Brain swelling image
Optical Coherence Tomography (OCT) works by using light waves to take cross-section pictures of the back of the eye, allowing doctors to not only see each individual layer, but measure each layer’s thickness.

Imaging techniques ordinarily used by eye doctors to monitor the optic nerve could offer a non-invasive method of measuring and managing potentially dangerous swelling in the skull, a new UK study led by researchers at the University of Birmingham has found. 

Intracranial pressure (ICP) – or pressure within the skull often caused by a recent brain injury – is a potentially fatal condition that can damages brain tissue. Currently, the most common way to measure the level of pressure is using a lumbar puncture to remove and analyse a sample of spinal fluid, however this can result in complications and can cause patient distress.

However, this latest study looking at potential non-invasive alternatives may have found the answer in the form of a technique ordinarily used by ophthalmologists. Optical Coherence Tomography (OCT) works by using light waves to take cross-section pictures of the back of the eye, allowing doctors to not only see each individual layer, but measure each layer’s thickness.

The longitudinal cohort study analysed data collected from 3 randomized clinical trials, conducted between April 2014 and August 2019. 104 female participants aged between 18 and 45, all with idiopathic intracranial hypertension, were recruited from 5 NHS trusts across the UK. Participants were split into two cohorts with some of the participants receiving a small telemetric implant placed on the cranial bone to measure levels of intracranial pressure while lumbar punctures were used to measure ICP over a 24 month period in the second cohort. Both cohorts also received OCT imaging to measure the thickness of the optic nerve and macula.

Results from cohort 1 showed direct correlation between mean levels of pressure within the skull and OCT measures with optic nerve head central thickness the most closely associated with ICP. Cohort 2 also demonstrated a correlation between thickness of the optic nerve and ICP. These correlations were seen at all follow up points of the study for example at 12 months, a decrease in central thickness (by 50µm) was associated with a decrease in pressure of 5cm H²O. Results suggest the potential for OCT to be used as a tool to inform clinicians of changes in ICP, as well as a method of monitoring and predicting levels of pressure in idiopathic intracranial hypertension.   

Senior author Professor Alex Sinclair from the University of Birmingham’s Institute of Metabolism and Systems Research said: “Non-invasive measures of ICP have been sought for many years. Here we demonstrate the utility of using optic nerve head thickness to reflect changes in ICP. This will have important implications for disease monitoring and guiding treatment decisions. We are seeing a change in practice away from performing regular lumbar punctures in IIH to using OCT scanning to predict ICP and guide management”

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