-analysis. Ageing Res Rev 82:101773. 

Taylor JA, Greenhaff PA, Bartlett DB, Jackson TA, Duggal NA, Lord JM (2022) Multisystem physiological perspective of human frailty and its modulation by physical activity. Physiol Rev 103:1137-1191. 

J Conway, M Certo, J M Lord, C Mauro and Duggal NA (2021) Understanding the role of host metabolites in the induction of immunesenescence; future strategies for keeping the ageing population healthy. British Journal Pharmacology.

J Conway and Duggal NA (2021) Ageing of the microbiome: potential influences on immunesenenscence and inflammaging. Ageing Research Review.

Duggal NA, Niemiro G, Harridge SDR, Simpson RJ, Lord JM. (2019) Can physical activity ameliorate immunosenescence and thereby reduce age-related multi-morbidity?Nat Rev Immunol 19(9):563-572.

View all publications in research portal