Multi-million pound award aims to create new breakthrough therapies

A health consortium has been awarded £7 million by Innovate UK to ensure more patients benefit from a new generation of breakthrough therapies

A recently formed health consortium, jointly led by the National Institute for Health Research Birmingham Biomedical Research Centre (NIHR BRC) and NHS Wales, has been awarded £7 million by Innovate UK to ensure more patients benefit from a new generation of breakthrough therapies.

The Midlands and Wales collaborative is one of only three centres in Britain awarded funding from the Industrial Strategy Challenge Fund by Innovate UK, the government’s innovation agency, to develop an advanced therapy treatment centre.

The Midlands & Wales Advanced Therapy Treatment Centre (MW-ATTC) will operate from four centres: University Hospitals Birmingham NHS Foundation Trust (UHB), Cardiff and Vale University Health Board, Abertawe Bro Morgannwg University Health Board and Nottingham University Hospital.

The NIHR Birmingham BRC is a partnership between University Hospitals Birmingham NHS Foundation Trust and the University of Birmingham, and has a long-standing track record in cell therapy innovation and translation. NHS Wales will be joint lead for this centre, though the Welsh Blood Service (WBS), Velindre NHS Trust.

Its vision is to enable UK Advanced Therapy Medicinal Product (ATMP) companies to reach the clinical market, whilst building clinical capacity across the UK to benefit patient outcomes.

ATMPs, which can be cell or gene therapies, show great potential in treating patients with conditions that cannot be cured with current treatments. These include arthritis, liver disease, several types of cancer, and diabetic ulcers.

Professor Philip Newsome, Director of the Midlands-Wales Advanced Therapy Treatment Centre, Director of the University of Birmingham’s Centre for Liver Research and Honorary Consultant Hepatologist at UHB, said: “The anticipated Advanced Therapy Treatment Centre outputs will ultimately give patients with challenging illnesses access to breakthrough medicines.

“We will demonstrate that the UK is an excellent location for advanced therapy medicinal product research and development by working together for patients and innovators, to reinforce the UK's position as a world leader in this important field.”

ATMPs are just beginning to be available, with the UK playing a leading role.
However, even when new ATMP therapies are developed and shown to be effective, there are major challenges in rolling them out to patients. The MW-ATTC will address these challenges.

Catherine O’Brien, Director of the Welsh Blood Service and consortium lead for NHS Wales said: “The programme will cover aspects of advanced therapy development, deployment and practical consideration for the pathway, from diagnosis to delivery of treatments in a clinical setting. The collaborative brings together a wide range of expertise to deliver these developments in routine clinical practice.”

The combined expertise of the project’s industrialists, clinicians, academics
and computer system experts will work with major teaching hospitals across the Midlands and Wales, reaching almost 15 million people and providing a unique opportunity to set up cell therapy to succeed.

The MW-ATTC project will last for three years and is funded by a total of £9 million, with an additional £2 million from further revenues on top of the £7 investment from Innovate UK.

Collaborations in Leeds/Newcastle/Edinburgh - the Northern Alliance - and a Manchester group (iMatch), will also be establishing advanced therapies treatment centres at the same time and, together with the Midlands-Wales consortium, will ensure the project benefits are implemented nationally as part of the bid requirements. The Cell and Gene Therapy Catapult will play a co-ordination role for the network and provide support to the network.

The partners in the Midlands-Wales consortium all have specific expertise in different aspects of delivering advanced therapies. They are Asymptote Limited (part of GE Healthcare), Thermo Electron Limited, Trakcel Limited, Cellular Therapeutics Ltd, Rexgenero Limited, NHS Blood and Transplant, World Courier (UK) Limited, Cell Medica Limited, Nottingham University Hospitals NHS Trust, Miltenyi Biotec Limited and Orbsen Therapeutics UK Ltd.

The network co-ordinated by the Cell & Gene Therapy Catapult will increase the capacity of the NHS to deliver these disruptive medicines by developing systems and processes within the trusts and hospitals capable of delivering advanced therapies to patients. We plan to share the learnings and systems from the network to other centres in the UK. Once established, the systems could potentially be rolled out as a global model for the adoption of advanced therapies.

The potential commercial and economic value of this sector is large with estimates that it could generate £10bn in revenue for the UK and 18,000 industry jobs by 2035. Locally over the next five years, we expect the project to create 175 high value jobs in industry and within the NHS, and our industrialist partners will develop new therapies, products, services fit for deployment across the NHS.


Ends

For more information or to arrange interviews with Professor Philip Newsome contact Emma McKinney, Communications Manager (Health Sciences), University of Birmingham, on 0121 414 6681.

Notes to Editor:

  • The University of Birmingham is ranked amongst the world’s top 100 institutions. Its work brings people from across the world to Birmingham, including researchers, teachers and more than 5,000 international students from over 150 countries.
  • University Hospitals Birmingham NHS Foundation Trust (UHB) is one of the highest performing healthcare organisations in Europe with a proven international reputation for its quality of care, information technology, clinical education and training and research. UHB is a regional centre for cancer, has the second largest renal dialysis programme in the UK and has the largest solid organ transplantation programme in Europe. It also provides a series of highly specialist cardiac and liver services and is a major specialist centre for burns and plastic surgery. The Trust is also a regional Neuroscience and Major Trauma Centre and is world-renowned for its trauma care. The Trust employs more than 9,000 staff and runs the largest single site hospital in the country.
  • Birmingham Health Partners is a strategic alliance between the NHS and University of Birmingham, which sits at the centre of a regional population of over five million people. Accelerating patient access to new, innovative medicines and technologies is at the heart of what the organisation does. Excellent academics and clinicians working together, along with a very large and diverse catchment area, give Birmingham and the broader West Midlands a comparative advantage in translational research, in particular clinical trialling.
  • The National Institute for Health Research (NIHR): improving the health and wealth of the nation through research. Established by the Department of Health, the NIHR:
  1. funds high quality research to improve health
  2. trains and supports health researchers
  3. provides world-class research facilities
  4. works with the life sciences industry and charities to benefit all
  5. involves patients and the public at every step
  6. For further information, visit the NIHR website 


• The Welsh Blood Service is an operational division of Velindre NHS Trust and delivers the collection, processing and distribution of blood components to all hospitals in Wales. It also provides clinical and technical support services for the organ transplant and haematopoietic stem cell transplant programme in Wales. It manages the Welsh Bone Marrow Donor Registry.

• Velindre NHS Trust is managerially responsible for the Welsh Blood Service and Velindre Cancer Centre. The Trust also hosts the NHS Wales Informatics Service, National Shared Services Partnership And Heath Technology Wales.