Skip to main content
PRI news item - vit D and PRI logo

Vitamin D is a potent anticancer agent and active against a wide variety of types of cancer cells. A major drawback to the use of vitamin D to treat cancer is that vitamin D raises blood calcium, in other words it has a calcaemic action. This can lead to a heart attack and coma. Chemists at the Pharmaceutical Research Institute in Warsaw have now synthesized new vitamins D that are potent anticancer agents and that have a lowered calcaemic action. The activity of the new vitamins D against leukaemia cells has been tested by colleagues at the Universities of Wroclaw, Ben-Gurion of the Negev and Birmingham. The new agents provide a way forward towards a safer and more effective treatment for acute leukaemia whereby the leukaemia cells are driven by vitamin D to mature and die naturally.

PRI news item - Partner institutions - bigger

doi:10.1016/j.jsbmb.2015.08.025 Bolla, N. R., Corcoran, A., Yasuda, K., Chodyński, M., Krajewski, K., Cmoch, P., Marcinkowska, E., Brown, G., Sakaki, T. and Kutner, A. (2016)  Synthesis and evaluation of geometric analogs of 1α,25-dihydroxyvitamin D2 as potential therapeutics. Journal of Steroid Biochemistry & Molecular Biology. 164: 50-55.

doi:10.1016/j.jsbmb.2015.09.033 Corcoran, A., Bermudez, M. A., Seoane, S., Perez-Fernandez, R., Krupa, M., Pietraszek, A., Chodyński, M., Kutner, A., Brown, G. and Marcinkowska, E. (2016) Biological evaluation of new vitamin D2 analogues. Journal of Steroid Biochemistry and Molecular Biology. 164: 66-71. 

doi:10.1016/j.jsbmb.2015.08.022 Nadkarni, S., Chodynski, M., Krajewski, K., Cmoch, P., Marcinkowska, E., Brown, G. and Kutner, A. (2016) Convergent synthesis of double point modified analogs of 1α,25-dihydroxyvitamin D2 for biological evaluation. Journal of Steroid Biochemistry and Molecular Biology. 164: 45-49. 

doi:10.1016/j.jsbmb.2015.09.014 Nachliely, M., Sharony, E., Kutner, A. and Danilenko, M. (2016) Novel analogs of 1,25-dihydroxyvitamin D2 combined with a plant polyphenol as highly efficient inducers of differentiation in human acute myeloid leukemia cells. Journal of Steroid Biochemistry & Molecular Biology164: 59-65.

doi: 10.3390/ijms17071068 Nachliely, M., Sharony, E., Bolla, N. R., Kutner, A. and Danilenko, M. (2016) Prodifferentiation activity of novel vitamin D2 analogs PRI-1916 and PRI-1917 and their combinations with a plant polyphenol in acute myeloid leukemia cells. International Journal of Molecular Sciences. 17: 1068.

doi: 10.3390/ijms17050729 Marcinkowska, E., Wallace, G. R. and Brown, G. (2016) The use of 1α,25-dihydroxyvitamin D3 as an anticancer agent. International Journal of Molecular Sciences. 17: 729.