The programme is being jointly led by Professor Elizabeth Sapey, who is Director of the Institute of Inflammation and Ageing at the University of Birmingham, Director of PIONEER the Health Data Research Hub for Acute Care, co-lead of the Infection and Acute Care research theme at the NIHR Birmingham Biomedical Research Centre, as well as an Honorary Consultant at the University Hospitals Birmingham NHS Foundation Trust, alongside Professor Sir Munir Pirmohamed from University of Liverpool, who is an Honorary Consultant at Liverpool University Hospital Foundation NHS Trust. It includes researchers from the universities of Dundee, Strathclyde, Manchester, Swansea, Leeds, Leicester and Bristol, as well as Liverpool and Birmingham.
“The programme is a real collaborative effort, bringing together experts from across the UK who will use patient data to shine a light on previously unknown adverse effects and drug interactions as well as identifying patients most at risk of negative outcomes associated with polypharmacy – taking lots of different medications. Rather than the research being conducted in a disease specific manner, it will cut across many conditions and give the big picture of how prescribing can have beneficial and negative consequences on health, as well as building tools to ensure medicines use is safer for patients,” comments Professor Elizabeth Sapey.
There will be a particular focus on those at highest risk from the adverse outcomes of polypharmacy including older adults, those with mental health conditions and during pregnancy. There will also be special attention on healthcare environments with the highest error rates. For example, previous studies suggest that half of patients undergoing transition of care from the community to hospital will experience an error with their medication. This large-scale data programme will help us to understand these pinch points better and create solutions to solve them.
Advances in medical care mean that people are living longer with multiple health conditions and medicines are important way to try to keep these medical conditions under control. Polypharmacy, where one person takes lots of medicines, is common, especially in older adults. Polypharmacy can lead to problems, as drug can often interact causing negative effects, and some people experience side effects from their medications. Prescribing errors and mistakes with medicines are also common, especially when people are taking several different medications.
