Birmingham Centre for Genome Biology

The Birmingham Centre for Genome Biology (BCGB) brings together experts from across the University of Birmingham who are working in diverse settings and research fields but who share the goal of understanding at a deep molecular level several key aspects of how genomes function.

Epigenetics & Gene Regulation

Understanding how cellular signals impact upon transcription factors and chromatin to control developmentally regulated gene expression and epigenetic modifications.

DNA Replication & Repair

Investigating mechanisms controlling the replication and maintenance of the genome, with a major focus on the DNA damage response and DNA repair, and genome stability.

Computational Biology

Understanding complex genetic data, and developing statistical methods for this purpose.

Second Birmingham Symposium

Thursday 4th-Friday 5th July 2019 Two day symposium on Genome Biology from genome stability and genetics to gene expression control

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Latest News FOR BCGB:

BCGB members braved the bad weather to go on the 2019 away day in June in the Malvern Hills. This year they climbed the highest peak in the Malvern Hills, arriving just as the mist and rain cleared. A memorable hike in challenging conditions was followed up by the BCGB dinner in Malvern.

Many of our BCGB members have shared in having exceptional recent success with both grant funding and publications based on their ground-breaking research (see below).

Dr Jo Parish and Dr Clare Davies were both promoted to Reader.

Professor Ian Tomlinson was elected as a Fellow of the Royal Society.

New grant awards for BCGB:

Recent major grants awarded to members of BCGB include

  • 3 CRUK Programme grants awarded to Dr Eva Petermann, Professor Jo Morris and Professor Tanja Stankovic
  • 2 Wellcome Trust awards to Dr Aga Gambus and Professor Ian Tomlinson
  • 3 Research council grants awarded to Professor Constanze Bonifer and Professor Peter Cockerill, Dr Padma-Sheela Jayaraman, Dr Marco Saporano, and Dr Eva Petermann

(See recent grant funding from BCGB group leaders  for a full listing of new grant awards)

BCGB Seminar series:

See the news and events section for a full listing of seminars. 

Major publications FOR BCGB:

There have already been about 20 high profile publications in 2018 and 2019 coming out of BCGB laboratories.

Professor Jo Morris published a paper in Nature describing a novel mechanism regulating the structure of the BRCA1 protein and how mutations in breast cancer prevent the BRCA1 protein from adopting the correct structure.

Professor Conny Bonifer and Professor Peter Cockerill published a series of 3 inter-related papers in Nature Genetics and Cancer Cell defining gene regulatory networks and therapeutic targets in acute myeloid leukaemia.

Professor Grant Stewart and Dr Martin Higgs had a publication in Molecular Cell showing how histone methylation protects against DNA damage.

Dr Aditi Kanhere had a publication in EMBO J on the role of JARID2 in cell differentiation.

Dr Aga Gambus published a study in Nature Cell Biology on the role of ubiquitin in DNA replication.

Professor Jo Morris had a paper in genes and Development on the role of SUMO in DNA repair.

Dr Sheela Jayaraman, Dr Eva Petermann, Dr Pawel Grzechnik, Professor Ferenc Mueller and Dr Chris Yau each had a publication in Nature Communications. 

 (see the publications section for a full listing of publications)