The challenge faced by the UK regions is to encourage wealth creation via the development of local businesses and by attracting and retaining Foreign Direct Investment (FDI). Local powers of attraction are heavily reliant on funding that flows from Whitehall and also the wider framework conditions that are determined by national policy. A key question is: how to encourage local growth? The answer is complex but includes connectivity or the quality of the local infrastructure network and the links to national infrastructure (airports, ports, the motorway network), the quality and quantity of skills in the location labour market, the quality of life in the area (schools, housing, arts) and local taxation. Encouraging local economies must also consider innovation; new product and process innovations create new business opportunities, but have the potential to destroy existing firms, products and processes. The British high street has been subjected to gales of creative destruction that include the rise of out-of-town shopping centres, e-commerce and the shift in emphasis towards the purchase of more services. These innovations have undermined the profitability of many British high streets leaving empty shops, but also the emergence of shopping areas that are dominated by charity shops. There have been many newspaper articles and radio and television programmes that have proclaimed the death of the British high street. On the one hand, many major retail chains have failed through a combination of new forms of competition, but also through business models that relied on excessive gearing or too much borrowing. On the other hand, there is an on-going process of restructuring that is one of the features of a capitalist economy – change creates and destroys. The high street has always been in a continual process of change and adaptation. Nevertheless, one thing that has not changed is the perception that retailers are wealthy and are able to support two related industries.