News and Events

Latest News

STOP-ACEi extension approved

We are delighted to confirm that the EME funding committee have agreed to support an extension to the STOP-ACEi trial. This extension will allow the planned 3 years of follow-up to be completed for all the participants.  This is really fantastic news as it will ensure as complete a dataset as possible for analysis of the primary outcome, which is measured at the 3 year time point.


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Events

STOP-ACEi Research Nurse Teleconferences

The teleconferences are aimed at staff that are involved in the practical running of the trial such as research nurses and data managers. If you do not already receive an invite to these events and would like to call in then please contact the STOP-ACEi team.

  • Wednesday 12 June 2019, 3pm
  • Thursday 12 September 2019, 2pm
  • Tuesday 3 December 2019, 3pm

Archive News and Events

STOP-ACEi Sponsor Changes Name

The sponsor for the STOP-ACEi trial have recently changed their name. They are now called Hull University Teaching Hospitals NHS Trust.

STOP-ACEi Reaches Recruitment Target

The STOP-ACEi trial has reached it's recruitment target of 410 participants. This will give us the statistical power needed to answer our clinical question – whether it is best to STOP or CONTINUE use of ACEi and ARBs in advanced CKD. Thank you to all our patients and participating sites.

Key Milestone Reached

An important milestone for the trial has just been reached. The very first STOP-ACEi participant has recently completed their final trial visit, bringing to an end 3 years of follow-up.

STOP-ACEi Investigator Meeting 2017

The STOP-ACEi Investigator Meeting 2017 was held on 12th September in Sheffield. Thank you to all the attendees. Please see the STOP-ACEi Meetings page for further information and copies of the presentation slides.

STOP-ACEi research nurse teleconferences

The teleconferences are aimed at staff that are involved in the practical running of the trial such as research nurses and data managers. If you do not already receive an invite to these events and would like to call in then please contact the STOP-ACEi team.

  • Thursday 17 August 2017, 2pm
  • Thursday 12 October 2017, 2pm

300 patients recruited

The total number of patients recruited into the STOP-ACEi trial has now exceeded 300. Thank you to all our researchers and patients. Up-to-date recruitment numbers can be found on the STOP-ACEi recruitment page.

First centre opens in Northern Ireland

Welcome to the team at Antrim Area Hospital, Northern Health and Social Care Trust who opened to recruitment in February 2017. There are now 34 centres open to patient recruitment for STOP-ACEi with more currently in set-up.

STOP-ACEi investigator meetings 2016

The STOP-ACEi Investigator Meetings were held on 1st September and 2nd September in London and Leeds. Thank you to everyone that attended. Please see the STOP-ACEi Meetings page for further information and copies of the presentation slides.

Over 1000 follow-up forms now received

A clinical trial is useless if it does not collect the data necessary to address the research question. We are delighted to say that we have now received over 1000 participant follow-up forms and nearly 300 completed Quality of Life Questionnaires. This demonstrates the huge effort made by every patient, doctor, nurse, data manager and collaborator involved in the trial. Thank you for your important contribution.

Chief Investigator and collaborators publish review on use of ACE Inhibitors and ARBs in advanced CKD

Anyone involved in STOP-ACEi might be interested to read this review, recently published in NEPHRON: https://www.karger.com/Article/FullText/447068

200 patients recruited!

The total number of patients recruited into the STOP-ACEi trial has now exceeded 200. Thank you to all our researchers and patients. Up-to-date recruitment numbers can be found on the STOP-ACEi recruitment page.

UK Kidney Week, 7th - 10th June 2016

UK Kidney Week 2016 takes place at the ICC Birmingham in June. A STOP-ACEi poster will be on display at the UK Kidney Research Consortium stand. A STOP-ACEi update meeting will also take place during the event. More information on this meeting will be sent out soon however if you are interested in attending then please contact the STOP-ACEi team. We look forward to seeing you there.

STOP-ACEi Investigator Teleconferences, February 2016

A series of teleconferences will be held for STOP-ACEi investigators to discuss the study. We hope that all interested investigators will be able to call in on one of the following dates:

  • Monday 15th February 2016, 17:00-18:00
  • Thursday 18th February 2016, 17:00-18:00
  • Monday 22nd February 2016, 17:00-18:00

First STOP-ACEi publication!

We are very pleased to say that a paper describing the rationale and design of the STOP-ACEi trial was published in October 2015 in Nephrology Dialysis Transplantation. Details are on the publications page, and the full paper is available here.

Research nurse teleconferences

Due to their popularity, a joint teleconference for research nurses and other trial support staff at participating centres will be held every month. Teleconference details will be sent out to participating patient recruitment centres. The dates for upcoming meetings are:

  • Thursday 15th October, 3pm
  • Monday 9th November, 3pm
  • Tuesday 8th December, 3pm
  • Wednesday 20th January, 3pm

100 Patients and counting

July 2015 set a new record for total patients recruited in one month at 19. The total recruitment for STOP-ACEi has now reached the milestone of 100 patients. Thank you to all the STOP-ACEi collaborators for all their hard work.

With 25 centres now open and more to follow we hope that recruitment will continue to improve. Up-to-date recruitment numbers can be found on the STOP-ACEi recruitment page.

British Renal Society Conference 2015

Professor Sunil Bhandari and Marie Valente both attended the conference and a STOP-ACEi poster was presented. Feedback was very positive and several new sites showed an interest in taking part in the study.

Closing in on 100!

June 2015 set a new record for total patients recruited in one month at 16. The total recruitment for the trial is now fast approaching 100. Thank you to all the STOP-ACEi collaborators for all their hard work.

With 23 centres now open and more to follow we hope that recruitment will continue to improve. Up-to-date recruitment numbers can be found on the STOP-ACEi recruitment page.

50 Participants and Counting!

We are pleased to announce that we have now recruited over 50 participants to the STOP-ACEi trial. Thank you to all the STOP-ACEi callaborators for all their hard work.

With 20 centres now open and more opening soon we hope that recruitment will continue to climb. Up-to-date recruitment numbers can be found on the STOP-ACEi recruitment page.

Investigator Meeting - 1 May 2015

The STOP-ACEi Investigator Meeting was held on 1 May 2015 at the University of Birmingham Medical School. The event was a big success - thank you to everyone that attended. Please see the STOP-ACEi Meetings page for further information and copies of the presentation slides.

First STOP-ACEi participant recruited!

We are delighted to announce that STOP-ACEi recruited its first participant on Friday 11th July 2014. Thank you to Professor Sunil Bhandari and his team at Hull Royal Infirmary for recruiting the first patient.

Thank you to all the STOP-ACEi collaborators that are working hard to set up STOP-ACEi at their centre. We hope to see other centres approved and recruiting very soon.

Investigator Launch Meeting - 3rd April 2014

The STOP-ACEi Investigator Launch Meeting was held on 3rd April 2014 at the University of Birmingham conference park. The event was a great success - thank you to all that attended. Please see the STOP-ACEi Meetings page for further information and copies of the presentation slides.

STOP-ACEi approvals

REC approval for STOP-ACEi was received on 29th January 2014 (Ref.: 13/YH/0394).  MHRA CTA approval was received on 12th December 2013 (Ref.: 21411/0242/001-0001).

The lead R&D application is currently in process and the study has been adopted onto the UK CRN Portfolio.

STOP-ACEi is currently in set-up and we aim to start recruitment in June 2014.

STOP-ACEi grant starts

STOP-ACEi is funded by the NIHR/MRC EME Programme (Ref. 11/30/07) and the project officially started on 1st Feb 2014.