Professor David J. Hodson BVSc (Hons) PhD FRCVS

David Hodson

Institute of Metabolism and Systems Research
Honorary Senior Research Fellow

Contact details

Email
d.hodson@bham.ac.uk
Twitter
@daveyboyhod
View my research portal
Address
Institute of Metabolism and Systems Research (IMSR)
Institute of Biomedical Research
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

David is an Honorary Senior Research Fellow and ERC Starting Grant holder.  He has particular interest in using multidisciplinary and innovative approaches (e.g. biophotonics, mouse genetics, modelling, chemical biology) to tackle challenging research questions in metabolism. The overall objective of his work is to identify new mechanisms through which pancreatic alpha-, beta- and delta-cells fail during type 1 diabetes and type 2 diabetes. Further details can be found at https://www.isletbiologylab.com

Qualifications

  • Fellow of the Royal College of Veterinary Surgeons (FRCVS), London, 2018
  • Doctor of Philosophy (PhD), University of Bristol, 2008
  • Bachelor of Veterinary Science with Honours (BVSc Hons), University of Bristol, 2005

Biography

David Hodson - Next generation tools to understand endocrine function in health and disease
Life Sciences in Six - Professor David Hodson
Dr David Hodson: Diabetes research breakthrough
Being a Birmingham Fellow

David Hodson completed a degree in Veterinary Science before undertaking doctoral studies in reproductive physiology and circadian biology at the University of Bristol with Dr Domingo Tortonese. Subsequently, in 2008, he moved to the laboratory of Dr. Patrice Mollard at the Institut de Genomique Fonctionnelle in Montpellier France (CNRS), where, supported by a Fellowship from the Fondation de la Recherche Medicale (FRM), he pursued postdoctoral studies focused on understanding how endocrine cells residing within the mammalian pituitary gland function as three-dimensional networks to generate hormone release. Following award of a Diabetes UK RD Lawrence Fellowship in 2012, David moved to the Department of Medicine at Imperial College London, where he set up a research group devoted to understanding islet cell heterogeneity in health and disease. In 2016, David moved to the nascent Institute of Metabolism and Systems Research (IMSR) at the University of Birmingham where he led the Islet Biology Group.

Teaching

Postgraduate supervision

Currently supervisor to two PhD students and two MSc students.

Research

Research in the Islet Biology Lab tackles challenging questions concerning the regulation of hormone release from pancreatic islets in health and disease. The major aims of the group are to develop novel tools and imaging approaches to understand how alpha, beta and delta cells, which reside within the islet, release hormone to maintain normal glucose. Importantly, we use tissue from individuals with type 1 and type 2 diabetes, as well as animal models, to understand what goes wrong in relevant pathologies. The group is highly inter-disciplinary, and with colleagues in Europe and North America, we combine chemistry, biology and genetics to open up new avenues of exploration in islet biology.

Other activities

  • Senior Birmingham Fellow, University of Birmingham, 2016-2018
  • Non-Clinical Lecturer in Cell Biology, Imperial College London, 2012-2016
  • FRM Postdoctoral Fellow, CNRS Montpellier, 2010-2012
  • ANR Postdoctoral Fellow, CNRS Montpellier, 2008-2012
  • Locum Veterinary Surgeon, Bristol, 2005-2008

Publications

Recent publications

Article

Ast, J, Novak, AN, Podewin, T, Fine, NHF, Jones, B, Tomas, A, Birke, R, Roßmann, K, Mathes, B, Eichhorst, J, Lehmann, M, Linnemann, AK, Hodson, DJ & Broichhagen, J 2022, 'Expanded LUXendin color palette for GLP1R detection and visualization in vitro and in vivo', JACS Au, vol. 2, no. 4, pp. 1007-1017. https://doi.org/10.1021/jacsau.2c00130

Pauza, AG, Thakka, P, Tasic, T, Felippe, I, Bishop, P, Greenwood, MP, Rysevaite-Kyguoliene, K, Ast, J, Broichhagen, J, Hodson, D, Salgado, HC, Pauza, DH, Japundzic-Zigon, N, Paton, JFR & Murphy, D 2022, 'GLP1R attenuates sympathetic response to high glucose via carotid body inhibition', Circulation, vol. 130, no. 5, pp. 694-707. https://doi.org/10.1161/CIRCRESAHA.121.319874

Hoang, M, Jentz, E, Janssen, S, Nasteska, D, Cuozzo, F, Hodson, D, Tupling, R, Fong, G-H & Joseph, J 2022, 'Isoform-specific roles of prolyl hydroxylases in the regulation of pancreatic β-cell function', Endocrinology, vol. 163, no. 1, bqab226, pp. 1-17. https://doi.org/10.1210/endocr/bqab226

Karsai, M, Zuellig, RA, Lehmann, R, Cuozzo, F, Nasteska, D, Luca, E, Hantel, C, Hodson, D, Spinas, GA, Rutter, G & Gerber, PA 2022, 'Lack of ZnT8 protects pancreatic islets from hypoxia- and cytokine induced cell death', Journal of Endocrinology, vol. 253, no. 1, pp. 1-11. https://doi.org/10.1530/JOE-21-0271

Westbrook, R, Bridges, E, Roberts, J, Escribano Gonzalez, C, Eales, K, Vettore, L, Walker, P, Vera-Siguenza, E, Rana, H, Cuozzo, F, Eskla, K-L, Vellama, H, Shaaban, A, Nixon, C, Luuk, H, Lavery, G, Hodson, D, Harris, AL & Tennant, D 2022, 'Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions', Cell Reports, vol. 38, no. 5, 110320. https://doi.org/10.1016/j.celrep.2022.110320

Birke, R, Ast, J, Roosen, DA, Lee, J, Roßmann, K, Huhn, C, Mathes, B, Lisurek, M, Bushir, D, Sun, H, Jones, B, Lehmann, M, Levitz, J, Haucke, V, Hodson, D & Broichhagen, J 2022, 'Sulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins', Organic and Biomolecular Chemistry. https://doi.org/10.1039/D1OB02216D

Allen, SL, Seabright, AP, Quinlan, JI, Dhaliwal, A, Williams, FR, Fine, NHF, Hodson, DJ, Armstrong, MJ, Elsharkaway, AM, Greig, CA, Lai, Y-C, Lord, JM, Lavery, GG & Breen, L 2022, 'The effect of ex vivo human serum from liver disease patients on cellular protein synthesis and growth', Cells, vol. 11, no. 7, 1098. https://doi.org/10.3390/cells11071098

Lucey, M, Ashik, T, Marzook, A, Wang, Y, Goulding, J, Oishi, A, Broichhagen, J, Hodson, DJ, Minnion, J, Elani, Y, Jockers, R, Briddon, SJ, Bloom, SR, Tomas, A & Jones, B 2021, 'Acylation of the incretin peptide exendin-4 directly impacts glucagon-like peptide-1 receptor signaling and trafficking', Molecular Pharmacology, vol. 100, no. 4, pp. 319-334. https://doi.org/10.1124/molpharm.121.000270

Costa, A, Ai, M, Nunn, N, Culotta, I, Hunter, J, Boutagouga Boudjadja, M, Valencia-Torres, L, Aviello, G, Hodson, D, Snider, B, Coskun, T, Emmerson, P, Luckman, S & D'Agostino, G 2021, 'Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation', Molecular metabolism. https://doi.org/10.1016/j.molmet.2021.101407

Marzook, A, Chen, S, Pickford, P, Lucey, MA, Wang, Y, Corrêa, IR, Broichhagen, J, Hodson, D, Salem, V, Rutter, GA, Tan, TM, Bloom, SR, Tomas, A & Jones, B 2021, 'Evaluation of efficacy- versus affinity-driven agonism with biased GLP-1R ligands P5 and exendin-F1', Biochemical Pharmacology, vol. 190, 114656. https://doi.org/10.1016/j.bcp.2021.114656

Cadilhac, C, Bachy, I, Foget, A, Hodson, D, Jahannault-Talignani, C, Furley, A, Ayrault, O, Mollard, P, Sotelo, C & Ango, F 2021, 'Excitatory granule neuron precursors orchestrate laminar localization and differentiation of cerebellar inhibitory interneuron subtype', Cell Reports, vol. 34, no. 13, 108904. https://doi.org/10.1016/j.celrep.2021.108904

Nasteska, D, Fine, N, Ashford, F, Cuozzo, F, Viloria, K, Smith, G, Dahir, A, Dawson, PWJ, Lai, Y-C, Bastidas-Ponce, A, Bakhti, M, Rutter, G, Fiancette, R, Nano, R, Piemonti, L, Lickert, H, Zhou, Q, Akerman, I & Hodson, D 2021, 'PDX1LOW MAFALOW β-cells contribute to islet function and insulin release', Nature Communications, vol. 12, no. 1, 674. https://doi.org/10.1038/s41467-020-20632-z

Pickford, P, Lucey, MA, Rujan, R-M, McGlone, ER, Bitsi, S, Ashford, F, Corrêa, IR, Hodson, D, Tomas, A, Deganutti, G, Reynolds, CA, Owen, B, Tan, TM, Minnion, J, Jones, B & Bloom, SR 2021, 'Partial agonism improves the anti-hyperglycaemic efficacy of an oxyntomodulin-derived GLP-1R/GCGR co-agonist', Molecular metabolism, vol. 51, 101242. https://doi.org/10.1016/j.molmet.2021.101242

Nasteska, D, Cuozzo, F, Viloria, K, Johnson, E, Thakker, A, Bakar, RB, Westbrook, R, Barlow, J, Hoang, M, Joseph, J, Lavery, G, Akerman, I, Cantley, J, Hodson, L, Tennant, D & Hodson, D 2021, 'Prolyl-4-hydroxylase 3 maintains β-cell glucose metabolism during fatty acid excess in mice', JCI Insight, vol. 6, no. 16, e140288. https://doi.org/10.1172/jci.insight.140288

Olaniru, O, Cheng, J, Ast, J, Arvaniti, A, Atanes, P, Huang, GC, King, A, Jones, P, Broichhagen, J, Hodson, D & Persaud, SJ 2021, 'SNAP-tag-enabled super-resolution imaging reveals constitutive and agonist-dependent trafficking of GPR56 in pancreatic β-cells', Molecular metabolism, vol. 53, 101285. https://doi.org/10.1016/j.molmet.2021.101285

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