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‘Tetraspanin Tspan9 regulates platelet collagen receptor GPVI lateral diffusion and activation’ is the Plenary Paper in the latest issue of the journal Platelets

Graduate student Lizzie Haining (left) and colleagues in the group of Mike Tomlinson (right) have reported the first characterisation of mice deficient for the tetraspanin Tspan9.  Lizzie used cutting-edge fluorescent imaging techniques, including the first single particle tracking to be done in platelets, to show defective GPVI function in the absence of Tspan9.  This work has therapeutic implications because the platelet collagen receptor GPVI is a promising drug target for the treatment of heart attack and stroke.  Lizzie is now a postdoctoral researcher in Steve Watson’s group in the Institute of Cardiovascular Sciences.

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