FT-ICR Mass Spectrometry

Fourier transform ion cyclotron resonance (FT-ICR) is the highest performance mass spectrometry technique available, offering unrivalled resolution and mass accuracy.  The instrument at Birmingham also offers unique techniques for ion manipulation and fragmentation thus providing structural information.

Bruker SolariX XROur instrument, the Bruker SolariX XR, is a hybrid mass spectrometer combining a 7 Tesla FT-ICR with a front-end quadrupole. The instrument offers ultrahigh resolution (up to 10,000,000 resolving power at m/z 400) and sub-ppm mass accuracy, both of which are essential for the analysis of complex mixtures and high molecular weight species. The instrument has attomolar sensitivity for peptides and a m/z range of 100-10,000.

The SolariX XR is coupled to a Triversa Nanomate (Advion) chip-based electrospray system. Both nano and capillary flow on-line LC are available.

Tandem mass spectrometry capabilities include electron capture dissociation (ECD), electron transfer dissociation (ETD) and collision induced dissociation (CID), and sustained off-resonance irradiation (SORI).