A new paper from the Soller lab published in Molecular and Cellular Biology (MCB) shows that neuronally co-expressed ELAV/Hu proteins have distinct functions in vivo in Drosophila, but that they can share targets even with related Sex-lethal depending on concentration and localization. These in vivo studies are an important step forward to understand the mechanisms used by RNA binding proteins for target specific regulation of mRNA processing leading to differential gene expression.

Regulation of neuronal genes by co-expressed ELAV/Hu family RNA binding proteins

You can read the paper here:

Concentration and localization of co-expressed ELAV/Hu proteins control specificity of mRNA processing.

Zaharieva E, Haussmann IU, Bräuer U, Soller M.
Mol Cell Biol. 2015 Jun 29. pii: MCB.00473-15. [Epub ahead of print]
PMID: 26124284